The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation
Open accessAbstract
The recent major increase in the global incidence of type 2 diabetes suggests that most cases of this disease are caused by changes in environment and lifestyle. All major risk factors for type 2 diabetes (overnutrition, low dietary fibre, sedentary lifestyle, sleep deprivation and depression) have been found to induce local or systemic low-grade inflammation that is usually transient or milder in individuals not at risk for type 2 diabetes. By contrast, inflammatory responses to lifestyle factors are more pronounced and prolonged in individuals at risk of type 2 diabetes and appear to occur also in the pancreatic islets. Chronic low-grade inflammation will eventually lead to overt diabetes if counter-regulatory circuits to inflammation and metabolic stress are compromised because of a genetic and/or epigenetic predisposition. Hence, it is not the lifestyle change per se but a deficient counter-regulatory response in predisposed individuals which is crucial to disease pathogenesis. Novel approaches of intervention may target these deficient defence mechanisms.
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Cites
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BackgroundInfluentialInterleukin-1-receptor antagonist in type 2 diabetes mellitus
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Self-citationIKK-β links inflammation to obesity-induced insulin resistance
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Cited by
Dietary factors and low-grade inflammation in relation to overweight and obesity
Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098
Self-citation(2014) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70102-0 · Cited by 800
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Kolb, H., & Martin, S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0901-x · Cited by 717
Self-citationImpact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation
Bach Knudsen, K. E., Lærke, H. N., Hedemann, M. S., Nielsen, T. S., Ingerslev, A. K., Gundelund Nielsen, D. S., Theil, P. K., Purup, S., Hald, S., Schioldan, A. G., et al. (2018) · Nutrients · doi:10.3390/nu10101499 · Cited by 572
Butyrate and other short-chain fatty acids as modulators of immunity: What relevance for health?
Meijer, K., de Vos, P., & Priebe, M. G. (2010) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32833eebe5 · Cited by 443
Metadata
- Authors
- Kolb, H., & Mandrup-Poulsen, T.
- Venue
- Diabetologia
- Published
- 2009-11-05
- Volume
- 53
- Issue
- 1
- Pages
- 10-20
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2019728528
- Cited by
- 292
- References
- 29
- FWCI
- 13.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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