Cited by 115Pancreatic function and diabetesDiabetes Treatment and ManagementDiabetes and associated disorders

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Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

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MacDonald, M. J., Longacre, M. J., Langberg, E.-C., Tibell, A., Kendrick, M. A., Fukao, T., Ostenson, C.-G.·2009·Diabetologia

DOI 10.1007/s00125-009-1319-6PMC PMC2903059

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Abstract

Aims/hypothesis Glucose-stimulated insulin secretion is defective in patients with type 2 diabetes. We sought to acquire new information about enzymes of glucose metabolism, with an emphasis on mitochondrial enzymes, by comparing pancreatic islets of type 2 diabetes patients with those of non-diabetic controls.Methods Expression of genes encoding 13 metabolic enzymes was estimated with microarrays and activities of up to nine metabolic enzymes were measured.Results The activities of the mitochondrial enzymes, glycerol phosphate dehydrogenase, pyruvate carboxylase (PC) and succinyl-CoA:3-ketoacid-CoA transferase (SCOT) were decreased by 73%, 65% and 92%, respectively, in the diabetic compared with the non-diabetic islets. ATP citrate lyase, a cytosolic enzyme of the mitochondrial citrate pyruvate shuttle, was decreased 57%. Activities of propionyl-CoA carboxylase, NADP-isocitrate dehydrogenase, cytosolic malic enzyme, aspartate aminotransferase and malate dehydrogenase were not significantly different from those of the control. The low activities of PC and SCOT were confirmed with western blots, which showed that their protein levels were low. The correlation of relative mRNA signals with enzyme activities was good in four instances, moderate in four instances and poor in one instance. In diabetic islets, the mRNA signal of the islet cell-enriched transcription factor musculoaponeurotic fibrosarcoma oncogene homologue A, which regulates expression of islet genes, including the PC gene, was decreased to 54% of the control level. PC activity and protein levels in the non-diabetic islets were significantly lower than in islets from non-diabetic rodents.Conclusions/interpretation Low levels of certain islet metabolic enzymes, especially mitochondrial enzymes, are associated with human type 2 diabetes.

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Authors: MacDonald, M. J., Longacre, M. J., Langberg, E.-C., Tibell, A., Kendrick, M. A., Fukao, T., & Ostenson, C.-G.
Affiliations: University of Wisconsin–Madison (US)
Karolinska Institutet (SE)
Gifu University (JP)
Corresponding author: MacDonald, M. J.
ORCID: MacDonald, M. J.
Kendrick, M. A.
Venue: Diabetologia
Publisher: Springer Science and Business Media LLC
Published: 2009-03-19
Volume: 52
Issue: 6
Pages: 1087-1091
ISSN: 0012-186X (ISSN-L)
1432-0428
DOI: 10.1007/s00125-009-1319-6
PMC: PMC2903059
OpenAlex: W2083850806
Cited by: 115
References: 10
Citations by year: 2026: 1 · 2025: 8 · 2024: 2 · 2023: 1 · 2022: 5 · 2021: 6 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 10 · 2016: 5 · 2015: 8 · 2014: 8 · 2013: 11 · 2012: 7
FWCI: 10.45
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.springer.com/tdm (tdm)
Locations: Diabetologia (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Vetenskapsrådet
National Institutes of Health (DK28348)
National Institute of Diabetes and Digestive and Kidney Diseases (DK 28348, R01DK028348)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Keywords: type 2 diabetes, pancreatic islets, glucose metabolism enzymes, mitochondrial enzymes, pyruvate carboxylase, glycerol-3-phosphate dehydrogenase, ATP citrate lyase, Maf transcription factors, glucose-stimulated insulin secretion, islet gene expression
MeSH terms: Adult, Aged, Aspartate Aminotransferases, ATP Citrate (pro-S)-Lyase, Diabetes Mellitus, Type 2, Female, Glycerolphosphate Dehydrogenase, Humans, Isocitrate Dehydrogenase, Malate Dehydrogenase, Male, Middle Aged, Pyruvate Carboxylase, Blotting, Western, Coenzyme A-Transferases, Polymerase Chain Reaction, Methylmalonyl-CoA Decarboxylase

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Decreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes

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