Biomarkers of Oxidative Damage in Human Disease

Neurodegenerative diseases and oxidative stress

Barnham, K. J., Masters, C. L., & Bush, A. I. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1330 · Cited by 3,683 · see citing works

Measuring reactive species and oxidative damage <i>in vivo</i> and in cell culture: how should you do it and what do the results mean?

Halliwell, B., & Whiteman, M. (2004) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0705776 · Cited by 2,238 · see citing works

Effects of Long-term Vitamin E Supplementation on Cardiovascular Events and Cancer: A Randomized Controlled Trial

(2005) · JAMA · doi:10.1001/jama.293.11.1338 · Cited by 1,209 · see citing works

Amyloid β-peptide (1-42)-induced Oxidative Stress and Neurotoxicity: Implications for Neurodegeneration in Alzheimer's Disease Brain. A Review

Allan Butterfield, D. (2002) · Free Radical Research · doi:10.1080/1071576021000049890 · Cited by 786 · see citing works

Antioxidant Therapy in Acute Central Nervous System Injury: Current State

Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568 · see citing works

Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy

Shishehbor, M. H., Aviles, R. J., Brennan, M.-L., Fu, X., Goormastic, M., Pearce, G. L., Gokce, N., Keaney, J. F., Penn, M. S., Sprecher, D. L., et al. (2003) · JAMA · doi:10.1001/jama.289.13.1675 · Cited by 464 · see citing works

Proteomic method identifies proteins nitrated <i>in vivo</i> during inflammatory challenge

Aulak, K. S., Miyagi, M., Yan, L., West, K. A., Massillon, D., Crabb, J. W., & Stuehr, D. J. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221269198 · Cited by 350 · see citing works

Abnormalities in nitric oxide and its derivatives in lung cancer

Masri, F. A., Comhair, S. A. A., Koeck, T., Xu, W., Janocha, A., Ghosh, S., Dweik, R. A., Golish, J., Kinter, M., Stuehr, D. J., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200411-1523oc · Cited by 128 · see citing works

Free radicals and antioxidants in normal physiological functions and human disease

Valko, M., Leibfritz, D., Moncol, J., Cronin, M. T. D., Mazur, M., & Telser, J. (2007) · The International Journal of Biochemistry &amp; Cell Biology · doi:10.1016/j.biocel.2006.07.001 · Cited by 14,269 · see citing works

Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging

Jomova, K., Raptova, R., Alomar, S. Y., Alwasel, S. H., Nepovimova, E., Kuca, K., & Valko, M. (2023) · Archives of Toxicology · doi:10.1007/s00204-023-03562-9 · Cited by 2,638 · see citing works

Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies

Bhatti, J. S., Bhatti, G. K., & Reddy, P. H. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.11.010 · Cited by 1,655 · see citing works

Is depression associated with increased oxidative stress? A systematic review and meta-analysis

Black, C. N., Bot, M., Scheffer, P. G., Cuijpers, P., & Penninx, B. W. J. H. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.09.025 · Cited by 711 · see citing works

Drug-induced oxidative stress and toxicity

Deavall, D. G., Martin, E. A., Horner, J. M., & Roberts, R. (2012) · Journal of Toxicology · doi:10.1155/2012/645460 · Cited by 689 · see citing works

Redox status expressed as GSH:GSSG ratio as a marker for oxidative stress in paediatric tumour patients

ZITKA, O., SKALICKOVA, S., GUMULEC, J., MASARIK, M., ADAM, V., HUBALEK, J., TRNKOVA, L., KRUSEOVA, J., ECKSCHLAGER, T., & KIZEK, R. (2012) · Oncology Letters · doi:10.3892/ol.2012.931 · Cited by 664 · see citing works

Oxidative stress, inflammation and treatment response in major depression

Lindqvist, D., Dhabhar, F. S., James, S. J., Hough, C. M., Jain, F. A., Bersani, F. S., Reus, V. I., Verhoeven, J. E., Epel, E. S., Mahan, L., et al. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.11.031 · Cited by 473 · see citing works

The complex interplay of iron metabolism, reactive oxygen species, and reactive nitrogen species: insights into the potential of various iron therapies to induce oxidative and nitrosative stress

Koskenkorva-Frank, T. S., Weiss, G., Koppenol, W. H., & Burckhardt, S. (2013) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2013.09.001 · Cited by 406 · see citing works

An Overview of the Role of Lipofuscin in Age-Related Neurodegeneration

Moreno-García, A., Kun, A., Calero, O., Medina, M., & Calero, M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00464 · Cited by 372 · see citing works

Nitrates/Nitrites in Food—Risk for Nitrosative Stress and Benefits

Karwowska, M., & Kononiuk, A. (2020) · Antioxidants · doi:10.3390/antiox9030241 · Cited by 360 · see citing works

Protein oxidation - Formation mechanisms, detection and relevance as biomarkers in human diseases

Kehm, R., Baldensperger, T., Raupbach, J., & Höhn, A. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101901 · Cited by 348 · see citing works

Mitochondrial Dysfunction, Oxidative Stress, Neuroinflammation, and Metabolic Alterations in the Progression of Alzheimer's Disease: A Meta-Analysis of In Vivo Magnetic Resonance Spectroscopy Studies

Song, T., Song, X., Zhu, C., Patrick, R., Skurla, M., Santangelo, I., Green, M., Harper, D., Ren, B., Forester, B. P., et al. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101503 · Cited by 346 · see citing works

Melatonin: Action as antioxidant and potential applications in human disease and aging

Bonnefont-Rousselot, D., & Collin, F. (2010) · Toxicology · doi:10.1016/j.tox.2010.04.008 · Cited by 320 · see citing works

Roles of oxidative stress in polycystic ovary syndrome and cancers

Zuo, T., Zhu, M., & Xu, W. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/8589318 · Cited by 319 · see citing works

Antioxidant Supplementation during Exercise Training: Beneficial or Detrimental?

Peternelj, T.-T., & Coombes, J. S. (2011) · Sports Medicine · doi:10.2165/11594400-000000000-00000 · Cited by 314 · see citing works

Biomarkers of lipid peroxidation in clinical material

Niki, E. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.03.020 · Cited by 297 · see citing works

Antioxidants from Plants Protect against Skin Photoaging

Petruk, G., Del Giudice, R., Rigano, M. M., & Monti, D. M. (2018) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2018/1454936 · Cited by 283 · see citing works

Role of Selenoproteins in Redox Regulation of Signaling and the Antioxidant System: A Review

Zhang, Y., Roh, Y. J., Han, S.-J., Park, I., Lee, H. M., Ok, Y. S., Lee, B. C., & Lee, S.-R. (2020) · Antioxidants · doi:10.3390/antiox9050383 · Cited by 267 · see citing works

Oxidative Stress and Huntington’s Disease: The Good, the Bad, and the Ugly

Kumar, A., & Ratan, R. R. (2016) · Journal of Huntington s Disease · doi:10.3233/jhd-160205 · Cited by 236 · see citing works

4-Hydroxynonenal in the Pathogenesis and Progression of Human Diseases

Shoeb, M., Ansari, N., Srivastava, S., & Ramana, K. (2013) · Current Medicinal Chemistry · doi:10.2174/09298673113209990181 · Cited by 230 · see citing works

Effects of cannabidiol interactions with Wnt/&amp;beta;-catenin pathway and PPAR&amp;gamma; on oxidative stress and neuroinflammation in Alzheimer's disease

Vallée, A., Lecarpentier, Y., Guillevin, R., & Vallée, J.-N. (2017) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmx073 · Cited by 226 · see citing works

Regulation of the Catalytic Activity and Structure of Human Thioredoxin 1 via Oxidation and S-Nitrosylation of Cysteine Residues

Hashemy, S. I., & Holmgren, A. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m801047200 · Cited by 192 · see citing works

Oxidative stress is increased in sarcopenia and associated with cardiovascular disease risk in sarcopenic obesity

Bellanti, F., Romano, A. D., Lo Buglio, A., Castriotta, V., Guglielmi, G., Greco, A., Serviddio, G., & Vendemiale, G. (2018) · Maturitas · doi:10.1016/j.maturitas.2017.12.002 · Cited by 158 · see citing works

Challenging homeostasis to define biomarkers for nutrition related health

van Ommen, B., Keijer, J., Heil, S. G., & Kaput, J. (2009) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.200800390 · Cited by 167 · see citing works

The Double-Edged Sword of Oxidative Stress in Skin Damage and Melanoma: From Physiopathology to Therapeutical Approaches

Emanuelli, M., Sartini, D., Molinelli, E., Campagna, R., Pozzi, V., Salvolini, E., Simonetti, O., Campanati, A., & Offidani, A. (2022) · Antioxidants · doi:10.3390/antiox11040612 · Cited by 132 · see citing works

Correlation of oxidant status with oxidative tissue damage in patients with rheumatoid arthritis

Datta, S., Kundu, S., Ghosh, P., De, S., Ghosh, A., & Chatterjee, M. (2014) · Clinical Rheumatology · doi:10.1007/s10067-014-2597-z · Cited by 123 · see citing works

The p53/p21/p16 and <scp>PI3K</scp>/Akt signaling pathways are involved in the ameliorative effects of maltol on D‐galactose‐induced liver and kidney aging and injury

Sha, J., Li, J., Zhou, Y., Yang, J., Liu, W., Jiang, S., Wang, Y., Zhang, R., Di, P., & Li, W. (2021) · Phytotherapy Research · doi:10.1002/ptr.7142 · Cited by 112 · see citing works

Plasmalogen phospholipids protect internodal myelin from oxidative damage

Luoma, A. M., Kuo, F., Cakici, O., Crowther, M. N., Denninger, A. R., Avila, R. L., Brites, P., & Kirschner, D. A. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.03.012 · Cited by 97 · see citing works

Toxicity, toxicokinetics and biodistribution of dextran stabilized Iron oxide Nanoparticles for biomedical applications

Remya, N. S., Syama, S., Sabareeswaran, A., & Mohanan, P. V. (2016) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2016.06.119 · Cited by 97 · see citing works

Garlic increases antioxidant levels in diabetic and hypertensive rats determined by a modified peroxidase method

Drobiova, H., Thomson, M., Al-Qattan, K., Peltonen-Shalaby, R., Al-Amin, Z., & Ali, M. (2011) · Evidence-Based Complementary and Alternative Medicine · doi:10.1093/ecam/nep011 · Cited by 91 · see citing works

Antioxidants in Personalized Nutrition and Exercise

Margaritelis, N. V., Paschalis, V., Theodorou, A. A., Kyparos, A., & Nikolaidis, M. G. (2018) · Advances in Nutrition · doi:10.1093/advances/nmy052 · Cited by 84 · see citing works

Aging related changes in circulating reactive oxygen species (ROS) and protein carbonyls are indicative of liver oxidative injury

Luceri, C., Bigagli, E., Femia, A. P., Caderni, G., Giovannelli, L., & Lodovici, M. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2017.12.017 · Cited by 79 · see citing works

Oxidative challenge in Alzheimer's disease: state of knowledge and future needs

Cervellati, C., Wood, P. L., Romani, A., Valacchi, G., Squerzanti, M., Sanz, J. M., Ortolani, B., & Zuliani, G. (2016) · Journal of Investigative Medicine · doi:10.1136/jim-2015-000017 · Cited by 75 · see citing works

Mangiferin from <i>Salacia chinensis</i> Prevents Oxidative Stress and Protects Pancreatic <b> <i>β</i> </b> -Cells in Streptozotocin-Induced Diabetic Rats

Sellamuthu, P. S., Arulselvan, P., Muniappan, B. P., Fakurazi, S., & Kandasamy, M. (2013) · Journal of Medicinal Food · doi:10.1089/jmf.2012.2480 · Cited by 70 · see citing works

Positive correlation between plasma nitrite and performance during high-intensive exercise but not oxidative stress in healthy men

Dreißigacker, U., Wendt, M., Wittke, T., Tsikas, D., & Maassen, N. (2010) · Nitric Oxide · doi:10.1016/j.niox.2010.05.003 · Cited by 57 · see citing works

The interdependence of the reactive species of oxygen, nitrogen, and carbon

Bild, W., Ciobica, A., Padurariu, M., & Bild, V. (2013) · Journal of Physiology and Biochemistry · doi:10.1007/s13105-012-0162-2 · Cited by 44 · see citing works

Increased oxidative stress levels and normal antioxidant enzyme activity in circulating mononuclear cells from patients of familial hypercholesterolemia

Real, J. T., Martínez-Hervás, S., Tormos, M. C., Domenech, E., Pallardó, F. V., Sáez-Tormo, G., Redon, J., Carmena, R., Chaves, F. J., Ascaso, J. F., et al. (2010) · Metabolism · doi:10.1016/j.metabol.2009.07.026 · Cited by 30 · see citing works

Oxidative DNA damage and reduced expression of DNA repair genes: Role in primary open angle glaucoma (POAG)

Mohanty, K., Dada, R., & Dada, T. (2017) · Ophthalmic Genetics · doi:10.1080/13816810.2016.1261904 · Cited by 30 · see citing works

Hydrogen peroxide-induced oxidative stress, acetylcholinesterase inhibition, and mediated brain injury attenuated by <i>Thymus algeriensis</i>

Guesmi, F., Bellamine, H., & Landoulsi, A. (2018) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0107 · Cited by 27 · see citing works

Circulating peroxiredoxin 4 and type 2 diabetes risk: the Prevention of Renal and Vascular Endstage Disease (PREVEND) study

Abbasi, A., Corpeleijn, E., Gansevoort, R. T., Gans, R. O. B., Struck, J., Schulte, J., Hillege, H. L., van der Harst, P., Stolk, R. P., Navis, G., et al. (2014) · Diabetologia · doi:10.1007/s00125-014-3278-9 · Cited by 27 · see citing works

Do low molecular weight antioxidants contribute to the Protection against oxidative damage? The interrelation between oxidative stress and low molecular weight antioxidants based on data from the MARK-AGE study

Pinchuk, I., Kohen, R., Stuetz, W., Weber, D., Franceschi, C., Capri, M., Hurme, M., Grubeck-Loebenstein, B., Schön, C., Bernhardt, J., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109061 · Cited by 17 · see citing works

Methionine oxidation products as biomarkers of oxidative damage to proteins and modulators of cellular metabolism and toxicity

Davies, M. J. (2025) · Redox Biochemistry and Chemistry · doi:10.1016/j.rbc.2025.100052 · Cited by 11 · see citing works

Waist circumference and dual-energy X-ray absorptiometry measures of overall and central obesity are similarly associated with systemic oxidative stress in women

Cervellati, C., Bonaccorsi, G., Cremonini, E., Romani, A., Castaldini, C., Ferrazzini, S., Giganti, M., Fila, E., Massari, L., & Bergamini, C. M. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2013.860618 · Cited by 10 · see citing works