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Fertility is reduced in women and in men with type 1 diabetes: results from the Type 1 Diabetes Genetics Consortium (T1DGC)
Open accessAbstract
Aims/hypothesis A recent Finnish study described reduced fertility in patients with childhood-onset type 1 diabetes. The Type 1 Diabetes Genetics Consortium (T1DGC) is an international programme studying the genetics and pathogenesis of type 1 diabetes that includes families with the disease. Our aim was to assess fertility, defined as number of offspring, in the affected and unaffected siblings included in the T1DGC.Methods Clinical information from participants aged ≥18 years at the time of examination was included in the present analysis. The number of offspring of affected and unaffected siblings was compared (in families including both) and the influence of birth year, disease duration and age of onset was assessed, the last in affected siblings only, using Poisson regression models.Results A total of 3010 affected and 801 unaffected adult siblings that belonged to 1761 families were assessed. The mean number of offspring was higher in the unaffected than in the affected individuals, and the difference between the two groups was more pronounced in women than men. Poisson regression analysis showed that both sex and birth cohort significantly affected the differences between groups. In the affected siblings, adult onset (≥18 years), female sex and older birth cohort were associated with higher fertility.Conclusions/interpretation Patients with type 1 diabetes have fewer children than their unaffected siblings. This effect is more evident in women and in older birth cohorts. Onset of type 1 diabetes as an adult rather than a child is associated with a higher number of offspring, even after accounting for birth cohort and disease duration.
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Glycemic control worsens when persons with type 1 or type 2 diabetes move from pediatric to adult care.
“Glycemic control has been shown to worsen during transition from pediatric to adult care for persons with T1D and T2D.1534,1535”
From American Association of Clinical Endocrinology Clinical Practice Guideline: Developing a Diabetes Mellitus Comprehensive Care Plan-2022 Update. (2022) · cites this paper as [1534]
The Methods and Results compare fertility by age of type 1 diabetes onset, not outcomes during a move from pediatric to adult care. The Discussion says information on glycaemic control was unavailable. Searches for care transition and glycaemic control found no passage addressing worsening control in either type 1 or type 2 diabetes. (LLM, conf=0.77)
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Metadata
- Authors
- T1DGC, O. B. O. T., Wiebe, J. C., Santana, A., Medina-Rodríguez, N., Hernández, M., Nóvoa, J., Mauricio, D., & Wägner, A. M.
- Affiliations
- Hospital Universitario Insular de Gran Canaria (ES)
- Universidad de Las Palmas de Gran Canaria (ES)
- Corresponding author
- Wägner, Ana M.
- Venue
- Diabetologia
- Published
- 2014-09-14
- Volume
- 57
- Issue
- 12
- Pages
- 2501-2504
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2065100064
- Cited by
- 51
- References
- 7
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 6 · 2023: 1 · 2022: 7 · 2021: 5 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 4 · 2015: 2
- FWCI
- 1.97
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Acceda (Universidad de Las Palmas de Gran Canaria) (submittedVersion)
- Funders
- Juvenile Diabetes Research Foundation International (U01 DK062418)
- European Foundation for the Study of Diabetes
- Novo Nordisk
- Instituto de Salud Carlos III (PI11/, PI 10/02310, PI11/02441)
- National Institute of Allergy and Infectious Diseases
- National Institute of Diabetes and Digestive and Kidney Diseases (DK062418, U01DK062418)
- National Institute of Child Health and Human Development
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Health Sciences › Medicine › Reproductive Medicine › Reproductive Health and Technologies
- Keywords
- type 1 diabetes, fertility, offspring number, sex differences, adult-onset type 1 diabetes, birth cohort, disease duration
- MeSH terms
- Adult, Birth Rate, Diabetes Mellitus, Type 1, Female, Fertility, Humans, Infertility, Female, Infertility, Male, Male, Parity, Pregnancy, Risk Factors, Young Adult
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