The DOI matches its Crossref record; 40 of the 41 references it cites were found in a registry or an index.
Sedentary time, breaks in sedentary time and metabolic variables in people with newly diagnosed type 2 diabetes
Open accessAbstract
Aims/hypothesis We investigated whether objectively measured sedentary time and interruptions in sedentary time are associated with metabolic factors in people with type 2 diabetes. Methods We studied 528 adults (30-80 years) with newly diagnosed type 2 diabetes, who were participants in a diet and physical activity intervention. Waist circumference (WC), fasting HDL-cholesterol, insulin and glucose levels, HOMA of insulin resistance (HOMA-IR) and physical activity (accelerometer) were measured at baseline and at 6 months follow-up. Linear regression models were used to investigate cross-sectional and longitudinal associations of accelerometer-derived sedentary time and breaks in sedentary time (BST) with metabolic variables. Results In cross-sectional analyses each hour of sedentary time was associated with larger WC (unstandardised regression coefficient [B] [95% CI] 1.89 cm [0.94, 2.83]; p < 0.001), higher insulin (B = 8.22 pmol/l [2.80, 13.65]; p = 0.003) and HOMA-IR (B = 0.42 [0.14, 0.70]; p = 0.004), and lower HDL-cholesterol (B = -0.04 mmol/l [-0.06, -0.01]; p = 0.005). Adjustment for WC attenuated all associations. Each BST was associated with lower WC (B = -0.15 cm [- 0.24, -0.05]; p = 0.003) and there was evidence of a weak linear association with HDL-cholesterol, but no association with insulin levels or HOMA-IR. Volume of sedentary time at baseline predicted HDL-cholesterol (B = -0.05 mmol/l [-0.08, -0.01]; p = 0.007), insulin levels (B = 8.14 pmol/l [0.1.51, 14.78]; p = 0.016) and HOMA-IR (B = 0.49 [0.08, 0.90]; p = 0.020) at 6 months, though not WC. Baseline BST did not substantially predict any metabolic variables at follow-up. No change was seen in sedentary time or BST between baseline and 6 months follow-up. Conclusions/interpretation Higher sedentary time is associated with a poorer metabolic profile in people with type 2 diabetes.
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“More time spent in sedentary behaviors was associated with an increased risk of developing diabetes and poorer metabolic and inflammatory profiles in those with T2DM.”
From The Impact of Physical Activity in Patients With Type 2 Diabetes (2025) · cites this paper as [80]
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Cites
Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin
(2002) · New England Journal of Medicine · doi:10.1056/nejmoa012512 · Cited by 19,011
Pan, X.-R., Li, G.-W., Hu, Y.-H., Wang, J.-X., Yang, W.-Y., An, Z.-X., Hu, Z.-X., Juan-Lin, Xiao, J.-Z., Cao, H.-B., et al. (1997) · Diabetes Care · doi:10.2337/diacare.20.4.537 · Cited by 4,320
Systematic review and meta-analysis
Gillies, A. (2019) · CRC Press eBooks · doi:10.1201/9781315377315-19 · Cited by 2,876
Amount of Time Spent in Sedentary Behaviors in the United States, 2003-2004
Matthews, C. E., Chen, K. Y., Freedson, P. S., Buchowski, M. S., Beech, B. M., Pate, R. R., & Troiano, R. P. (2008) · American Journal of Epidemiology · doi:10.1093/aje/kwm390 · Cited by 2,631
Too Much Sitting: The Population Health Science of Sedentary Behavior
Owen, N., Healy, G. N., Matthews, C. E., & Dunstan, D. W. (2010) · Exercise and Sport Sciences Reviews · doi:10.1097/jes.0b013e3181e373a2 · Cited by 2,202
Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program
Lévy, J., Matthews, D. R., & Hermans, M. P. (1998) · Diabetes Care · doi:10.2337/diacare.21.12.2191 · Cited by 2,023
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The Finnish Diabetes Prevention Study (DPS)
Lindström, J., Louheranta, A., Mannelin, M., Rastas, M., Salminen, V., Eriksson, J., Uusitupa, M., Tuomilehto, J., & for the Finnish Diabetes Prevention Study Group (2003) · Diabetes Care · doi:10.2337/diacare.26.12.3230 · Cited by 1,848
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Sitting time and mortality from all causes, cardiovascular disease, and cancer
KATZMARZYK, P. T., CHURCH, T. S., CRAIG, C. L., & BOUCHARD, C. (2009) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3181930355 · Cited by 1,611
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Too much sitting – A health hazard
Dunstan, D. W., Howard, B., Healy, G. N., & Owen, N. G. (2012) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2012.05.020 · Cited by 637
“ence was also observed in adults with newly diagnosed type 2 diabetes [50].”
BackgroundInterrupting long periods of sitting: good STUFF
Rutten, G. M., Savelberg, H. H. C. M., Biddle, S., & Kremers, S. (2013) · International Journal of Behavioral Nutrition and Physical Activity · doi:10.1186/1479-5868-10-1 · Cited by 503
“Although little is known about the thresholds for time spent sitting or how long sitting should be interrupted before it evokes health consequences, evidence shows that short breaks in sitting may prevent these degrading processes [2,10,11].”
BackgroundSchram, M. T., Sep, S. J. S., Kallen, C., Dagnelie, P. C., Koster, A., Schaper, N. C., Henry, R. M. A., & Stehouwer, C. D. A. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9889-0 · Cited by 457
Meta‐analysis of the relationship between breaks in sedentary behavior and cardiometabolic health
Chastin, S. F. M., Egerton, T., Leask, C., & Stamatakis, E. (2015) · Obesity · doi:10.1002/oby.21180 · Cited by 363
“One study included participants only with recently diagnosed type 2 diabetes (19) and two studies focussed on the participants with known risk of diabetes (21,22).”
BackgroundHow Physically Active Are People Following Stroke? Systematic Review and Quantitative Synthesis
Fini, N. A., Holland, A. E., Keating, J. L., Simek, J., & Bernhardt, J. A. (2017) · Physical Therapy · doi:10.1093/ptj/pzx038 · Cited by 354
Metadata
- Authors
- Cooper, A. R., Sebire, S., Montgomery, A. A., Peters, T. J., Sharp, D. J., Jackson, N., Fitzsimons, K., Dayan, C. M., & Andrews, R. C.
- Affiliations
- University of Bristol (GB)
- Cardiff University (GB)
- Corresponding author
- Cooper, A. R.
- Venue
- Diabetologia
- Published
- 2011-12-14
- Volume
- 55
- Issue
- 3
- Pages
- 589-599
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2171170053
- Cited by
- 195
- References
- 41
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 15 · 2023: 10 · 2022: 5 · 2021: 12 · 2020: 14 · 2019: 12 · 2018: 14 · 2017: 26 · 2016: 16 · 2015: 23 · 2014: 20 · 2013: 20 · 2012: 3
- FWCI
- 8.87
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion)
- University of Birmingham Research Portal (University of Birmingham) (submittedVersion, other-oa)
- Funders
- National Institute for Health and Care Research (PB-PG-0610-22352)
- Economic and Social Research Council (ES/G007543/1)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- sedentary time, metabolic risk factors, waist circumference, insulin resistance, HOMA-IR, HDL cholesterol, insulin levels, physical activity, newly diagnosed diabetes, cardiovascular risk, glycemic control, HbA1c
- MeSH terms
- Adult, Aged, Aged, 80 and over, Cross-Sectional Studies, Diabetes Mellitus, Type 2, England, Female, Humans, Insulin, Insulin Resistance, Cholesterol, HDL, Longitudinal Studies, Male, Middle Aged, Motor Activity, Patient Compliance, Time Factors, Cohort Studies, Body Mass Index, Overweight, Young Adult, Sedentary Behavior
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