Cited by 27Redox biology and oxidative stressAdipokines, Inflammation, and Metabolic DiseasesParaoxonase enzyme and polymorphisms

Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study

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Abbasi, Ali, Corpeleijn, Eva, Gansevoort, Ron T., Gans, Rijk O. B., Struck, Joachim, Schulte, Janin, Hillege, Hans L., van der Harst, Pim +3 more·2014·Diabetologia

Abstract

AIMS/HYPOTHESIS: Oxidative stress plays a key role in the development of type 2 diabetes mellitus. We previously showed that the circulating antioxidant peroxiredoxin 4 (Prx4) is associated with cardiometabolic risk factors. We aimed to evaluate the association of Prx4 with type 2 diabetes risk in the general population. METHODS: We analysed data on 7,972 individuals from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study (49% men, aged 28-75 years) with no diabetes at baseline. Logistic regression models adjusted for age, sex, smoking, waist circumference, hypertension and family history of diabetes were used to estimate the ORs for type 2 diabetes. RESULTS: During a median follow up of 7.7 years, 496 individuals (288 men; 58%) developed type 2 diabetes. The median (Q1-Q3) Prx4 level was 0.84 (0.53-1.40) U/l in individuals who developed type 2 diabetes and 0.68 (0.43-1.08) U/l in individuals who did not develop type 2 diabetes. For every doubling of Prx4 levels, the adjusted OR (95% CI) for type 2 diabetes was 1.16 (1.05-1.29) in the whole population; by sex, it was 1.31 (1.14-1.50) for men and 1.03 (0.87-1.21) for women. Further adjustment for other clinical measures did not materially change the results. The addition of Prx4 to a validated diabetes risk score significantly improved the prediction of type 2 diabetes in men (p = 0.002 for reclassification improvement). CONCLUSIONS/INTERPRETATION: Our findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes. For men, taking Prx4 into consideration can improve type 2 diabetes prediction over a validated diabetes risk score; in contrast, there is no improvement in risk prediction for women.

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Authors
Abbasi, A., Corpeleijn, E., Gansevoort, R. T., Gans, R. O. B., Struck, J., Schulte, J., Hillege, H. L., van der Harst, P., Stolk, R. P., Navis, G., & Bakker, S. J. L.
Affiliations
  • University Medical Center Groningen (NL)
  • Thermo Fisher Scientific (Germany) (DE)
Corresponding author
Abbasi, Ali
Venue
Diabetologia
Published
2014-06-04
Volume
57
Issue
9
Pages
1842-1849
ISSN
  • 0012-186X (ISSN-L)
  • 1432-0428
OpenAlex
W2153300257
Cited by
27
References
43
Citations by year
2025: 1 · 2024: 7 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 4 · 2015: 2
FWCI
1.37
Type
journal article
Language
en
Open access
Locations
  • Diabetologia (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
  • Apollo (University of Cambridge) (submittedVersion, cc-by)
Funders
  • Rijksuniversiteit Groningen
  • Nierstichting (01C-104)
  • Diabetes Fonds (01C-104)
  • Nederlandse Organisatie voor Wetenschappelijk Onderzoek (825.13.004)
  • Universitair Medisch Centrum Groningen
  • Center for Translational Molecular Medicine (01 C-104)
  • Medical Research Council (MC-U106179471, MC_UU_12015/1)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
  • Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
Keywords
peroxiredoxin 4, type 2 diabetes, oxidative stress, circulating biomarkers, diabetes risk prediction, sex differences, diabetes risk score, PREVEND study
MeSH terms
Adult, Age Factors, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Smoking, Peroxiredoxins, Waist Circumference

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