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TMEM55A-mediated PI5P signalling regulates alpha cell actin depolymerisation and glucagon secretion

Liu, Xiong, dos Santos, Theodore, Spigelman, Aliya F., Duckett, Shawn, Smith, Nancy, Suzuki, Kunimasa, MacDonald, Patrick E.·2025·Diabetologia
DOI 10.1007/s00125-025-06411-9PMC PMC12176968

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Research works printed but not linked: 49

  1. MacDonald PE, Rorsman P (2023) Metabolic messengers: glucagon. Nat Metab 5(2):186–192. https://doi.org/10.1038/s42255-022-00725-3 · DOI
  2. Gylfe E (2016) Glucose control of glucagon secretion-’There’s a brand-new gimmick every year’. Upsala J Med Sci 121(2):120–132. https://doi.org/10.3109/03009734.2016.1154905 · DOI
  3. Zhang Q, Ramracheya R, Lahmann C et al (2013) Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes. Cell Metab 18(6):871–882. https://doi.org/10.1016/j.cmet.2013.10.014 · DOI · Paper page
  4. Chow RH, Lund PE, Loser S, Panten U, Gylfe E (1995) Coincidence of early glucose-induced depolarization with lowering of cytoplasmic Ca2+ in mouse pancreatic beta-cells. J Physiol 485(Pt 3):607–617. https://doi.org/10.1113/jphysiol.1995.sp020756 · DOI
  5. Bansal P, Wang Q (2008) Insulin as a physiological modulator of glucagon secretion. Am J Physiol Endocrinol Metab 295(4):E751-761. https://doi.org/10.1152/ajpendo.90295.2008 · DOI
  6. Gromada J, Bokvist K, Ding WG et al (1997) Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channels. J Gen Physiol 110(3):217–228. https://doi.org/10.1085/jgp.110.3.217 · DOI
  7. El K, Campbell JE (2020) The role of GIP in O±-cells and glucagon secretion. Peptides 125:170213. https://doi.org/10.1016/j.peptides.2019.170213 · DOI
  8. Li P, Bademosi AT, Luo J, Meunier FA (2018) Actin remodeling in regulated exocytosis: toward a mesoscopic view. Trends Cell Biol 28(9):685–697. https://doi.org/10.1016/j.tcb.2018.04.004 · DOI
  9. Wang B, Lin H, Li X et al (2020) The adaptor protein APPL2 controls glucose-stimulated insulin secretion via F-actin remodeling in pancreatic OI-cells. Proc Natl Acad Sci U S A 117(45):28307–28315. https://doi.org/10.1073/pnas.2016997117 · DOI
  10. Li W, Li A, Yu B et al (2024) In situ structure of actin remodeling during glucose-stimulated insulin secretion using cryo-electron tomography. Nat Commun 15(1):1311. https://doi.org/10.1038/s41467-024-45648-7 · DOI
  11. Varadi A, Tsuboi T, Rutter GA (2005) Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cells. Mol Biol Cell 16(6):2670–2680. https://doi.org/10.1091/mbc.e04-11-1001 · DOI
  12. Viloria K, Nasteska D, Briant LJB et al (2020) Vitamin-D-binding protein contributes to the maintenance of O± cell function and glucagon secretion. Cell Rep 31(11):107761. https://doi.org/10.1016/j.celrep.2020.107761 · DOI
  13. Ng XW, Chung YH, Asadi F, Kong C, Ustione A, Piston DW (2022) RhoA as a signaling hub controlling glucagon secretion from pancreatic O±-cells. Diabetes 71(11):2384–2394. https://doi.org/10.2337/db21-1010 · DOI
  14. Asadi F, Gunawardana SC, Dolle RE, Piston DW (2024) An orally available compound suppresses glucagon hypersecretion and normalizes hyperglycemia in type 1 diabetes. JCI insight 9(2):e172626. https://doi.org/10.1172/jci.insight.172626 · DOI
  15. Ungewickell A, Hugge C, Kisseleva M et al (2005) The identification and characterization of two phosphatidylinositol-4,5-bisphosphate 4-phosphatases. Proc Natl Acad Sci U S A 102(52):18854–18859. https://doi.org/10.1073/pnas.0509740102 · DOI · Paper page
  16. Dai XQ, Camunas-Soler J, Briant LJB et al (2022) Heterogenous impairment of O± cell function in type 2 diabetes is linked to cell maturation state. Cell Metab 34(2):256-268.e255. https://doi.org/10.1016/j.cmet.2021.12.021 · DOI
  17. Lin H, Suzuki K, Smith N et al (2024) A role and mechanism for redox sensing by SENP1 in OI-cell responses to high fat feeding. Nat Commun 15(1):334. https://doi.org/10.1038/s41467-023-44589-x · DOI
  18. Ewald JD, Lu Y, Ellis CE et al (2025) HumanIslets.com: improving accessibility, integration, and usability of human research islet data. Cell Metab 37(1):7–11. https://doi.org/10.1016/j.cmet.2024.09.001 · DOI
  19. Omar-Hmeadi M, GuДЌek A, Barg S (2023) Local PI(4,5)P(2) signaling inhibits fusion pore expansion during exocytosis. Cell Rep 42(2):112036. https://doi.org/10.1016/j.celrep.2023.112036 · DOI
  20. Walter AM, Müller R, Tawfik B et al (2017) Phosphatidylinositol 4,5-bisphosphate optical uncaging potentiates exocytosis. eLife 6:e30203. https://doi.org/10.7554/eLife.30203 · DOI
  21. Vicinanza M, Korolchuk VI, Ashkenazi A et al (2015) PI(5)P regulates autophagosome biogenesis. Mol Cell 57(2):219–234. https://doi.org/10.1016/j.molcel.2014.12.007 · DOI
  22. Viaud J, Lagarrigue F, Ramel D et al (2014) Phosphatidylinositol 5-phosphate regulates invasion through binding and activation of Tiam1. Nat Commun 5:4080. https://doi.org/10.1038/ncomms5080 · DOI
  23. Jones DR, Foulger R, Keune WJ, Bultsma Y, Divecha N (2013) PtdIns5P is an oxidative stress-induced second messenger that regulates PKB activation. FASEB J Off Publ Feder Am Soc Exp Biol 27(4):1644–1656. https://doi.org/10.1096/fj.12-218842 · DOI
  24. Al-Momany A, Li L, Alexander RT, Ballermann BJ (2014) Clustered PI(4,5)P(2) accumulation and ezrin phosphorylation in response to CLIC5A. J Cell Sci 127(Pt 24):5164–5178. https://doi.org/10.1242/jcs.147744 · DOI
  25. Chen MZ, Zhu X, Sun HQ et al (2009) Oxidative stress decreases phosphatidylinositol 4,5-bisphosphate levels by deactivating phosphatidylinositol- 4-phosphate 5-kinase beta in a Syk-dependent manner. J Biol Chem 284(35):23743–23753. https://doi.org/10.1074/jbc.M109.036509 · DOI
  26. Rameh LE, Blind RD (2023) 25B Years of PI5P. Front Cell Dev Biol 11:1272911. https://doi.org/10.3389/fcell.2023.1272911 · DOI
  27. Oppelt A, Lobert VH, Haglund K et al (2013) Production of phosphatidylinositol 5-phosphate via PIKfyve and MTMR3 regulates cell migration. EMBO Rep 14(1):57–64. https://doi.org/10.1038/embor.2012.183 · DOI
  28. Ramel D, Lagarrigue F, Pons V et al (2011) Shigella flexneri infection generates the lipid PI5P to alter endocytosis and prevent termination of EGFR signaling. Sci Signal 4(191):ra61. https://doi.org/10.1126/scisignal.2001619 · DOI
  29. Spiering D, Hodgson L (2011) Dynamics of the Rho-family small GTPases in actin regulation and motility. Cell Adhes Migr 5(2):170–180. https://doi.org/10.4161/cam.5.2.14403 · DOI
  30. Bisaria A, Hayer A, Garbett D, Cohen D, Meyer T (2020) Membrane-proximal F-actin restricts local membrane protrusions and directs cell migration. Science (New York, NY) 368(6496):1205–1210. https://doi.org/10.1126/science.aay7794 · DOI
  31. Kahn SE, Cooper ME, Del Prato S (2014) Pathophysiology and treatment of type 2 diabetes: perspectives on the past, present, and future. Lancet (London, England) 383(9922):1068–1083. https://doi.org/10.1016/s0140-6736(13)62154-6 · DOI · Paper page
  32. Scherm MG, Wyatt RC, Serr I, Anz D, Richardson SJ, Daniel C (2022) Beta cell and immune cell interactions in autoimmune type 1 diabetes: how they meet and talk to each other. Mol Metab 64:101565. https://doi.org/10.1016/j.molmet.2022.101565 · DOI
  33. Girard J (2017) Glucagon, a key factor in the pathophysiology of type 2 diabetes. Biochimie 143:33–36. https://doi.org/10.1016/j.biochi.2017.10.004 · DOI
  34. Pal P, Taylor M, Lam PY et al (2023) Parkinson’s VPS35[D620N] mutation induces LRRK2-mediated lysosomal association of RILPL1 and TMEM55B. Sci Adv 9(50):eadj1205. https://doi.org/10.1126/sciadv.adj1205 · DOI · Paper page
  35. Rudnik S, Heybrock S, Saftig P, Damme M (2022) S-palmitoylation determines TMEM55B-dependent positioning of lysosomes. J Cell Sci 135(5):jcs258566. https://doi.org/10.1242/jcs.258566 · DOI
  36. Takemasu S, Nigorikawa K, Yamada M et al (2019) Phosphorylation of TMEM55B by Erk/MAPK regulates lysosomal positioning. J Biochem 166(2):175–185. https://doi.org/10.1093/jb/mvz026 · DOI · Paper page
  37. Morioka S, Nigorikawa K, Okada E et al (2018) TMEM55a localizes to macrophage phagosomes to downregulate phagocytosis. J Cell Sci 131(5):jcs213272. https://doi.org/10.1242/jcs.213272 · DOI · Paper page
  38. Gozani O, Karuman P, Jones DR et al (2003) The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Cell 114(1):99–111. https://doi.org/10.1016/s0092-8674(03)00480-x · DOI
  39. Kalwat MA, Thurmond DC (2013) Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet OI cells. Exp Mol Med 45(8):e37. https://doi.org/10.1038/emm.2013.73 · DOI
  40. Eitzen G (2003) Actin remodeling to facilitate membrane fusion. Biochimica et Biophysica Acta 1641(2–3):175–181. https://doi.org/10.1016/s0167-4889(03)00087-9 · DOI
  41. Polino AJ, Ng XW, Rooks R, Piston DW (2023) Disrupting actin filaments enhances glucose-stimulated insulin secretion independent of the cortical actin cytoskeleton. J Biol Chem 299(11):105334. https://doi.org/10.1016/j.jbc.2023.105334 · DOI
  42. Kolic J, Manning Fox JE, Chepurny OG et al (2016) PI3 kinases p110O± and PI3K-C2OI negatively regulate cAMP via PDE3/8 to control insulin secretion in mouse and human islets. Mol Metab 5(7):459–471. https://doi.org/10.1016/j.molmet.2016.05.003 · DOI
  43. Kolic J, Spigelman AF, Smith AM, Manning Fox JE, MacDonald PE (2014) Insulin secretion induced by glucose-dependent insulinotropic polypeptide requires phosphatidylinositol 3-kinase Oi in rodent and human OI-cells. J Biol Chem 289(46):32109–32120. https://doi.org/10.1074/jbc.M114.577510 · DOI
  44. Pigeau GM, Kolic J, Ball BJ et al (2009) Insulin granule recruitment and exocytosis is dependent on p110gamma in insulinoma and human beta-cells. Diabetes 58(9):2084–2092. https://doi.org/10.2337/db08-1371 · DOI
  45. Hajmrle C, Smith N, Spigelman AF et al (2016) Interleukin-1 signaling contributes to acute islet compensation. JCI Insight 1(4):e86055. https://doi.org/10.1172/jci.insight.86055 · DOI
  46. Herianto S, Rathod J, Shah P et al (2021) Systematic analysis of phosphatidylinositol-5-phosphate-interacting proteins using yeast proteome microarrays. Anal Chem 93(2):868–877. https://doi.org/10.1021/acs.analchem.0c03463 · DOI
  47. Olsen HL, Theander S, Bokvist K, Buschard K, Wollheim CB, Gromada J (2005) Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cells. Endocrinology 146(11):4861–4870. https://doi.org/10.1210/en.2005-0800 · DOI · Paper page
  48. Omar-Hmeadi M, Lund PE, Gandasi NR, Tengholm A, Barg S (2020) Paracrine control of O±-cell glucagon exocytosis is compromised in human type-2 diabetes. Nat Commun 11(1):1896. https://doi.org/10.1038/s41467-020-15717-8 · DOI · Paper page
  49. Kolic J, Sun WG, Cen HH et al (2024) Proteomic predictors of individualized nutrient-specific insulin secretion in health and disease. Cell Metab 36(7):1619-1633 e1615. https://doi.org/10.1016/j.cmet.2024.06.001 · DOI

Cited by

Sorted by citations

Metadata

Authors
Liu, X., dos Santos, T., Spigelman, A. F., Duckett, S., Smith, N., Suzuki, K., & MacDonald, P. E.
ORCID
Venue
Diabetologia
Publisher
Springer Science and Business Media LLC
Published
2025-03-26
Volume
68
Issue
7
Pages
1509-1523
ISSN
  • 0012-186X
  • 1432-0428
DOI
10.1007/s00125-025-06411-9
PMC
PMC12176968
Cited by
4
References
4
Language
en
Licence
Funders
  • Diabetes Canada (OG-3-24-5829-PM)
  • Canadian Institutes of Health Research (FS 148451, PS 186226, TG 179092)
  • Breakthrough T1D (5-SRA-2021-1149-S-B)

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