Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Ridker, Paul M; Hennekens, Charles H; Roitman-Johnson, Beatrice; Stampfer, Meir J; Allen, Jean

doi:10.1016/s0140-6736(97)09032-6

Cited by 1,229Atherosclerosis and Cardiovascular DiseasesLipoproteins and Cardiovascular HealthAcute Myocardial Infarction Research

Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Ridker, Paul M, Hennekens, Charles H, Roitman-Johnson, Beatrice, Stampfer, Meir J, Allen, Jean·1998·The Lancet

DOI 10.1016/s0140-6736(97)09032-6

Open this paper in CoChat — free account

Abstract

Background The intercellular adhesion molecule ICAM-1 mediates adhesion and transmigration of leucocytes to the vascular endothelial wall, a step proposed to be critical in the initiation and progression of atherosclerosis. Whether concentrations of soluble ICAM-1 (sICAM-1) are raised in apparently healthy individuals who later suffer acute myocardial infarction is unknown.Methods We obtained baseline plasma samples from a prospective cohort of 14,916 healthy men enrolled in the Physicians' Health Study. With a nested case-control design, we measured sICAM-1 concentrations for 474 participants who developed a first myocardial infarction, and 474 controls (participants who remained healthy throughout the 9-year follow-up). Cases were matched to controls according to age and smoking status at the time of myocardial infarction.Findings We found a significant association between increasing concentration of sICAM-1 and risk of future myocardial infarction (p = 0.003), especially among participants with baseline sICAM-1 concentrations in the highest quartile (> 260 ng/mL; relative risk 1.6 [95% Cl 1.1-2.4], p = 0.02). This association was present overall as well as among non-smokers, and persisted after control for lipid and non-lipid risk factors. In multivariate analyses, the risk of future myocardial infarction was 80% higher for participants with baseline sICAM-1 concentrations in the highest quartile (relative risk 1.8 [1.1-2.8], p = 0.02). Similar risk estimates were seen among non-smokers. We found slight but significant correlations between sICAM-1 and fibrinogen, high-density-lipoprotein cholesterol, homocysteine, triglycerides, tissue-type plasminogen-activator antigen, and C-relative protein, but adjustment for these altered the risk little. The risk of myocardial infarction associated with raised concentrations of sICAM-1 seemed to increase with length of follow-up.Interpretation Our data support the hypothesis that cellular mediators of inflammation have a role in atherogenesis and provide a clinical basis to consider antiadhesion therapies as a novel means of cardiovascular disease prevention.

Integrity signals

Registry

Crossref · 10.1016/s0140-6736(97)09032-6

Cites

34 of 34 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

sICAM-1 has been shown to be associated with increased risk of future nonfatal cardiovascular events and incident diabetes.
“sICAM-1 has been shown to be associated with increased risk of future nonfatal cardiovascular events and incident diabetes. 37,38”
From Comprehensive Long-Term Changes in Cardiovascular Risk Biomarkers With Tirzepatide (2026) · cites this paper as [37]

The pathogenesis of atherosclerosis: a perspective for the 1990s
Ross, R. (1993) · Nature · doi:10.1038/362801a0 · Cited by 10,618 · see citing works
Adhesion receptors of the immune system
Springer, T. A. (1990) · Nature · doi:10.1038/346425a0 · Cited by 6,477 · see citing works
Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men
Ridker, P. M., Cushman, M., Stampfer, M. J., Tracy, R. P., & Hennekens, C. H. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704033361401 · Cited by 5,504 · see citing works
Induction by IL 1 and interferon-gamma: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1).
Dustin, M. L., Rothlein, R., Bhan, A. K., Dinarello, C. A., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.1.245 · Cited by 2,450 · see citing works
Final Report on the Aspirin Component of the Ongoing Physicians' Health Study
Steering Committee of the Physicians' Health Study Research Group (1989) · New England Journal of Medicine · doi:10.1056/nejm198907203210301 · Cited by 2,269 · see citing works
Molecular Bases of the Acute Coronary Syndromes
Libby, P. (1995) · Circulation · doi:10.1161/01.cir.91.11.2844 · Cited by 2,029 · see citing works
Endothelial Expression of a Mononuclear Leukocyte Adhesion Molecule During Atherogenesis
Cybulsky, M. I., & Gimbrone, M. A. (1991) · Science · doi:10.1126/science.1990440 · Cited by 1,710 · see citing works
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober, J. S., Gimbrone, M. A., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.6.1893 · Cited by 1,413 · see citing works
The expression of the adhesion molecules ICAM‐1, VCAM‐1, PECAM, and E‐selectin in human atherosclerosis
Davies, M. J., Gordon, J. L., Gearing, A. J. H., Pigott, R., Woolf, N., Katz, D. R., & Kyriakopoulos, A. (1993) · The Journal of Pathology · doi:10.1002/path.1711710311 · Cited by 777 · see citing works
Soluble forms of E-selectin, ICAM-1 and VCAM-1 are present in the supernatants of cytokine activated cultured endothelial cells
Pigott, R., Dillon, L. P., Hemingway, I., & Gearing, A. J. H. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)91234-h · Cited by 650 · see citing works
Expression of intercellular adhesion molecule-1 in atherosclerotic plaques.
Poston, R. N., Haskard, D. O., Coucher, J., Gall, N. P., & Johnson-Tidey, R. R. (1992) · PubMed Central · Cited by 583 · see citing works
Leucocyte-endothelial interactions and regulation of leucocyte migration
Adams, D., & Shaw, S. (1994) · The Lancet · doi:10.1016/s0140-6736(94)92029-x · Cited by 580 · see citing works
Endogenous tissue-type plasminogen activator and risk of myocardial infarction
Ridker, P. M., Vaughan, D. E., Manson, J., Hennekens, C. H., & Stampfer, M. (1993) · The Lancet · doi:10.1016/0140-6736(93)90998-v · Cited by 580 · see citing works
Neovascular Expression of E-Selectin, Intercellular Adhesion Molecule-1, and Vascular Cell Adhesion Molecule-1 in Human Atherosclerosis and Their Relation to Intimal Leukocyte Content
O’Brien, K. D., McDonald, T. O., Chait, A., Allen, M. D., & Alpers, C. E. (1996) · Circulation · doi:10.1161/01.cir.93.4.672 · Cited by 573 · see citing works
A Prospective Study of Lipoprotein(a) and the Risk of Myocardial Infarction
Ridker, P. M. (1993) · JAMA · doi:10.1001/jama.1993.03510180065035 · Cited by 512 · see citing works
E-selectin and intercellular adhesion molecule-1 are released by activated human endothelial cells in vitro.
Leeuwenberg, J. F. M., Smeets, E. F., Neefjes, J., Shaffer, M., Cinek, T., Jeunhomme, T. M. A. A., Ahern, T. J., & Buurman, W. A. (1992) · PubMed Central · Cited by 510 · see citing works
ENDOTHELIAL-LEUKOCYTE ADHESION MOLECULES IN HUMAN DISEASE
Bevilacqua, M. P., Nelson, R. M., Mannori, G., & Cecconi, O. (1994) · Annual Review of Medicine · doi:10.1146/annurev.med.45.1.361 · Cited by 456 · see citing works
Cell adhesion molecules in coronary artery disease
Jang, Y., Lincoff, A. M., Plow, E. F., & Topol, E. J. (1994) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(94)90162-7 · Cited by 395 · see citing works
Fibrinogen mediates leukocyte adhesion to vascular endothelium through an ICAM-1-dependent pathway
Languino, L. R., Plescia, J., Alain Duperray, B., Brian, A. A., Plow, E. F., Geltosky, J. E., & Altieri, D. C. (1993) · Cell · doi:10.1016/0092-8674(93)90367-y · Cited by 343 · see citing works
Adhesion molecules on the endothelium and mononuclear cells in human atherosclerotic lesions.
van der Wal, A. C., Das, P. K., Tigges, A. J., & Becker, A. E. (1992) · PubMed Central · Cited by 336 · see citing works
Interrelation of Hyperhomocyst(e)inemia, Factor V Leiden, and Risk of Future Venous Thromboembolism
Ridker, P. M., Hennekens, C. H., Selhub, J., Miletich, J. P., Malinow, M. R., & Stampfer, M. J. (1997) · Circulation · doi:10.1161/01.cir.95.7.1777 · Cited by 335 · see citing works
Levels of Soluble Cell Adhesion Molecules in Patients With Dyslipidemia
Hackman, A. M., Abe, Y., Insull, W., Pownall, H. J., Smith, L. C., Dunn, K., Gotto, A. M., & Ballantyne, C. M. (1996) · Circulation · doi:10.1161/01.cir.93.7.1334 · Cited by 310 · see citing works
Circulating Vascular Cell Adhesion Molecule-1 Correlates With the Extent of Human Atherosclerosis in Contrast to Circulating Intercellular Adhesion Molecule-1, E-Selectin, P-Selectin, and Thrombomodulin
Peter, K., Nawroth, P. P., Conradt, C., Nordt, T. K., Weiss, T., Boehme, M. W. J., Wünsch, A., Allenberg, J. R., Kübler, W., & Bode, C. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.3.505 · Cited by 306 · see citing works
Coronary endothelial and cardiac protective effects of a monoclonal antibody to intercellular adhesion molecule-1 in myocardial ischemia and reperfusion.
L, X., Lefer, D. J., Lefer, A. M., & Rothlein, R. (1992) · Circulation · doi:10.1161/01.cir.86.3.937 · Cited by 292 · see citing works
Circulating Endothelial Cell/Leukocyte Adhesion Molecules in Atherosclerosis
Blann, A. D., & McCollum, C. N. (1994) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1648827 · Cited by 258 · see citing works
Plasma concentration of cross-linked fibrin degradation product (D-dimer) and the risk of future myocardial infarction among apparently healthy men.
Ridker, P. M., Hennekens, C. H., Cerskus, A. L., & Stampfer, M. J. (1994) · Circulation · doi:10.1161/01.cir.90.5.2236 · Cited by 243 · see citing works
Various cell types in human atherosclerotic lesions express ICAM-1. Further immunocytochemical and immunochemical studies employing monoclonal antibody 10F3.
OYu, P., Peclo, M. M., & Gown, A. M. (1992) · PubMed · Cited by 154 · see citing works
Prevention of In vitro neutrophil adhesion to endothelial cells through shedding of L-selectin by C-reactive protein and peptides derived from C-reactive protein.
Zouki, C., Beauchamp, M., Baron, C., & Filep, J. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119561 · Cited by 152 · see citing works
Molecular Identification of a Novel Fibrinogen Binding Site on the First Domain of ICAM-1 Regulating Leukocyte-Endothelium Bridging
Alain Duperray, B., Languino, L. R., Plescia, J., McDowall, A., Hogg, N., Craig, A. G., Berendt, A. R., & Altieri, D. C. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.1.435 · Cited by 123 · see citing works
THE INFLUENCE OF SMOKING ON SOLUBLE ADHESION MOLECULES AND ENDOTHELIAL CELL MARKERS
Blann, A. D., Steele, C., & McCollum, C. N. (1997) · Thrombosis Research · doi:10.1016/s0049-3848(97)00031-5 · Cited by 96 · see citing works
Inhibition of Intimal Hyperplasia After Balloon Injury by Antibodies to Intercellular Adhesion Molecule-1 and Lymphocyte Function–Associated Antigen-1
Yasukawa, H., Imaizumi, T., Matsuoka, H., NAKASHIMA, A., & Morimatsu, M. (1997) · Circulation · doi:10.1161/01.cir.95.6.1515 · Cited by 92 · see citing works
A Mitogenic Action for Fibrinogen Mediated through Intercellular Adhesion Molecule-1
Gardiner, E. E., & D’Souza, S. E. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.24.15474 · Cited by 53 · see citing works
Adhesion molecules of the immune system
Issekutz, T. B. (1993) · Journal of Neuroimmunology · doi:10.1016/0165-5728(93)90142-l · Cited by 35 · see citing works
A Role for Intercellular Adhesion Molecule-1 in Restenosis
Plow, E. F., & D’Souza, S. E. (1997) · Circulation · doi:10.1161/01.cir.95.6.1355 · Cited by 12 · see citing works

Flagged first, then by citations

1 of the 35 references couldn’t be matched to a known paper.

Sorted by citations

Inflammation and Atherosclerosis
Libby, P., Ridker, P. M., & Maseri, A. (2002) · Circulation · doi:10.1161/hc0902.104353 · Cited by 7,724 · see citing works
Self-citation
C-reactive protein and other markers of inflammation in the prediction of cardiovascular disease in women
Ridker, P. M., Hennekens, C. H., Buring, J. E., & Rifai, N. (2000) · New England Journal of Medicine · doi:10.1056/nejm200003233421202 · Cited by 5,850 · see citing works
The Effects of Plant Flavonoids on Mammalian Cells:Implications for Inflammation, Heart Disease, and Cancer
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882 · see citing works
“artery disease (Ridker et al., 1998).”
Endothelial Function and Dysfunction: Testing and Clinical Relevance
Deanfield, J. E., Halcox, J. P., & Rabelink, T. J. (2007) · Circulation · doi:10.1161/circulationaha.106.652859 · Cited by 2,710 · see citing works
Role of Oxidative Modifications in Atherosclerosis
Stocker, R., & Keaney, J. F. (2004) · Physiological Reviews · doi:10.1152/physrev.00047.2003 · Cited by 2,611 · see citing works
The clinical implications of endothelial dysfunction
Widlansky, M. E., Gokce, N., Keaney, J. F., & Vita, J. A. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00994-x · Cited by 1,749 · see citing works
“In obese women, a yearlong program of low fat diet and exercise reduced plasma levels of tumor necrosis factoralpha, interleukin-6, soluble ICAM-1, and soluble vascular cell adhesion molecule-1 (VCAM-1) (52).”
BackgroundInfluential
Current Concepts of the Pathogenesis of the Acute Coronary Syndromes
Libby, P. (2001) · Circulation · doi:10.1161/01.cir.104.3.365 · Cited by 1,550 · see citing works
Prevalence and Correlates of Accelerated Atherosclerosis in Systemic Lupus Erythematosus
Roman, M. J., Shanker, B., Davis, A., Lockshin, M. D., Sammaritano, L. R., Simantov, R., Crow, M. K., Schwartz, J. E., Paget, S. A., Devereux, R. B., et al. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa035471 · Cited by 1,422 · see citing works
Inflammation as a Cardiovascular Risk Factor
Willerson, J. T., & Ridker, P. M. (2004) · Circulation · doi:10.1161/01.cir.0000129535.04194.38 · Cited by 1,304 · see citing works
Prevention of coronary heart disease in clinical practice: Recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention1European Society of Cardiology, European Atherosclerosis Society, European Society of Hypertension, International Society of Behavioural Medicine, European Society of General Practice/Family Medicine, European Heart Network.1,2Published simultaneously in the European Heart Journal 1998;19:1434–1503 and the Journal of Hypertension (Summary only) 1998;16(10).2
Wood, D., Backer, G. D., Færgeman, O., Graham, I. D., Mancia, G., & Pyörälà, K. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)90209-x · Cited by 1,251 · see citing works
Adhesion molecules and atherosclerosis
Blankenberg, S., Barbaux, S., & Tiret, L. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00097-2 · Cited by 1,075 · see citing works
“[83] Ridker PM, Hennekens CH, Roitman-Johnson B, Stampfer MJ, Allen J.”
BackgroundResultInfluential
Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year
Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A. M., & Giugliano, D. (2002) · Circulation · doi:10.1161/hc0702.104279 · Cited by 994 · see citing works
Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms
Jain, M. K., & Ridker, P. M. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1901 · Cited by 916 · see citing works
Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction
Lopez-Garcia, E., Schulze, M. B., Fung, T. T., Meigs, J. B., Rifai, N., Manson, J. E., & Hu, F. B. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.4.1029 · Cited by 881 · see citing works
“Higher concentrations of E-selectin and sICAM-1 have been observed in patients with ischemic heart disease (23), and baseline plasma concentrations of sICAM-1 are predictors of myocardial infarction in apparently healthy men (24).”
Background
Stress, inflammation and cardiovascular disease
Black, P. H., & Garbutt, L. D. (2002) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(01)00302-6 · Cited by 793 · see citing works
Novel Clinical Markers of Vascular Wall Inflammation
Blake, G. J., & Ridker, P. M. (2001) · Circulation Research · doi:10.1161/hh2101.099270 · Cited by 754 · see citing works
Blood Pressure and Inflammation in Apparently Healthy Men
Chae, C. U., Lee, R. T., Rifai, N., & Ridker, P. M. (2001) · Hypertension · doi:10.1161/01.hyp.38.3.399 · Cited by 716 · see citing works
Inflammatory bio‐markers and cardiovascular risk prediction
Blake, G., & Ridker, P. M. (2002) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.2002.01019.x · Cited by 702 · see citing works
ICAM-1 signaling in endothelial cells
Lawson, C., & Wolf, S. (2009) · Pharmacological Reports · doi:10.1016/s1734-1140(09)70004-0 · Cited by 670 · see citing works
“A significant correlation between sICAM-1 concentrations and future coronary artery disease has been demonstrated by several groups [34, 55, 71], but refuted by others [70].”
Result
Effect of Postmenopausal Hormones on Inflammation-Sensitive Proteins: The Postmenopausal Estrogen/Progestin Interventions (PEPI) Study
Cushman, M., Legault, C., Barrett-Connor, E., Stefanick, M. L., Kessler, C., Judd, H. L., Sakkinen, P. A., & Tracy, R. P. (1999) · Circulation · doi:10.1161/01.cir.100.7.717 · Cited by 660 · see citing works
“Hysterectomy, yes 20 (28) 20 (27) 18 (25) 18 (24) 20 (27)”
Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.
Lopez-Garcia, E., Schulze, M. B., Meigs, J. B., Manson, J. E., Rifai, N., Stampfer, M. J., Willett, W. C., & Hu, F. B. (2005) · The Journal of Nutrition · doi:10.1093/jn/135.3.562 · Cited by 600 · see citing works
“, patients with coronary heart disease had higher levels of E-selectin and sICAM-1 (23), and baseline plasma levels of sICAM-1 were predictors of myocardial infarction among apparently healthy men (24).”
Background
Accelerated atherosclerosis: An extraarticular feature of rheumatoid arthritis?
Doornum, S. V., McColl, G., & Wicks, I. P. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10089 · Cited by 605 · see citing works
Acute Systemic Inflammation Impairs Endothelium-Dependent Dilatation in Humans
Hingorani, A. D., Cross, J. M., Kharbanda, R. K., Mullen, M. J., Bhagat, K., Taylor, M., Donald, A. E., Palacios‐Callender, M., Griffin, G. E., Deanfield, J. E., et al. (2000) · Circulation · doi:10.1161/01.cir.102.9.994 · Cited by 605 · see citing works
Circulating Cell Adhesion Molecules and Death in Patients With Coronary Artery Disease
Blankenberg, S., Rupprecht, H. J., Bickel, C., Peetz, D., Hafner, G., Tiret, L., Meyer, J., & for the AtheroGene Investigators (2001) · Circulation · doi:10.1161/hc3701.095949 · Cited by 593 · see citing works
Soluble P-Selectin and the Risk of Future Cardiovascular Events
Ridker, P. M., Buring, J. E., & Rifai, N. (2001) · Circulation · doi:10.1161/01.cir.103.4.491 · Cited by 564 · see citing works
Postprandial endothelial activation in healthy subjects and in type 2 diabetic patients: Role of fat and carbohydrate meals
Nappo, F., Esposito, K., Cioffi, M., Giugliano, G., Molinari, A. M., Paolisso, G., Marfella, R., & Giugliano, D. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01741-2 · Cited by 555 · see citing works
“Soluble forms of cellular adhesion found in plasma are considered an index of endothelial activation and even a molecular marker of early atherosclerosis (15).”
Background
Anti-inflammatory therapies for cardiovascular disease
Ridker, P. M., & Lüscher, T. F. (2014) · European Heart Journal · doi:10.1093/eurheartj/ehu203 · Cited by 558 · see citing works
“Epidemiological data have long shown strong positive associations betweensoluble levels of these adhesionmolecules and futurevascular events and thus multiple adhesion molecules serve as potential vasculoprotective targets for atherothrombosis.(61)”
Background
High-sensitivity C-reactive protein: a novel and promising marker of coronary heart disease.
Rifai, N., & Ridker, P. (2001) · Clinical Chemistry · doi:10.1093/clinchem/47.3.403 · Cited by 592 · see citing works
Placental Debris, Oxidative Stress and Pre-eclampsia
Redman, C. W. G., & Sargent, I. L. (2000) · Placenta · doi:10.1053/plac.2000.0560 · Cited by 508 · see citing works
Heavy Metal Poisoning and Cardiovascular Disease
Alissa, E. M., & Ferns, G. A. (2011) · Journal of Toxicology · doi:10.1155/2011/870125 · Cited by 493 · see citing works
“predictive for CVD [85].”
Endothelial Dysfunction in Chronic Inflammatory Diseases
Steyers, C. M., & Miller, F. J. (2014) · International Journal of Molecular Sciences · doi:10.3390/ijms150711324 · Cited by 478 · see citing works
“Efforts to define plasma biomarkers for endothelial dysfunction have largely focused on soluble intercellular adhesion molecules (CAMs), including intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule (VCAM-1), E-selectin and others [20,21].”
Background
High-sensitivity C-reactive protein
Bassuk, S. S., Rifai, N., & Ridker, P. M. (2004) · Current Problems in Cardiology · doi:10.1016/s0146-2806(04)00074-x · Cited by 483 · see citing works
Immunomodulation and Anti-Inflammatory Effects of Garlic Compounds
Arreola, R., Quintero-Fabián, S., López-Roa, R. I., Flores-Gutiérrez, E. O., Reyes‐Grajeda, J. P., Carrera-Quintanar, L., & Ortuño‐Sahagún, D. (2015) · Journal of Immunology Research · doi:10.1155/2015/401630 · Cited by 464 · see citing works
“Among these are markers of systemic inflammation, such as high-sensitivity C-reactive protein (CRP), and acute-phase protein [91], serum amyloid A, cytokines such as IL-6, and adhesion molecules such as soluble intercellular adhesion molecule type 1 (ICAM-1) [92, 93] and vascular cell adhesion molecule-1 (VCAM-1) [94].”
Background
Assessment and treatment of endothelial dysfunction in humans
Anderson, T. J. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00259-4 · Cited by 443 · see citing works
“predictive of future myocardial infarction (20).”
Established and Emerging Plasma Biomarkers in the Prediction of First Atherothrombotic Events
Ridker, P. M., Brown, N. J., Vaughan, D. E., Harrison, D. G., & Mehta, J. L. (2004) · Circulation · doi:10.1161/01.cir.0000133444.17867.56 · Cited by 418 · see citing works
Short- and Long-Term Antibiotic Treatment Reduces Airway and Systemic Inflammation in Non–Cystic Fibrosis Bronchiectasis
Chalmers, J. D., Smith, M. P., McHugh, B. J., Doherty, C., Govan, J. R. W., & Hill, A. T. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201203-0487oc · Cited by 408 · see citing works
“These findings may have relevance beyond airway inflammation because raised levels of endothelium-derived inflammatory markers (particularly ICAM-1) have been linked to an increased frequency of myocardial infarction (32), stroke (33), and diabetes (34), which are increased in patients with chronic lung disease, in ad…”
Background
NF-κB Inhibition Ameliorates Angiotensin II–Induced Inflammatory Damage in Rats
Müller, D. N., Dechend, R., Mervaala, E. M. A., Park, J.-K., Schmidt, F. H., Fiebeler, A., Theuer, J., Breu, V., Ganten, D., Haller, H. G., et al. (2000) · Hypertension · doi:10.1161/01.hyp.35.1.193 · Cited by 404 · see citing works
Ageing, tumour necrosis factor-alpha (TNF- α ) and atherosclerosis
Brüünsgaard, H., Skinhøj, P., Pedersen, B. K., Schroll, M., & Pedersen, B. K. (2000) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2000.01281.x · Cited by 402 · see citing works
ABO Blood Group and the Risk of Pancreatic Cancer
Wolpin, B. M., Chan, A. T., Hartge, P., Chanock, S. J., Kraft, P., Hunter, D. J., Giovannucci, E. L., & Fuchs, C. S. (2009) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djp020 · Cited by 399 · see citing works
Relation between markers of systemic vascular inflammation and smoking in women
Bermudez, E. A., Rifai, N., Buring, J. E., Manson, J. E., & Ridker, P. M. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02284-1 · Cited by 385 · see citing works
Soluble adhesion molecules and prediction of coronary heart disease: a prospective study and meta-analysis
Malik, I. S., Danesh, J., Whincup, P. H., Bhatia, V. K., Papacosta, O., Walker, M., LENNON, L. T., Thomson, A. G., & Haskard, D. O. (2001) · The Lancet · doi:10.1016/s0140-6736(01)06104-9 · Cited by 389 · see citing works
Cellular adhesion molecules and atherogenesis
Price, D. T., & Loscalzo, J. (1999) · The American Journal of Medicine · doi:10.1016/s0002-9343(99)00153-9 · Cited by 388 · see citing works
Pathogenesis of atherosclerosis: A multifactorial process.
Singh, R. B., Mengi, S. A., Xu, Y., Arneja, A. S., & Dhalla, N. S. (2002) · PubMed Central · Cited by 381 · see citing works
Consumption of (n-3) Fatty Acids Is Related to Plasma Biomarkers of Inflammation and Endothelial Activation in Women
López‐García, E., Schulze, M. B., Manson, J. E., Meigs, J. B., Albert, C. M., Rifai, N., Willett, W. C., & Hu, F. B. (2004) · Journal of Nutrition · doi:10.1093/jn/134.7.1806 · Cited by 378 · see citing works
“Higher levels of E-selectin and sICAM-1 were also observed in patients with coronary heart disease (37), and baseline plasma levels of sICAM-1 are predictors of myocardial infarction among apparently healthy men (38).”
Background
Inflammation and Atherosclerosis
Hartman, J., & Frishman, W. H. (2014) · Cardiology in Review · doi:10.1097/crd.0000000000000021 · Cited by 371 · see citing works
Novel Inflammatory Markers of Coronary Risk
Libby, P., & Ridker, P. M. (1999) · Circulation · doi:10.1161/01.cir.100.11.1148 · Cited by 375 · see citing works
Circulating markers of inflammation and atherosclerosis
Lind, L. (2003) · Atherosclerosis · doi:10.1016/s0021-9150(03)00012-1 · Cited by 369 · see citing works
“[59] Ridker PM, Hennekens CH, Roitman-Johnson B, et al.”
Background
Inflammatory Markers and the Metabolic Syndrome
Koh, K. K., Han, S. H., & Quon, M. J. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.06.082 · Cited by 368 · see citing works
Effect of Postprandial Hypertriglyceridemia and Hyperglycemia on Circulating Adhesion Molecules and Oxidative Stress Generation and the Possible Role of Simvastatin Treatment
Ceriello, A., Quagliaro, L., Piconi, L., Assaloni, R., Da Ros, R., Maier, A., Esposito, K., & Giugliano, D. (2004) · Diabetes · doi:10.2337/diabetes.53.3.701 · Cited by 362 · see citing works
“Soluble forms of some cellular adhesion molecules can be found in plasma, and it has been suggested that elevated plasma levels of some cellular adhesion molecules may be an index of endothelial activation (6) or even a molecular marker of early atherosclerosis (7).”
Background
Elevated Levels of VE-Cadherin-Positive Endothelial Microparticles in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease
Koga, H., Sugiyama, S., Kugiyama, K., Watanabe, K., Fukushima, H., Tanaka, T., Sakamoto, T., Yoshimura, M., Jinnouchi, H., & Ogawa, H. (2005) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2005.02.047 · Cited by 362 · see citing works
Dietary modulation of endothelial function: implications for cardiovascular disease
Brown, A. A., & Hu, F. B. (2001) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/73.4.673 · Cited by 350 · see citing works
Nontraditional Risk Factors and Biomarkers for Cardiovascular Disease: Mechanistic, Research, and Clinical Considerations for Youth
Balagopal, P., de Ferranti, S. D., Cook, S., Daniels, S. R., Gidding, S. S., Hayman, L. L., McCrindle, B. W., Mietus‐Snyder, M., & Steinberger, J. (2011) · Circulation · doi:10.1161/cir.0b013e31821c7c64 · Cited by 353 · see citing works
Arsenic and Cardiovascular Disease
States, J. C., Srivastava, S., Chen, Y., & Barchowsky, A. (2008) · Toxicological Sciences · doi:10.1093/toxsci/kfn236 · Cited by 351 · see citing works
“Circulating markers of systemic inflammation and endothelial dysfunction such as soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular adhesion molecule-1 (sVCAM-1) are predictive for CVD (Blankenberg et al., 2001; Hwang et al., 1997; Ridker et al., 1998, 2000).”
Anti-inflammatory and immunomodulatory effects of statins
Blanco‐Colio, L. M., Tuñón, J., Martı́n-Ventura, J. L., & Egido, J. (2003) · Kidney International · doi:10.1046/j.1523-1755.2003.00744.x · Cited by 346 · see citing works
Novel Association of ABO Histo-Blood Group Antigen with Soluble ICAM-1: Results of a Genome-Wide Association Study of 6,578 Women
Paré, G., Chasman, D. I., Kellogg, M., Zee, R. Y. L., Rifai, N., Badola, S., Miletich, J. P., & Ridker, P. M. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000118 · Cited by 341 · see citing works
“Finally, plasma concentration of sICAM-1 has been shown to provide unique predictive value for the risk of myocardial infarction (MIM 608446), ischemic stroke (MIM 601367), peripheral arterial disease (MIM 606787) and noninsulin-dependent diabetes mellitus (MIM 125853) in epidemiological studies [5–7].”
Background
Lifestyle Modification Improves Endothelial Function in Obese Subjects With the Insulin Resistance Syndrome
Hamdy, O., Ledbury, S., Mullooly, C., Jarema, C., Porter, S., Ovalle, K., Moussa, A., Caselli, A., Caballero, A. E., Economides, P. A., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2119 · Cited by 335 · see citing works
“Circulating soluble adhesion molecules are valuable markers of atherosclerosis, and particularly the elevated sICAM levels were found to be associated with increased risk of future myocardial infarction in healthy men (26).”
Inhibition of Phosphatidylinositol 3-Kinase Enhances Mitogenic Actions of Insulin in Endothelial Cells
Montagnani, M., Golovchenko, I., Kim, I., Koh, G. Y., Goalstone, M. L., Mundhekar, A. N., Johansen, M. L., Kucik, D. F., Quon, M. J., & Draznin, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m103728200 · Cited by 328 · see citing works
Effects of obstructive sleep apnea on circulating ICAM-1, IL-8, and MCP-1
Ohga, E., Tomita, T., Wada, H., Yamamoto, H., Nagase, T., & Ouchi, Y. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00177.2002 · Cited by 328 · see citing works
“Moreover, the circulating ICAM-1 level may indicate a risk of future myocardial infarction, suggesting that antiadhesion therapies can be considered as a novel therapeutic means of cardiovascular disease (26).”
Background
Vascular inflammation in hypertension and diabetes: molecular mechanisms and therapeutic interventions
Savoia, C., & Schiffrin, E. L. (2007) · Clinical Science · doi:10.1042/cs20060247 · Cited by 326 · see citing works
Evaluating Novel Cardiovascular Risk Factors: Can We Better Predict Heart Attacks?
Ridker, P. M. (1999) · Annals of Internal Medicine · doi:10.7326/0003-4819-130-11-199906010-00018 · Cited by 323 · see citing works
Prostaglandins, Leukotrienes and Essential Fatty Acids
Kaur, G., Sinclair, A. J., Cameron‐Smith, D., Barr, D. P., Molero, J. C., & Konstantopoulos, N. (2009) · Cited by 321 · see citing works
The Association Between Major Depression and Levels of Soluble Intercellular Adhesion Molecule 1, Interleukin-6, and C-Reactive Protein in Patients With Recent Acute Coronary Syndromes
Lespérance, F., Frasure‐Smith, N., Théroux, P., & Irwin, M. R. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.2.271 · Cited by 305 · see citing works
Inflammatory Markers and Sleep Disturbance in Major Depression
Motivala, S. J., Sarfatti, A., Olmos, L., & Irwin, M. R. (2005) · Psychosomatic Medicine · doi:10.1097/01.psy.0000149259.72488.09 · Cited by 286 · see citing works
“Prospective data further indicate that sICAM and IL-6, directly implicated in atherosclerotic disease processes, predict risk for myocardial infarction independent of cholesterol levels, smoking status, and obesity (53,54).”
Background
Influence of dietary supplementation with long-chain n-3 or n-6 polyunsaturated fatty acids on blood inflammatory cell populations and functions and on plasma soluble adhesion molecules in healthy adults.
Thies, F., Miles, E. A., Nebe‐von‐Caron, G., Powell, J. R., Hurst, T. L., Newsholme, E. A., & Calder, P. C. (2001) · Lipids · doi:10.1007/s11745-001-0831-4 · Cited by 279 · see citing works
“The plasma concentrations of these molecules are elevated during inflammatory conditions (2), increase with age (3‐5), are higher in individuals with cardiovascular disease (3,5,6), and are predictive of future myocardial infarction ( 7 ).”
Background
Circulating markers of endothelial function in cardiovascular disease
Constans, J., & Conri, C. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2005.12.030 · Cited by 277 · see citing works
Angiotensin II is associated with activation of NF-κB-mediated genes and downregulation of PPARs
Tham, D. M., Martin-McNulty, B., Wang, Y.-X., Wilson, D. W., Vergona, R. A., Sullivan, M. E., Dole, W. P., & Rutledge, J. C. (2002) · Physiological Genomics · doi:10.1152/physiolgenomics.00062.2002 · Cited by 276 · see citing works
Plasma tumour necrosis factor-α and early carotid atherosclerosis in healthy middle-aged men
Skoog, T. (2002) · European Heart Journal · doi:10.1053/euhj.2001.2805 · Cited by 275 · see citing works
“That the plasma concentration of the soluble form of at least one cellular adhesion molecule, intercellular adhesion molecule type-1 (sICAM-1), is in fact elevated several years before the occurrence of clinical manifestations of coronary artery disease was recently demonstrated in two prospective epidemiological stud…”
Markers of Inflammation and Rapid Coronary Artery Disease Progression in Patients With Stable Angina Pectoris
Zouridakis, E., y, P. A., Arroyo‐Espliguero, R., Fredericks, S., & Kaski, J. C. (2004) · Circulation · doi:10.1161/01.cir.0000142664.18739.92 · Cited by 274 · see citing works
Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial
Estruch, R., Sacanella, E., Badı́a, E., Antúnez, E., Nicolas, J. M., Fernández‐Solà, J., Rotilio, D., de Gaetano, G., Rubin, E., & Urbano-Márquez, A. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.03.006 · Cited by 271 · see citing works
“Although high concentrations of some soluble cellular adhesion molecules are associated with an increased risk of vascular events [21–23], no data are available on clinical conditions or interventions associated with reduced levels of these molecules.”
Background
Anticytokine Agents: Targeting Interleukin Signaling Pathways for the Treatment of Atherothrombosis
Ridker, P. M. (2019) · Circulation Research · doi:10.1161/circresaha.118.313129 · Cited by 260 · see citing works
Self-citation
Impairment of Endothelial Functions by Acute Hyperhomocysteinemia and Reversal by Antioxidant Vitamins
Nappo, F. (1999) · JAMA · doi:10.1001/jama.281.22.2113 · Cited by 270 · see citing works
“Soluble forms of cellular adhesion molecules found in plasma are considered an index of endothelial activation and even a molecular marker of early atherosclerosis.(26)”
Background
Microvascular Reactivity and Inflammatory Cytokines in Painful and Painless Peripheral Diabetic Neuropathy
Doupis, J., Lyons, T. E., Wu, S., Gnardellis, C., Dinh, T., & Veves, A. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2385 · Cited by 266 · see citing works
Antioxidant vitamin and mineral supplements for preventing age-related macular degeneration
Evans, J. R., & Lawrenson, J. G. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd000253.pub4 · Cited by 266 · see citing works
Increased levels of circulating ICAM-1, VCAM-1, and L-selectin in obstructive sleep apnea syndrome
Ohga, E., Nagase, T., Tomita, T., Teramoto, S., Matsuse, T., Katayama, H., & Ouchi, Y. (1999) · Journal of Applied Physiology · doi:10.1152/jappl.1999.87.1.10 · Cited by 265 · see citing works
“Moreover, the circulating ICAM-1 level may indicate a risk of future myocardial infarction, suggesting that antiadhesion therapies can be considered as a novel therapeutic means to treat cardiovascular disease (22).”
Background
Circulating Cell Adhesion Molecules Are Correlated With Ultrasound-Based Assessment of Carotid Atherosclerosis
Rohde, L. E. P., Lee, R. T., Rivero, J., Jamacochian, M., Arroyo, L. H., Briggs, W. H., Rifai, N., Libby, P., Creager, M. A., & Ridker, P. M. (1998) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.18.11.1765 · Cited by 260 · see citing works
“Finally, prospective data from a large cohort of apparently healthy men indicate that elevated baseline levels of sICAM-1 are associated with increased future myocardial infarction.(30) Circulating levels of VCAM-1 have been associated with the extent of clinical atherosclerosis as measured angiographically in patient…”
Background
Inflammatory Markers of Coronary Risk
Rader, D. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010193431609 · Cited by 260 · see citing works
Coffee consumption and markers of inflammation and endothelial dysfunction in healthy and diabetic women
López‐García, E., van Dam, R. M., Qi, L., & Hu, F. B. (2006) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/84.4.888 · Cited by 257 · see citing works
“All these molecules have been found to predict cardiovascular disease (27) and to be associated with cardiovascular events (28, 29).”
Background
Total homocysteine and cardiovascular disease
Nygard, O. K., Vollset, S. E., Refsum, H., Brattström, L. E., & Ueland, P. M. (1999) · Journal of Internal Medicine · doi:10.1046/j.1365-2796.1999.00512.x · Cited by 256 · see citing works
The role of marine omega‐3 (<b><i>n</i></b>‐3) fatty acids in inflammatory processes, atherosclerosis and plaque stability
Calder, P. C. (2012) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100710 · Cited by 255 · see citing works
“sICAM-1 concentration was shown to be an independent predictor of coronary heart disease [7,8].”
Background
Beyond High-Density Lipoprotein Cholesterol Levels
deGoma, E. M., deGoma, R. L., & Rader, D. J. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.03.016 · Cited by 251 · see citing works
“Expression of adhesion molecules represents a ynamic process, activated by inflammatory cytokines (53) nd vascular injury (54) and up-regulated in atherosclerosis n both animals (55) and humans (56,57).”
Background
Angiotensin II Stimulates Intercellular Adhesion Molecule-1 (ICAM-1) Expression by Human Vascular Endothelial Cells and Increases Soluble ICAM-1 Release In Vivo
Pastore, L., Tessitore, A., Martinotti, S., Toniato, E., Alesse, E., Bravi, M. C., Ferri, C., Desideri, G., Gulino, A., & Santucci, A. (1999) · Circulation · doi:10.1161/01.cir.100.15.1646 · Cited by 249 · see citing works
Long-Term Effects of a High-Protein, Low-Carbohydrate Diet on Weight Control and Cardiovascular Risk Markers in Obese Hyperinsulinemic Subjects
Brinkworth, G. D., Noakes, M., Keogh, J. B., Luscombe, N. D., Wittert, G. A., & Clifton, P. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802617 · Cited by 245 · see citing works
Vascular Effects of Estrogen and Cholesterol-Lowering Therapies in Hypercholesterolemic Postmenopausal Women
Koh, K. K., Cardillo, C., Bui, M. N., Hathaway, L., Csákó, G., Waclawiw, M. A., Panza, J. A., & Cannon, R. O. (1999) · Circulation · doi:10.1161/01.cir.99.3.354 · Cited by 244 · see citing works
PREMATURE ATHEROSCLEROSIS IN SYSTEMIC LUPUS ERYTHEMATOSUS
Bruce, I. N., Gladman, D. D., & Urowitz, M. B. (2000) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70138-1 · Cited by 241 · see citing works
Preanalytic and Analytic Sources of Variations in C-reactive Protein Measurement: Implications for Cardiovascular Disease Risk Assessment
Ledue, T. B., & Rifai, N. (2003) · Clinical Chemistry · doi:10.1373/49.8.1258 · Cited by 241 · see citing works
Coronary heart disease risk: Low-density lipoprotein and beyond
Shaya, G. E., Leucker, T. M., Jones, S. R., Martin, S. S., & Toth, P. P. (2021) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2021.04.002 · Cited by 243 · see citing works
Fibrinogen Deposition at the Postischemic Vessel Wall Promotes Platelet Adhesion During Ischemia-Reperfusion In Vivo
Maßberg, S., Enders, G. A., Matos, F. C. D. M., Tomic, L. I. D., Leiderer, R., Eisenmenger, S., Meßmer, K., & Krombach, F. (1999) · Blood · doi:10.1182/blood.v94.11.3829 · Cited by 241 · see citing works
Association of C-Reactive Protein With Carotid Atherosclerosis in Men and Women: The Framingham Heart Study
Wang, T. J., Nam, B., Wilson, P. W. F., Wolf, P. A., Levy, D. A., Polak, J. F., D’Agostino, R. B., & O’Donnell, C. J. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000034543.78801.69 · Cited by 241 · see citing works
Contributions of Depressive Mood and Circulating Inflammatory Markers to Coronary Heart Disease in Healthy European Men
Empana, J. P., Sykes, D. H., Luc, G., Juhan-Vague, I., Arveiler, D., Ferrières, J., Amouyel, P., Bingham, A., Montaye, M., Ruidavets, J., et al. (2005) · Circulation · doi:10.1161/01.cir.0000164203.54111.ae · Cited by 235 · see citing works
ABO Blood Group and Risk of Coronary Heart Disease in Two Prospective Cohort Studies
He, M., Wolpin, B. M., Rexrode, K. M., Manson, J. E., Rimm, E. B., Hu, F. B., & Qi, L. (2012) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.248757 · Cited by 241 · see citing works
The metabolic syndrome and cardiovascular disease
Bonora, E. (2006) · Annals of Medicine · doi:10.1080/07853890500401234 · Cited by 231 · see citing works
High Density Lipoproteins (HDL) Interrupt the Sphingosine Kinase Signaling Pathway
Xia, P., Vadas, M. A., Rye, K., Barter, P. J., & Gamble, J. R. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.46.33143 · Cited by 234 · see citing works
Soluble intercellular adhesion molecule-1 (sICAM-1): an overview.
Witkowska, A. M., & Borawska, M. H. (2004) · PubMed · Cited by 232 · see citing works
Effects of nasal continuous positive airway pressure on soluble cell adhesion molecules in patients with obstructive sleep apnea syndrome
Chin, K., Nakamura, T., Shimizu, K., Mishima, M., Nakamura, T., Miyasaka, M., & Ohi, M. (2000) · The American Journal of Medicine · doi:10.1016/s0002-9343(00)00580-5 · Cited by 229 · see citing works
High-Density Lipoprotein and Coronary Heart Disease
Natarajan, P., Ray, K. K., & Cannon, C. P. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2010.01.008 · Cited by 228 · see citing works
Soluble Intercellular Adhesion Molecule-1, Soluble Vascular Adhesion Molecule-1, and the Development of Symptomatic Peripheral Arterial Disease in Men
Pradhan, A. D., Rifai, N., & Ridker, P. M. (2002) · Circulation · doi:10.1161/01.cir.0000025636.03561.ee · Cited by 229 · see citing works
Can Apical Periodontitis Modify Systemic Levels of Inflammatory Markers? A Systematic Review and Meta-analysis
Gomes, M. S., Blattner, T. C., Filho, M. S., Grecca, F. S., Hugo, F. N., FOUAD, A. F., & Reynolds, M. A. (2013) · Journal of Endodontics · doi:10.1016/j.joen.2013.06.014 · Cited by 231 · see citing works
Circulating Adhesion Molecules in Humans
Marfella, R., Esposito, K., Giunta, R. E., Coppola, G., Angelis, L. D., Farzati, B., Paolisso, G., & Giugliano, D. (2000) · Circulation · doi:10.1161/01.cir.101.19.2247 · Cited by 221 · see citing works
Prospective Study of Chlamydia pneumoniae IgG Seropositivity and Risks of Future Myocardial Infarction
Ridker, P. M., Kundsin, R. B., Stampfer, M. J., Poulin, S. A., & Hennekens, C. H. (1999) · Circulation · doi:10.1161/01.cir.99.9.1161 · Cited by 215 · see citing works
Cellular biomarkers of endothelial health: microparticles, endothelial progenitor cells, and circulating endothelial cells
Burger, D. E., & Touyz, R. M. (2012) · Journal of the American Society of Hypertension · doi:10.1016/j.jash.2011.11.003 · Cited by 212 · see citing works
“Moreover, in the Physician’s Health Study, high plasma levels of soluble ICAM were associated with a risk of future myocardial infarction, although this was not true of soluble VCAM1 levels.(72,73) C-reactive protein, a protein found in plasma that rises in response to inflammation, is an independent predictor of abno…”
Background

Plasma concentration of soluble vascular cell adhesion molecule-1 and subsequent cardiovascular risk
de Lemos, J. A., Hennekens, C. H., & Ridker, P. M. (2000) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(00)00742-7 · Cited by 163 · see citing works
Soluble intercellular adhesion molecule 1 was associated with an increased risk for MI in healthy men
Kitching, A. D. (1998) · ACP Journal Club · doi:10.7326/acpjc-1998-129-1-020
Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events in patients with chronic coronary heart disease
Haim, M., Tanné, D., Boyko, V., Reshef, T., Goldbourt, U., Leor, J., Mekori, Y. A., & Behar, S. (2002) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(02)01728-x · Cited by 102 · see citing works
Early increase in levels of soluble inter-cellular adhesion molecule-1 (sICAM-1). Potential risk factor for the acute coronary syndromes
O'malley, T. (2001) · European Heart Journal · doi:10.1053/euhj.2000.2480 · Cited by 86 · see citing works
Increased Plasma Soluble Intercellular Adhesion Molecule-1 Levels in Patients With Acute Myocardial Infarction
Kaikita, K., Ogawa, H., Yasue, H., Sakamoto, T., Miyao, Y., Suefuji, H., Soejima, H., Tayama, S., Hayasaki, K., Honda, T., et al. (1997) · Japanese Circulation Journal-english Edition · doi:10.1253/jcj.61.741 · Cited by 21 · see citing works

Authors: Ridker, P. M., Hennekens, C. H., Roitman-Johnson, B., Stampfer, M. J., & Allen, J.
Affiliations: Brigham and Women's Hospital (US)
R&D Systems (United States) (US)
Corresponding author: Ridker, Paul M
ORCID: Ridker, Paul M
Hennekens, Charles H
Stampfer, Meir J
Venue: The Lancet
Publisher: Elsevier BV
Published: 1998-01
Volume: 351
Issue: 9096
Pages: 88-92
ISSN: 0099-5355 (ISSN-L)
0140-6736
DOI: 10.1016/s0140-6736(97)09032-6
OpenAlex: W2138809584
Cited by: 1,229
References: 35
Citations by year: 2026: 7 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 16 · 2020: 17 · 2019: 23 · 2018: 14 · 2017: 28 · 2016: 27 · 2015: 25 · 2014: 38 · 2013: 27 · 2012: 36
FWCI: 26.16
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: The Lancet (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Health Sciences › Medicine › Surgery › Lipoproteins and Cardiovascular Health
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Acute Myocardial Infarction Research
Keywords: soluble intercellular adhesion molecule-1, sICAM-1, myocardial infarction, atherosclerosis, inflammation, endothelial cell adhesion, anti-adhesion therapy, cardiovascular risk, fibrinogen, homocysteine, tissue plasminogen activator, C-reactive protein, healthy men, Physicians' Health Study
MeSH terms: Antioxidants, Arteriosclerosis, Aspirin, Double-Blind Method, Humans, Male, Middle Aged, Myocardial Infarction, Platelet Aggregation Inhibitors, Prospective Studies, Risk Factors, Multivariate Analysis, Case-Control Studies, Intercellular Adhesion Molecule-1, beta Carotene

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Plasma concentration of soluble intercellular adhesion molecule 1 and risks of future myocardial infarction in apparently healthy men

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks