Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study
Open accessAbstract
AIMS/HYPOTHESIS: Oxidative stress plays a key role in the development of type 2 diabetes mellitus. We previously showed that the circulating antioxidant peroxiredoxin 4 (Prx4) is associated with cardiometabolic risk factors. We aimed to evaluate the association of Prx4 with type 2 diabetes risk in the general population. METHODS: We analysed data on 7,972 individuals from the Prevention of Renal and Vascular End-stage Disease (PREVEND) study (49% men, aged 28-75 years) with no diabetes at baseline. Logistic regression models adjusted for age, sex, smoking, waist circumference, hypertension and family history of diabetes were used to estimate the ORs for type 2 diabetes. RESULTS: During a median follow up of 7.7 years, 496 individuals (288 men; 58%) developed type 2 diabetes. The median (Q1-Q3) Prx4 level was 0.84 (0.53-1.40) U/l in individuals who developed type 2 diabetes and 0.68 (0.43-1.08) U/l in individuals who did not develop type 2 diabetes. For every doubling of Prx4 levels, the adjusted OR (95% CI) for type 2 diabetes was 1.16 (1.05-1.29) in the whole population; by sex, it was 1.31 (1.14-1.50) for men and 1.03 (0.87-1.21) for women. Further adjustment for other clinical measures did not materially change the results. The addition of Prx4 to a validated diabetes risk score significantly improved the prediction of type 2 diabetes in men (p = 0.002 for reclassification improvement). CONCLUSIONS/INTERPRETATION: Our findings suggest that elevated serum Prx4 levels are associated with a higher risk of incident type 2 diabetes. For men, taking Prx4 into consideration can improve type 2 diabetes prediction over a validated diabetes risk score; in contrast, there is no improvement in risk prediction for women.
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Peroxiredoxin 4 has been proposed as a suitable biomarker of oxidative stress in diabetes.
“PRX4 has been proposed as a suitable biomarker of oxidative stress in diabetes (Abbasi et al. 2014).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as Abbasi et al. 2014
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Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging
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- Authors
- Abbasi, A., Corpeleijn, E., Gansevoort, R. T., Gans, R. O. B., Struck, J., Schulte, J., Hillege, H. L., van der Harst, P., Stolk, R. P., Navis, G., & Bakker, S. J. L.
- Affiliations
- University Medical Center Groningen (NL)
- Thermo Fisher Scientific (Germany) (DE)
- Corresponding author
- Abbasi, Ali
- ORCID
- Venue
- Diabetologia
- Published
- 2014-06-04
- Volume
- 57
- Issue
- 9
- Pages
- 1842-1849
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- PMC
- PMC4119240
- OpenAlex
- W2153300257
- Cited by
- 27
- References
- 43
- Citations by year
- 2025: 1 · 2024: 7 · 2023: 3 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 2 · 2017: 4 · 2016: 4 · 2015: 2
- FWCI
- 1.37
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Locations
- Diabetologia (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- University of Groningen research database (University of Groningen / Centre for Information Technology) (submittedVersion)
- Apollo (University of Cambridge) (submittedVersion, cc-by)
- Funders
- Rijksuniversiteit Groningen
- Nierstichting (01C-104)
- Diabetes Fonds (01C-104)
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek (825.13.004)
- Universitair Medisch Centrum Groningen
- Center for Translational Molecular Medicine (01 C-104)
- Medical Research Council (MC-U106179471, MC_UU_12015/1)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- peroxiredoxin 4, type 2 diabetes, oxidative stress, circulating biomarkers, diabetes risk prediction, sex differences, diabetes risk score, PREVEND study
- MeSH terms
- Adult, Age Factors, Aged, Diabetes Mellitus, Type 2, Female, Humans, Male, Middle Aged, Risk Factors, Sex Factors, Smoking, Peroxiredoxins, Waist Circumference
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