A novel mechanism regulating insulin secretion involving Herpud1 in mice

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Herp, a New Ubiquitin-like Membrane Protein Induced by Endoplasmic Reticulum Stress

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A Diabetes Outcome Progression Trial (ADOPT)

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Polymorphisms in the TCF7L2, CDKAL1 and SLC30A8 genes are associated with impaired proinsulin conversion

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Characterization of an ERAD Pathway for Nonglycosylated BiP Substrates, which Require Herp

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Genetic Regulation of Metabolic Pathways in β-Cells Disrupted by Hyperglycemia

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Endoplasmic Reticulum Stress-inducible Protein, Herp, Enhances Presenilin-mediated Generation of Amyloid β-Protein

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Herp Stabilizes Neuronal Ca2+ Homeostasis and Mitochondrial Function during Endoplasmic Reticulum Stress

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Genetic Analysis of Glucose Tolerance in Inbred Mouse Strains: Evidence for Polygenic Control

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Genetic Background Determines the Size and Structure of the Endocrine Pancreas

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Herp enhances ER-associated protein degradation by recruiting ubiquilins

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The Influence of Genetic Background on the Expression of Mutations at the Diabetes Locus in the Mouse: III. Effect of H-2 Haplotype and Sex

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Comparison of Insulin Secretory Function in Two Mouse Models with Different Susceptibility to β-Cell Failure

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Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes

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Herp Regulates Hrd1-mediated Ubiquitylation in a Ubiquitin-like Domain-dependent Manner

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Derlin-1 Deficiency Is Embryonic Lethal, Derlin-3 Deficiency Appears Normal, and Herp Deficiency Is Intolerant to Glucose Load and Ischemia in Mice

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The Deletion Variant of Nicotinamide Nucleotide Transhydrogenase (Nnt) Does Not Affect Insulin Secretion or Glucose Tolerance

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Fructose-1,6-Bisphosphatase Overexpression in Pancreatic β-Cells Results in Reduced Insulin Secretion

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The influence of genetic background on the induction of oxidative stress and impaired insulin secretion in mouse islets

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Variant in sulfonylurea receptor-1 gene is associated with high insulin concentrations in non-diabetic Mexican Americans: SUR-1 gene variant and hyperinsulinemia

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Systems genetics of susceptibility to obesity-induced diabetes in mice

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Obesity and Type 2 diabetes: Slow down!—Can metabolic deceleration protect the islet beta cell from excess nutrient-induced damage?

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The influence of genetic background on the expression of mutations at the diabetes locus in the mouse. III. Effect of H-2 haplotype and sex

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The Endoplasmic Reticulum Stress-Inducible Protein, Herp, Is a Potential Triggering Antigen for Anti-DNA Response

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Genetic analysis of glucose tolerance in inbred mouse strains. Evidence for polygenic control

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A quantitative trait locus that accounts for glucose intolerance maps to chromosome 8 in hereditary obese KK-Ay mice

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Quantitative Trait Loci on Chromosome 8q24 for Pancreatic β-Cell Function and 7q11 for Insulin Sensitivity in Obese Nondiabetic White and Black Families

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Comparison of Insulin Secretory Function in Two Mouse Models with Different Susceptibility to -Cell Failure

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Systems Genetics: The Next Generation in Genetics Research?

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Murine Nr4a1 and Herpud1 are up-regulated by Wnt-1, but the homologous human genes are independent from β-catenin activation

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Metabolic Flexibility as an Adaptation to Energy Resources and Requirements in Health and Disease

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Systems proteomics of liver mitochondria function

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Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Reference Population

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Targeted pharmacological therapy restores β-cell function for diabetes remission

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Genome‐wide mRNA profiling identifies RCAN1 and GADD45A as regulators of the transitional switch from survival to apoptosis during ER stress

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Damage to enteric neurons occurs in mice that develop fatty liver disease but not diabetes in response to a high‐fat diet

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A Genetic Screen Identifies Hypothalamic Fgf15 as a Regulator of Glucagon Secretion

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Multi-omic human pancreatic islet endoplasmic reticulum and cytokine stress response mapping provides type 2 diabetes genetic insights

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GM-CSF driven myeloid cells in adipose tissue link weight gain and insulin resistance via formation of 2-aminoadipate

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HERP Binds TBK1 To Activate Innate Immunity and Repress Virus Replication in Response to Endoplasmic Reticulum Stress

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Differentially Expressed Genes Regulating Glutathione Metabolism, Protein-Folding, and Unfolded Protein Response in Pancreatic β-Cells in Type 2 Diabetes Mellitus

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A new role for HERPUD1 and ERAD activation in osteoblast differentiation and mineralization

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Single-Cell Transcriptional Profiling of Mouse Islets Following Short-Term Obesogenic Dietary Intervention

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Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption

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Postnatal maturation of calcium signaling in islets of Langerhans from neonatal mice

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NAD(P)H quinone oxidoreductase 1 inhibits the proteasomal degradation of homocysteine-induced endoplasmic reticulum protein

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Effects of dietary 25-hydroxycholecalciferol and vitamin D3 on performance, meat yield, bone characteristics, innate immune response and gene expression of Ross 308 broilers grown on reused or fresh litter

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A genetic screen identifies Crat as a regulator of pancreatic beta-cell insulin secretion

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Featured interactome of homocysteine-inducible endoplasmic reticulum protein uncovers novel binding partners in response to ER stress

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HERPUD1 governs tumor cell mitochondrial function via inositol 1,4,5-trisphosphate receptor-mediated calcium signaling

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Comparative Multi-omic Mapping of Human Pancreatic Islet Endoplasmic Reticulum and Cytokine Stress Responses Provides Insights into Type 2 Diabetes GeneticsPreprint

Sokolowski, E. K., Kursawe, R., Selvam, V., Bhuiyan, R. M., Thibodeau, A., Zhao, C. G., Spracklen, C. N., Ucar, D., & Stitzel, M. L. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.17.580646 · Cited by 2 · see citing works

Targeted pharmacological therapy restores β-cell function for diabetes remission

Sachs, S., Bastidas-Ponce, A., Tritschler, S., Bakhti, M., Böttcher, A., Sanchez-Garrido, M. A., Tarquis-Medina, M., Kleinert, M., Fischer, K. L., Jall, S., et al. (2021) · Yearbook of pediatric endocrinology · doi:10.1530/ey.18.10.14

Islet Inflammation and Metabolic Homeostasis

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Single-cell sequencing combined with transcriptome sequencing to reveal the molecular mechanisms related to integrated stress responses in atherosclerosis

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Increased nicotinamide nucleotide transhydrogenase levels predispose to insulin hypersecretion in a mouse strain susceptible to diabetes

Aston‐Mourney, K., Wong, N., Kebede, M. A., Zraika, S., Balmer, L. A., McMahon, J. M., Fam, B. C., Favaloro, J. M., Proietto, J., Morahan, G., et al. (2007) · Diabetologia · doi:10.1007/s00125-007-0814-x · Cited by 74 · see citing works

Comparison of Insulin Secretory Function in Two Mouse Models with Different Susceptibility to β-Cell Failure

Kooptiwut, S., Zraika, S., Thorburn, A. W., Dunlop, M., Darwiche, R., Kay, T. W. H., Proietto, J., & Andrikopoulos, S. (2002) · Endocrinology · doi:10.1210/endo.143.6.8859 · Cited by 79 · see citing works

Increased Nnt activity leads to insulin hypersecretion and susceptibility to diabetes in mice

Andrikopoulos, S., Aston‐Mourney, K., Kebede, M. A., Wong, N., Fam, B. C., Favaloro, J. M., Proietto, J., & Morahan, G. (2007)

Sweet Taste Receptors Regulate Basal Insulin Secretion and Contribute to Compensatory Insulin Hypersecretion During the Development of Diabetes in Male Mice

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Gene loci associated with insulin secretion in islets from nondiabetic mice

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