Block versus Random Amphiphilic Glycopolymer Nanopaticles as Glucose-Responsive Vehicles
Abstract
To explore the effect of polymer structure on their self-assembled aggregates and their unique characteristics, this study was devoted to developing a series of amphiphilic block and random phenylboronic acid-based glycopolymers by RAFT polymerization. The amphiphilic glycopolymers were successfully self-assembled into spherically shaped nanoparticles with narrow size distribution in aqueous solution. For block and random copolymers with similar monomer compositions, block copolymer nanoparticles exhibited a more regular transmittance change with the increasing glucose level, while a more evident variation of size and quicker decreasing tendency in I/I0 behavior in different glucose media were observed for random copolymer nanoparticles. Cell viability of all the polymer nanoparticles investigated by MTT assay was higher than 80%, indicating that both block and random copolymers had good cytocompatibility. Insulin could be encapsulated into both nanoparticles, and insulin release rate for random glycopolymer was slightly quicker than that for the block ones. We speculate that different chain conformations between block and random glycopolymers play an important role in self-assembled nanoaggregates and underlying glucose-sensitive behavior.
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Previous studies have highlighted that not only composition, but also architecture and monomer distributions of copolymers could strongly affect their thermal, mechanical and aggregation properties.
“Previous studies have highlighted that not only the composition, but also the architecture and monomers distributions of copolymers could strongly affect their thermal, mechanical and aggregation properties [36,37,38].”
From Thermo-Rheological and Shape Memory Properties of Block and Random Copolymers of Lactide and ε-Caprolactone (2021) · cites this paper as [37]
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Self-citation
- Authors
- Guo, Q., Zhang, T., An, J., Wu, Z., Zhao, Y., Dai, X., Zhang, X., & Li, C.
- Affiliations
- Nankai University (CN)
- Tianjin Medical University (CN)
- Corresponding author
- Zhang, Xinge
- Venue
- Biomacromolecules
- Publisher
- American Chemical Society (ACS)
- Published
- 2015-09-30
- Volume
- 16
- Issue
- 10
- Pages
- 3345-3356
- ISSN
- 1525-7797 (ISSN-L)
- 1526-4602
- OpenAlex
- W2317788757
- Cited by
- 75
- References
- 67
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2022: 4 · 2021: 15 · 2020: 8 · 2019: 10 · 2018: 12 · 2017: 12 · 2016: 8
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biomacromolecules (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of Tianjin City (14JYBJC29400)
- National Natural Science Foundation of China (21474055, 51173085)
- Ministry of Education of the People's Republic of China (20130031110014, IRT1257)
- Topics
- Physical Sciences › Chemistry › Organic Chemistry › Advanced Polymer Synthesis and Characterization
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Keywords
- phenylboronic acid, block copolymers, random copolymers, RAFT polymerization, self-assembly, insulin encapsulation, insulin secretion, chain conformation, cytocompatibility, glucose detection
- MeSH terms
- Glucose, Magnetic Resonance Spectroscopy, Polymers, Microscopy, Electron, Transmission, Nanoparticles
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