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Similar risk of malignancy with insulin glargine and neutral protamine Hagedorn (NPH) insulin in patients with type 2 diabetes: findings from a 5 year randomised, open-label study
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“Randomized clinical trial data from an open-label 5-year trial of insulin glargine versus NPH insulin did not find evidence of excess cancer risk (all sites combined) in the insulin glargine arm (118), although among the ∼1,000 subjects randomized, there was a very small number of cancer end points (57 cancer cases in the glargine arm and 62 cases in the NPH arm).”
From Diabetes and Cancer (2010) · cites this paper as [118]
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Metadata
- Authors
- Rosenstock, J., Fonseca, V., McGill, J. B., Riddle, M., Hallé, J. P., Hramiak, I., Johnston, P., & Davis, M.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Tulane University (US)
- Washington University in St. Louis (US)
- Oregon Health & Science University (US)
- Université de Montréal (CA)
- Western University (CA)
- University of Wisconsin–Madison (US)
- Corresponding author
- Rosenstock, J.
- Venue
- Diabetologia
- Published
- 2009-07-16
- Volume
- 52
- Issue
- 9
- Pages
- 1971-1973
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC2723677
- OpenAlex
- W2135096382
- Cited by
- 141
- References
- 5
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 1 · 2020: 1 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 5 · 2015: 6 · 2014: 14 · 2013: 16 · 2012: 16
- FWCI
- 20.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Diabetologia (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Diabetes Association
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- GlaxoSmithKline
- Sanofi
- Tulane University
- McGill University
- MannKind Corporation
- Daiichi-Sankyo
- Novo Nordisk
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- insulin glargine, neutral protamine Hagedorn insulin, type 2 diabetes, cancer risk, cancer incidence, long-acting insulin, insulin analogues
- MeSH terms
- Insulin Glargine, Diabetes Mellitus, Type 2, Diabetic Retinopathy, Humans, Hypoglycemic Agents, Insulin, Insulin, Isophane, Neoplasms, Risk Factors, Insulin, Long-Acting
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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