Are elevated circulating intercellular adhesion molecule 1 levels more strongly predictive of diabetes than vascular risk? Outcome of a prospective study in the elderly
Open accessAbstract
Aims/hypothesis The aim of this prospective study was to determine whether circulating intercellular adhesion molecule (ICAM) 1, as a potential surrogate of 'endothelial activation', is more strongly associated with risk of vascular events than with incident diabetes.Methods We related baseline ICAM-1 levels to vascular events (866 CHD and stroke events in 5,685 participants) and incident diabetes (292 in 4,945 without baseline diabetes) in the elderly over 3.2 years of follow-up.Results ICAM-1 levels correlated positively with triacylglycerol but negatively with LDL- and HDL-cholesterol. ICAM-1 levels were higher in those who developed diabetes (388.6 +/- 1.42 vs 369.4 +/- 1.39 ng/ml [mean+/-SD], p = 0.011) and remained independently associated with new-onset diabetes (HR 1.84, 95% CI 1.26-2.69, p = 0.0015 per unit increase in log[ICAM-1] after adjusting for classical risk factors and C-reactive protein). By contrast, ICAM-1 levels were not significantly (p = 0.40) elevated in those who had an incident vascular event compared with those who remained event-free, and corresponding adjusted risk associations were null (HR 0.98, 95% CI 0.80-1.22, p = 0.89) in analyses adjusted for other risk factors.Conclusions/interpretation We show that elevated ICAM-1 levels are associated with risk of incident diabetes in the elderly at risk, despite no association with incident cardiovascular disease risk. We suggest that perturbations in circulating ICAM-1 levels are aligned more towards diabetes risk.
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sICAM-1 has been shown to be associated with increased risk of future nonfatal cardiovascular events and incident diabetes.
“sICAM-1 has been shown to be associated with increased risk of future nonfatal cardiovascular events and incident diabetes. 37,38”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [38]
The Results report that elevated ICAM-1 was associated with incident diabetes, but not with the primary CVD endpoint, coronary events, or stroke events in this elderly cohort. The Introduction mentions earlier studies linking ICAM-1 to vascular events, but does not establish the claimed association specifically for future nonfatal cardiovascular events. (LLM, conf=0.88)
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- Authors
- for the Prospective Study of Pravastatin in the Elderly at Risk Trial Study Group, Sattar, N., Murray, H. M., Welsh, P., Blauw, G. J., Buckley, B. M., de Craen, A. J., Ford, I., Forouhi, N. G., Freeman, D. J., Jukema, J. W., Macfarlane, P. W., Murphy, M. B., Packard, C. J., Stott, D. J., Westendorp, R. G. J., & Shepherd, J.
- Affiliations
- University of Glasgow (GB)
- Leiden University Medical Center (NL)
- Addenbrooke's Hospital (GB)
- Leiden University (NL)
- Cork University Hospital (IE)
- Corresponding author
- Sattar, N.
- ORCID
- Venue
- Diabetologia
- Published
- 2008-11-22
- Volume
- 52
- Issue
- 2
- Pages
- 235-239
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2041327684
- Cited by
- 19
- References
- 9
- Citations by year
- 2026: 1 · 2022: 2 · 2020: 1 · 2019: 2 · 2016: 2 · 2013: 1 · 2012: 3
- FWCI
- 1.68
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Lenus, The Irish Health Repository (Dr Steevens Hospital Library) (submittedVersion)
- Funders
- Stroke Association
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Keywords
- ICAM-1, circulating biomarkers, new-onset diabetes, cardiovascular events, coronary artery disease, stroke, endothelial activation, older adults, vascular risk, C-reactive protein
- MeSH terms
- Aged, Aged, 80 and over, Blood Pressure, Cholesterol, Diabetes Mellitus, Endothelium, Vascular, Female, Follow-Up Studies, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Myocardial Infarction, Predictive Value of Tests, Prospective Studies, Risk Factors, Time Factors, Incidence, Pravastatin, Intercellular Adhesion Molecule-1, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Stroke
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