Mitochondrial signals drive insulin secretion in the pancreatic β-cell
Open accessAbstract
β-Cell nutrient sensing depends on mitochondrial function. Oxidation of nutrient-derived metabolites in the mitochondria leads to plasma membrane depolarization, Ca(2+) influx and insulin granule exocytosis. Subsequent mitochondrial Ca(2+) uptake further accelerates metabolism and oxidative phosphorylation. Nutrient activation also increases the mitochondrial matrix pH. This alkalinization is required to maintain elevated insulin secretion during prolonged nutrient stimulation. Together the mitochondrial Ca(2+) rise and matrix alkalinization assure optimal ATP synthesis necessary for efficient activation of the triggering pathway of insulin secretion. The sustained, amplifying pathway of insulin release also depends on mitochondrial Ca(2+) signals, which likely influence the generation of glucose-derived metabolites serving as coupling factors. Therefore, mitochondria are both recipients and generators of signals essential for metabolism-secretion coupling. Activation of these signaling pathways would be an attractive target for the improvement of β-cell function and the treatment of type 2 diabetes.
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Mitochondria fulfill a crucial role in determining cellular, tissue, and systemic metabolic flexibility.
“Additionally, insulin secretion from pancreatic β cells (104) and synthesis and secretion of adipokines from WAT is dependent on mitochondrial function (105), suggesting that mitochondria fulfill a crucial role in determining cellular, tissue, and systemic metabolic flexibility.”
From Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease (2018) · cites this paper as [104]
Cites
DeFronzo, R. A. (2009) · Diabetes · doi:10.2337/db09-9028 · Cited by 3,016 · see citing works
Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
Baughman, J. M., Perocchi, F., Girgis, H. S., Plovanich, M. E., Belcher-Timme, C. A., Sancak, Y., Bao, X., Strittmatter, L., Goldberger, O., Bogorad, R., et al. (2011) · Nature · doi:10.1038/nature10234 · Cited by 1,926 · see citing works
A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter
Stefani, D. D., Raffaello, A., Teardo, E., Szabò, I., & Rizzuto, R. (2011) · Nature · doi:10.1038/nature10230 · Cited by 1,431 · see citing works
Haigis, M. C., Mostoslavsky, R., Haigis, K. M., Fahie, K., Christodoulou, D. C., Murphy, A. J., Valenzuela, D. M., Yancopoulos, G. D., Karow, M., Blander, G., et al. (2006) · Cell · doi:10.1016/j.cell.2006.06.057 · Cited by 1,162 · see citing works
Five stages of evolving beta-cell dysfunction during progression to diabetes
Weir, G. C., & Bonner-Weir, S. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s16 · Cited by 1,126 · cited 2× · see citing works
“Failure of the b-cell to compensate adequately causes impaired glucose tolerance and progression to overt type 2 diabetes (Weir and Bonner-Weir, 2004; Defronzo, 2009). b-Cells sense nutrients such as glucose or the branched chain amino acid leucine via their uptake and intracellular metabolism.”
BackgroundRegulation of mitochondrial dehydrogenases by calcium ions
Denton, R. M. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.005 · Cited by 885 · see citing works
MICU1 encodes a mitochondrial EF hand protein required for Ca2+ uptake
Perocchi, F., Gohil, V. M., Girgis, H. S., Bao, X. R., McCombs, J. E., Palmer, A. E., & Mootha, V. K. (2010) · Nature · doi:10.1038/nature09358 · Cited by 881 · see citing works
Regulation of insulin release by calcium.
Wollheim, C. B., & Sharp, G. W. (1981) · Physiological Reviews · doi:10.1152/physrev.1981.61.4.914 · Cited by 849 · see citing works
Self-citationNCLX is an essential component of mitochondrial Na + /Ca 2+ exchange
Palty, R., Silverman, W. F., Hershfinkel, M., Caporale, T., Sensi, S. L., Parnis, J., Nolte, C., Fishman, D., Shoshan‐Barmatz, V., Herrmann, S., et al. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908099107 · Cited by 789 · see citing works
A Lesson in Metabolic Regulation Inspired by the Glucokinase Glucose Sensor Paradigm
Matschinsky, F. (1996) · Diabetes · doi:10.2337/diab.45.2.223 · Cited by 721 · see citing works
FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
Biddinger, S. B., & Kahn, C. R. (2005) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 700 · see citing works
Gilon, P., & Henquin, J. (2001) · Endocrine reviews · doi:10.1210/edrv.22.5.0440 · Cited by 540 · see citing works
Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis
Maechler, P., & Wollheim, C. B. (1999) · Nature · doi:10.1038/45280 · Cited by 507 · see citing works
Self-citationGembal, M., Gilon, P., & Henquin, J. C. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115714 · Cited by 494 · see citing works
Regulation of insulin secretion: a matter of phase control and amplitude modulation
Henquin, J. C. (2009) · Diabetologia · doi:10.1007/s00125-009-1314-y · Cited by 493 · see citing works
Sekine, N., Cirulli, V., Regazzi, R., Brown, L. J., Giné, E., Tamarit‐Rodriguez, J., Girotti, M., Marie, S., MacDonald, M. J., & Wollheim, C. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)37629-9 · Cited by 446 · see citing works
Self-citationCa 2+ activation of heart mitochondrial oxidative phosphorylation: role of the F 0 /F 1 -ATPase
Territo, P. R., Mootha, V. K., French, S. A., & Balaban, R. S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.278.2.c423 · Cited by 441 · see citing works
Silva, J. P., Köhler, M., Graff, C., Oldfors, A., Magnuson, M. A., Berggren, P.-O., & Larsson, N.-G. (2000) · Nature Genetics · doi:10.1038/81649 · Cited by 433 · see citing works
Metabolic Fate of Glucose in Purified Islet Cells
Schuit, F., De Vos, A., Farfari, S., Moens, K., Pipeleers, D., Brun, T., & Prentki, M. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18572 · Cited by 421 · see citing works
Fatty Acid Signaling in the β-Cell and Insulin Secretion
Nolan, C. J., Murthy, M. S., Delghingaro‐Augusto, V., Peyot, M., & Prentki, M. (2006) · Diabetes · doi:10.2337/db06-s003 · Cited by 405 · see citing works
Islet β-cell secretion determines glucagon release from neighbouring α-cells
Ishihara, H., Maechler, P., Gjinovci, A., Herrera, P. L., & Wollheim, C. B. (2003) · Nature Cell Biology · doi:10.1038/ncb951 · Cited by 380 · see citing works
Self-citationL-leucine and a nonmetabolized analogue activate pancreatic islet glutamate dehydrogenase
Sener, A., & Malaisse, W. J. (1980) · Nature · doi:10.1038/288187a0 · Cited by 354 · see citing works
Dynamic Regulation of the Mitochondrial Proton Gradient during Cytosolic Calcium Elevations
Poburko, D., Domingo, J. S., & Demaurex, N. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.159962 · Cited by 332 · see citing works
Glucose stimulates proinsulin biosynthesis by a dose-dependent recruitment of pancreatic beta cells
Schuit, F. C., In't Veld, P. A., & Pipeleers, D. G. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.11.3865 · Cited by 308 · see citing works
Regulation of insulin secretion: role of mitochondrial signalling
Jitrapakdee, S., Wutthisathapornchai, A., Wallace, J. C., & MacDonald, M. J. (2010) · Diabetologia · doi:10.1007/s00125-010-1685-0 · Cited by 293 · see citing works
Murphy, R., Turnbull, D. M., Walker, M., & Hattersley, A. T. (2008) · Diabetic Medicine · doi:10.1111/j.1464-5491.2008.02359.x · Cited by 290 · see citing works
Patterson, G. H., Knobel, S. M., Arkhammar, P. O. G., Thastrup, M., & Piston, D. W. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.090098797 · Cited by 284 · see citing works
Metabolic cycling in control of glucose-stimulated insulin secretion.
Jensen, M., Joseph, J., Ronnebaum, S., Burgess, S. C., Sherry, A., & Newgard, C. (2008) · American Journal of Physiology. Endocrinology and Metabolism · doi:10.1152/ajpendo.90604.2008 · Cited by 282 · see citing works
Ivarsson, R., Quintens, R., Dejonghe, S., Tsukamoto, K., in ’t Veld, P., Renström, E., & Schuit, F. C. (2005) · Diabetes · doi:10.2337/diabetes.54.7.2132 · Cited by 265 · see citing works
Lu, D., Mulder, H., Zhao, P., Burgess, S. C., Jensen, M. V., Kamzolova, S. V., Newgard, C. B., & Sherry, A. D. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.052005699 · Cited by 265 · see citing works
Farfari, S., Schulz, V., Corkey, B. E., & Prentki, M. (2000) · Diabetes · doi:10.2337/diabetes.49.5.718 · Cited by 263 · see citing works
Pralong, W. F., Bartley, C., & Wollheim, C. B. (1990) · The EMBO Journal · doi:10.1002/j.1460-2075.1990.tb08079.x · Cited by 262 · see citing works
Self-citationGPR40 Is Necessary but Not Sufficient for Fatty Acid Stimulation of Insulin Secretion In Vivo
Latour, M. G., Alquier, T., Oseid, E. A., Tremblay, C. C., Jetton, T. L., Luo, J., Lin, D. C.-H., & Poitout, V. (2007) · Diabetes · doi:10.2337/db06-1532 · Cited by 259 · see citing works
Gilon, P., & Henquin, J. C. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)36744-4 · Cited by 251 · see citing works
Portal and Peripheral Vein Immunoreactive Insulin Concentrations Before and After Glucose Infusion
Blackard, W. G., & Nelson, N. C. (1970) · Diabetes · doi:10.2337/diab.19.5.302 · Cited by 247 · see citing works
Ronnebaum, S. M., Ilkayeva, O., Burgess, S. C., Joseph, J. W., Lu, D., Stevens, R. D., Becker, T. C., Sherry, A. D., Newgard, C. B., & Jensen, M. V. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m511908200 · Cited by 230 · see citing works
Klingenberg, M., & Rottenberg, H. (1977) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1977.tb11298.x · Cited by 210 · see citing works
Novel aspects of the molecular mechanisms controlling insulin secretion
Eliasson, L., Abdulkader, F., Braun, M., Galvanovskis, J., Hoppa, M. B., & Rorsman, P. (2008) · The Journal of Physiology · doi:10.1113/jphysiol.2008.155317 · Cited by 198 · see citing works
Ishihara, H., Wang, H., Drewes, L. R., & Wollheim, C. B. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7515 · Cited by 193 · see citing works
Self-citationBeta-cell mitochondria in the regulation of insulin secretion: a new culprit in Type II diabetes
Wollheim, C. B. (2000) · Diabetologia · doi:10.1007/s001250050044 · Cited by 191 · see citing works
Self-citationDynamic pacing of cell metabolism by intracellular Ca2+ transients.
Pralong, W. F., Spät, A., & Wollheim, C. B. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)46986-4 · Cited by 185 · see citing works
Self-citationTissue-specific disallowance of housekeeping genes: The other face of cell differentiationPreprint
Thorrez, L., Laudadio, I., Deun, K. V., Quintens, R., Hendrickx, N., Granvik, M., Lemaire, K., Schraenen, A., Lommel, L. V., Lehnert, S., et al. (2010) · Genome Research · doi:10.1101/gr.109173.110 · Cited by 182 · see citing works
Maechler, P., Kennedy, E. D., Pozzan, T., & Wollheim, C. B. (1997) · The EMBO Journal · doi:10.1093/emboj/16.13.3833 · Cited by 181 · see citing works
Self-citationMitochondrial GTP regulates glucose-stimulated insulin secretion.
Kibbey, R., Pongratz, R. L., Romanelli, A. J., Wollheim, C., Cline, G., & Shulman, G. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.02.008 · Cited by 178 · see citing works
Self-citationNicholls, D. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m510916200 · Cited by 175 · see citing works
Identification of genes selectively disallowed in the pancreatic islet
Pullen, T. J., Khan, A., Barton, G. R., Butcher, S., Sun, G., & Rutter, G. A. (2010) · Islets · doi:10.4161/isl.2.2.11025 · Cited by 169 · see citing works
A Signaling Role of Glutamine in Insulin Secretion
Li, C., Buettger, C. W., Kwagh, J., Matter, A. M., Daikhin, Y., Nissim, I. B., Collins, H. W., Yudkoff, M., Stanley, C. A., & Matschinsky, F. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311502200 · Cited by 159 · see citing works
Regulation of Leucine-stimulated Insulin Secretion and Glutamine Metabolism in Isolated Rat Islets
Li, C., Najafi, H., Daikhin, Y., Nissim, I. B., Collins, H. W., Yudkoff, M., Matschinsky, F. M., & Stanley, C. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m210577200 · Cited by 158 · see citing works
Hoppa, M. B., Collins, S., Ramracheya, R., Hodson, L., Amisten, S., Zhang, Q., Johnson, P., Ashcroft, F. M., & Rorsman, P. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.011 · Cited by 152 · see citing works
Cytosolic and Mitochondrial Malic Enzyme Isoforms Differentially Control Insulin Secretion
Pongratz, R. L., Kibbey, R. G., Shulman, G. I., & Cline, G. W. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602954200 · Cited by 151 · see citing works
Effects of depletion of mitochondrial DNA in metabolism secretion coupling in INS-1 cells.
Kennedy, E. D., Maechler, P., & Wollheim, C. B. (1998) · Diabetes · doi:10.2337/diabetes.47.3.374 · Cited by 151 · see citing works
Self-citationDuchen, M. R., Smith, P. A., & Ashcroft, F. M. (1993) · Biochemical Journal · doi:10.1042/bj2940035 · Cited by 150 · see citing works
Otonkoski, T., Kaminen‐Ahola, N., Ustinov, J., Lapatto, R., Meißner, T., Mayatepek, E., Kere, J., & Sipilä, I. (2003) · Diabetes · doi:10.2337/diabetes.52.1.199 · Cited by 150 · see citing works
Soejima, A., Inoue, K., Takai, D., Kaneko, M., Ishihara, H., Oka, Y., & Hayashi, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.42.26194 · Cited by 149 · see citing works
Mitochondrial Matrix Calcium Is an Activating Signal for Hormone Secretion
Wiederkehr, A., Szanda, G., Akhmedov, D., Mataki, C., Heizmann, C. W., Schoonjans, K., Pozzan, T., Spät, A., & Wollheim, C. B. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.015 · Cited by 149 · see citing works
Self-citationStark, R., Pasquel, F., Turcu, A., Pongratz, R. L., Roden, M., Cline, G., Shulman, G., & Kibbey, R. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.011775 · Cited by 146 · see citing works
Kennedy, E. D., Rizzuto, R., Theler, J., Pralong, W. F., Bastianutto, C., Pozzan, T., & Wollheim, C. B. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119071 · Cited by 146 · see citing works
Self-citationGlucose-Stimulated Oscillations in Free Cytosolic ATP Concentration Imaged in Single Islet β-Cells
AINSCOW, E. K., & Rutter, G. A. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s162 · Cited by 144 · see citing works
de Timary, P., van den Berghe, G., & Henquin, J. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.34.20559 · Cited by 144 · see citing works
Hellman, B., Idahl, L., Lernmark, Å., Sehlin, J., & Täljedal, I. (1974) · Biochemical Journal · doi:10.1042/bj1380033 · Cited by 139 · see citing works
Dynamics of O2 consumption in rat pancreatic islets
Hutton, J. C., & Malaisse, W. J. (1980) · Diabetologia · doi:10.1007/bf00276821 · Cited by 129 · see citing works
13C NMR Isotopomer Analysis of Anaplerotic Pathways in INS-1 Cells
Cline, G. W., Pongratz, R. L., Papas, K. K., Kibbey, R. G., & Shulman, G. I. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311842200 · Cited by 122 · see citing works
Rubı́, B., del Arco, A., Bartley, C., Satrústegui, J., & Maechler, P. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409303200 · Cited by 120 · see citing works
Rat neonatal beta cells lack the specialised metabolic phenotype of mature beta cells
Jermendy, Á., Toschi, E., Aye, T., Koh, A., Aguayo‐Mazzucato, C., Sharma, A., Weir, G. C., Sgroi, D. C., & Bonner‐Weir, S. (2011) · Diabetologia · doi:10.1007/s00125-010-2036-x · Cited by 118 · see citing works
Gauthier, B. R., Wiederkehr, A., Baquié, M., Dai, C., Powers, A. C., Kerr-Conte, J., Pattou, F., MacDonald, R. J., Ferrer, J., & Wollheim, C. B. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.07.002 · Cited by 115 · see citing works
Self-citationDecreased levels of metabolic enzymes in pancreatic islets of patients with type 2 diabetes
MacDonald, M. J., Longacre, M. J., Langberg, E.-C., Tibell, A., Kendrick, M. A., Fukao, T., & Ostenson, C.-G. (2009) · Diabetologia · doi:10.1007/s00125-009-1319-6 · Cited by 115 · see citing works
Synaptotagmins bind calcium to release insulin
Gauthier, B. R., & Wollheim, C. B. (2008) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.90568.2008 · Cited by 115 · see citing works
Self-citationCa2+ controls slow NAD(P)H oscillations in glucose‐stimulated mouse pancreatic islets
Luciani, D. S., Misler, S., & Polonsky, K. S. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2005.101766 · Cited by 114 · see citing works
Malmgren, S., Nicholls, D. G., Taneera, J., Bacos, K., Koeck, T., Tamaddon, A., Wibom, R., Groop, L., Ling, C., Mulder, H., et al. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.026708 · Cited by 106 · see citing works
Koeck, T., Olsson, A. H., Nitert, M. D., Sharoyko, V. V., Ladenvall, C., Kotova, O., Reiling, E., Rönn, T., Parikh, H., Taneera, J., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2010.12.007 · Cited by 105 · see citing works
Pralong, W. F., Hunyady, L., Várnai, P., Wollheim, C. B., & Spät, A. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.1.132 · Cited by 104 · see citing works
Self-citationMaechler, P., Wang, H.-Y., & Wollheim, C. (1998) · FEBS Letters · doi:10.1016/s0014-5793(97)01618-9 · Cited by 103 · see citing works
Self-citationStimulation by d -glucose of mitochondrial oxidative events in islet cells
Sener, A., & Malaisse, W. J. (1987) · Biochemical Journal · doi:10.1042/bj2460089 · Cited by 100 · see citing works
The role of pyruvate carboxylase in insulin secretion and proliferation in rat pancreatic beta cells
Xu, J., Han, J., Long, Y. S., Epstein, P. N., & Liu, Y. Q. (2008) · Diabetologia · doi:10.1007/s00125-008-1130-9 · Cited by 99 · see citing works
Carobbio, S., Frigerio, F., Rubı́, B., Vetterli, L., Bloksgaard, M., Gjinovci, A., Pournourmohammadi, S., Herrera, P. L., Reith, W., Mandrup, S., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806295200 · Cited by 96 · see citing works
α-Ketoisocaproate-Induced Hypersecretion of Insulin by Islets from Diabetes-Susceptible Mice
Rabaglia, M. E., Gray-Keller, M. P., Frey, B. L., Shortreed, M. R., Smith, L. M., & Attie, A. D. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00573.2004 · Cited by 96 · see citing works
Shedding light on the mitochondrial permeability transition
Ricchelli, F., Šileikytė, J., & Bernardi, P. (2011) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2011.02.012 · Cited by 92 · see citing works
Regulation of pancreatic β-cell mitochondrial metabolism: influence of Ca2+, substrate and ADP
Civelek, V. N., Deeney, J. T., SHALOSKY, N. J., Tornheim, K., Hansford, R. G., Prentki, M., & Corkey, B. E. (1996) · Biochemical Journal · doi:10.1042/bj3180615 · Cited by 85 · see citing works
Kobayashi, T., Nakanishi, K., Nakase, H., Kajio, H., Okubo, M., Murase, T., & Kosáka, K. (1997) · Diabetes · doi:10.2337/diacare.46.10.1567 · Cited by 83 · see citing works
Increase in cellular glutamate levels stimulates exocytosis in pancreatic β‐cells
Høy, M., Maechler, P., Efanov, A. M., Wollheim, C. B., Berggren, P., & Gromada, J. (2002) · FEBS Letters · doi:10.1016/s0014-5793(02)03500-7 · Cited by 78 · see citing works
Self-citationRonnebaum, S. M., Jensen, M. V., Hohmeier, H. E., Burgess, S. C., Zhou, Y.-P., Qian, S., MacNeil, D. J., Howard, A., Thornberry, N. A., Ilkayeva, O., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804665200 · Cited by 77 · see citing works
Clocquet, A. R., Egan, J. M., Stoffers, D. A., Muller, D. C., Wideman, L., Chin, G., Clarke, W. L., Hanks, J. B., Habener, J. F., & Elahi, D. (2000) · Diabetes · doi:10.2337/diabetes.49.11.1856 · Cited by 75 · see citing works
Lee, B., Miles, P. D. G., Vargas, L., Luan, P., Glasco, S., Kushnareva, Y., Kornbrust, E. S., Grako, K. A., Wollheim, C. B., Maechler, P., et al. (2003) · Diabetes · doi:10.2337/diabetes.52.4.965 · Cited by 73 · see citing works
Self-citationMatrix alkalinization: a novel mitochondrial signal for sustained pancreatic β‐cell activation
Wiederkehr, A., Park, K., Dupont, O.-N., Demaurex, N., Pozzan, T., Cline, G. W., & Wollheim, C. B. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.302 · Cited by 72 · see citing works
Self-citationOhta, M., NELSON, D. S., Nelson, J., Meglasson, M. D., & Erecińska, M. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)38196-1 · Cited by 70 · see citing works
Fransson, U., Rosengren, A. H., Schuit, F. C., Renström, E., & Mulder, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0263-y · Cited by 70 · see citing works
Li, C., Matter, A. M., Kelly, A. T., Petty, T. J., Najafi, H., MacMullen, C., Daikhin, Y., Nissim, I. B., Lazarow, A., Kwagh, J., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600994200 · Cited by 68 · see citing works
Desensitization of Mitochondrial Ca2+ and Insulin Secretion Responses in the Beta Cell
Maechler, P., Kennedy, E. D., Wang, H., & Wollheim, C. B. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.33.20770 · Cited by 65 · see citing works
Self-citationPeyot, M., Gray, J. P., Lamontagne, J., Smith, P. J., Holz, G. G., Madiraju, S. R. M., Prentki, M., & Heart, E. A. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006221 · Cited by 64 · see citing works
Akhmedov, D., Braun, M., Mataki, C., Park, K., Pozzan, T., Schoonjans, K., Rorsman, P., Wollheim, C. B., & Wiederkehr, A. (2010) · The FASEB Journal · doi:10.1096/fj.10-162222 · Cited by 59 · see citing works
Self-citationTransamination Is Required for α-Ketoisocaproate but Not Leucine to Stimulate Insulin Secretion*
Zhou, Y., Jetton, T. L., Goshorn, S., Lynch, C. J., & She, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.136846 · Cited by 59 · see citing works
Spégel, P., Malmgren, S., Sharoyko, V., Newsholme, P., Koeck, T., & Mulder, H. (2011) · Biochemical Journal · doi:10.1042/bj20100655 · Cited by 51 · see citing works
Pentosephosphate Shunt Activity of Rat Pancreatic Islets: Its Dependence on Glucose Concentration*
Verspohl, E. J., Händel, M., & AMMON, P. T. (1979) · Endocrinology · doi:10.1210/endo-105-5-1269 · Cited by 50 · see citing works
Mármol, P., Pardo, B., Wiederkehr, A., del Arco, A., Wollheim, C. B., & Satrústegui, J. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m806729200 · Cited by 46 · see citing works
Self-citationWeaver, C. D., Gundersen, V., & Verdoorn, T. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1647 · Cited by 44 · see citing works
β-Cell-specific pyruvate dehydrogenase deficiency impairs glucose-stimulated insulin secretion
Srinivasan, M., Choi, C. S., Ghoshal, P., Pliss, L., Pandya, J. D., Hill, D. J., Cline, G. W., & Patel, M. S. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00339.2010 · Cited by 42 · see citing works
The export of metabolites from mitochondria and anaplerosis in insulin secretion
MacDonald, M. J. (2002) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/s0304-4165(02)00443-9 · Cited by 40 · see citing works
Feldmann, N., del Rio, R. M., Gjinovci, A., Tamarit-Rodriguez, J., Wollheim, C. B., & Wiederkehr, A. (2011) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2011.02.019 · Cited by 39 · see citing works
Self-citationMalic enzyme is present in mouse islets and modulates insulin secretion
Xu, J., Han, J., Long, Y. S., Hollister‐Lock, J., Weir, G. C., Epstein, P. N., & Liu, Y. Q. (2008) · Diabetologia · doi:10.1007/s00125-008-1155-0 · Cited by 36 · see citing works
Doliba, N. M., Wehrli, S. L., Vatamaniuk, M. Z., Qin, W. D., Buettger, C. W., Collins, H. W., & Matschinsky, F. M. (2007) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00282.2006 · Cited by 36 · see citing works
Insulinotropic action of glutamic acid dimethyl ester
Sener, A., Conget, I., Rasschaert, J., Leclercq-Meyer, V., Villanueva‐Peñacarrillo, M. L., Valverde, I., & Malaisse, W. J. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.4.e573 · Cited by 35 · see citing works
Portal Vein Insulin Concentrations in Diabetic Subjects
Blackard, W. G., & Nelson, N. C. (1971) · Diabetes · doi:10.2337/diab.20.5.286 · Cited by 32 · see citing works
Nishi, Y., Fujimoto, S., Sasaki, M., Mukai, E., Sato, H., Sato, Y., Tahara, Y., Nakamura, Y., & Inagaki, N. (2011) · Biochemical Journal · doi:10.1042/bj20101708 · Cited by 28 · see citing works
Brown, L. J., Longacre, M. J., Hasan, N. M., Kendrick, M. A., Stoker, S. W., & MacDonald, M. J. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040394 · Cited by 25 · see citing works
Emerson, P., van Haeften, T. W., Pimenta, W. P., Plummer, E., Woerle, H. J., Mitrakou, A., Szoke, E., Gerich, J. E., & Meyer, C. (2009) · Metabolism · doi:10.1016/j.metabol.2008.12.004 · Cited by 15 · see citing works
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DeFronzo, R. A., Ferrannini, E., Groop, L., Henry, R. R., Herman, W. H., Holst, J. J., Hu, F. B., Kahn, C. R., Raz, I., Shulman, G. I., et al. (2015) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2015.19 · Cited by 2,611 · see citing works
The machineries, regulation and cellular functions of mitochondrial calcium
Giorgi, C., Marchi, S., & Pinton, P. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0052-8 · Cited by 941 · see citing works
Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease
Smith, R. L., Soeters, M. R., Wüst, R. C. I., & Houtkooper, R. H. (2018) · Endocrine Reviews · doi:10.1210/er.2017-00211 · Cited by 787 · see citing works
Oxidative stress and calcium dysregulation by palmitate in type 2 diabetes
Ly, L. D., Xu, S., Choi, S.-K., Ha, C.-M., Thoudam, T., Cha, S.-K., Wiederkehr, A., Wollheim, C. B., Lee, I.-K., & Park, K.-S. (2017) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.157 · Cited by 378 · see citing works
Self-citationp16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
Helman, A., Klochendler, A., Azazmeh, N., Gabai, Y., Horwitz, E., Anzi, S., Swisa, A., Condiotti, R., Granit, R. Z., Nevo, Y., et al. (2016) · Nature Medicine · doi:10.1038/nm.4054 · Cited by 351 · see citing works
The Role of Oxidative Stress in Pancreatic β Cell Dysfunction in Diabetes
Eguchi, N., Vaziri, N. D., Dafoe, D. C., & Ichii, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041509 · Cited by 354 · see citing works
Fatty Acid-Induced Lipotoxicity in Pancreatic Beta-Cells During Development of Type 2 Diabetes
Oh, Y. S., Bae, G. D., Baek, D. J., Park, E., & Jun, H. (2018) · Frontiers in Endocrinology · doi:10.3389/fendo.2018.00384 · Cited by 307 · see citing works
Functional diversity of small nucleolar RNAs
Bratkovič, T., Božič, J., & Rogelj, B. (2020) · Nucleic Acids Research · doi:10.1093/nar/gkz1140 · Cited by 272 · see citing works
Calcium release channel RyR2 regulates insulin release and glucose homeostasis
Santulli, G., Pagano, G., Sardu, C., Xie, W., Reiken, S. R., D’Ascia, S. L., Cannone, M., Marziliano, N., Trimarco, B., Guise, T. A., et al. (2015) · Journal of Clinical Investigation · doi:10.1172/jci79273 · Cited by 239 · see citing works
Yan, L., & Wu, J. (2015) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s82272 · Cited by 223 · see citing works
Calcium signaling in pancreatic β-cells in health and in Type 2 diabetes.
Gilon, P., Chae, H., Rutter, G., & Ravier, M. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.09.001 · Cited by 212 · see citing works
DNA methylation in the pathogenesis of type 2 diabetes in humans
Davegårdh, C., García-Calzón, S., Bacos, K., & Ling, C. (2018) · Molecular Metabolism · doi:10.1016/j.molmet.2018.01.022 · Cited by 194 · see citing works
Zhang, E., Mohammed Al-Amily, I., Mohammed, S., Luan, C., Asplund, O., Ahmed, M., Ye, Y., Ben-Hail, D., Soni, A., Vishnu, N., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2018.09.008 · Cited by 171 · see citing works
“ATP generated by glucose oxidation in b cell mitochondria couples metabolism to plasma membrane depolarization, which increases cytosolic Ca2+ and insulin exocytosis (Wiederkehr and Wollheim, 2012).”
BackgroundSelf-citationKuna, R. S., Girada, S. B., Asalla, S., Vallentyne, J., Maddika, S., Patterson, J. T., Smiley, D. L., DiMarchi, R. D., & Mitra, P. (2013) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00551.2012 · Cited by 150 · see citing works
Alam, M. R., Groschner, L. N., Parichatikanond, W., Liang, K., Bondarenko, A. I., Rost, R., Waldeck‐Weiermair, M., Malli, R., & Graier, W. F. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.392084 · Cited by 140 · see citing works
Ofori, J. K., Salunkhe, V. A., Bagge, A., Vishnu, N., Nagao, M., Mulder, H., Wollheim, C. B., Eliasson, L., & Esguerra, J. L. S. (2017) · Scientific Reports · doi:10.1038/srep44986 · Cited by 102 · see citing works
Self-citationMitochondrial Reactive Oxygen Species and Type 1 Diabetes
Chen, J., Stimpson, S. E., Fernandez‐Bueno, G. A., & Mathews, C. E. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7346 · Cited by 100 · see citing works
Klemen, M. S., Dolenšek, J., Rupnik, M. S., & Stožer, A. (2017) · Islets · doi:10.1080/19382014.2017.1342022 · Cited by 95 · see citing works
Cnop, M., Mulder, H., & Igoillo‐Esteve, M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12216 · Cited by 93 · see citing works
The pathogenetic role of β-cell mitochondria in type 2 diabetes
Fex, M., Nicholas, L. M., Vishnu, N., Medina, A., Sharoyko, V. V., Nicholls, D. G., Spégel, P., & Mulder, H. (2018) · Journal of Endocrinology · doi:10.1530/joe-17-0367 · Cited by 91 · see citing works
Contribution of Oxidative Stress and Impaired Biogenesis of Pancreatic β-Cells to Type 2 Diabetes
Ježek, P., Jabůrek, M., & Plecitá‐Hlavatá, L. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2018.7656 · Cited by 88 · see citing works
The impact of IUGR on pancreatic islet development and β-cell function
Boehmer, B. H., Limesand, S. W., & Rozance, P. J. (2017) · Journal of Endocrinology · doi:10.1530/joe-17-0076 · Cited by 82 · see citing works
Characterization of Stimulus-Secretion Coupling in the Human Pancreatic EndoC-βH1 Beta Cell Line
Andersson, L. E., Valtat, B., Bagge, A., Sharoyko, V. V., Nicholls, D. G., Ravassard, P., Scharfmann, R., Spégel, P., & Mulder, H. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120879 · Cited by 74 · see citing works
Mitochondrial dynamics and morphology in beta-cells
Stiles, L., & Shirihai, O. S. (2012) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2012.05.004 · Cited by 74 · see citing works
Yu, C., Wang, Y., Peng, J., Shen, Q., Chen, M., Tang, W., Li, X., Cai, C., Wang, B., Cai, S., et al. (2017) · Oncotarget · doi:10.18632/oncotarget.19747 · Cited by 73 · see citing works
Transcribing β-cell mitochondria in health and disease
Mulder, H. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.05.014 · Cited by 72 · see citing works
Heikkilä, E., Hermant, A., Thévenet, J., Bermont, F., Kulkarni, S. S., Ratajczak, J., Domingo, J. S., Dioum, E. M., Cantó, C., Barron, D., et al. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14757 · Cited by 71 · see citing works
Self-citationMitoNEET-Parkin Effects in Pancreatic α- and β-Cells, Cellular Survival, and Intrainsular Cross Talk
Kusminski, C. M., Chen, S., Ye, R., Sun, K., Wang, Q. A., Spurgin, S. B., Sanders, P. E., Brozinick, J. T., Geldenhuys, W. J., Li, W.-H., et al. (2016) · Diabetes · doi:10.2337/db15-1323 · Cited by 70 · see citing works
Quan, X., Nguyen, T. T., Choi, S.-K., Xu, S., Das, R., Cha, S., Kim, N., Han, J., Wiederkehr, A., Wollheim, C. B., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.632547 · Cited by 65 · see citing works
Self-citationMathematical models of electrical activity of the pancreatic β-cell: A physiological review
Félix‐Martínez, G. J., & Godínez-Fernández, J. R. (2014) · Islets · doi:10.4161/19382014.2014.949195 · Cited by 63 · see citing works
Nguyen, T. T., Quan, X., Hwang, K., Xu, S., Das, R., Choi, S.-K., Wiederkehr, A., Wollheim, C. B., Cha, S., & Park, K. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2015 · Cited by 59 · see citing works
Self-citationKleiner, S., Gomez, D. R., Megra, B., Na, E., Bhavsar, R., Cavino, K., Xin, Y., Rojas, J. L. V., Gutiérrez, G. D., Zambrowicz, B., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721418115 · Cited by 58 · see citing works
Mitok, K. A., Freiberger, E. C., Schueler, K. L., Rabaglia, M. E., Stapleton, D. S., Kwiecien, N. W., Malec, P. A., Hebert, A. S., Broman, A. T., Kennedy, R. T., et al. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ra117.001102 · Cited by 58 · see citing works
Sharoyko, V. V., Abels, M., Sun, J., Nicholas, L. M., Mollet, I. G., Stamenkovic, J., Göhring, I., Malmgren, S., Storm, P., Fadista, J., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddu288 · Cited by 56 · see citing works
Mitochondrial VDAC, the Na+/Ca2+ Exchanger, and the Ca2+ Uniporter in Ca2+ Dynamics and Signaling
Shoshan‐Barmatz, V., & De, S. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-55858-5_13 · Cited by 56 · see citing works
Caballero-Solares, A., Viegas, I., Salgado, M. C. D. O., Siles, A. M., Sáez-Arteaga, A., Metón, I., Baanante, I. V., & Fernández, F. (2015) · Aquaculture · doi:10.1016/j.aquaculture.2015.03.025 · Cited by 51 · see citing works
Georgiadou, E., Haythorne, E., Dickerson, M. T., López–Noriega, L., Pullen, T. J., Xavier, G. D. S., Davis, S., Martínez-Sánchez, A., Semplici, F., Rizzuto, R., et al. (2020) · Diabetologia · doi:10.1007/s00125-020-05148-x · Cited by 48 · see citing works
Novel approaches to drug discovery for the treatment of type 2 diabetes
Xu, X. Y., Wang, G., Zhou, T., Chen, L., Chen, J., & Shen, X. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2014.941352 · Cited by 49 · see citing works
Ahn, C., An, B., & Jeung, E. (2015) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.05.017 · Cited by 48 · see citing works
Dynamin-Related Protein-1 Controls Fusion Pore Dynamics During Platelet Granule Exocytosis
Koseoglu, S., Dilks, J. R., Peters, C. G., Fitch, J. L., Fadel, N. A., Jasuja, R., Italiano, J. E., Haynes, C. L., & Flaumenhaft, R. C. (2013) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.112.255737 · Cited by 47 · see citing works
Cao, M., Lu, X., Liu, G., Su, Y., Li, Y., & Zhou, J. (2017) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2017.5400 · Cited by 45 · see citing works
RetractedType 1 diabetes mellitus: Inflammation, mitophagy, and mitochondrial function
Blagov, A. V., Summerhill, V. I., Sukhorukov, V. N., Popov, M. A., Grechko, A. V., & Orekhov, A. N. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.07.002 · Cited by 43 · see citing works
Bermont, F., Hermant, A., Benninga, R., Chabert, C., Jacot, G. E., Domingo, J. S., Kraus, M. R.-C., Feige, J. N., & Marchi, U. D. (2020) · Nutrients · doi:10.3390/nu12020538 · Cited by 43 · see citing works
Defects in β-Cell Ca2+ Dynamics in Age-Induced Diabetes
Li, L., Trifunović, A., Köhler, M. G., Wang, Y., Berglund, J. P., Illies, C., Juntti‐Berggren, L., Larsson, N., & Berggren, P. (2014) · Diabetes · doi:10.2337/db13-1855 · Cited by 42 · see citing works
Redox Homeostasis in Pancreatic Cells
Ježek, P., Dlasková, A., & Plecitá‐Hlavatá, L. (2012) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2012/932838 · Cited by 42 · see citing works
Ca 2+ Effects on ATP Production and Consumption Have Regulatory Roles on Oscillatory Islet Activity
McKenna, J. P., Ha, J., Merrins, M. J., Satin, L. S., Sherman, A., & Bertram, R. (2016) · Biophysical Journal · doi:10.1016/j.bpj.2015.11.3526 · Cited by 40 · see citing works
Taddeo, E. P., Alsabeeh, N., Baghdasarian, S., Wikström, J. D., Ritou, E., Sereda, S. B., Erion, K., Li, J., Stiles, L., Abdulla, M., et al. (2019) · Diabetes · doi:10.2337/db19-0379 · Cited by 40 · see citing works
Göhring, I., Sharoyko, V. V., Malmgren, S., Andersson, L. E., Spégel, P., Nicholls, D. G., & Mulder, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.507335 · Cited by 39 · see citing works
Chareyron, I., Christen, S., Moco, S., Valsesia, A., Lassueur, S., Dayon, L., Wollheim, C. B., Domingo, J. S., & Wiederkehr, A. (2020) · Diabetologia · doi:10.1007/s00125-020-05275-5 · Cited by 38 · see citing works
Self-citationAoyagi, K., Ohara‐Imaizumi, M., Itakura, M., Torii, S., Akimoto, Y., Nishiwaki, C., Nakamichi, Y., Kishimoto, T., Kawakami, H., Harada, A., et al. (2016) · Diabetes · doi:10.2337/db15-1207 · Cited by 36 · see citing works
Mitochondrial Heterogeneity in Metabolic Diseases
Ngo, J., Osto, C. A., Villalobos, F., & Shirihai, O. S. (2021) · Biology · doi:10.3390/biology10090927 · Cited by 35 · see citing works
Ma, Z., Moruzzi, N., Catrina, S., Grill, V., & Björklund, A. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.088 · Cited by 33 · see citing works
Salvucci, M., Neufeld, Z., & Newsholme, P. (2013) · PLoS ONE · doi:10.1371/journal.pone.0052611 · Cited by 32 · see citing works
Sun, Y., Yang, J., Liu, W., Yao, G., Xu, F., Hayashi, T., Onodera, S., & Ikejima, T. (2019) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-019-03572-1 · Cited by 31 · see citing works
Diané, A., Al-Shukri, N. A., Mu-u-min, R., & Al-Siddiqi, H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03327-5 · Cited by 34 · see citing works
Panten, U., Willenborg, M., Schumacher, K., Hamada, A., Ghaly, H., & Rustenbeck, I. (2013) · Metabolism · doi:10.1016/j.metabol.2013.05.006 · Cited by 31 · see citing works
Karunakaran, U., Lee, J. E., Elumalai, S., Moon, J. S., & Won, K. C. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.05.038 · Cited by 32 · see citing works
Thrombin stimulates insulin secretion via protease-activated receptor-3
Hänzelmann, S., Wang, J., Güney, E., Tang, Y., Zhang, E., Axelsson, A. S., Nenonen, H. A., Salehi, A. A., Wollheim, C. B., Zetterberg, E., et al. (2015) · Islets · doi:10.1080/19382014.2015.1118195 · Cited by 29 · see citing works
Self-citationCalcium-dependent physiologic and pathologic stimulus-metabolic response coupling in hepatocytes
Gaspers, L. D., Mémin, E., & Thomas, A. P. (2012) · Cell Calcium · doi:10.1016/j.ceca.2012.04.009 · Cited by 28 · see citing works
Osipovich, A. B., Stancill, J. S., Cartailler, J., Dudek, K. D., & Magnuson, M. A. (2020) · Diabetes · doi:10.2337/db19-1145 · Cited by 28 · see citing works
Ittner, A., Bertz, J., Chan, T. Y. B., van Eersel, J., Polly, P., & Ittner, L. M. (2014) · Diabetologia · doi:10.1007/s00125-014-3230-z · Cited by 27 · see citing works
Integrating insulin secretion and ER stress in pancreatic β-cells
Lemaire, K., & Schuit, F. C. (2012) · Nature Cell Biology · doi:10.1038/ncb2594 · Cited by 27 · see citing works
Maxel, T., Smidt, K., Petersen, C. C., Honoré, B., Christensen, A. K., Jeppesen, P. B., Brock, B., Rungby, J., Palmfeldt, J., & Larsen, A. (2019) · Scientific Reports · doi:10.1038/s41598-019-44954-1 · Cited by 26 · see citing works
Spégel, P., Andersson, L. E., Storm, P., Sharoyko, V. V., Göhring, I., Rosengren, A. H., & Mulder, H. (2015) · Endocrinology · doi:10.1210/en.2014-1391 · Cited by 25 · see citing works
New Data on Cylindrospermopsin Toxicity
Chichova, M., Tasinov, O., Shkodrova, M., Mishonova, M., Sazdova, I., Ilieva, B., Doncheva-Stoimenova, D., Kiselova-Kaneva, Y. D., Raikova, N., Uzunov, B., et al. (2021) · Toxins · doi:10.3390/toxins13010041 · Cited by 24 · see citing works
Kim, Y. K., Joung, K. H., Ryu, M. J., Kim, S. J., Kim, H., Chung, H. K., Lee, M. H., Lee, S. E., Choi, M. J., Chang, J. Y., et al. (2015) · Diabetologia · doi:10.1007/s00125-015-3506-y · Cited by 24 · see citing works
Tseng, W.-W., Chu, C.-H., Lee, Y., Zhao, S., Chen, C., Ho, Y., & Wei, A. (2024) · Communications Biology · doi:10.1038/s42003-024-06955-3 · Cited by 23 · see citing works
Glucose Acutely Reduces Cytosolic and Mitochondrial H 2 O 2 in Rat Pancreatic Beta Cells
Deglasse, J.-P., Roma, L. P., Pastor‐Flores, D., Gilon, P., Dick, T. P., & Jonas, J. (2018) · Antioxidants and Redox Signaling · doi:10.1089/ars.2017.7287 · Cited by 23 · see citing works
Is Type 2 Diabetes a Primary Mitochondrial Disorder?
Weksler‐Zangen, S. (2022) · Cells · doi:10.3390/cells11101617 · Cited by 22 · see citing works
Glucose-Lowering Effects of Imeglimin and Its Possible Beneficial Effects on Diabetic Complications
Yanai, H., Adachi, H., Hakoshima, M., & Katsuyama, H. (2023) · Biology · doi:10.3390/biology12050726 · Cited by 23 · see citing works
β-Cell Mitochondrial Dysfunction: Underlying Mechanisms and Potential Therapeutic Strategies
Darwish, R., Alcibahy, Y., Abu-Sharia, G., & Butler, A. E. (2025) · Cells · doi:10.3390/cells14231861 · Cited by 24 · see citing works
Topf, F., Schvartz, D., Gaudet, P., Priego‐Capote, F., Zufferey, A., Turck, N., Binz, P., Fontana, P., Wiederkehr, A., Finamore, F., et al. (2013) · Translational Proteomics · doi:10.1016/j.trprot.2013.03.002 · Cited by 21 · see citing works
Self-citationSignaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells
Chowdhury, A. I., Satagopam, V., Manukyan, L., Artemenko, K. A., Fung, Y. M. E., Schneider, R., Bergquist, J., & Bergsten, P. (2013) · Journal of Proteome Research · doi:10.1021/pr400864w · Cited by 21 · see citing works
Domingo, J. S., Galindo, A. N., Cominetti, O., Marchi, U. D., Cutillas, P. R., Dayon, L., & Wiederkehr, A. (2019) · Cell Communication and Signaling · doi:10.1186/s12964-019-0326-6 · Cited by 20 · see citing works
Self-citationKovačević, B., Ionescu, C. M., Jones, M., Wagle, S. R., Lewkowicz, M., Đanić, M., Mikov, M., Mooranian, A., & Al‐Salami, H. (2022) · Gels · doi:10.3390/gels8060358 · Cited by 20 · see citing works
Rountree, A. M., Neal, A. S., Lisowski, M., Rizzo, N. O., Radtke, J. R., White, S., Luciani, D. S., Kim, F., Hampe, C. S., & Sweet, I. R. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.556050 · Cited by 20 · see citing works
Yagasaki, H., Sano, F., Narusawa, H., Watanabe, D., Kaga, Y., Kobayashi, K., Asano, Y., Nagata, M., Yonei, A., & Inukai, T. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62873 · Cited by 19 · see citing works
Differential Regulation of ERK1/2 and mTORC1 Through T1R1/T1R3 in MIN6 Cells
Wauson, E., Guerra, M. L., Dyachok, J., McGlynn, K., Giles, J., Ross, E. M., & Cobb, M. H. (2015) · Molecular Endocrinology · doi:10.1210/me.2014-1181 · Cited by 19 · see citing works
Mitochondrial Calcium Signaling in Pancreatic β-Cell
Weiser, A., Feige, J., & de Marchi, U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052515 · Cited by 17 · see citing works
Xie, K., Xu, B., Zhang, Y., Chen, M., Ji, Y., Wang, J., Huang, Z., Zhou, K., Xia, Y., & Tang, W. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26518 · Cited by 19 · see citing works
Holz, G. G., Leech, C. A., & Chepurny, O. G. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.06.023 · Cited by 18 · see citing works
Hals, I. K., Bruerberg, S. G., Ma, Z.-H., Scholz, H., Björklund, A., & Grill, V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0138558 · Cited by 17 · see citing works
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Griesche, N., Sanchez, G., Hermans, C., & Idevall‐Hagren, O. (2019) · Journal of Cell Science · doi:10.1242/jcs.228544 · Cited by 16 · see citing works
Medini, H., Cohen, T., & Mishmar, D. (2021) · Scientific Reports · doi:10.1038/s41598-020-80334-w · Cited by 17 · see citing works
Park, K., Wiederkehr, A., & Wollheim, C. B. (2012) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2012.16.1.71 · Cited by 17 · see citing works
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Ramadori, G., Ljubicic, S., Ricci, S., Mikropoulou, D., Brénachot, X., Veyrat‐Durebex, C., Aras, E., Ioris, R. M., Altirriba, J., Malle, E. K., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11498-x · Cited by 16 · see citing works
Schulze, T., Morsi, M., Brüning, D., Schumacher, K., & Rustenbeck, I. (2016) · Endocrine · doi:10.1007/s12020-015-0701-z · Cited by 14 · see citing works
Stamenkovic, J., Andersson, L. E., Adriaenssens, A. E., Bagge, A., Sharoyko, V. V., Gribble, F. M., Reimann, F. M., Wollheim, C. B., Mulder, H., & Spégel, P. (2015) · Biochemical Journal · doi:10.1042/bj20140697 · Cited by 17 · see citing works
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Self-citationGrenko, C. M., Taylor, H. J., Bonnycastle, L. L., Xue, D., Lee, B. N., Weiss, Z., Yan, T., Swift, A. J., Mansell, E. C., Lee, A., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06214-4 · Cited by 16 · see citing works
Zhong, L., Yeh, T.-Y. J., Hao, J., Pourtabatabaei, N., Mahata, S. K., Shao, J., Chessler, S. D., & Chi, N. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122948 · Cited by 15 · see citing works
Weksler‐Zangen, S., Aharon‐Hananel, G., Mantzur, C., Aouizerat, T., Gurgul-Convey, E., Raz, I., & Saada, A. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00451.2013 · Cited by 14 · see citing works
Branco, R. C. S., Camargo, R. L., Batista, T. M., Vettorazzi, J. F., Borck, P. C., Santos‐Silva, J. C. R., Boschero, A. C., Zoppi, C. C., & Carneiro, E. M. (2017) · The FASEB Journal · doi:10.1096/fj.201600326rrr · Cited by 14 · see citing works
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Shcherbina, L., Edlund, A., Esguerra, J. L. S., Abels, M., Zhou, Y., Ottosson-Laakso, E., Wollheim, C. B., Hansson, O., Eliasson, L., & Wierup, N. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.02.027 · Cited by 14 · see citing works
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Ishikawa, K., Yamamoto, S., Hattori, S., Nishimura, N., Mito, T., Matsumoto, H., Miyakawa, T., & Nakada, K. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.2139-18.2018 · Cited by 14 · see citing works
Al-Amily, I. M., Sjögren, M., Dunér, P., Mohammad, T., Wollheim, C. B., & Salehi, A. A. (2023) · Biomolecules · doi:10.3390/biom13030557 · Cited by 13 · see citing works
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Quan, X., Das, R., Xu, S., Cline, G. W., Wiederkehr, A., Wollheim, C. B., & Park, K. (2013) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2013.08.003 · Cited by 13 · see citing works
Self-citationPereira, A. P. A., Angolini, C. F. F., de Souza-Sporkens, J. C., da Silva, T. A., Oliveira, H. C. F., & Pastore, G. M. (2021) · Food Research International · doi:10.1016/j.foodres.2021.110589 · Cited by 11 · see citing works
Sall, I. M., Hașaș, A.-D., Amiali, M., Vodnar, D. C., Aziez, M., Semzenisi, E., Hodor, D., Pop, R., & Tăbăran, F. (2025) · Plants · doi:10.3390/plants14121776 · Cited by 9 · see citing works
- Authors
- Wiederkehr, A., & Wollheim, C. B.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Wiederkehr, Andreas
- Wollheim, Claes B.
- Venue
- Molecular and Cellular Endocrinology
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 353
- Issue
- 1-2
- Pages
- 128-137
- ISSN
- 0303-7207 (ISSN-L)
- OpenAlex
- W2040651543
- Cited by
- 133
- References
- 105
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 8 · 2019: 12 · 2018: 14 · 2017: 12 · 2016: 8 · 2015: 17 · 2014: 12 · 2013: 12 · 2012: 6
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- Licence
- Locations
- Molecular and Cellular Endocrinology (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Funders
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Agence Nationale pour la Gestion des Déchets Radioactifs
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin secretion, pancreatic beta cells, mitochondrial function, mitochondrial calcium uptake, mitochondrial matrix pH, membrane depolarization, calcium influx, insulin granule exocytosis, ATP production, nutrient sensing, type 2 diabetes
- MeSH terms
- Insulin Secretion, Adenosine Triphosphate, Animals, Calcium, Cell Membrane, Diabetes Mellitus, Type 2, Exocytosis, Humans, Insulin, Membrane Potentials, Mitochondria, Oxidative Phosphorylation, Insulin-Secreting Cells
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