Accelerometer-derived sedentary and physical activity time in overweight=obese adults with type 2 diabetes: cross-sectional associations with cardiometabolic biomarkers
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OBJECTIVE: To examine the associations of sedentary time and physical activity with biomarkers of cardiometabolic health, including the potential collective impact of shifting mean time use from less- to more-active behaviours (cross-sectionally, using isotemporal substitution), in adults with type 2 diabetes. METHODS: Participants with overweight/obese body mass index (BMI; ≥25 kg/m2) (n = 279; 158 men, mean [SD] age = 58.2 [8.6] years) wore Actigraph GT1M accelerometers (waking hours; seven days) to assess moderate- to vigorous-intensity physical activity (MVPA), light-intensity activity, and sedentary time (segregated into non-prolonged [accumulated in bouts <30min] and prolonged [accumulated in bouts ≥30 min]). Cross-sectional associations with waist circumference, BMI, fasting blood (HbA1c, glucose, triacylglycerols, high-density lipoprotein cholesterol), and blood pressure of these activity variables (30 min/day increments) were examined adjusted for confounders and wear then, if significant, examined using isotemporal substitution modelling. RESULTS: Waist circumference and BMI were significantly (p<0.05) associated with more prolonged sedentary time and less light-intensity activity. Light intensity activity was also significantly associated with lower fasting plasma glucose (relative rate: 0.98, 95% CI: 0.97, 1.00; p<0.05). No biomarker was significantly associated with non-prolonged sedentary time or MVPA. Lower mean prolonged sedentary time (-30 min/day) with higher mean light intensity time (+30 min/day) was significantly associated with lower waist circumference (β = -0.77, 95% CI: -1.33, -0.22 cm). Lower mean prolonged sedentary time (-30 min/day) with either 30 min/day higher mean non-prolonged sedentary time (β = -0.35, 95%CI: -0.70, -0.01 kg/m2) or light-intensity time (β = -0.36, -0.61, -0.11 kg/m2) was associated with significantly lower average BMI. CONCLUSIONS: Significantly improved mean levels of waist circumference and BMI were observed when shifting time from prolonged sedentary to non-prolonged sedentary or light-intensity activity (cross-sectionally). Lifestyle interventions in overweight/obese adults with type 2 diabetes might consider targeting shifts in these non-MVPA activities to more rigorously evaluate their potential cardiometabolic benefit in this population.
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In adults with type 2 diabetes, interrupting sedentary time with short, regular, frequent episodes of light-intensity physical activity attenuates postprandial glucose, insulin, C-peptide and triglycerides, and reduces waist circumference, BMI and blood pressure.
“In adults with T2D, the interruption of sedentary time with short, regular and frequent episodes of light-intensity physical activity such as walking or simple resistance activities attenuates the level of postprandial glucose, insulin, C-peptide and triglycerides [45], and reduces waist circumference, body mass index (BMI) [46] and blood pressure [47].”
From Impact of a primary care-based mobile health intervention to ‘sit less and move more’ on HbA1c, blood pressure, and other clinical outcomes in office employees with type 2 diabetes: A randomized controlled trial (2025) · cites this paper as [46]
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- Authors
- Healy, G. N., Winkler, E. A. H., Brakenridge, C. L., Reeves, M. M., & Eakin, E. G.
- Affiliations
- Baker Heart and Diabetes Institute (AU)
- The University of Queensland (AU)
- Corresponding author
- Healy, Genevieve N.
- ORCID
- Venue
- PLoS ONE
- Publisher
- Public Library of Science (PLoS)
- Published
- 2015-03-16
- Volume
- 10
- Issue
- 3
- Pages
- e0119140
- ISSN
- 1932-6203 (ISSN-L)
- PMC
- PMC4361561
- OpenAlex
- W2050640962
- Cited by
- 123
- References
- 34
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 6 · 2023: 6 · 2022: 9 · 2021: 17 · 2020: 8 · 2019: 9 · 2018: 19 · 2017: 21 · 2016: 13 · 2015: 9
- FWCI
- 15.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- PLoS ONE (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- eSpace (Curtin University) (submittedVersion)
- Figshare (submittedVersion, cc-by)
- Funders
- Diabetes Australia
- Servier
- Medical Research Council
- National Health and Medical Research Council
- Topics
- Health Sciences › Medicine › Physiology › Physical Activity and Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Obesity, Physical Activity, Diet
- Keywords
- sedentary time, physical activity, type 2 diabetes, overweight, obesity, cardiometabolic biomarkers, waist circumference, body mass index, light physical activity, moderate-to-vigorous physical activity, isotemporal substitution, HbA1c, fasting blood glucose, blood pressure, HDL cholesterol, triglycerides, accelerometer
- MeSH terms
- Blood Glucose, Blood Pressure, Cardiovascular Diseases, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Female, Humans, Cholesterol, HDL, Male, Middle Aged, Motor Activity, Obesity, Triglycerides, Biomarkers, Overweight, Waist Circumference, Sedentary Behavior
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