Body temperature regulation in diabetes

Kenny, Glen P.; Sigal, Ronald J.; McGinn, Ryan

doi:10.1080/23328940.2015.1131506

Cited by 297Thermoregulation and physiological responsesCardiovascular and exercise physiologyEffects of Environmental Stressors on Livestock

Body temperature regulation in diabetes

Open access

Kenny, Glen P., Sigal, Ronald J., McGinn, Ryan·2016·Temperature

DOI 10.1080/23328940.2015.1131506PMC PMC4861190

Open this paper in CoChat — free account Open PDF

Abstract

The effects of type 1 and type 2 diabetes on the body's physiological response to thermal stress is a relatively new topic in research. Diabetes tends to place individuals at greater risk for heat-related illness during heat waves and physical activity due to an impaired capacity to dissipate heat. Specifically, individuals with diabetes have been reported to have lower skin blood flow and sweating responses during heat exposure and this can have important consequences on cardiovascular regulation and glycemic control. Those who are particularly vulnerable include individuals with poor glycemic control and who are affected by diabetes-related complications. On the other hand, good glycemic control and maintenance of aerobic fitness can often delay the diabetes-related complications and possibly the impairments in heat loss. Despite this, it is alarming to note the lack of information regarding diabetes and heat stress given the vulnerability of this population. In contrast, few studies have examined the effects of cold exposure on individuals with diabetes with the exception of its therapeutic potential, particularly for type 2 diabetes. This review summarizes the current state of knowledge regarding the impact of diabetes on heat and cold exposure with respect to the core temperature regulation, cardiovascular adjustments and glycemic control while also considering the beneficial effects of maintaining aerobic fitness.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1080/23328940.2015.1131506

Cites

191 of 191 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Hypoglycemia is known to qualitatively increase sweating rates as the body seeks to lower core temperature to conserve energy.
“For example, hypoglycemia is known to qualitatively increase sweating rates as the body seeks to lower core temperature to conserve energy52.”
From A wearable patch for continuous analysis of thermoregulatory sweat at rest (2021) · cites this paper as [52]
The ‘Glycemic control during thermal stress’ section says hypoglycemia causes marked increases in sweating through sympathetic activation. It says core temperature may decrease during rest, but does not say that the body increases sweating to conserve energy; it also cautions that any benefit may disappear during whole-body heat stress. Page numbers were not available in our copy. (LLM, conf=0.90)
Experimental — accuracy not yet measured
People with diabetes mellitus have lower skin blood flow and dysregulated thermoregulatory responses during heat exposure.
“Furthermore, people with DM have been reported to have lower skin blood flow and dysregulated thermoregulatory responses during heat exposure, which is associated with dysregulated thermal, cardiovascular, and glycemic control6–8.”
From Sleep and temperature data from wearable devices support noninvasive detection of diabetes mellitus in a large-scale, retrospective analysis (2026) · cites this paper as [6]
Features of sleep-wake time series can directly capture insomnia-like patterns in sleep related to diabetes mellitus.
“Similarly, features of sleep-wake time series can directly capture insomnia-like patterns in sleep related to DM6,34,43,44.”
From Sleep and temperature data from wearable devices support noninvasive detection of diabetes mellitus in a large-scale, retrospective analysis (2026) · cites this paper as [6]
The Type 1 diabetes > Heat stress passages discuss sweating, skin blood flow, and body heat storage, not sleep. Searches for “sleep,” “insomnia,” and “actigraphy sleep-wake time series” found no passage in our copy addressing whether time-series features capture diabetes-related insomnia-like patterns. (LLM, conf=0.75)
Experimental — accuracy not yet measured
Within a night, the complexity of the distal body temperature time series is related to the autonomic nervous system's health during sleep.
“Within a night, the complexity of the distal body temperature time series has been related to the autonomic nervous system’s (ANS) health during sleep6,34.”
From Sleep and temperature data from wearable devices support noninvasive detection of diabetes mellitus in a large-scale, retrospective analysis (2026) · cites this paper as [6]
The Basic temperature regulation > Heat stress and Type 1 diabetes > Heat stress passages discuss skin blood flow, sweating, and neuropathy, but not the complexity of distal temperature time series during sleep. Searches for sleep, nocturnal temperature, time-series complexity, and entropy found no passage addressing the claimed relationship; page numbers were unavailable in our copy. (LLM, conf=0.76)
Experimental — accuracy not yet measured

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

International Diabetes Federation 2017
Carracher, A. M., Marathe, P. H., & Close, K. L. (2018) · Journal of Diabetes · doi:10.1111/1753-0407.12644 · Cited by 13,369 · see citing works
Type 1 diabetes
Atkinson, M. A., Eisenbarth, G. S., & Michels, A. W. (2014) · The Lancet · doi:10.1016/s0140-6736(13)60591-7 · Cited by 2,713 · see citing works
Heat Stroke
Bouchama, A., & Knochel, J. P. (2002) · New England Journal of Medicine · doi:10.1056/nejmra011089 · Cited by 1,898 · see citing works
Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future
Kahn, S. E., Cooper, M. E., & Del Prato, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)62154-6 · Cited by 1,743 · see citing works
The Effects of Climate Change on Cardiac Health
De Blois, J., Kjellstrom, T., Agewall, S., Ezekowitz, J. A., Armstrong, P. W., & Atar, D. (2015) · Cardiology · doi:10.1159/000398787 · Cited by 1,697 · see citing works
Physical Activity Advice Only or Structured Exercise Training and Association With HbA <sub>1c</sub> Levels in Type 2 Diabetes: A Systematic Review and Meta-analysis
Umpierre, D. (2011) · JAMA · doi:10.1001/jama.2011.576 · Cited by 1,358 · cited 2× · see citing works
“A recent meta-analysis by Umpierre et al.181 reported a mean decrease in HbA1c following a structured exercise intervention >12 weeks of ~0.7%.”
MethodInfluential
UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality
Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318 · cited 1× · see citing works
“The activity of brown adipose tissue has been shown to be characterized by uncoupling protein-1, a mitochondrial protein, and has been reported to have a pronounced role inwhole-body thermogenesis even under resting conditions.(155) While brown adipose tissue activity is reported to be relatively lower in individuals…”
Background
Projection of the year 2050 burden of diabetes in the US adult population: dynamic modeling of incidence, mortality, and prediabetes prevalence
Boyle, J. P., Thompson, T. J., Gregg, E. W., Barker, L. E., & Williamson, D. F. (2010) · Population Health Metrics · doi:10.1186/1478-7954-8-29 · Cited by 1,309 · cited 1× · see citing works
“Advanced age is a particularly important risk factor for type 2 diabetes, with diabetes prevalence rate reaching as high as 33% in older adults who are obese.(190) Given that the mean age of the workforce is increasing rapidly, employers are faced increasingly with the challenge of accommodating individuals with chron…”
Background
Genetics, pathogenesis and clinical interventions in type 1 diabetes
Bluestone, J. A., Herold, K., & Eisenbarth, G. (2010) · Nature · doi:10.1038/nature08933 · Cited by 1,265 · cited 1× · see citing works
“Type 1 diabetes was formerly known as juvenile diabetes due to its common presentation in children and adolescents, and is characterized by the endocrine pancreas ceasing to produce insulin following the immune-mediated destruction of b-islet cells.(2)”
BackgroundInfluential
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1.9 million people
Shah, A. D., Langenberg, C., Rapsomaniki, E., Denaxas, S., Pujades-Rodriguez, M., Gale, C. P., Deanfield, J., Smeeth, L., Timmis, A., & Hemingway, H. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70219-0 · Cited by 1,225 · see citing works
Brown adipose tissue regulates glucose homeostasis and insulin sensitivity
Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180 · cited 1× · see citing works
“exposure activates brown adipose tissue which is highly metabolically active and oxidizes triglycerides and glucose as fuel.(154) The activity of brown adipose tissue has been shown to be characterized by uncoupling protein-1, a mitochondrial protein, and has been reported to have a pronounced role inwhole-body thermo…”
Background
Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes.
Bucala, R., Tracey, K. J., & Cerami, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115014 · Cited by 1,162 · see citing works
Centers for Disease Control and Prevention. State Indicator Report on Physical Activity, 2014. Atlanta, GA: U.S. Department of Health and Human Services; 2014
McGuire, S. (2014) · Advances in Nutrition · doi:10.3945/an.114.007211 · Cited by 1,122 · see citing works
Emerging epidemic of type 2 diabetes in youth
Rosenbloom, A. L., Joe, J. R., Young, R. S., & Winter, W. E. (1999) · Diabetes Care · doi:10.2337/diacare.22.2.345 · Cited by 1,019 · cited 1× · see citing works
“Type 2 diabetes tends to present later in life with a mean onset age of 54 years,(94) although the mean age at diagnosis is rapidly decreasing(95) due in part to the longstanding increase in diagnosis in the pediatric population.(96) In general, type 2 diabetes is linked to general health status and lifestyle as it ha…”
Background
Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
Williams, S. B., Cusco, J. A., Roddy, M.-A., Johnstone, M. T., & Creager, M. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00522-6 · Cited by 1,014 · see citing works
Excess Mortality among Persons with Type 2 Diabetes
Tancredi, M., Rosengren, A., Svensson, A., Kosiborod, M., Pivodic, A., Guðbjörnsdóttir, S., Wedel, H., Clements, M. A., Dahlqvist, S., & Lind, M. (2015) · New England Journal of Medicine · doi:10.1056/nejmoa1504347 · Cited by 996 · see citing works
Incidence of diabetes in youth in the United States
SEARCH for Diabetes in Youth Study Group*, T. W. G. F. T. (2007) · JAMA · doi:10.1001/jama.297.24.2716 · Cited by 991 · see citing works
Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans
Ouellet, V., Labbé, S. M., Blondin, D. P., Phoenix, S., Guérin, B., Haman, F., Turcotte, É. E., Richard, D., & Carpentier, A. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60433 · Cited by 985 · cited 1× · see citing works
“On the other hand, non-shivering thermogenesis is primarily mediated by metabolically active brown adipose tissue.(38) Although shivering is undoubtedly the major contributor to increases in heat production, studies postulate that non-shivering thermogenesis remains an important physiological response especially durin…”
Background
Effects of Different Modes of Exercise Training on Glucose Control and Risk Factors for Complications in Type 2 Diabetic Patients
Snowling, N. J., & Hopkins, W. G. (2006) · Diabetes Care · doi:10.2337/dc06-1317 · Cited by 813 · see citing works
Heat stress in older individuals and patients with common chronic diseases
Kenny, G. P., Yardley, J., Brown, C., Sigal, R. J., & Jay, O. (2010) · Canadian Medical Association Journal · doi:10.1503/cmaj.081050 · Cited by 771 · cited 1× · see citing works
“hypertension.(139) During heat stress, especially during exercise in the heat, hypertensive individuals experience greater elevations in blood pressure due to increased peripheral resistance which can restrict heat loss due to the reductions skin blood flow, which ultimately lead to more pronounced increases in core t…”
BackgroundSelf-citation
The Association Between Cardiovascular Autonomic Neuropathy and Mortality in Individuals With Diabetes
Maser, R. E., Mitchell, B. D., Vinik, A. I., & Freeman, R. L. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1895 · Cited by 678 · cited 1× · see citing works
“For instance, type 2 diabetes is associated with reduced sympathetic neural control of blood pressure(123) which manifests as greater orthostatic intolerance compared to age-matched controls.(124) In addition, individuals with type 2 diabetes exhibit a decline in baroreflex sensitivity(125) which is closely associated…”
Background
Regulation of Internal Body Temperature
Hammel, H. T., & Pierce, J. B. (1968) · Annual Review of Physiology · doi:10.1146/annurev.ph.30.030168.003233 · Cited by 626 · cited 1× · see citing works
“function]) mechanisms.(32,33) In the context of wholebody heat loss under heat stress conditions which are compensable (i.”
Background
Excess hospital admissions during the July 1995 heat wave in Chicago
Semenza, J. (1999) · American Journal of Preventive Medicine · doi:10.1016/s0749-3797(99)00025-2 · Cited by 619 · cited 1× · see citing works
“In fact, individuals with type 2 diabetes have up to a 56% greater risk for hospitalization and/or mortality during a heat wave.(106) One recent study assessed the influence of age and type 2 diabetes during passive heat exposure in a room set at 43 C for 3 hours.”
Background
Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus
Hanssen, M. J. W., Joris Hoeks, J., Brans, B. T., van der Lans, A. A. J. J., Schaart, G., van den Driessche, J. J., Jörgensen, J. A., Boekschoten, M. V., Hesselink, M. K. C., Havekes, B., et al. (2015) · Nature Medicine · doi:10.1038/nm.3891 · Cited by 587 · cited 2× · see citing works
“In fact, Hanssen et al.157 reported that only 10 days of cold acclimation (14- 15 C) in individuals with type 2 diabetes induced a 43% increase in insulin sensitivity which was explained by a 60% increase in GLUT-4 translocation (i.e., themembrane channel that allows glucose to enter amuscle cell or adipocyte).”
Background
Genetics of type 1A diabetes
Concannon, P., Rich, S. S., & Nepom, G. T. (2009) · New England Journal of Medicine · doi:10.1056/nejmra0808284 · Cited by 510 · see citing works
Dysfunction of Endothelial Nitric Oxide Synthase and Atherosclerosis
Kawashima, S., & Yokoyama, M. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000125114.88079.96 · Cited by 455 · cited 1× · see citing works
“adversely alter endothelial function through interfering with nitric oxide signaling.(110) In fact, one study reported that the relative nitric oxide-dependent vasodilation during whole-body passive heating was similar between healthy controls and those with type 2 diabetes; however, absolute skin blood flow was lower…”
Background
DIABETES MELLITUS
Himsworth, H. P. (1936) · The Lancet · doi:10.1016/s0140-6736(01)36134-2 · Cited by 441 · see citing works
What are the health benefits of physical activity in type 1 diabetes mellitus? A literature review
Chimen, M., Kennedy, A., Nirantharakumar, K., Pang, T. T., Andrews, R., & Narendran, P. (2012) · Diabetologia · doi:10.1007/s00125-011-2403-2 · Cited by 438 · see citing works
The Concurrent Accumulation of Intra-Abdominal and Subcutaneous Fat Explains the Association Between Insulin Resistance and Plasma Leptin Concentrations
Cnop, M., Landchild, M. J., Vidal, J., Havel, P. J., Knowles, N. G., Carr, D. R., Wang, F., Hull, R. L., Boyko, E. J., Retzlaff, B. M., et al. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1005 · Cited by 432 · see citing works
Increased platelet and red cell counts, blood viscosity, and plasma cholesterol levels during heat stress, and mortality from coronary and cerebral thrombosis
Keatinge, W. R., Coleshaw, S., Easton, J. C., Cotter, F. E., Mattock, M. B., & Chelliah, R. (1986) · The American Journal of Medicine · doi:10.1016/0002-9343(86)90348-7 · Cited by 400 · cited 1× · see citing works
“Dehydration associated with prolonged exposure to extreme heat conditions can induce significant alterations of blood composition (increased in red blood cell count, blood viscosity and platelet counts) which, if left unchecked, can increase the risk of coagulation, and subsequently cerebral and coronary thromboses.(1…”
Background
Weight Gain at the Time of Menopause
Wing, R. R. (1991) · Archives of Internal Medicine · doi:10.1001/archinte.1991.00400010111016 · Cited by 394 · see citing works
Who is Sensitive to Extremes of Temperature?: A Case-Only Analysis
Schwartz, J. (2005) · Epidemiology · doi:10.1097/01.ede.0000147114.25957.71 · Cited by 387 · cited 2× · see citing works
“Individuals with types 1 and 2 diabetes are reported to be particularly vulnerable during extreme heat events as they account for a disproportionate number of hospitalizations and deaths.(19) The most recently published physical activity recommendations for individuals with diabetes highlight their susceptibility to a…”
Background
Restoration of Muscle Mitochondrial Function and Metabolic Flexibility in Type 2 Diabetes by Exercise Training Is Paralleled by Increased Myocellular Fat Storage and Improved Insulin Sensitivity
Meex, R. C. R., Schrauwen-Hinderling, V. B., Moonen-Kornips, E., Schaart, G., Mensink, M., Phielix, E., van de Weijer, T., Sels, J.-P., Schrauwen, P., & Hesselink, M. K. C. (2010) · Diabetes · doi:10.2337/db09-1322 · Cited by 355 · cited 1× · see citing works
“Surprisingly, these improvements in insulin sensitivity surpass even those of long-term exercise training which is currently regarded as the best management strategy for type 2 diabetes.(158) Taken together, it appears that mild cold exposuremay be useful for themanagement of type 2 diabetes as a third lifestyle facto…”
Background
Impact of physical activity on glycemic control and prevalence of cardiovascular risk factors in adults with type 1 diabetes: a cross-sectional multicenter study of 18,028 patients
Bohn, B., Herbst, A., Pfeifer, M., Krakow, D., Zimny, S., Kopp, F., Melmer, A., Steinacker, J. M., & Holl, R. W. (2015) · Diabetes Care · doi:10.2337/dc15-0030 · Cited by 321 · cited 1× · see citing works
“Individuals with type 1 diabetes are known to be at increased risk for cardiovascular disease and hypertension;(13) however, this can be minimized by healthy habits including physical activity and good glycemic control.(75) On the other hand, baroreflex sensitivity has been reportedly reduced with type 1 diabetes in r…”
Background
Thermometry, Calorimetry, and Mean Body Temperature during Heat Stress
Kenny, G. P., & Jay, O. (2013) · Comprehensive physiology · doi:10.1002/cphy.c130011 · Cited by 314 · see citing works
Self-citation
Cardiovascular function in the heat‐stressed human
Crandall, C. G., & González‐Alonso, J. (2010) · Acta Physiologica · doi:10.1111/j.1748-1716.2010.02119.x · Cited by 314 · cited 1× · see citing works
“Therefore, while any impairments in resting cardiovascular function are minimal or non-detectable, individuals with type 1 diabetes may be at increased risk for cardiovascular-related limitations under stress such as during exercise, especially when performed in the heat due to the exponential increase in the requirem…”
Background
Maillard Reaction-Mediated Molecular Damage to Extracellular Matrix and Other Tissue Proteins in Diabetes, Aging, and Uremia
Monnier, V. M., Sell, D. R., Nagaraj, R. H., Miyata, S., Grandhee, S. K., Odetti, P. R., & Ibrahim, S. A. (1992) · Diabetes · doi:10.2337/diab.41.2.s36 · Cited by 309 · cited 1× · see citing works
“, diabetes tends to accelerate any age-related changes).(45,147)”
Background
Type 1 diabetes and coronary artery disease
Orchard, T. J., Costacou, T., Kretowski, A., & Nesto, R. W. (2006) · Diabetes Care · doi:10.2337/dc06-1161 · Cited by 305 · see citing works
Increased Brown Adipose Tissue Oxidative Capacity in Cold-Acclimated Humans
Blondin, D. P., Labbé, S. M., Tingelstad, H. C., Noll, C., Kunach, M., Phoenix, S., Guérin, B., Turcotte, É. E., Carpentier, A. C., Richard, D., et al. (2014) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-3901 · Cited by 300 · see citing works
Meta-analysis of the age-associated decline in maximal aerobic capacity in men: relation to training status
Wilson, T. M., & Tanaka, H. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.3.h829 · Cited by 298 · see citing works
Changes in Age at Diagnosis of Type 2 Diabetes Mellitus in the United States, 1988 to 2000
Koopman, R. J. (2005) · The Annals of Family Medicine · doi:10.1370/afm.214 · Cited by 291 · see citing works
Age alters the cardiovascular response to direct passive heating
Minson, C. T., Wladkowski, S. L., Cardell, A. F., Pawelczyk, J. A., & Kenney, W. L. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.84.4.1323 · Cited by 288 · cited 2× · see citing works
“Minson et al.(140) showed that older men have a markedly lower increase in total blood flow directed to the skin during a passive heat stress maintained to the individual’s limit of thermal tolerance.”
Background
Thermoregulatory Sweating Abnormalities in Diabetes Mellitus
Fealey, R. D., Low, P. A., & Thomas, J. E. (1989) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(12)65338-5 · Cited by 274 · cited 2× · see citing works
“The primary factors associated with this decrease in sweating include longstanding diabetes, poor glycemic control, and the presence of neuropathy which seem to have an important role in altering the peripheral properties of the sweat glands.(54,111) For instance, the sweat glands from individuals with type 2 diabetes…”
Background
Mechanisms of Heat Exchange: Biophysics and Physiology
Gagge, A. P., & Gonzalez, R. R. (1996) · Comprehensive physiology · doi:10.1002/cphy.cp040104 · Cited by 272 · see citing works
Intermittent high glucose enhances ICAM-1, VCAM-1 and E-selectin expression in human umbilical vein endothelial cells in culture: The distinct role of protein kinase C and mitochondrial superoxide production
QUAGLIARO, L., PICONI, L., ASSALONI, R., DAROS, R., MAIER, A., ZUODAR, G., & CERIELLO, A. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2005.03.015 · Cited by 268 · cited 1× · see citing works
“Importantly, these effects are strongly dependent upon glycemic control, albeit it has been postulated that episodes of acute hyperglycemia exert more damage than chronically poor management of glycemia.(118)”
Background
Physical Activity and Diabetes
Sigal, R. J., Armstrong, M. J., Colby, P., Kenny, G. P., Plotnikoff, R. C., Reichert, S. M., & Riddell, M. C. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.01.018 · Cited by 256 · see citing works
Self-citation
Resistance Versus Aerobic Exercise
Yardley, J. E., Kenny, G. P., Perkins, B. A., Riddell, M. C., Balaa, N., Malcolm, J., Boulay, P., Khandwala, F., & Sigal, R. J. (2013) · Diabetes Care · doi:10.2337/dc12-0963 · Cited by 250 · see citing works
Self-citation
THE SYMPATHETIC NERVOUS SYSTEM IN DIABETIC NEUROPATHY
Low, P. A., WALSH, J. C., Huang, C. Y., & McLeod, J. G. (1975) · Brain · doi:10.1093/brain/98.3.341 · Cited by 234 · cited 1× · see citing works
“Furthermore, this blunted responsiveness is at least in part attributed to the reduction in the control of blood vessel diameter by the sympathetic nervous system.(45,123) Collectively, there is some evidence to indicate that individuals with type 2 diabetes may be less able to prevent decreases in core temperature as…”
Background
Brown adipose tissue and thermogenesis
Fenzl, A., & Kiefer, F. W. (2014) · Hormone Molecular Biology and Clinical Investigation · doi:10.1515/hmbci-2014-0022 · Cited by 227 · see citing works
Thermoregulatory responses to hypothalamic cooling in unanesthetized dogs
Hammel, H. T., Hardy, J. D., & Fusco, M. M. (1960) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1960.198.3.481 · Cited by 218 · cited 1× · see citing works
“During thermal stress, sensory information is sent from the peripheral (in the skin and muscle) and central (in the brain) thermoreceptors to the pre-optic anterior hypothalamus of the brain which is believed to coordinate thermoeffector responses to achieve heat balance.(26,27)”
Background
Impaired skin microvascular function in children, adolescents, and young adults with type 1 diabetes.
Khan, F., Elhadd, T. A., Greene, S. A., & Belch, J. J. F. (2000) · Diabetes Care · doi:10.2337/diacare.23.2.215 · Cited by 214 · cited 1× · see citing works
“reported similar increases in skin blood flow between non-neuropathic individuals with type 1 diabetes and their healthy counterparts (albeit responses were blunted in neuropathic individuals) whereas other work has shown clear diabetesrelated impairments in skin blood flow.(47,48) In the context of eccrine sweating,…”
Result
Brown adipose tissue activity as a target for the treatment of obesity/insulin resistance
Poher, A.-L., Altirriba, J., Veyrat‐Durebex, C., & Rohner‐Jeanrenaud, F. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00004 · Cited by 213 · cited 1× · see citing works
“Taken together, it appears that mild cold exposuremay be useful for themanagement of type 2 diabetes as a third lifestyle factor (along with diet and exercise) to optimize health.(24,159) However, further examination is required to determine the long-term effects of cold exposure and the optimal exposure level that is…”
Background
Hot-Tub Therapy for Type 2 Diabetes Mellitus
Hooper, P. L. (1999) · New England Journal of Medicine · doi:10.1056/nejm199909163411216 · Cited by 208 · see citing works
Temperature Regulation During Exercise
GISOLFI, C. V., & Wenger, C. B. (1984) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-198401000-00013 · Cited by 202 · cited 1× · see citing works
“One of the strongest determinants of the rate of heat loss is the level of hyperthermia as measured by mean body temperature which has traditionally been defined as a composite of core and skin temperatures.(31) Upon exposure to heat stress (i.”
Background
The biology of the colonizing ape
Wells, J. C. K., & Stock, J. T. (2007) · American Journal of Physical Anthropology · doi:10.1002/ajpa.20735 · Cited by 198 · cited 1× · see citing works
“, finding shelter, adding clothing layers, making fire) must be employed in order to prevent precipitous decreases in core temperature.(34) In addition, multiple physiological processes are activated during cold exposure in order to minimize heat loss and under conditions of severe and/or prolonged cold stress, increa…”
Background
The relative influence of physical fitness, acclimatization state, anthropometric measures and gender on individual reactions to heat stress
Havenith, G., & van Middendorp, H. (1990) · European Journal of Applied Physiology and Occupational Physiology · doi:10.1007/bf00236062 · Cited by 198 · cited 1× · see citing works
“6 and 7).(184,185) However, some have reported no”
Background
Skeletal muscle blood flow independently modulates insulin-mediated glucose uptake
Baron, A., Steinberg, H. O., Brechtel, G., & Johnson, A. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.2.e248 · Cited by 198 · see citing works
Determinants of Exercise Capacity in Patients With Type 2 Diabetes
Fang, Z. Y., Sharman, J. E., Prins, J. B., & Marwick, T. H. (2005) · Diabetes Care · doi:10.2337/diacare.28.7.1643 · Cited by 197 · cited 1× · see citing works
“cardiac output during exercise due to left ventricular diastolic dysfunction.(119,120) Moreover, a recent study has noted a ~20% reduction in exercise capacity in their participants with uncomplicated type 2 diabetes relative to their healthy counterparts.”
Background
Mechanisms and controllers of eccrine sweating in humans
Crandall, C. G. (2009) · Frontiers in Bioscience-Scholar · doi:10.2741/s94 · Cited by 195 · cited 1× · see citing works
“especially during physically activity in the heat, is stimulated by cholinergic nerves to expel sweat onto the skin which is subsequently evaporated.(30) It is the evaporation of sweat that cools the body and as such sweat loss due to dripping provides no thermoregulatory benefit and facilitates a state of progressive…”
Background
Effect of physical training on peripheral sweat production
Buono, M. J., & Sjoholm, N. T. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.65.2.811 · Cited by 185 · cited 1× · see citing works
“6 and 7).(184,185) However, some have reported no”
Background
Impaired defense of core temperature in aged humans during mild cold stress
DeGroot, D. W., & Kenney, W. L. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00074.2006 · Cited by 184 · see citing works
Aerobic exercise and the lipid profile in type 1 diabetic men: a randomized controlled trial
LAAKSONEN, D. E., ATALAY, M., NISKANEN, L. K., MUSTONEN, J., &NA;, C. K., LAKKA, T. A., & UUSITUPA, M. I. J. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200009000-00003 · Cited by 174 · see citing works
A systematic review and meta-analysis of exercise interventions in adults with type 1 diabetes
Yardley, J. E., Hay, J. L., Abou-Setta, A. M., Marks, S. D., & McGavock, J. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.09.038 · Cited by 163 · cited 4× · see citing works
“Despite this, a recent meta-analysis of the randomized trials of aerobic or resistance exercise on glycemic control in individuals with type 1 diabetes by Yardley et al.(169) concluded that there is insufficient evidence to ascertain the effect of exercise training on HbA1c.”
BackgroundInfluential
Measurement and prediction of peak shivering intensity in humans
Eyolfson, D. A., Tikuisis, P., Xu, X., Weseen, G. L., & Giesbrecht, G. G. (2001) · European Journal of Applied Physiology · doi:10.1007/s004210000329 · Cited by 161 · cited 1× · see citing works
“Shivering intensity is dictated by changes in mean body temperature,(36,37) and maximal heat production of a shivering individual can increase up to 5-fold from baseline or to ~40% of maximal aerobic capacity.(36) On the other hand, non-shivering thermogenesis is primarily mediated by metabolically active brown adipos…”
Background
Quantification of sweat gland innervation
Gibbons, C. H., Illigens, B. M. W., Wang, N., & Freeman, R. L. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a2e8b8 · Cited by 161 · cited 1× · see citing works
“In fact, the latter mechanism has received some support by observations depicting lower sweat gland nerve densities associated with sympathetic nerve impairments.(73)”
Background
The Long-Term Effects of Type 1 Diabetes Treatment and Complications on Health-Related Quality of Life
Jacobson, A. M., Braffett, B. H., Cleary, P. A., Gubitosi‐Klug, R., & Larkin, M. E. (2013) · Diabetes Care · doi:10.2337/dc12-2109 · Cited by 161 · see citing works
Drug-Induced Hyperhidrosis and Hypohidrosis
Cheshire, W. P., & Fealey, R. D. (2008) · Drug Safety · doi:10.2165/00002018-200831020-00002 · Cited by 159 · see citing works
Preferred Room Temperature of Young vs Aged Males: The Influence of Thermal Sensation, Thermal Comfort, and Affect
Taylor, N. A. S., Allsopp, N. K., & Parkes, D. G. (1995) · The Journals of Gerontology Series A · doi:10.1093/gerona/50a.4.m216 · Cited by 143 · see citing works
Is exercise a therapeutic tool for improvement of cardiovascular risk factors in adolescents with type 1 diabetes mellitus? A randomised controlled trial
Salem, M. A., AboElAsrar, M. A., Elbarbary, N. S., ElHilaly, R. A., & Refaat, Y. M. (2010) · Diabetology & Metabolic Syndrome · doi:10.1186/1758-5996-2-47 · Cited by 140 · see citing works
Large differences in peak oxygen uptake do not independently alter changes in core temperature and sweating during exercise
Jay, O., Bain, A. R., Deren, T. M., Sacheli, M., & Cramer, M. N. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00257.2011 · Cited by 139 · cited 1× · see citing works
“differences in heat loss following short-term exercise training(186) or between independent groups with large differences in aerobic fitness in young individuals.(187) A recent study by Stapleton and colleagues(188) showed that the age-related decline in aerobic fitness (~7% per decade(189)) explained some of the age-…”
Background
Effects of Heat Stress on Thermoregulatory Responses in Congestive Heart Failure Patients
Cui, J. G., Arbab‐Zadeh, A., Prasad, A., Durand, S., Levine, B. D., & Crandall, C. G. (2005) · Circulation · doi:10.1161/circulationaha.105.540773 · Cited by 136 · cited 1× · see citing works
“These agerelated changes in cardiovascular function to heat stress is further impaired in individuals with pre-existing cardiac dysfunction(127) such that increases in skin blood flow and therefore heat exchange is severely compromised.(130,133) Heart failure and peripheral arterial disease are the most common initial…”
Background
Differences in Foot and Forearm Skin Microcirculation in Diabetic Patients With and Without Neuropathy
Arora, S., Smakowski, P., Frykberg, R. G., Simeone, L. R., Freeman, R. L., LoGerfo, F. W., & Veves, A. (1998) · Diabetes Care · doi:10.2337/diacare.21.8.1339 · Cited by 135 · cited 2× · see citing works
“For instance, a study by Arora et al.46 reported similar increases in skin blood flow between non-neuropathic individuals with type 1 diabetes and their healthy counterparts (albeit responses were blunted in neuropathic individuals) whereas other work has shown clear diabetesrelated impairments in skin blood flow.47,4…”
Background
Seasonal Variation in Glucocorticoid Activity in Healthy Men1
Walker, B. R., Best, R., Noon, J. P., Watt, G. C. M., & Webb, D. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.12.4430 · Cited by 133 · cited 1× · see citing works
“In contrast, the differences in glycemia in a colder environment may be related to counter-regulatory hormone signaling such as increases in plasma cortisol production together with greater glucocorticoid responsiveness which results in lower insulin sensitivity.(170) While no studies have yet assessed the direct impa…”
Background
Effects of Exercise Training on Insulin Sensitivity in Adolescents with Type I Diabetes
Landt, K. W., Campaigne, B. N., James, F. W., & Sperling, M. A. (1985) · Diabetes Care · doi:10.2337/diacare.8.5.461 · Cited by 131 · see citing works
Biological activity of C-peptide on the skin microcirculation in patients with insulin-dependent diabetes mellitus.
Forst, T. M., Kunt, T., Pohlmann, T., Goitom, K., Engelbach, M., Beyer, J., & Pfützner, A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2147 · Cited by 125 · cited 1× · see citing works
“In fact, infusion of C-peptide in those with type 1 diabetes was successful in reversing the group’s impairment in skin blood flow relative to healthy individuals.(61) Others have noted impairments in endothelium-dependent and endothelium–independent vasodilation 62 along with reduced nitric oxide bioavailability due…”
Background
Heat tolerance of exercising obese and lean women.
Bar‐Or, O., Lundegren, H. M., & BUSKIRK, E. R. (1969) · Journal of Applied Physiology · doi:10.1152/jappl.1969.26.4.403 · Cited by 125 · cited 1× · see citing works
“This is exacerbated by reductions in whole-body heat exchange associated with the smaller body surface area-to-mass ratio in obese individuals.(143) Specifically, an obese person has a smaller body surface area-to-body mass ratio for effective sweat evaporation than a leaner person of the same height since his/her gre…”
Background
The influence of chronic health problems on work ability and productivity at work: a longitudinal study among older employees
Leijten, F., van den Heuvel, S. G., Ybema, J. F., van der Beek, A. J., Robroek, S. J., & Burdorf, A. (2014) · Scandinavian Journal of Work Environment & Health · doi:10.5271/sjweh.3444 · Cited by 124 · cited 1× · see citing works
“Importantly, a diagnosis of any chronic health condition has a negative impact on the productivity of the worker almost immediately with a noticeable reduction in work output within 1 year.(191) To date, there have been few studies in the area of chronic health conditions and the older worker; however, based on the av…”
Background
Small fiber neuropathy is associated with the metabolic syndrome
Pittenger, G. L., Mehrabyan, A., Simmons, K., Amandarice, Dublin, C., Barlow, P., & Vinik, A. I. (2005) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2005.3.113 · Cited by 116 · cited 1× · see citing works
“, HbA1c); however, it has been suggested that the presence/severity of neuropathy is more closely explained by an inverse relationship with high-density lipoprotein-cholesterol.(97) Collectively, individuals with type 2 diabetes are a particularly vulnerable population group due to their tendency to have relatively po…”
Background
Aging impairs heat loss, but when does it matter?
Stapleton, J. M., Poirier, M. P., Flouris, A. D., Boulay, P., Sigal, R. J., Malcolm, J., & Kenny, G. P. (2014) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00722.2014 · Cited by 116 · cited 1× · see citing works
“7).(188) Altogether, aerobic fitness in healthy adults likely plays an important role in the capacity for heat loss and explains some of the attenuated heat 134 G.”
BackgroundSelf-citation
Impaired stroke volume and aerobic capacity in female adolescents with type 1 and type 2 diabetes mellitus
Gusso, S., Hofman, P., Lalande, S., Cutfield, W., Robinson, E., & Baldi, J. C. (2008) · Diabetologia · doi:10.1007/s00125-008-1012-1 · Cited by 113 · see citing works
Resting and maximal forearm skin blood flows are reduced in hypertension.
Carberry, P. A., Shepherd, A. M. M., & Johnson, J. M. (1992) · Hypertension · doi:10.1161/01.hyp.20.3.349 · Cited by 112 · see citing works
A simple and valid method to determine thermoregulatory sweating threshold and sensitivity
Cheuvront, S. N., Bearden, S. E., Kenefick, R. W., Ely, B. R., DeGroot, D. W., Sawka, M. N., & Montain, S. J. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00250.2009 · Cited by 112 · cited 1× · see citing works
“function]) mechanisms.(32,33) In the context of wholebody heat loss under heat stress conditions which are compensable (i.”
Background
Divergence of intracellular and extracellular HSP72 in type 2 diabetes: does fat matter?
Rodrigues-Krause, J. D. C., Krause, M. D. S., O’Hagan, C., VITO, G. D., Boreham, C. A., Murphy, C., Newsholme, P., & Colleran, G. (2012) · Cell Stress and Chaperones · doi:10.1007/s12192-011-0319-x · Cited by 107 · cited 1× · see citing works
“The mechanisms for these improvements remain unclear; however, it has been postulated that increases in muscle blood flow associated with heating(164) and/or activation of heat shock protein 70.(165)”
Background
Cold exposure – an approach to increasing energy expenditure in humans
Lichtenbelt, W. D. V. M., Kingma, B., van der Lans, A. A. J. J., & Schellen, L. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.01.001 · Cited by 107 · cited 1× · see citing works
“Taken together, it appears that mild cold exposuremay be useful for themanagement of type 2 diabetes as a third lifestyle factor (along with diet and exercise) to optimize health.(24,159) However, further examination is required to determine the long-term effects of cold exposure and the optimal exposure level that is…”
Background
Physical Inactivity and Mortality Risk
Kokkinos, P. F., Sheriff, H. M., & Kheirbek, R. (2011) · Cardiology Research and Practice · doi:10.4061/2011/924945 · Cited by 106 · cited 1× · see citing works
“Aerobic fitness is an important determinant of health status for any individual and higher aerobic fitness is associated with lower all-cause mortality.(183) In the context of thermoregulatory control, higher levels of aerobic fitness and or physically activity have been suggested to improve the capacity to dissipate…”
Background
Heart Rate Variability and Baroreflex Sensitivity in Hypertensive Subjects With and Without Metabolic Features of Insulin Resistance Syndrome
Pikkujämsä, S. M. (1998) · American Journal of Hypertension · doi:10.1016/s0895-7061(98)00035-1 · Cited by 106 · cited 1× · see citing works
“In addition, individuals with type 2 diabetes exhibit a decline in baroreflex sensitivity(125) which is closely associated with the level of insulin resistance.(126) Consequently, it would be expected that individuals with type 2 diabetes are less able to maintain blood pressure and cardiovascular stability during an…”
Background
Seasonal Variation in Glucocorticoid Activity in Healthy Men
Walker, B. R. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4015 · Cited by 102 · see citing works
Impairment of Peripheral Blood Flow Responses in Diabetes Resembles an Enhanced Aging Effect
Stansberry, K. B., Hill, M. A., Shapiro, S. A., McNitt, P. M., Bhatt, B. A., & Vinik, A. I. (1997) · Diabetes Care · doi:10.2337/diacare.20.11.1711 · Cited by 100 · cited 3× · see citing works
“However, other findings indicate that maximal cutaneous vasodilation elicited pharmacologically and/or via local heating can be reduced in individuals with type 1 diabetes.(45) On the other hand, it remains uncertain whether the impaired maximal cutaneous vasodilation is paralleled by reduced submaximal skin blood flo…”
Background
Aging and Body Composition
Going, S. B., WILLIAMS, D., & Lohman, T. G. (1995) · Exercise and Sport Sciences Reviews · doi:10.1249/00003677-199500230-00016 · Cited by 99 · cited 1× · see citing works
“Changes in body composition occur with age such that older adults tend to have greater body fat and less muscle mass with this pattern of response being more pronounced in individuals with type 2 diabetes.(132,142)”
Background
Reductions in Individual Work Productivity Associated with Type 2 Diabetes Mellitus
Lavigne, J. E., Phelps, C. E., Mushlin, A. I., & Lednar, W. M. (2003) · PharmacoEconomics · doi:10.2165/00019053-200321150-00006 · Cited by 95 · cited 3× · see citing works
“Importantly, it was noted in this study that the productivity losses were not reflected in a higher productivity cost since individuals with type 2 diabetes had lower salaries on average.(192) Thus, the area of type 2 diabetes in the older worker is becoming an important area of focus with the development of exposure…”
BackgroundMethodInfluential
Cardiac Dysfunction during Exercise in Uncomplicated Type 2 Diabetes
Regensteiner, J. G., Bauer, T. A., Reusch, J. E. B., Quaife, R. A., Chen, M. Y., SMITH, S. C., MILLER, T. M., Groves, B. Μ., & Wolfel, E. E. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181942051 · Cited by 93 · cited 1× · see citing works
“cardiac output during exercise due to left ventricular diastolic dysfunction.(119,120) Moreover, a recent study has noted a ~20% reduction in exercise capacity in their participants with uncomplicated type 2 diabetes relative to their healthy counterparts.”
Background
Impaired skin blood flow response to environmental heating in chronic heart failure
GREEN, D. J., Maiorana, A., Siong, J. H. J., Burke, V., Erickson, M., Minson, C. T., Bilsborough, W., & O’Driscoll, G. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi655 · Cited by 89 · cited 1× · see citing works
“These agerelated changes in cardiovascular function to heat stress is further impaired in individuals with pre-existing cardiac dysfunction(127) such that increases in skin blood flow and therefore heat exchange is severely compromised.(130,133) Heart failure and peripheral arterial disease are the most common initial…”
Background
Retinal Vascular Geometry Predicts Incident Retinopathy in Young People With Type 1 Diabetes
Benitez‐Aguirre, P., Craig, M. E., Sasongko, M. B., Jenkins, A. J., Wong, T. Y., Wang, J. J., Cheung, N., & Donaghue, K. C. (2011) · Diabetes Care · doi:10.2337/dc10-2419 · Cited by 88 · see citing works
Management of accidental hypothermia and cold injury
Petrone, P., Asensio, J. A., & Marini, C. P. (2014) · Current Problems in Surgery · doi:10.1067/j.cpsurg.2014.07.004 · Cited by 87 · cited 1× · see citing works
“Based on the observations that individuals with type 1 diabetes demonstrate greater skin blood flow under baseline resting conditions which enhances dry heat loss (this is thought to be associated with the hyperinsulinemic state(44)) combined with the evidence of hypoglycemia-mediated blunting of shivering thermogenes…”
Background
Retinal Arteriolar Tortuosity is Associated With Retinopathy and Early Kidney Dysfunction in Type 1 Diabetes
Sasongko, M. B., Wong, T. Y., Donaghue, K. C., Cheung, N., Jenkins, A. J., Benitez‐Aguirre, P., & Wang, J. J. (2011) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2011.06.005 · Cited by 87 · see citing works
Multiple complications and frequent severe hypoglycaemia in ‘elderly’ and ‘old’ patients with Type 1 diabetes
Schütt, M., Fach, E.-M., Seufert, J., Kerner, W., Lang, W., Zeyfang, A., Welp, R., Holl, R. W., & for the DPV Initiative and the German BMBF Competence Network Diabetes Mellitus (2012) · Diabetic Medicine · doi:10.1111/j.1464-5491.2012.03681.x · Cited by 85 · cited 1× · see citing works
“In addition, improved diabetes management and care strategies have led to markedly increased life expectancy along with reduced incidence of associated complications.(40,41) However, longer life expectancy has also caused a rapidly increasing number of older adults living with type 1 diabetes.”
Background
Nonselective NOS inhibition blunts the sweat response to exercise in a warm environment
Welch, G., Foote, K. M., Hansen, C., & Mack, G. W. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.90809.2008 · Cited by 83 · cited 1× · see citing works
“induced sweating during exercise has been recently well established.(113,114)”
Background
Management of Type 1 Diabetes in Older Adults
Dhaliwal, R., & Weinstock, R. S. (2014) · Diabetes Spectrum · doi:10.2337/diaspect.27.1.9 · Cited by 83 · cited 1× · see citing works
“In addition, improved diabetes management and care strategies have led to markedly increased life expectancy along with reduced incidence of associated complications.(40,41) However, longer life expectancy has also caused a rapidly increasing number of older adults living with type 1 diabetes.”
Background
Contribution of nitric oxide to cutaneous microvascular dilation in individuals with type 2 diabetes mellitus
Sokolnicki, L. A., Roberts, S. K., Wilkins, B. W., Basu, A., & Charkoudian, N. (2006) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00365.2006 · Cited by 83 · cited 1× · see citing works
“In fact, one study reported that the relative nitric oxide-dependent vasodilation during whole-body passive heating was similar between healthy controls and those with type 2 diabetes; however, absolute skin blood flow was lower in the latter group.(109) Moreover, there is evidence to support an endothelium-independen…”
Background
Does vitamin C enhance nitric oxide bioavailability in a tetrahydrobiopterin-dependent manner? In vitro, in vivo and clinical studies
Mortensen, A., & Lykkesfeldt, J. (2014) · Nitric Oxide · doi:10.1016/j.niox.2013.12.001 · Cited by 80 · cited 1× · see citing works
“increased formation of advanced glycosylated end products(69) which can suppress nitric oxide bioavailability and augment basal oxidative stress which affects skin blood flow control.(70,71)”
Background
Thermoregulatory model for prediction of long-term cold exposure
Xu, X., Tikuisis, P., Gonzalez, R., & Giesbrecht, G. G. (2004) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2004.01.004 · Cited by 80 · see citing works
Delayed threshold for active cutaneous vasodilation in patients with Type 2 diabetes mellitus
Wick, D. E., Roberts, S. K., Basu, A., Sandroni, P., Fealey, R. D., Sletten, D. M., & Charkoudian, N. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00943.2005 · Cited by 79 · cited 2× · see citing works
“While little information is available regarding the central versus peripheral mechanisms underlying diabetes-related skin blood flow responses, one study implicated a lower onset threshold for vasodilation as the primary factor to explain a lower skin blood flow; an indication that the modulation of skin blood flow is…”
Background
Older Adults with Type 2 Diabetes Store More Heat during Exercise
Kenny, G. P., Stapleton, J. M., Yardley, J. E., Boulay, P., & Sigal, R. J. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3182940836 · Cited by 79 · cited 7× · see citing works
“With respect to individuals with diabetes, none of the exercise studies have considered fitness as a potential factor as the healthy controls were all matched for maximal aerobic capacity along with age and physical characteristics.(57-59,108)”
BackgroundResultInfluentialSelf-citation
The concept of regulation for human body temperature
Werner, J. (1980) · Journal of Thermal Biology · doi:10.1016/0306-4565(80)90003-0 · Cited by 77 · cited 1× · see citing works
“, vasodilation) and sweating, both of which are modulated by sympathetic nerves.(28,29) The action of vasodilation opens the skin’s blood vessels to allow greater blood flow to the skin which increases skin temperature, and thereby increasing the gradient for dry heat exchange between the skin and the external environ…”
Background
Redistribution of Sudomotor Responses Is an Early Sign of Sympathetic Dysfunction in Type 1 Diabetes
Hoeldtke, R. D., Bryner, K. D., Horvath, G. G., Phares, R. W., Broy, L. F., & Hobbs, G. R. (2001) · Diabetes · doi:10.2337/diabetes.50.2.436 · Cited by 77 · see citing works
Prevalence of somatic small fiber neuropathy in obesity
Herman, R. M., Brower, J. B., Stoddard, D. G., Casano, A. R., Targovnik, J. H., Herman, J., & Tearse, P. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803418 · Cited by 74 · cited 1× · see citing works
“While there are a limited number of studies examining the effects of heat stress in older obese individuals during exercise, it has been shown that obesity is associated with reductions in heat tolerance and impairments in the activation of heat loss responses of skin blood flow and sweating.(134,141) This is exacerba…”
Background
Seasonal Changes in Preprandial Glucose, A1C, and Blood Pressure in Diabetic Patients
Liang, W. W. (2007) · Diabetes Care · doi:10.2337/dc07-0597 · Cited by 71 · see citing works
Obesity and the Occurrence of Heat Disorders
Chung, N. K., & Pin, C. H. (1996) · Military Medicine · doi:10.1093/milmed/161.12.739 · Cited by 70 · cited 1× · see citing works
“5 times more likely to experience a heat-related fatality compared to lean age-matched individuals.(129)”
Background
Long-term physical training in female Type 1 (insulin-dependent) diabetic patients: absence of significant effect on glycaemic control and lipoprotein levels
Wallberg‐Henriksson, H., GUNNARSSON, R., Rössner, S., & Wahren, J. (1986) · Diabetologia · doi:10.1007/bf02427281 · Cited by 70 · see citing works
Chronic exercise is associated with enhanced cutaneous blood flow in Type 2 diabetes
Colberg, S. R., Stansberry, K. B., McNitt, P. M., & Vinik, A. I. (2002) · Journal of Diabetes and its Complications · doi:10.1016/s1056-8727(01)00222-7 · Cited by 70 · cited 1× · see citing works
“Importantly, these effects appear to depend on fitness such that those with type 2 diabetes who engage in physical activity have reduced impairments in skin vasodilation, albeit individuals with type 2 diabetes exhibit reduced maximal skin blood flow irrespective of fitness.(103) On the other hand, studies of local sw…”
Background
The broad clinical phenotype of Type 1 diabetes at presentation
Merger, S. R., Leslie, R. D., & Boehm, B. O. (2012) · Diabetic Medicine · doi:10.1111/dme.12048 · Cited by 69 · cited 1× · see citing works
“Diabetes care plans must consider adjustments for the age-related changes in functional status and incorporate appropriate accommodations for individuals who may be less able to manage their glycemia.(42) Furthermore, the earlyonset of type 1 diabetes results in a longer burden of disease, and therefore increased diab…”
Background
A rise in ambient temperature augments insulin absorption in diabetic patients
Koivisto, V. A., FORTNEY, S. M., Hendler, R., & Felig, P. (1981) · Metabolism · doi:10.1016/0026-0495(81)90122-0 · Cited by 67 · see citing works
Platelet cNOS Activity Is Reduced in Patients with IDDM and NIDDM
Bruno, G., Trucco, F., Zumpano, E., Tagliabue, M., Bisceglie, C. D., Pescarmona, G., & Martina, V. (1998) · Thrombosis and Haemostasis · doi:10.1055/s-0037-1614937 · Cited by 65 · cited 1× · see citing works
“Others have noted impairments in endothelium-dependent and endothelium–independent vasodilation 62 along with reduced nitric oxide bioavailability due primarily to diminished nitric oxide synthase activity.(63).”
Background
Evidence of defective cardiovascular regulation in insulin-dependent diabetic patients without clinical autonomic dysfunction
Weston, P. J., James, M. A., Panerai, R. B., McNally, P. G., Potter, J. F., & Thurston, H. (1998) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(98)00094-1 · Cited by 63 · see citing works
Glycemic Status Affects Cardiopulmonary Exercise Response in Athletes with Type I Diabetes
Baldi, J. C., Cassuto, N. A., Foxx‐Lupo, W. T., Wheatley, C. M., & Snyder, E. M. (2010) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181d1fdb3 · Cited by 63 · see citing works
Comparison of skin microvascular reactivity with hemostatic markers of endothelial dysfunction and damage in type 2 diabetes
Waeber, B. (2008) · Vascular Health and Risk Management · doi:10.2147/vhrm.s4175 · Cited by 62 · cited 1× · see citing works
“Of particular importance, these diabetes-related changes in skin blood flow appear to be closely associated with the duration of diabetes and/or the presence of related complications.(98,99) While little information is available regarding the central versus peripheral mechanisms underlying diabetes-related skin blood…”
Background
Assessment of baroreceptor-cardiac reflex sensitivity using time domain analysis in patients with IDDM and the relation to left ventricular mass index
Panerai, R. B., McCullough, A. J., Weston, P. J., McNally, P. G., Potter, J. F., Swales, J. D., James, M. A., & Thurston, H. (1996) · Diabetologia · doi:10.1007/s001250050587 · Cited by 62 · see citing works
Comparison of directly stimulated with axon‐reflex–mediated sudomotor responses in human subjects and in patients with diabetes
Kihara, M., Opfer‐Gehrking, T. L., & Low, P. A. (1993) · Muscle & Nerve · doi:10.1002/mus.880160612 · Cited by 62 · see citing works
Endothelium-Dependent and -Independent Vascular Dysfunction in Type 1 Diabetes
Chan, N. N., Vallance, P. J., & Colhoun, H. M. (2003) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000072968.00157.6b · Cited by 61 · see citing works
Effect of a local heating device on insulin and glucose pharmacokinetic profiles in an open-label, randomized, two-period, one-way crossover study in patients with type 1 diabetes using continuous subcutaneous insulin infusion
Raz, I., Weiss, R., Yegorchikov, Y., Bitton, G., Nagar, R., & Pesach, B. (2009) · Clinical Therapeutics · doi:10.1016/j.clinthera.2009.05.010 · Cited by 60 · see citing works
Do Heat Events Pose a Greater Health Risk for Individuals with Type 2 Diabetes?
Yardley, J. E., Stapleton, J. M., Sigal, R. J., & Kenny, G. P. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0324 · Cited by 60 · cited 1× · see citing works
“However, individuals with type 2 diabetes appear to have lower skin blood flow relative to their age-matched controls.(18) Although this may be perceived as beneficial in the context of minimizing heat dissipation during cold exposure, type 2 diabetes is also associated with marked impairments in vascular responsivene…”
BackgroundSelf-citation
Physical Activity and Diabetes
Salvatoni, A., Cardani, R., Biasoli, R., Salmaso, M., Paoli, A. D., & Nespoli, L. (2013) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2013.02.009 · Cited by 60 · see citing works
Effects of C‐peptide on Microvascular Blood Flow and Blood Hemorheology
Forst, T. M., & Kunt, T. (2003) · Journal of Diabetes Research · doi:10.1080/15438600490424532 · Cited by 59 · cited 1× · see citing works
“For example, the absence of C-peptide (produced in pancreatic islet b cells) is known to have an important role in microvascular blood flow in a manner which is nitric oxide-dependent.(60) In fact, infusion of C-peptide in those with type 1 diabetes was successful in reversing the group’s impairment in skin blood flow…”
Background
Daily steps are low year-round and dip lower in fall/winter: findings from a longitudinal diabetes cohort
Dasgupta, K., Joseph, L., Pilote, L., Strachan, I. B., Sigal, R. J., & Chan, C. (2010) · Cardiovascular Diabetology · doi:10.1186/1475-2840-9-81 · Cited by 59 · cited 1× · see citing works
“, an indicator of the level of physical activity) during the autumn/winter compared to the spring/summer months.(172) The mechanism underlying these divergent responses in glycemia between those with type 1 and type 2 diabetes in response to environmental factors is unknown and deserves further scrutiny.”
BackgroundSelf-citation
Effect of mild essential hypertension on control of forearm blood flow during exercise in the heat
Kenney, W. L., Kamon, E., & BUSKIRK, E. R. (1984) · Journal of Applied Physiology · doi:10.1152/jappl.1984.56.4.930 · Cited by 58 · cited 1× · see citing works
“However, the effects on skin blood flow have yielded mixed results when assessed under passive heating conditions(128,131,136) whereas consistent reductions in skin blood flow have been measured during exercise in the heat.(137,138) To the best of our knowledge, the effects on sweating have not been studied although m…”
Background
Thermoregulatory reflexes and cutaneous active vasodilation during heat stress in hypertensive humans
Kellogg, D. L., Morris, S. R., Rodriguez, S. B., Liu, Y., Grossmann, M., Stagni, G., & Shepherd, A. M. M. (1998) · Journal of Applied Physiology · doi:10.1152/jappl.1998.85.1.175 · Cited by 56 · see citing works
Diabetic anhidrosis
Goodman, J. I. (1966) · The American Journal of Medicine · doi:10.1016/0002-9343(66)90040-4 · Cited by 56 · cited 1× · see citing works
“In the context of eccrine sweating, the general pattern in individuals with type 1 diabetes is relative lower body anhidrosis along with upper body eu- or hyperhidrosis(49,50) which can lead to global anhidrosis.(51) Importantly, these reductions in skin blood flow and sweating in those with type 1 diabetes have been…”
Background
Evaluation of microvascular endothelial function in patients with type 1 diabetes using laser-Doppler perfusion monitoring: Which method to choose?
Gomes, M. B., Matheus, A. S. D. M., & Tibiriçá, E. V. (2008) · Microvascular Research · doi:10.1016/j.mvr.2008.04.003 · Cited by 54 · see citing works
Cardiac output and skin blood flow in lean and obese individuals during exercise in the heat
Vroman, N. B., BUSKIRK, E. R., & Hodgson, J. L. (1983) · Journal of Applied Physiology · doi:10.1152/jappl.1983.55.1.69 · Cited by 53 · cited 1× · see citing works
“While there are a limited number of studies examining the effects of heat stress in older obese individuals during exercise, it has been shown that obesity is associated with reductions in heat tolerance and impairments in the activation of heat loss responses of skin blood flow and sweating.(134,141) This is exacerba…”
Background
Effect of Glycemic Control on Sudomotor Denervation in Type 2 Diabetes
Luo, K., Chao, C., Hsieh, P.-C., Lue, J., & Hsieh, S. (2012) · Diabetes Care · doi:10.2337/dc11-1607 · Cited by 52 · cited 2× · see citing works
“For instance, the sweat glands from individuals with type 2 diabetes with poor glycemic control exhibit exacerbated reductions in peri-glandular nerve terminals and in the innervation index.(111,112) On the other TEMPERATURE 129”
Background
Impaired cerebral blood flow and oxygenation during exercise in type 2 diabetic patients
Kim, Y.-S., Seifert, T., Brassard, P., Rasmussen, P. V., Vaag, A. A., Nielsen, H. B., Secher, N. H., & LIESHOUT, J. J. V. (2015) · Physiological Reports · doi:10.14814/phy2.12430 · Cited by 50 · cited 1× · see citing works
“This was linked to a marked decrease in cerebral perfusion during exercise as a consequence of lower cardiac output.(121) Impor-”
Background
Impairments in Local Heat Loss in Type 1 Diabetes during Exercise in the Heat
Carter, M. R., McGinn, R. N., Barrera‐Ramirez, J., Sigal, R. J., & Kenny, G. P. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000350 · Cited by 49 · cited 9× · see citing works
“Given the reduced thermosensitivity of the sweating response in those with type 1 diabetes, Carter et al.(58) surmised that the diabetes-related changes in sweating were due to peripherally-mediated changes such as reduced acetylcholine sensitivity, altered physical properties of the actual sweat glands and/or interru…”
BackgroundResultInfluentialSelf-citation
Control aspects of human temperature regulation
Werner, J. (1981) · Automatica · doi:10.1016/0005-1098(81)90052-2 · Cited by 48 · cited 1× · see citing works
“, vasodilation) and sweating, both of which are modulated by sympathetic nerves.(28,29) The action of vasodilation opens the skin’s blood vessels to allow greater blood flow to the skin which increases skin temperature, and thereby increasing the gradient for dry heat exchange between the skin and the external environ…”
Background
Subclinical pain and thermal sensory dysfunction in children and adolescents with Type 1 diabetes mellitus
Abad, F. H. H., Díaz‐Gómez, N. M., Rodríguez, I., Pérez, R., & Delgado, J. A. (2002) · Diabetic Medicine · doi:10.1046/j.1464-5491.2002.00793.x · Cited by 46 · see citing works
Maintaining Thermogenesis in Cold Exposed Humans: Relying on Multiple Metabolic Pathways
Blondin, D. P., Tingelstad, H. C., Mantha, O. L., Gosselin, C., & Haman, F. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130043 · Cited by 45 · see citing works
Diastolic Function Is Reduced in Adolescents With Type 1 Diabetes in Response to Exercise
Gusso, S., Pinto, T. E., Baldi, J. C., Robinson, E., Cutfield, W. S., & Hofman, P. L. (2012) · Diabetes Care · doi:10.2337/dc11-2331 · Cited by 45 · see citing works
Combined Effect of Exercise and Ambient Temperature on Insulin Absorption and Postprandial Glycemia in Type I Patients
Rönnemaa, T., & Koivisto, V. A. (1988) · Diabetes Care · doi:10.2337/diacare.11.10.769 · Cited by 44 · cited 1× · see citing works
“Hot ambient conditions can also independently modulate glycemia by increasing insulin absorption and are reported to have additive effects to exercise in decreasing blood glucose levels.(56) These findings were supported during exercise wherein 75% of participants with type 1 diabetes required glucose supplementation…”
Background
The Effect of Type-2-Diabetes-Related Vascular Endothelial Dysfunction on Skin Physiology and Activities of Daily Living
Petrofsky, J. S. (2011) · Journal of Diabetes Science and Technology · doi:10.1177/193229681100500319 · Cited by 44 · see citing works
Sweat production during global heating and during isometric exercise in people with diabetes.
PETROFSKY, J. S., Lee, S., Patterson, C., Cole, M. D., & Stewart, B. G. (2005) · PubMed · Cited by 44 · see citing works
Sympathetic control of reflex cutaneous vasoconstriction in human aging
Greaney, J. L., Alexander, L. M., & Kenney, W. L. (2015) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00527.2015 · Cited by 43 · cited 1× · see citing works
“Along these lines, older adults are known to have a reduced ability to defend core temperature during cold exposure, even that which is relatively mild.(148,149)”
Background
Quantitation of Sudomotor Innervation in Skin Biopsies of Patients With Diabetic Neuropathy
Luo, K., Chao, C., Chen, Y., Huang, C., Yang, N. C., Kan, H., Wang, S.-H., Yang, W., & Hsieh, S. (2011) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e318230b0f4 · Cited by 42 · cited 1× · see citing works
“For instance, the sweat glands from individuals with type 2 diabetes with poor glycemic control exhibit exacerbated reductions in peri-glandular nerve terminals and in the innervation index.(111,112) On the other TEMPERATURE 129”
Background
Comparative physiological responses of normotensive and essentially hypertensive men to exercise in the heat
Kenney, W. L., & Kamon, E. (1984) · European Journal of Applied Physiology · doi:10.1007/bf00433392 · Cited by 42 · cited 1× · see citing works
“However, the effects on skin blood flow have yielded mixed results when assessed under passive heating conditions(128,131,136) whereas consistent reductions in skin blood flow have been measured during exercise in the heat.(137,138) To the best of our knowledge, the effects on sweating have not been studied although m…”
Background
Is insulin-dependent diabetes mellitus environmentally induced?
Maclaren, N., & Atkinson, M. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207303270509 · Cited by 41 · cited 1× · see citing works
“Although the causes of type 1 diabetes remain to be elucidated, it is probably caused by a combination of genetic predisposition (with >40 loci known to affect susceptibility)(3) and various environmental factors including stress and viruses.(4) On the other hand, type 2 diabetes is most often diagnosed in adults and…”
Background
Impaired increases in skin sympathetic nerve activity contribute to age‐related decrements in reflex cutaneous vasoconstriction
Greaney, J. L., Stanhewicz, A. E., Kenney, W. L., & Alexander, L. M. (2015) · The Journal of Physiology · doi:10.1113/jp270062 · Cited by 40 · see citing works
Seasonal Variation of HbA1c in Intensive Treatment of Children with Type 1 Diabetes
Nordfeldt, S., & Ludvigsson, J. (2000) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2000.13.5.529 · Cited by 39 · see citing works
Divergent roles of plasma osmolality and the baroreflex on sweating and skin blood flow
Lynn, A. G., Gagnon, D., Binder, K., Boushel, R., & Kenny, G. P. (2011) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00411.2011 · Cited by 39 · cited 2× · see citing works
“Recently, a few studies demonstrated that the combination of hyperosmolality and hypovolemia presented augmented effects to further exacerbate the impairments of heat loss in healthy individuals.(27,174) In contrast, a different study demonstrated that an acute episode of hyperglycemia (as induced by hyperinsulinemich…”
BackgroundResultSelf-citation
Central and Peripheral Cardiovascular Impairments Limit V·O2peak in Type 1 Diabetes
Rissanen, A., Tikkanen, H. O., Koponen, A. S., Aho, J. M., & Peltonen, J. E. (2014) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0000000000000419 · Cited by 39 · cited 3× · see citing works
“In addition, a recent study observed that even after accounting for any differences in cardiac function, otherwise healthy individuals with type 1 diabetes had reduced peak blood flow to the active muscles.(74)”
Background
Hypothermia
Danzl, D. F. (2002) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-2002-20589 · Cited by 39 · see citing works
Seasonal Variations of Severe Hypoglycemia in Patients With Type 1 Diabetes Mellitus, Type 2 Diabetes Mellitus, and Non-diabetes Mellitus
Tsujimoto, T., Yamamoto‐Honda, R., Kajio, H., Kishimoto, M., Noto, H., Hachiya, R., Kimura, A., Kakei, M., & Noda, M. (2014) · Medicine · doi:10.1097/md.0000000000000148 · Cited by 34 · cited 3× · see citing works
“Consistent with these findings during heat stress, seasonal variations in glycemia have been reported such that HbA1c levels for type 1 diabetes are clinically lower during the spring/summer relative to the autumn/winter months(166,167) with differences recently noted to be as high as 3%.(168) Moreover, Tsujimoto et a…”
BackgroundInfluential
Central angiotensin modulation of baroreflex control of renal sympathetic nerve activity in the rat: influence of dietary sodium
DiBona, G. F. (2003) · Acta Physiologica Scandinavica · doi:10.1046/j.1365-201x.2003.01074.x · Cited by 33 · see citing works
Low total haemoglobin mass, blood volume and aerobic capacity in men with type 1 diabetes
Koponen, A. S., Peltonen, J. E., Päivinen, M. K., Aho, J. M., Hägglund, H., Uusitalo, A. L. T., Lindholm, H. J., & Tikkanen, H. O. (2012) · European Journal of Applied Physiology · doi:10.1007/s00421-012-2532-4 · Cited by 32 · cited 1× · see citing works
“Furthermore, type 1 diabetes has been closely associated with reductions in blood volume which reduces the total amount of fluid available for circulation.(74,80) Therefore, while any impairments in resting cardiovascular function are minimal or non-detectable, individuals with type 1 diabetes may be at increased risk…”
Background
Local sensory nerve control of skin blood flow during local warming in type 2 diabetes mellitus
Strom, N. A., Sawyer, J. R., Roberts, S. K., Kingsley‐Berg, S. M., & Charkoudian, N. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01077.2009 · Cited by 32 · see citing works
Early Endothelial Dysfunction in Young Type 1 Diabetics
Hurks, R., Eisinger, M. J., Goovaerts, I., Gaal, L. V., Vrints, C. J., Weyler, J., Hendriks, J. M., Schil, P. E. V., & Lauwers, P. (2009) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2009.01.015 · Cited by 32 · see citing works
Differential impairment of the sudomotor and nociceptor axon‐reflex in diabetic peripheral neuropathy
Berghoff, M., Kilo, S., Hilz, M. J., & Freeman, R. L. (2006) · Muscle & Nerve · doi:10.1002/mus.20497 · Cited by 31 · see citing works
Diminished skin blood flow in Type I diabetes: evidence for non-endothelium-dependent dysfunction
Katz, A., Ekberg, K., Johansson, B., & Wahren, J. (2001) · Clinical Science · doi:10.1042/cs1010059 · Cited by 30 · cited 1× · see citing works
“reported similar increases in skin blood flow between non-neuropathic individuals with type 1 diabetes and their healthy counterparts (albeit responses were blunted in neuropathic individuals) whereas other work has shown clear diabetesrelated impairments in skin blood flow.(47,48) In the context of eccrine sweating,…”
Result
Effect of glycaemic control on the vascular nitric oxide system in patients with type 1 diabetes
Rodríguez‐Mañas, L., Bonnardeaux, P. L.-D., Torregrossa, R. P., Álvarez, M. N., Solı́s, J., Pavón, I., Peiró, C., & Sánchez‐Ferrer, C. F. (2003) · Journal of Hypertension · doi:10.1097/00004872-200306000-00013 · Cited by 29 · see citing works
Autonomic control during acute hypoglycemia in type 1 diabetes mellitus
Limberg, J. K., Farni, K. E., Taylor, J. L., Dube, S., Basu, A., Basu, R., Wehrwein, E. A., & Joyner, M. J. (2014) · Clinical Autonomic Research · doi:10.1007/s10286-014-0253-y · Cited by 27 · cited 1× · see citing works
“While this may result in a decrease in core temperature during resting conditions, the associated dysfunction of the autonomic nervous system may eliminate any potential benefits during whole-body heat stress.(59,76) Similarly, episodes of hyperglycemia can also have an important negative impact on core temperature re…”
Background
Skin Microvascular Reactivity in Children and Adolescents with Type 1 Diabetes in Relation to Levels of Physical Activity and Aerobic Fitness
Roche, D. M., Edmunds, S., Cable, N. T., Didi, M., & Stratton, G. (2008) · Pediatric Exercise Science · doi:10.1123/pes.20.4.426 · Cited by 27 · cited 1× · see citing works
“Importantly, these reductions in skin blood flow and sweating in those with type 1 diabetes have been related to longer disease duration,(47,52) poorer glycemic control as assessed by higher hemoglobin A1c (HbA1c) levels, 45,50-52 greater degrees of neuropathy, and/or lower aerobic fitness.(53) Despite the fact that t…”
Background
Is Whole-Body Thermoregulatory Function Impaired in Type 1 Diabetes Mellitus?
Yardley, J. E., Stapleton, J. M., Carter, M. R., Sigal, R. J., & Kenny, G. P. (2013) · Current Diabetes Reviews · doi:10.2174/1573399811309020004 · Cited by 27 · cited 1× · see citing works
“Individuals with type 1 diabetes are typically diagnosed during childhood or early adulthood (incidence peaks between ages 10-14 years(39)), are leaner and typically have minimal or no comorbidities at diagnosis.(17) In addition, improved diabetes management and care strategies have led to markedly increased life expe…”
BackgroundSelf-citation
Mechanisms underlying the postexercise baroreceptor-mediated suppression of heat loss
McGinn, R. N., Paull, G., Meade, R. D., Fujii, N., & Kenny, G. P. (2014) · Physiological Reports · doi:10.14814/phy2.12168 · Cited by 27 · cited 1× · see citing works
“induced sweating during exercise has been recently well established.(113,114)”
BackgroundSelf-citation
Muscle Blood Flow in Diabetes Mellitus: Evidence of Abnormality After Exercise
Menon, R. K., Grace, A. A., Burgoyne, W., Fonseca, V. A., James, I. M., & Dandona, P. (1992) · Diabetes Care · doi:10.2337/diacare.15.5.693 · Cited by 27 · cited 1× · see citing works
“reported a lower magnitude of postexercise hypotension for individuals with type 1 diabetes as early as 20 minutes after exercise which is consistent with prior observations of reduced postexercise muscle blood flow reported in individuals with diabetes.(86) Interestingly, in the study by McGinn et al.”
Result
Chapter 12 The effects of drugs on thermoregulation during exposure to hot environments
Lomax, P., & Schönbaum, E. (1998) · Progress in brain research · doi:10.1016/s0079-6123(08)62037-3 · Cited by 26 · cited 1× · see citing works
“In fact, some studies suggest that the use of antihypertensive medications (diuretics, vasodilators, b-blockers) can reduce heat tolerance during exercise in the heat.(144,145)”
Background
Whole-Body Heat Loss during Exercise in the Heat Is Not Impaired in Type 1 Diabetes
Stapleton, J. M., Yardley, J. E., Boulay, P., Sigal, R. J., & Kenny, G. P. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31829002f3 · Cited by 25 · cited 3× · see citing works
“, engaged in physical activity 3 times per week for 20 min) with type 1 diabetes during dynamic exercise was only published in 2013.(57) Specifically, Stapleton et al.”
BackgroundMethodInfluentialSelf-citation
Heart Rate Variability in Type 2 Diabetes Mellitus
Stuckey, M. I., & Petrella, R. J. (2013) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.2013008103 · Cited by 25 · cited 1× · see citing works
“In fact, some evidence indicates that heart rate variability can be a predictor for any diabetes-related complications.(117) Importantly, these effects are strongly dependent upon glycemic control, albeit it has been postulated that episodes of acute hyperglycemia exert more damage than chronically poor management of…”
Background
Modification of the rat aortic wall during ageing; possible relation with decrease of peptidergic innervation
Connat, J., Busseuil, D., Gambert, S., Ody, M., Tébaldini, M., Gamboni, S., Faivre, B., Quiquerez, A., Millet, M., Michaut, P., et al. (2001) · Anatomy and Embryology · doi:10.1007/s429-001-8002-0 · Cited by 24 · see citing works
Autonomic Stress and Balance—the Impact of Age and Diabetes
PETROFSKY, J. S., Focil, N., Prowse, M., Kim, Y., Berk, L., Bains, G. S., & Lee, S. (2010) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2009.0125 · Cited by 24 · cited 1× · see citing works
“In line with this, individuals with type 2 diabetes show impairments relative to age-matched controls in heart rate variability (an indicator of autonomic nervous system function) at rest and during postural manipulation.(116) In fact, some evidence indicates that heart rate variability can be a predictor for any diab…”
Background
Short-term exercise training does not improve whole-body heat loss when rate of metabolic heat production is considered
Stapleton, J. M., Gagnon, D., & Kenny, G. P. (2010) · European Journal of Applied Physiology · doi:10.1007/s00421-010-1380-3 · Cited by 20 · see citing works
Self-citation
Ascorbic acid: what do we really NO?
Holowatz, L. A. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01187.2011 · Cited by 18 · cited 1× · see citing works
“increased formation of advanced glycosylated end products(69) which can suppress nitric oxide bioavailability and augment basal oxidative stress which affects skin blood flow control.(70,71)”
Background
Abnormalities of the cardiovascular response to cold pressor test in type 1 diabetes. Correlation with blood glucose control
Friedman, H. S. (1984) · Archives of Internal Medicine · doi:10.1001/archinte.144.1.43 · Cited by 18 · see citing works
Does type 1 diabetes alter post‐exercise thermoregulatory and cardiovascular function in young adults?
McGinn, R., Carter, M. R., Barrera‐Ramirez, J., Sigal, R. J., Flouris, A. D., & Kenny, G. P. (2014) · Scandinavian Journal of Medicine and Science in Sports · doi:10.1111/sms.12344 · Cited by 16 · cited 8× · see citing works
“, the same participants) examining the postexercise response in thermal (and cardiovascular responses), McGinn et al.(59) showed that despite these differences in core temperature that persisted throughout the 60 min recovery period, local heat loss responses were similar”
BackgroundResultInfluentialSelf-citation
Basal and exercise-induced skeletal muscle blood flow is augmented in type I diabetes mellitus
Skyrme-Jones, R. A. P., Berry, K. L., O’Brien, R. C., & Meredith, I. T. (1999) · Clinical Science · doi:10.1042/cs0980111 · Cited by 15 · see citing works
EFFECT OF UROTENSIN II ON SKIN MICROVESSEL TONE IN DIABETIC PATIENTS WITHOUT HEART FAILURE OR ESSENTIAL HYPERTENSION
Zomer, E., de Ridder, I., Kompa, A. R., Komesaroff, P. A., Gilbert, R., & Krum, H. (2008) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2008.04960.x · Cited by 15 · cited 2× · see citing works
“Based on the observations that individuals with type 1 diabetes demonstrate greater skin blood flow under baseline resting conditions which enhances dry heat loss (this is thought to be associated with the hyperinsulinemic state44) combined with the evidence of hypoglycemia-mediated blunting of shivering thermogenesis…”
Result
Decreased Circulatory Response to Hypovolemic Stress in Young Women With Type 1 Diabetes
Lindenberger, M., Lindström, T., & Länne, T. (2013) · Diabetes Care · doi:10.2337/dc13-0468 · Cited by 14 · cited 1× · see citing works
“Specifically, the latter was evidenced by reduced redistribution of peripheral blood toward the central circulation and is consistent in males and females.(89,90)”
Background
Sympathetic sudomotor disturbance in early type 1 diabetes mellitus is linked to lipid peroxidation
Hoeldtke, R. D., Bryner, K. D., Hoeldtke, M. E., Christie, I., Ganser, G. H., Hobbs, G. R., & Riggs, J. E. (2006) · Metabolism · doi:10.1016/j.metabol.2006.06.023 · Cited by 14 · see citing works
Cerebral Hemodynamics and Systemic Endothelial Function Are Already Impaired in Well-Controlled Type 2 Diabetic Patients, with Short-Term Disease
Palazzo, P., Maggio, P., Altavilla, R., Flaviani, A. D., Giordani, I., Malandrucco, I., Picconi, F., Passarelli, F., Pasqualetti, P., Ercolani, M., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083287 · Cited by 14 · see citing works
The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: A possible link between cytokine production and sympathetic transmission
Donoso, M. V., Gómez, C. R., Orriantia, M. Á., Pérez, V., Torres, C. A., Coddou, C., Nelson, P., Maisey, K. R., Morales, B., Fernández, R., et al. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.09.018 · Cited by 14 · see citing works
Diabetes: Sweat Response and Heart Rate Variability During Electrical Stimulation in Controls and People With Diabetes
Rand, S., & PETROFSKY, J. S. (2008) · Cited by 14 · see citing works
Brown adipose tissue thermogenesis in humans
Nuutila, P. (2013) · Diabetologia · doi:10.1007/s00125-013-3005-y · Cited by 13 · see citing works
Selective Enhancement of α2-Adrenoceptor-Mediated Vasoconstriction in Insulin-Dependent Diabetic Patients with Microalbuminuria
Bodmer, C. W., Schaper, N. C., Janssen, M., de Leeuw, P. W., & Williams, G. (1995) · Clinical Science · doi:10.1042/cs0880421 · Cited by 13 · see citing works
Energy and Climate Change Committee Inquiry on the Intergovernmental Panel on Climate Change (IPCC) 5th Assessment Review
Harding, R. J., & Huntingford, C. (2013) · Cited by 12 · see citing works
People with type 1 diabetes using short acting analogue insulins are less dehydrated than those with using human soluble insulin prior to onset of diabetic ketoacidosis
Dhatariya, K. (2008) · Medical Hypotheses · doi:10.1016/j.mehy.2008.06.027 · Cited by 11 · see citing works
Impaired compensatory response to hypovolaemic circulatory stress in type 1 diabetes mellitus
Lindenberger, M., Olsen, H., & Länne, T. (2011) · Diabetes and Vascular Disease Research · doi:10.1177/1479164111404576 · Cited by 11 · cited 2× · see citing works
“Specifically, the latter was evidenced by reduced redistribution of peripheral blood toward the central circulation and is consistent in males and females.(89,90)”
Background
Thermoregulatory responses to hyperinsulinaemic hypoglycaemia and euglycaemia in IDDM
Maggs, D. G., Macdonald, I. A., & Tattersall, R. B. (1994) · Diabetologia · doi:10.1007/bf00417693 · Cited by 10 · cited 1× · see citing works
“From a thermoregulatory perspective, hypoglycemia is known to induce sympathetic activation as evidenced by marked increases in sweating, limb blood flow, heart rate, and blood pressure.(173) While this may result in a decrease in core temperature during resting conditions, the associated dysfunction of the autonomic…”
Background
Thermoregulatory response to passive body heating in borderline hypertension
Drummond, P. D. (1993) · Clinical Autonomic Research · doi:10.1007/bf01829011 · Cited by 10 · see citing works
Blood flow in the skin of type 1 diabetic patients before and after combined pancreas/kidney transplantation
Eberl, N., Piehlmeier, W., Dachauer, S., König, A., Land, W. G., & Landgraf, R. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.555 · Cited by 10 · cited 1× · see citing works
“5% (indicating chronically elevated blood glucose levels) are strongly associated with reductions in skin blood flow,(66,67) and one study has linked even acute hyperglycemic episodes to irreversible vascular changes which could impair heat loss.(68) Finally, type 1 diabetes is associated with Figure 5.”
Background
Acute hyperglycaemia does not alter nitric oxide-mediated microvascular function in the skin of adolescents with type 1 diabetes
Naylor, L. H., Yusof, N. M., Paramalingam, N., Jones, T. W., Davis, E. A., & GREEN, D. J. (2013) · European Journal of Applied Physiology · doi:10.1007/s00421-013-2785-6 · Cited by 7 · see citing works
Effect of Local Heating on Postprandial Blood Glucose Excursions Using the InsuPad Device
Hermanns, N., Bitton, G., Reimer, A., Krichbaum, M., Kulzer, B., & Haak, T. (2014) · Journal of Diabetes Science and Technology · doi:10.1177/1932296814546162 · Cited by 7 · cited 1× · see citing works
“Even local heating of the insulin injection site can lower post-prandial glycemia through increasing insulin absorption and activity,(162,163) and has been suggested as a potential avenue to improve long-term glycemic control.(162) The mechanisms for these improvements remain unclear; however, it has been postulated t…”
Background
Older Adults Experience Greater Levels of Thermal and Cardiovascular Strain During Extreme Heat Exposures.
Kenny, G. P., Flouris, A. D., Dervis, S., Friesen, B. J., Sigal, R. J., Malcolm, J., & Poirier, M. P. (2015) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000477799.65084.9a · Cited by 6 · see citing works
Self-citation
Autonomic dysfunction associated with Type 1 diabetes: a role for fitness?
McGinn, R. N., & Kenny, G. P. (2014) · Clinical Autonomic Research · doi:10.1007/s10286-014-0262-x · Cited by 3 · cited 1× · see citing works
“is commonly regarded as a measure of autonomic nervous system function, baroreflex sensitivity is a vital cardiovascular reflex with important implications for blood pressure and possibly thermoregulatory control.(27,79) Furthermore, type 1 diabetes has been closely associated with reductions in blood volume which red…”
BackgroundSelf-citation
Abnormalities of the Cardiovascular Response to Cold Pressor Test in Type 1 Diabetes
Friedman, H. S. (1984) · Archives of Internal Medicine · doi:10.1001/archinte.1984.00350130049010 · cited 1×
“While no studies have yet assessed the direct impact of acute or chronic glycemia management on thermoregulatory responses to cold exposure, one study has indicated that short-term changes in HbA1c levels are closely and inversely correlated with the cardiovascular response to a cold pressor test.(171)”
Background
Untitled work
de Valk (1998) · doi:10.1002/(sici)1096-9136(199806)15:6

Flagged first, then by citations

Research works printed but not linked: 1

[16]IPCC Intergovernmental Panel on Climate Change. 5th Assessment Report of the Intergovernmental Panel on Climate Change. Cambridge, UK, 2013.

Sorted by citations

Hot weather and heat extremes: health risks
Ebi, K. L., Capon, A., Berry, P., Broderick, C., de Dear, R., Havenith, G., Honda, Y., Kovats, R. S., Ma, W., Malik, A., et al. (2021) · The Lancet · doi:10.1016/s0140-6736(21)01208-3 · Cited by 2,172 · see citing works
Physiology of sweat gland function: The roles of sweating and sweat composition in human health
Baker, L. B. (2019) · Temperature · doi:10.1080/23328940.2019.1632145 · Cited by 732 · see citing works
Physiological factors characterizing heat-vulnerable older adults: A narrative review
Meade, R. D., Akerman, A. P., Notley, S. R., McGinn, R. N., Poirier, P., Gosselin, P., & Kenny, G. P. (2020) · Environment International · doi:10.1016/j.envint.2020.105909 · Cited by 431 · see citing works
Self-citation
A wearable patch for continuous analysis of thermoregulatory sweat at rest
Nyein, H. Y. Y., Bariya, M., Tran, B., Ahn, C. H., Brown, B. J., Ji, W., Davis, N., & Javey, A. (2021) · Nature Communications · doi:10.1038/s41467-021-22109-z · Cited by 426 · see citing works
Physical Activity and Diabetes
Sigal, R. J., Armstrong, M. J., Bacon, S., Boulé, N. G., Dasgupta, K., Kenny, G. P., & Riddell, M. C. (2018) · Canadian Journal of Diabetes · doi:10.1016/j.jcjd.2017.10.008 · Cited by 258 · see citing works
Self-citation
Metabolic consequences of obesity and type 2 diabetes: Balancing genes and environment for personalized care
Pillon, N. J., Loos, R. J. F., Marshall, S. M., & Zierath, J. R. (2021) · Cell · doi:10.1016/j.cell.2021.02.012 · Cited by 238 · see citing works
Occupational heat strain in outdoor workers: A comprehensive review and meta-analysis
Ioannou, L. G., Foster, J., Morris, N. B., Piil, J. F., Havenith, G., Mekjavić, I. B., Kenny, G. P., Nybo, L., & Flouris, A. D. (2022) · Temperature · doi:10.1080/23328940.2022.2030634 · Cited by 236 · see citing works
Self-citation
Wearable Sweat Loss Measuring Devices: From the Role of Sweat Loss to Advanced Mechanisms and Designs
Zhong, B., Jiang, K., Wang, L., & Shen, G. (2021) · Advanced Science · doi:10.1002/advs.202103257 · Cited by 168 · see citing works
Direct calorimetry: a brief historical review of its use in the study of human metabolism and thermoregulation
Kenny, G. P., Notley, S. R., & Gagnon, D. (2017) · European Journal of Applied Physiology · doi:10.1007/s00421-017-3670-5 · Cited by 163 · see citing works
Self-citation
Individual Responses to Heat Stress: Implications for Hyperthermia and Physical Work Capacity
Foster, J., Hodder, S., Lloyd, A. B., & Havenith, G. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.541483 · Cited by 159 · see citing works
“There may be additional factors at play, and the interested reader is directed to two reviews for further reading (Ngo et al., 2005; Kenny et al., 2016).”
Background
Cardiovascular diseases, cold exposure and exercise
Ikäheimo, T. M. (2017) · Temperature · doi:10.1080/23328940.2017.1414014 · Cited by 150 · see citing works
“Cardiovascular diseases are also often connected to other comorbid conditions, such as diabetes [116,117] which itself also affects thermal responses [118].”
Background
An adipo-biliary-uridine axis that regulates energy homeostasis
Deng, Y., Wang, Z. V., Gordillo, R., An, Y., Zhang, C., Liang, Q., Yoshino, J., Cautivo, K. M., Brabander, J. K. D., Elmquist, J. K., et al. (2017) · Science · doi:10.1126/science.aaf5375 · Cited by 137 · see citing works
“Recently, diabetes has been linked to impairments in temperature control during exposure to thermal stress (43).”
Background
Restoration of thermoregulation after exercise
Kenny, G. P., & McGinn, R. N. (2016) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00517.2016 · Cited by 118 · see citing works
“Readers are referred to a recent detailed review on this topic (53).”
BackgroundSelf-citation
Indoor overheating: A review of vulnerabilities, causes, and strategies to prevent adverse human health outcomes during extreme heat events
Kenny, G. P., Tetzlaff, E. J., Journeay, W. S., Henderson, S. B., & O’Connor, F. K. (2024) · Temperature · doi:10.1080/23328940.2024.2361223 · Cited by 109 · see citing works
“Compared to the general population, adults with type 2 diabetes experience higher rates of heat-related morbidity and mortality during an EHE [3,33,138–142].”
BackgroundInfluentialSelf-citation
Medical devices, smart drug delivery, wearables and technology for the treatment of Diabetes Mellitus
Domingo‐Lopez, D. A., Lattanzi, G., Schreiber, L. H. J., Wallace, E. J., Wylie, R., O’Sullivan, J., Dolan, E. B., & Duffy, G. P. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114280 · Cited by 103 · see citing works
Engineering digital biomarkers of interstitial glucose from noninvasive smartwatches
Bent, B., Cho, P. J., Henriquez, M., Wittmann, A., Thacker, C., Feinglos, M. N., Crowley, M. J., & Dunn, J. (2021) · npj Digital Medicine · doi:10.1038/s41746-021-00465-w · Cited by 99 · see citing works
The effect of passive heating on heat shock protein 70 and interleukin-6: A possible treatment tool for metabolic diseases?
Faulkner, S. H., Jackson, S., Fatania, G. J., & Leicht, C. A. (2017) · Temperature · doi:10.1080/23328940.2017.1288688 · Cited by 92 · see citing works
“The implications for such a deficiency are wide ranging and may increase susceptibility to metabolic disease,(46,47) impaired vascular function(48) and even contribute to the impaired thermoregulatory control evident in individuals with diabetes.(49)”
Background
Risk of heat illness in men and women: A systematic review and meta-analysis
Gifford, R. M., Todisco, T., Stacey, M. J., Fujisawa, T., Allerhand, M., Woods, D. R., & Reynolds, R. M. (2018) · Environmental Research · doi:10.1016/j.envres.2018.10.020 · Cited by 91 · see citing works
“Several excellent reviews have been published summarizing sex-dependent aspects of such studies.(Charkoudian and Stachenfeld 2016; Gagnon and Kenny 2012; Kenny and Jay 2013; Kenny et al. 2016) Such studies do not explain our findings, since women have lower body surface area and cardiovascular fitness (Vogel and Fried…”
Association between Heat Exposure and Hospitalization for Diabetes in Brazil during 2000–2015: A Nationwide Case-Crossover Study
Xu, R., Zhao, Q., Coêlho, M. D. S. Z. S., Saldiva, P. H. N., Zoungas, S., Huxley, R., Abramson, M. J., Guo, Y., & Li, S. (2019) · Environmental Health Perspectives · doi:10.1289/ehp5688 · Cited by 92 · see citing works
“Compared to the general population, individuals with diabetes are more sensitive to extreme temperatures, especially heat, because of impaired thermoregulatory control, regardless of their diabetes type (Kenny et al. 2016).”
Background
Heat exhaustion
Kenny, G. P., Wilson, T. E., Flouris, A. D., & Fujii, N. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-64074-1.00031-8 · Cited by 90 · see citing works
Self-citation
The effect of the heatwave on the morbidity and mortality of diabetes patients; a meta-analysis for the era of the climate crisis
Moon, J. (2021) · Environmental Research · doi:10.1016/j.envres.2021.110762 · Cited by 89 · see citing works
Short-term association between ambient temperature and acute myocardial infarction hospitalizations for diabetes mellitus patients: A time series study
Lam, H. C. Y., Chan, J. C. N., Luk, A. O. Y., Chan, E. Y. Y., & Goggins, W. B. (2018) · PLoS Medicine · doi:10.1371/journal.pmed.1002612 · Cited by 88 · see citing works
Diabetes and climate change: current evidence and implications for people with diabetes, clinicians and policy stakeholders
Ratter-Rieck, J. M., Roden, M., & Herder, C. (2023) · Diabetologia · doi:10.1007/s00125-023-05901-y · Cited by 94 · see citing works
The effect of ambient temperature on type-2-diabetes: case-crossover analysis of 4+ million GP consultations across England
Hajat, S., Haines, A., Sarran, C. E., Sharma, A., Bates, C. J., & Fleming, L. E. (2017) · Environmental Health · doi:10.1186/s12940-017-0284-7 · Cited by 86 · see citing works
“This is probably due to compromised heat dissipation among diabetics which increases the risk of heat-related illness [2, 3].”
Background
Towards establishing evidence-based guidelines on maximum indoor temperatures during hot weather in temperate continental climates
Kenny, G. P., Flouris, A. D., Yagouti, A., & Notley, S. R. (2018) · Temperature · doi:10.1080/23328940.2018.1456257 · Cited by 87 · see citing works
Self-citation
Current concepts of active vasodilation in human skin
Wong, B. J., & Hollowed, C. G. (2016) · Temperature · doi:10.1080/23328940.2016.1200203 · Cited by 82 · see citing works
“For a more comprehensive review of temperature regulation in diabetics, the reader is referred to a recent review by Kenny et al.(119) To date, the most comprehensive information regarding thermoregulation in type 1 diabetes comes from a series of studies from the Kenny lab.”
Method
PNIPAM/PEDOT:PSS Hydrogels for Multifunctional Organic Electrochemical Transistors
Lopez‐Larrea, N., Wustoni, S., Peñas, M. I., Uribe, J., Dominguez‐Alfaro, A., Gallastegui, A., Inal, S., & Mecerreyes, D. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202403708 · Cited by 80 · see citing works
Activity modification in heat: critical assessment of guidelines across athletic, occupational, and military settings in the USA
Hosokawa, Y., Casa, D. J., Trtanj, J. M., Belval, L. N., Deuster, P. A., Giltz, S. M., Grundstein, A., Hawkins, M. D., Huggins, R. A., Jacklitsch, B. L., et al. (2019) · International Journal of Biometeorology · doi:10.1007/s00484-019-01673-6 · Cited by 79 · see citing works
Diabetes mellitus in the era of climate change
Vallianou, N. G., Geladari, E. V., Kounatidis, D. C., Geladari, C. V., Stratigou, T., Dourakis, S. P., Andreadis, E. A., & Dalamaga, Μ. (2020) · Diabetes & Metabolism · doi:10.1016/j.diabet.2020.10.003 · Cited by 74 · see citing works
Screening criteria for increased susceptibility to heat stress during work or leisure in hot environments in healthy individuals aged 31–70 years
Flouris, A. D., McGinn, R., Poirier, M. P., Louie, J. C., Ioannou, L. G., Tsoutsoubi, L., Sigal, R. J., Boulay, P., Hardcastle, S. G., & Kenny, G. P. (2018) · Temperature · doi:10.1080/23328940.2017.1381800 · Cited by 74 · see citing works
“Thus, our criteria require further validation to be used for more vulnerable populations including sedentary adults and patients with chronic diseases such as hypertension and type 2 diabetes.(59) Moreover, the air flow inside the direct calorimeter ensured all secreted sweat to be evaporated.”
Self-citation
Association of ambient extreme heat with pediatric morbidity: a scoping review
Uibel, D., Sharma, R., Piontkowski, D., Sheffield, P. E., & Clougherty, J. E. (2022) · International Journal of Biometeorology · doi:10.1007/s00484-022-02310-5 · Cited by 67 · see citing works
Heat exposure impacts on urban health: A meta-analysis.
Yang, X., Xu, X., Wang, Y.-Z., Yang, J., & Wu, X. (2024) · Science of the Total Environment · doi:10.1016/j.scitotenv.2024.174650 · Cited by 58 · see citing works
Endocrine effects of heat exposure and relevance to climate change
Hannan, F. M., Leow, M. K., LEE, J. K. W., Kovats, S. R., Elajnaf, T., Kennedy, S., & Thakker, R. V. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01017-4 · Cited by 64 · see citing works
“Diabetes mellitus is also associated with decreases in dermal blood flow and heat dissipation 92 .”
The modifying effects of heat and cold wave characteristics on cardiovascular mortality in 31 major Chinese cities
Chen, J., Zhou, M., Yang, J., Yin, P., Wang, B., Ou, C., & Liu, Q. (2020) · Environmental Research Letters · doi:10.1088/1748-9326/abaea0 · Cited by 61 · see citing works
Chronic Diseases Associated With Mortality in British Columbia, Canada During the 2021 Western North America Extreme Heat Event
Lee, M. J., McLean, K. E., Kuo, M., Richardson, G. R. A., & Henderson, S. B. (2023) · GeoHealth · doi:10.1029/2022gh000729 · Cited by 59 · see citing works
Impact of short-term exposure to extreme temperatures on diabetes mellitus morbidity and mortality? A systematic review and meta-analysis
Song, X., Jiang, L., Zhang, D., Wang, X., Ma, Y., Hu, Y., Tang, J. Y., Li, X., Huang, W., Meng, Y., et al. (2021) · Environmental Science and Pollution Research · doi:10.1007/s11356-021-14568-0 · Cited by 55 · see citing works
Global warming, heat-related illnesses, and the dermatologist
Williams, M. L. (2021) · International Journal of Women's Dermatology · doi:10.1016/j.ijwd.2020.08.007 · Cited by 60 · see citing works
“Most studies have also demonstrated impaired sweat responses in those who are diabetic, particularly in those with neuropathy (Kenny et al., 2016; Yardley et al., 2013).”
BackgroundInfluential
Disrupted circadian rhythms of body temperature, heart rate and fasting blood glucose in prediabetes and type 2 diabetes mellitus
Gubin, D. G., Nelaeva, A. A., Uzhakova, A. E., Хасанова, Ю. В., Cornélissen, G., & Weinert, D. (2017) · Chronobiology International · doi:10.1080/07420528.2017.1347670 · Cited by 54 · see citing works
“Regulation of body temperature (BT) and heart rate (HR) and their circadian rhythms can be compromised in T2DM patients (Kenny et al., 2016; Scott et al., 1987).”
Background
Exercise Heat Stress in Patients With and Without Type 2 Diabetes
Notley, S. R., Poirier, M. P., Sigal, R. J., D’Souza, A. W., Flouris, A. D., Fujii, N., & Kenny, G. P. (2019) · JAMA · doi:10.1001/jama.2019.10943 · Cited by 49 · see citing works
Self-citation
A Field Evaluation of Construction Workers’ Activity, Hydration Status, and Heat Strain in the Extreme Summer Heat of Saudi Arabia
Al-Bouwarthan, M., Quinn, M., Kriebel, D., & Wegman, D. H. (2020) · Annals of Work Exposures and Health · doi:10.1093/annweh/wxaa029 · Cited by 51 · see citing works
The relationship between climate change, globalization and non-communicable diseases in Africa: A systematic review
Siiba, A., Kangmennaang, J., Baatiema, L., & Luginaah, I. (2024) · PLoS ONE · doi:10.1371/journal.pone.0297393 · Cited by 48 · see citing works
Occupational heat stress management: Does one size fit all?
Notley, S. R., Flouris, A. D., & Kenny, G. P. (2019) · American Journal of Industrial Medicine · doi:10.1002/ajim.22961 · Cited by 46 · see citing works
Self-citation
Effects of Medications on Heat Loss Capacity in Chronic Disease Patients: Health Implications Amidst Global Warming
Wee, J., Tan, X. R., Gunther, S. H., Ihsan, M., Leow, M. K., Tan, D. S., Eriksson, J. G., & LEE, J. K. W. (2023) · Pharmacological Reviews · doi:10.1124/pharmrev.122.000782 · Cited by 47 · see citing works
“Growing evidence links diabetes to impaired thermoregulatory control that may result in adverse health outcomes, particularly in extreme heat events (Kenny et al., 2016).”
Influential
Appraisal of the heat vulnerability index in Punjab: A case study of spatial pattern for exposure, sensitivity, and adaptive capacity in megacity Lahore, Pakistan
Zuhra, S. S., Tabinda, A. B., & Yasar, A. (2019) · International Journal of Biometeorology · doi:10.1007/s00484-019-01784-0 · Cited by 40 · see citing works
Effect of heatwaves on daily hospital admissions in Portugal, 2000–18: an observational study
Alho, A. M., Oliveira, A. P., Viegas, S., & Nogueira, P. (2024) · The Lancet Planetary Health · doi:10.1016/s2542-5196(24)00046-9 · Cited by 40 · see citing works
Geographical disparities in the impacts of heat on diabetes mortality and the protective role of greenness in Thailand: A nationwide case-crossover analysis
He, Y., Cheng, L., Bao, J., Deng, S., Liao, W., Wang, Q., Tawatsupa, B., Hajat, S., & Huang, C. (2019) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2019.135098 · Cited by 40 · see citing works
Integration of Central and Peripheral Regulation of the Circulation during Exercise: Acute and Chronic Adaptations
Mueller, P. J., Clifford, P. S., Crandall, C. G., Smith, S. A., & Fadel, P. J. (2017) · Comprehensive physiology · doi:10.1002/cphy.c160040 · Cited by 48 · see citing works
Association between extreme ambient heat exposure and diabetes-related hospital admissions and emergency department visits: A systematic review
Gao, D., Friedman, S., Hosler, A. S., Sheridan, S. C., Zhang, W., & Lin, S. (2022) · Hygiene and Environmental Health Advances · doi:10.1016/j.heha.2022.100031 · Cited by 37 · see citing works
“People living with diabetes have a reduced ability to maintain a core temperature during heat stress (Kenny et al., 2016).”
BackgroundInfluential
Non-invasive blood glucose monitoring technology in diabetes management: review
Moses, J. C., Adibi, S., Wickramasinghe, N. S., Nguyen, L., Angelova, M. N., & Islam, S. M. S. (2024) · mHealth · doi:10.21037/mhealth-23-9 · Cited by 41 · see citing works
“The core body temperature of T1DM and T2DM participants vary from non-diabetics and could also be adversely affected due to thermal stress (i.e., hot and cold exposure) (54).”
Thermal facial image analyses reveal quantitative hallmarks of aging and metabolic diseases
Yu, Z., Zhou, Y., Mao, K., Pang, B., Wang, K., Jin, T., Zheng, H., Zhai, H., Wang, Y., Xu, X., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.05.012 · Cited by 39 · see citing works
Patient and Healthcare Professionals Perspectives on the Delivery of Exercise Education for Patients With Type 1 Diabetes
Litchfield, I. J., Andrews, R. C., Narendran, P., & Greenfield, S. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00076 · Cited by 37 · see citing works
“However, the implementation of this advice is influenced by numerous factors such as the duration and intensity of physical activity (23), the presence of co-morbidities (24), the level of patient engagement (25), and environmental parameters such as temperature (26).”
Background
Associations between cold spells and hospital admission and mortality due to diabetes: A nationwide multi-region time-series study in Korea
Kim, K., Lim, Y., Bae, S., Kim, J., Hwang, S., Kim, M.-J., Oh, J., Lim, H., Choi, J., & Kwon, H. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156464 · Cited by 37 · see citing works
How Does Ambient Air Temperature Affect Diabetes Mortality in Tropical Cities?
Seposo, X., Đăng, T. N., & Honda, Y. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14040385 · Cited by 36 · see citing works
“regulatory hormones, which can affect both acute and chronic glycemia [17,42].”
BackgroundInfluential
Skin vasoconstriction as a heat conservation thermoeffector
Johnson, J. M., & Kellogg, D. L. (2018) · Handbook of clinical neurology · doi:10.1016/b978-0-444-63912-7.00011-4 · Cited by 36 · see citing works
Association between heat exposure and hospitalization for diabetic ketoacidosis, hyperosmolar hyperglycemic state, and hypoglycemia in Japan
Miyamura, K., Nawa, N., Nishimura, H., Fushimi, K., & Fujiwara, T. (2022) · Environment International · doi:10.1016/j.envint.2022.107410 · Cited by 36 · see citing works
Hsp72 and Hsp90α mRNA transcription is characterised by large, sustained changes in core temperature during heat acclimation
Gibson, O. R., Tuttle, J. A., Watt, P., Maxwell, N., & Taylor, L. K. (2016) · Cell Stress and Chaperones · doi:10.1007/s12192-016-0726-0 · Cited by 35 · see citing works
“Some of the previously detailed disease states have marked impairments regarding their ability to thermoregulate [e.g. diabetes (Kenny et al. 2016) and multiple sclerosis (Romberg et al. 2012)].”
Background
Identifying sources of support and barriers to physical activity in pediatric type 1 diabetes
Livny, R., Said, W., Shilo, S., Bar‐Yoseph, R., Gal, S., Oren, M., Levy, M., Weiss, R., Shehadeh, N., Zuckerman‐Levin, N., et al. (2019) · Pediatric Diabetes · doi:10.1111/pedi.12938 · Cited by 34 · see citing works
“Another study found that beyond a certain metabolic heat load, heat dissipation during exercise in warm temperatures, is impaired in patients with T1D.(42,43) Patients and families should be familiar with the risk of postprandial hyperglycemia at cool temperatures or exercise-related hypoglycemia at warm temperatures,…”
BackgroundInfluential
Temperature and non‐communicable diseases: Evidence from Indonesia's primary health care system
Fritz, M. K. (2022) · Health Economics · doi:10.1002/hec.4590 · Cited by 37 · see citing works
“Increases in ambient temperature impair the skin blood flow as well as the sweating process which can have detrimental consequences for an individual’s glycemic control (Kenny et al., 2016).”
Background
Urban-rural disparity in heatwave effects on diabetes mortality in eastern China: A case-crossover analysis in 2016–2019
Tao, J., Zheng, H., Ho, H. C., Wang, X., Hossain, M. Z., Bai, Z., Wang, N., Su, H., Xu, Z., & Cheng, J. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.160026 · Cited by 33 · see citing works
Identification of the acclimation genes in transcriptomic responses to heat stress of White Pekin duck
Kim, J., Lim, K., Byun, M.-J., Lee, K., Yang, Y.-R., Park, M. N., Lim, D., Chai, H., Bang, H. T., Hwangbo, J., et al. (2017) · Cell Stress and Chaperones · doi:10.1007/s12192-017-0809-6 · Cited by 33 · see citing works
“A more recent study has tried to separate acute and chronic responses to HS and compared differentially expressed genes (DEGs) in the liver transcriptome using multiple distinct breed lines (Lan et al. 2016).”
BackgroundMethod
Early sepsis markers in patients admitted to intensive care unit with moderate-to-severe diabetic ketoacidosis
Blanchard, F., Charbit, J., Meersch, G. V. D., Popoff, B., Picod, A., Cohen, R., Chemouni, F., Gaudry, S., Bihan, H., & Cohen, Y. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00676-6 · Cited by 30 · see citing works
Perceived heat impacts and adaptive behaviours in different socio-demographic groups in the subtropics
Shih, W.-Y., Lung, S. C., & Hu, S. (2022) · International Journal of Disaster Risk Reduction · doi:10.1016/j.ijdrr.2022.102799 · Cited by 29 · see citing works
Increasing age is a major risk factor for susceptibility to heat stress during physical activity
McGinn, R. N., Poirier, M. P., Louie, J. C., Sigal, R. J., Boulay, P., Flouris, A. D., & Kenny, G. P. (2017) · Applied Physiology Nutrition and Metabolism · doi:10.1139/apnm-2017-0322 · Cited by 28 · see citing works
Self-citation
The effect of inflammation management on pH , temperature, and bacterial burden
Derwin, R., Patton, D., Strapp, H., & Moore, Z. E. H. (2022) · International Wound Journal · doi:10.1111/iwj.13970 · Cited by 28 · see citing works
“53 Notably, most temperature measurements in the current study were below the 33 (cid:1) C threshold that is argued to be needed for the cellular activity of neutrophils, fibroblasts, and epithelial cells.”
Background
Activation of autonomic thermoeffectors preceding the decision to behaviourally thermoregulate in resting humans
Schlader, Z. J., Coleman, G. L., Sackett, J. R., Sarker, S., Chapman, C. L., & Johnson, B. D. (2016) · Experimental Physiology · doi:10.1113/ep085837 · Cited by 28 · see citing works
“…populations at the greatest risk of morbidity and mortality during heat and cold waves (Anderson & Bell, 2009; Kenny et al. 2010; Kenney et al. 2014) are typically also those possessing altered control of skin blood flow [e.g. diabetics (Kenny et al. 2016), older adults (Kenney & Munce, 2003)].”
Background
Radiative Cooling Smart Textiles with Integrated Sensing for Adaptive Thermoregulation
Choi, Y. Y., Zhou, K. X., Woo, H. K., Patel, D., Salauddin, M., & Cai, L. (2024) · ACS Materials Letters · doi:10.1021/acsmaterialslett.4c01624 · Cited by 28 · see citing works
Intersecting vulnerabilities in human biology: Synergistic interactions between climate change and increasing obesity rates
Gildner, T. E., & Lévy, S. (2020) · American Journal of Human Biology · doi:10.1002/ajhb.23460 · Cited by 28 · see citing works
Cardioprotective effect of Notch signaling on the development of myocardial infarction complicated by diabetes mellitus
Wu, F., Yu, B., Zhang, X., & Zhang, Y. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.4932 · Cited by 26 · see citing works
“Diabetes mellitus (DM), or simply diabetes, is a metabolic disorder in which diabetic patients cannot appropriately regulate their blood glucose levels (4).”
Functional Changes Induced by Orexin A and Adiponectin on the Sympathetic/Parasympathetic Balance
Messina, A., Monda, M., Valenzano, A. A., Messina, G., Villano, I., Moscatelli, F., Cibelli, G., Marsala, G., Polito, R., Ruberto, M. F., et al. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00259 · Cited by 26 · see citing works
“In fact, in subjects suffering from T2DM, the thermoregulation is impaired, particularly the capacity to dissipate heat is reduced (Cavallaro et al., 2011; Kenny et al., 2016).”
Background
The effects of cool roofs on health, environmental, and economic outcomes in rural Africa: study protocol for a community-based cluster randomized controlled trial
Bunker, A., Compaoré, G., Sewe, M. O., Laurent, J. G. C., Zabré, P., Boudo, V., Ouédraogo, W. A., Ouèrmi, L., Jackson, S. T., Arisco, N., et al. (2024) · Trials · doi:10.1186/s13063-023-07804-0 · Cited by 26 · see citing works
“Heatwaves (intense periods of high ambient temperatures) increase cardio-vascular disease, heat stress, and heat stroke [2–6], as well as raise the risk of heat-related illness for individuals with diabetes [16].”
Background
Passive heat therapy: a promising preventive measure for people at risk of adverse health outcomes during heat extremes
Rodrigues, P., Orssatto, L. B. R., Gagnon, D., Dahhak, A., Hecksteden, A., Stewart, I. B., & Minett, G. M. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00701.2023 · Cited by 24 · see citing works
Association of heat and cold waves with cause-specific mortality in Iran: a systematic review and meta-analysis
Hadei, M., Hopke, P. K., Aghababaeian, H., Faridi, S., Firooz, M. H., & Ostadtaghizadeh, A. (2024) · Scientific Reports · doi:10.1038/s41598-024-74821-7 · Cited by 24 · see citing works
“One major reason for higher mortality rates in older people is that pre-existing health conditions are very common among this age group making them more vulnerable such that exposures to even short periods of heat can aggravate their health conditions by worsening disease-specific symptoms 41 .”
Background
Heat therapy shows benefit in patients with type 2 diabetes mellitus: a systematic review and meta-analysis
Sebők, J., Édel, Z., Váncsa, S., Farkas, N., Kiss, S., Erőss, B. M., Török, Z., Balogh, G. E., Balogi, Z., Nagy, R., et al. (2021) · International Journal of Hyperthermia · doi:10.1080/02656736.2021.2003445 · Cited by 28 · see citing works
Noninvasive Glucose Sensing In Vivo
Leung, H. M. C., Forlenza, G. P., Prioleau, T., & Zhou, X. (2023) · Sensors · doi:10.3390/s23167057 · Cited by 28 · see citing works
“Additionally, PwD struggle with body temperature control [188], which means they have different thermodynamics and have to be carefully considered.”
Background
Chronic Kidney Disease Among Agricultural Workers in Taiwan: A Nationwide Population-Based Study
Chang, C.-J., & Yang, H. (2023) · Kidney International Reports · doi:10.1016/j.ekir.2023.09.004 · Cited by 24 · see citing works
“33,34 We expected the farmer subgroup to show a higher association with increased ambient temperature and CKD; however, the results were not signi ﬁ cant.”
Result
The Impact of Heat Waves on Mortality among the Elderly: A Mini Systematic Review
Καλτσάτου, Α., Kenny, G. P., & Flouris, A. D. (2018) · Journal of Geriatric Medicine and Gerontology · doi:10.23937/2469-5858/1510053 · Cited by 24 · see citing works
Self-citation
Nonoptimal Temperature and Cardiovascular Health: A Scientific Statement From the American Heart Association
Hanneman, K. A., Alahmad, B., Ghosh, A., Khatana, S. A. M., Huang, M., Liu, J., Abadi, A. M., Khraishah, H., Beckie, T. M., Rajagopalan, S., et al. (2026) · Circulation · doi:10.1161/cir.0000000000001419 · Cited by 24 · see citing works
Passive heating and glycaemic control in non-diabetic and diabetic individuals: A systematic review and meta-analysis
Maley, M. J., Hunt, A. P., Stewart, I. B., Faulkner, S. H., & Minett, G. M. (2019) · PLoS ONE · doi:10.1371/journal.pone.0214223 · Cited by 23 · see citing works
Challenges arising for older workers from participating in a workplace intervention addressing work ability: a qualitative study from Germany
Sippli, K., Schmalzried, P., Rieger, M. A., & Voelter‐Mahlknecht, S. (2021) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-020-01639-x · Cited by 23 · see citing works
Behavioral thermoregulation in older adults with cardiovascular co-morbidities
Schlader, Z. J., Coleman, G. L., Sackett, J. R., Sarker, S., Chapman, C. L., Hostler, D. P., & Johnson, B. D. (2017) · Temperature · doi:10.1080/23328940.2017.1379585 · Cited by 23 · see citing works
Bias or biology? Importance of model interpretation in machine learning studies from electronic health records
Momenzadeh, A., Shamsa, A., & Meyer, J. G. (2022) · JAMIA Open · doi:10.1093/jamiaopen/ooac063 · Cited by 22 · see citing works
No effect of ascorbate on cutaneous vasodilation and sweating in older men and those with type 2 diabetes exercising in the heat
Fujii, N., Meade, R. D., Akbari, P., Louie, J. C., Alexander, L. M., Boulay, P., Sigal, R. J., & Kenny, G. P. (2017) · Physiological Reports · doi:10.14814/phy2.13238 · Cited by 22 · see citing works
“As such, we were also able to assess the influence of a passive heat stress on heat loss responses which has been shown to be attenuated in older adults with (Kenny et al. 2016a) and without type 2 diabetes (Kenny et al. 2015) relative to young adults.”
BackgroundInfluentialSelf-citation
Development of Non-Invasive Continuous Glucose Prediction Models Using Multi-Modal Wearable Sensors in Free-Living Conditions
Karunarathna, T. S., & Liang, Z. (2025) · Sensors · doi:10.3390/s25103207 · Cited by 24 · see citing works
“This multi-modal information can support continuous glucose estimation, given the reciprocal relationship between these factors and glucose regulation [27–33].”
Investigation of climate change impacts on long-term care facility occupants
Wollschlaeger, S., Sadhu, A., Ebrahimi, G., & Woo, A. (2021) · City and Environment Interactions · doi:10.1016/j.cacint.2021.100077 · Cited by 21 · see citing works
Diabetes and work: The need of a close collaboration between diabetologist and occupational physician
Iavicoli, I., Gambelunghe, A., Magrini, A., Mosconi, G., Soleo, L., Vigna, L., Trevisan, R., Bruno, A., Chiambretti, A., Scarpitta, A. M., et al. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.10.012 · Cited by 19 · see citing works
Burden of type 2 diabetes mellitus and risk factor attribution among older adults: A global, regional, and national analysis from 1990 to 2021, with projections up to 2040
Lin, L., Chen, P., Zhang, Y., Long, J., Wang, W., Sun, X., & Zhang, X. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16471 · Cited by 18 · see citing works
“45 Moreover, cardiovascular disease remains the leading cause of morbidity and mortality among patients with T2DM.”
Acute effect of passive heat exposure on markers of cardiometabolic function in adults with type 2 diabetes mellitus
Behzadi, P., Ravanelli, N., Gravel, H., Barry, H., Debray, A., Chaseling, G. K., Jacquemet, V., Neagoe, P., Nigam, A., Carpentier, A. C., et al. (2022) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00800.2021 · Cited by 19 · see citing works
Detecting Diabetic Ketoacidosis with Infection: Combating a Life-Threatening Emergency with Practical Diagnostic Tools
Ahmad, R., Narwaria, M., Singh, A., Kumar, S., & Haque, M. (2023) · Diagnostics · doi:10.3390/diagnostics13142441 · Cited by 17 · see citing works
Physical Exercise-Induced Cardiovascular and Thermoregulatory Adjustments Are Impaired in Rats Subjected to Cutaneous Artery Denervation
Lima, M. R. M., Pires, W., Fonseca, I. A. T., Joviano‐Santos, J. V., Ferreira, A. J., Coimbra, C. C., Lima, N. R. V., & Wanner, S. P. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00074 · Cited by 17 · see citing works
“, 2002); indeed, individuals with type 1 and type 2 diabetes mellitus, particularly patients with neuropathy, have impaired abilities to maintain TCORE during either hot or cold thermal stress (Kenny et al., 2016).”
Background
The metabolic upper critical temperature of the human thermoneutral zone
Henderson, M. E., & Halsey, L. G. (2022) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2022.103380 · Cited by 16 · see citing works
Considerations for occupational heat exposure: A scoping review
Cheveldayoff, P., Chowdhury, F., Shah, N., Burow, C. A., Figueiredo, M., Nguyen, N., Talbo, M. K., Jamasi, R., Katz, A., Pasquale, C., et al. (2023) · PLOS Climate · doi:10.1371/journal.pclm.0000202 · Cited by 16 · see citing works
Clinical evaluation of a cutaneous zero-heat-flux thermometer during cardiac surgery
Verheyden, C., Neyrinck, A., Laenen, A., Rex, S., & Gerven, E. V. (2021) · Journal of Clinical Monitoring and Computing · doi:10.1007/s10877-021-00758-1 · Cited by 16 · see citing works
Face-based machine learning diagnostics: applications, challenges and opportunities
Song, J., He, M., Zheng, X., Zhang, Y., Bi, C., Feng, J., Du, J., Li, H., & Shen, B. (2025) · Artificial Intelligence Review · doi:10.1007/s10462-025-11246-2 · Cited by 15 · see citing works
Thermal Effects of Topical Hyperbaric Oxygen Therapy in Hard-to-Heal Wounds—A Pilot Study
Kasprzyk-Kucewicz, T., Cholewka, A., Englisz-Jurgielewicz, B., Mucha, R., Relich, M., Kawecki, M., Sieroń–Stołtny, K., Onak, P., & Stanek, A. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18136737 · Cited by 15 · see citing works
“It is considered the second line of therapy for refractory wounds [27].”
Background
Smart Compression Sock for Early Detection of Diabetic Foot Ulcers
Billings, J., Gee, J. M. W., Ghulam, Z., & Abdullah, H. A. (2024) · Sensors · doi:10.3390/s24216928 · Cited by 14 · see citing works
“The SpO 2 sensor positioned on the hallux successfully monitored blood oxygen levels, a novel parameter in ulcer prevention.”
Background
Associations of heat and cold with hospitalizations and post-discharge deaths due to acute myocardial infarction: what is the role of pre-existing diabetes?
Xu, Z., Tong, S., Ho, H. C., Lin, H., Pan, H., & Cheng, J. (2021) · International Journal of Epidemiology · doi:10.1093/ije/dyab155 · Cited by 14 · see citing works
The association of indoor heat exposure with diabetes and respiratory 9-1-1 calls through emergency medical dispatch and services documentation
Uejio, C. K., Joiner, A., Gonsoroski, E., Tamerius, J. D., Jung, J., Moran, T. P., & Yancey, A. H. (2022) · Environmental Research · doi:10.1016/j.envres.2022.113271 · Cited by 14 · see citing works
Type 2 diabetes does not exacerbate body heat storage in older adults during brief, extreme passive heat exposure
Poirier, M. P., Notley, S. R., Boulay, P., Sigal, R. J., Friesen, B. J., Malcolm, J., Flouris, A. D., & Kenny, G. P. (2020) · Temperature · doi:10.1080/23328940.2020.1736760 · Cited by 14 · see citing works
“impairments in cutaneous vasodilation and sweating are exacerbated in individuals with T2D [8,29], which could affect whole-body heat exchange.”
BackgroundSelf-citation
The Association between Weather and Emergency Department Visitation for Diabetes in Roanoke, Virginia
Davis, R. E. L., Driskill, E. K., & Novicoff, W. M. (2022) · International Journal of Biometeorology · doi:10.1007/s00484-022-02303-4 · Cited by 14 · see citing works
Predicting healthspan and disease risks through biological age
Li, G., Cheng, L., Wong, I. N., Yin, Y., Chen, J., Liu, L., & Zhang, K. (2025) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2025.10.006 · Cited by 16 · see citing works

Is Whole-Body Thermoregulatory Function Impaired in Type 1 Diabetes Mellitus?
Yardley, J. E., Stapleton, J. M., Carter, M. R., Sigal, R. J., & Kenny, G. P. (2013) · Current Diabetes Reviews · doi:10.2174/1573399811309020004 · Cited by 27 · see citing works
Self-citation
Do Heat Events Pose a Greater Health Risk for Individuals with Type 2 Diabetes?
Yardley, J. E., Stapleton, J. M., Sigal, R. J., & Kenny, G. P. (2013) · Diabetes Technology & Therapeutics · doi:10.1089/dia.2012.0324 · Cited by 60 · see citing works
Self-citation
Whole-Body Heat Loss during Exercise in the Heat Is Not Impaired in Type 1 Diabetes
Stapleton, J. M., Yardley, J. E., Boulay, P., Sigal, R. J., & Kenny, G. P. (2013) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e31829002f3 · Cited by 25 · see citing works
Self-citation
Body Temperature Regulation During Exercise and Hyperthermia in Diabetics
Takeda, R., & Okazaki, K. (2018) · InTech eBooks · doi:10.5772/intechopen.74063 · Cited by 11 · see citing works
Blunted cardiovascular responses in individuals with type 2 diabetes and hypertension during cold and heat exposure
Rafieian, M., Farbu, E. H., Höper, A. C., Valtonen, R. I. P., Hyrkäs-Palmu, H., Perkiömäki, J. S., Crandall, C. G., Jaakkola, J. J. K., & Ikäheimo, T. M. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1558471 · Cited by 4 · see citing works

Authors: Kenny, G. P., Sigal, R. J., & McGinn, R.
Affiliations: University of Ottawa (CA)
University of Calgary (CA)
Corresponding author: Kenny, Glen P.
ORCID: Kenny, Glen P.
Sigal, Ronald J.
McGinn, Ryan
Venue: Temperature
Publisher: Informa UK Limited
Published: 2016-01-02
Volume: 3
Issue: 1
Pages: 119-145
ISSN: 2332-8940 (ISSN-L)
2332-8959
DOI: 10.1080/23328940.2015.1131506
PMC: PMC4861190
OpenAlex: W2231185364
Cited by: 297
References: 190
Citations by year: 2026: 26 · 2025: 37 · 2024: 40 · 2023: 29 · 2022: 55 · 2021: 24 · 2020: 18 · 2019: 24 · 2018: 17 · 2017: 20 · 2016: 7
FWCI: 2.66
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc
creativecommons.org/licenses/by-nc/3.0/ (vor)
Locations: Temperature (publishedVersion, cc-by-nc)
Europe PMC (PubMed Central) (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion, cc-by-nc)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology › Thermoregulation and physiological responses
Health Sciences › Medicine › Complementary and alternative medicine › Cardiovascular and exercise physiology
Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Effects of Environmental Stressors on Livestock
Keywords: diabetes mellitus, type 1 diabetes, type 2 diabetes, thermoregulation, heat stress, cold exposure, heat-related illness, heat dissipation, skin blood flow, sweating, glycemic control, cardiovascular regulation, core body temperature, cardiorespiratory fitness, diabetes complications

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Body temperature regulation in diabetes

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Self-check

Cites

Cited by

Related

Record

About these checks