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During autophagy mitochondria elongate, are spared from degradation and sustain cell viability

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Islet cell failure in type 2 diabetes

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Antioxidants prevent health-promoting effects of physical exercise in humans

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The genetic architecture of type 2 diabetes

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Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

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Saturated Fatty Acids Synergize with Elevated Glucose to Cause Pancreatic β-Cell Death

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Mitochondrial glutamate acts as a messenger in glucose-induced insulin exocytosis

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Role of NADH Shuttle System in Glucose-Induced Activation of Mitochondrial Metabolism and Insulin Secretion

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Mitochondrial Diabetes

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Impaired insulin secretion and β-cell loss in tissue-specific knockout mice with mitochondrial diabetes

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Overnight lowering of free fatty acids with Acipimox improves insulin resistance and glucose tolerance in obese diabetic and nondiabetic subjects.

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Altered lipid content inhibits autophagic vesicular fusion

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The FFA receptor GPR40 links hyperinsulinemia, hepatic steatosis, and impaired glucose homeostasis in mouse

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Diabetes mellitus associated with a pathogenic point mutation in mitochondrial DNA

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Glycemic index, glycemic load, and risk of type 2 diabetes: results from 3 large US cohorts and an updated meta-analysis

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Epidemiology of A3243G, the Mutation for Mitochondrial Encephalomyopathy, Lactic Acidosis, and Strokelike Episodes: Prevalence of the Mutation in an Adult Population

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Glucolipotoxicity of the pancreatic beta cell

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Mitochondrial Networking Protects β-Cells From Nutrient-Induced Apoptosis

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A 48-hour Lipid Infusion in the Rat Time-Dependently Inhibits Glucose-Induced Insulin Secretion and B Cell Oxidation Through a Process Likely Coupled to Fatty Acid Oxidation*

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Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion

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Autophagy in human type 2 diabetes pancreatic beta cells

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Loss of FFA2 and FFA3 increases insulin secretion and improves glucose tolerance in type 2 diabetes

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Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic β-cells

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Diabetes, glucose toxicity, and oxidative stress: A case of double jeopardy for the pancreatic islet β cell

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Diabetes causes marked inhibition of mitochondrial metabolism in pancreatic β-cells

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A role for glutathione peroxidase in protecting pancreatic β cells against oxidative stress in a model of glucose toxicity

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High-Fat Diet–Induced Lysosomal Dysfunction and Impaired Autophagic Flux Contribute to Lipotoxicity in the Kidney

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Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins

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Multiple environmental and genetic factors influence skeletal muscle PGC-1α and PGC-1β gene expression in twins

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Regulation of insulin secretion: role of mitochondrial signalling

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Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation

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Banting Lecture 2011

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Mitochondrial Bound Hexokinase Activity as a Preventive Antioxidant Defense

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Electron Transport Chain-dependent and -independent Mechanisms of Mitochondrial H2O2 Emission during Long-chain Fatty Acid Oxidation

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Glucose-regulated anaplerosis and cataplerosis in pancreatic beta-cells: possible implication of a pyruvate/citrate shuttle in insulin secretion.

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Hormone‐induced mitochondrial fission is utilized by brown adipocytes as an amplification pathway for energy expenditure

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Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation

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Chronic exposure to free fatty acid reduces pancreatic beta cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation.

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Troglitazone prevents mitochondrial alterations, β cell destruction, and diabetes in obese prediabetic rats

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Tissue triglycerides, insulin resistance, and insulin production: implications for hyperinsulinemia of obesity

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Peroxisome-generated hydrogen peroxide as important mediator of lipotoxicity in insulin-producing cells

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Fatty Acids Suppress Autophagic Turnover in β-Cells

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Oxidation of Fatty Acids Is the Source of Increased Mitochondrial Reactive Oxygen Species Production in Kidney Cortical Tubules in Early Diabetes

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Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation

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Mitochondrial disease and endocrine dysfunction

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An autosomal genomic scan for loci linked to prediabetic phenotypes in Pima Indians.

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Protective Role of Autophagy in Palmitate-Induced INS-1 β-Cell Death

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Genetic and epigenetic factors are associated with expression of respiratory chain component NDUFB6 in human skeletal muscle

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Free Fatty Acid–Induced Reduction in Glucose-Stimulated Insulin Secretion

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Mitochondrial GTP regulates glucose-stimulated insulin secretion.

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Persistent oxidative stress due to absence of uncoupling protein 2 associated with impaired pancreatic β-cell function.

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Glucolipotoxicity, β-Cells, and Diabetes: The Emperor Has No Clothes

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Interaction of free fatty acids with mitochondria: Coupling, uncoupling and permeability transition

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Mitochondrial DNA Is Required for Regulation of Glucose-stimulated Insulin Secretion in a Mouse Pancreatic Beta Cell Line, MIN6

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Watch your step when working with old paints and wash primer

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