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Cellular function in multicellular system for hormone-secretion: electrophysiological aspect of studies on α-, β- and δ-cells of the pancreatic islet

Kanno, T., Göpel, S., Rorsman, P., & Wakui, M. (2002) · Neuroscience Research · doi:10.1016/s0168-0102(01)00318-2 · Cited by 81 · see citing works

Cell coupling in mouse pancreatic β-cells measured in intact islets of Langerhans

Zhang, Q., Galvanovskis, J., Abdulkader, F., Partridge, C. J., Göpel, S. O., Eliasson, L., & Rorsman, P. (2008) · Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences · doi:10.1098/rsta.2008.0110 · Cited by 80 · see citing works

Defective Secretion of Islet Hormones in Chromogranin-B Deficient Mice

Obermüller, S., Calegari, F., King, A., Lindqvist, A., Lundquist, I., Salehi, A. A., Francolini, M., Rosa, P., Rorsman, P., Huttner, W. Β., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008936 · Cited by 80 · see citing works

Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol

Vikman, J., Jimenez‐Feltström, J., Nyman, P., & Eliasson, L. (2009) · The FASEB Journal · doi:10.1096/fj.08-105734 · Cited by 79 · see citing works

Glucose and Pharmacological Modulators of ATP-Sensitive K+ Channels Control [Ca2+]c by Different Mechanisms in Isolated Mouse α-Cells

Quoix, N., Cheng, R., Mattart, L., Zeinoun, Z., Guiot, Y., Beauvois, M. C., Henquin, J., & Gilon, P. (2008) · Diabetes · doi:10.2337/db07-1298 · Cited by 78 · see citing works

Electrical activity in pancreatic islet cells: The VRAC hypothesis

Best, L. C., Brown, P. D., Sener, A., & Malaisse, W. J. (2010) · Islets · doi:10.4161/isl.2.2.11171 · Cited by 77 · see citing works

Inhibitory Effects of Leptin on Pancreatic α-Cell Function

Tudurí, E., Marroquí, L., Soriano, S., Ropero, A. B., Batista, T. M., Piquer, S., López-Boado, M. Á., Carneiro, E. M., Gomis, R., Nadal, Á., et al. (2009) · Diabetes · doi:10.2337/db08-1787 · Cited by 78 · see citing works

Mechanisms of Exocytosis in Insulin‐Secreting B‐Cells and Glucagon‐Secreting A‐Cells

Barg, S. (2003) · Pharmacology & Toxicology · doi:10.1034/j.1600-0773.2003.920102.x · Cited by 75 · see citing works

Suppression of KATP channel activity protects murine pancreatic β cells against oxidative stress

Gier, B., Krippeit‐Drews, P., Sheiko, T. V., Aguilar‐Bryan, L., Bryan, J., Düfer, M., & Drews, G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci38817 · Cited by 75 · see citing works

Glucagon secretion and signaling in the development of diabetes

Gaisano, H. Y., MacDonald, P. E., & Vranić, M. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00349 · Cited by 75 · see citing works

Glucose control of glucagon secretion—‘There’s a brand-new gimmick every year’

Gylfe, E. (2016) · Upsala Journal of Medical Sciences · doi:10.3109/03009734.2016.1154905 · Cited by 71 · see citing works

Electrophysiological Characterization of Pancreatic Islet Cells in the Mouse Insulin Promoter-Green Fluorescent Protein Mouse

Leung, Y., Ahmed, I., Sheu, L., Tsushima, R. G., Diamant, N. E., Hara, M., & Gaisano, H. Y. (2005) · Endocrinology · doi:10.1210/en.2005-0803 · Cited by 74 · see citing works

The First γ-Carboxyglutamic Acid-containing Contryphan

Hansson, K., Ma, X., Eliasson, L., Czerwiec, E., Furie, B., Furie, B. C., Rorsman, P., & Stenflo, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m313825200 · Cited by 72 · see citing works

Oscillatory Membrane Potential Response to Glucose in Islet β-Cells: A Comparison of Islet-Cell Electrical Activity in Mouse and Rat

Manning Fox, J. E., Gyulkhandanyan, A. V., Satin, L. S., & Wheeler, M. B. (2006) · Endocrinology · doi:10.1210/en.2006-0424 · Cited by 70 · see citing works

Oscillations of membrane potential and cytosolic Ca2+ concentration in SUR1−/− beta cells

Düfer, M., Haspel, D., Krippeit-Drews, P., Aguilar-Bryan, L., Bryan, J., & Drews, G. (2004) · Diabetologia · doi:10.1007/s00125-004-1348-0 · Cited by 70 · see citing works

Regulated Exocytosis and Kiss-and-Run of Synaptic-Like Microvesicles in INS-1 and Primary Rat β-Cells

MacDonald, P. E., Obermüller, S., Vikman, J., Galvanovskis, J., Rorsman, P., & Eliasson, L. (2005) · Diabetes · doi:10.2337/diabetes.54.3.736 · Cited by 70 · see citing works

Submembrane ATP and Ca2+kinetics in α-cells: unexpected signaling for glucagon secretion

Li, J., Yu, Q., Ahooghalandari, P., Gribble, F. M., Reimann, F. M., Tengholm, A., & Gylfe, E. (2015) · The FASEB Journal · doi:10.1096/fj.14-265918 · Cited by 67 · see citing works

Unperturbed islet α‐cell function examined in mouse pancreas tissue slices

Huang, Y., Rupnik, M. S., & Gaisano, H. Y. (2010) · The Journal of Physiology · doi:10.1113/jphysiol.2010.200345 · Cited by 71 · see citing works

Quantitative analysis of mouse pancreatic islet architecture by serial block-face SEM

Pfeifer, C. R., Shomorony, A., Aronova, M. A., Zhang, G., Cai, T., Xu, H., Notkins, A. L., & Leapman, R. D. (2014) · Journal of Structural Biology · doi:10.1016/j.jsb.2014.10.013 · Cited by 68 · see citing works

Glucose‐induced electrical activity in rat pancreatic β‐cells: dependence on intracellular chloride concentration

Best, L. C. (2005) · The Journal of Physiology · doi:10.1113/jphysiol.2005.093740 · Cited by 67 · see citing works

Pancreatic α-cells – The unsung heroes in islet function

Wendt, A., & Eliasson, L. (2020) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2020.01.006 · Cited by 67 · see citing works

Pancreatic α-cell dysfunction in diabetes

Burcelin, R., Knauf, C., & Cani, P. D. (2008) · Diabetes & Metabolism · doi:10.1016/s1262-3636(08)73395-0 · Cited by 66 · see citing works

Dapagliflozin stimulates glucagon secretion at high glucose: experiments and mathematical simulations of human A-cells

Pedersen, M. G., Ahlstedt, I., El Hachmane, M. F., & Göpel, S. O. (2016) · Scientific Reports · doi:10.1038/srep31214 · Cited by 64 · see citing works

Different Metabolic Responses in α-, β-, and δ-Cells of the Islet of Langerhans Monitored by Redox Confocal Microscopy

Quesada, I., Todorova, M. G., & Soria, B. (2006) · Biophysical Journal · doi:10.1529/biophysj.105.069906 · Cited by 63 · see citing works

Novel standards in the measurement of rat insulin granules combining electron microscopy, high-content image analysis and in silico modelling

Fava, E., Dehghany, J., Ouwendijk, J., Müller, A., Niederlein, A., Verkade, P., Meyer‐Hermann, M., & Solimena, M. (2012) · Diabetologia · doi:10.1007/s00125-011-2438-4 · Cited by 63 · see citing works

Functional identification of islet cell types by electrophysiological fingerprinting

Briant, L. J. B., Zhang, Q., Vergari, E., Kellard, J. A., Rodriguez, B., Ashcroft, F. M., & Rorsman, P. (2017) · Journal of The Royal Society Interface · doi:10.1098/rsif.2016.0999 · Cited by 59 · see citing works

Glucose Decouples Intracellular Ca2+ Activity from Glucagon Secretion in Mouse Pancreatic Islet Alpha-Cells

Marchand, S. J. L., & Piston, D. W. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047084 · Cited by 56 · see citing works

Enhanced Glucose Tolerance by SK4 Channel Inhibition in Pancreatic β-Cells

Düfer, M., Gier, B., Wolpers, D., Krippeit-Drews, P., Ruth, P., & Drews, G. (2009) · Diabetes · doi:10.2337/db08-1324 · Cited by 56 · see citing works

Glucose Dependence of the Regulated Secretory Pathway in αTC1-6 Cells

McGirr, R., Ejbick, C. E., Carter, D. E., Andrews, J. D., Nie, Y., Friedman, T. C., & Dhanvantari, S. (2005) · Endocrinology · doi:10.1210/en.2005-0402 · Cited by 55 · see citing works

Characterization of Erg K+ Channels in α- and β-Cells of Mouse and Human Islets

Hardy, A. B., Fox, J. E. M., Giglou, P. R., Wijesekara, N., Bhattacharjee, A., Sultan, S., Gyulkhandanyan, A. V., Gaisano, H. Y., MacDonald, P. E., & Wheeler, M. B. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.040659 · Cited by 54 · see citing works

In Situ Electrophysiological Examination of Pancreatic α Cells in the Streptozotocin-Induced Diabetes Model, Revealing the Cellular Basis of Glucagon Hypersecretion

Huang, Y.-C., Rupnik, M., Karimian, N., Herrera, P., Gilon, P., Feng, Z.-P., & Gaisano, H. (2013) · Diabetes · doi:10.2337/db11-0786 · Cited by 49 · see citing works

Targeting of Voltage-Gated K + and Ca 2+ Channels and Soluble N -Ethylmaleimide-Sensitive Factor Attachment Protein Receptor Proteins to Cholesterol-Rich Lipid Rafts in Pancreatic α-Cells: Effects on Glucagon Stimulus-Secretion Coupling

Xia, F., Leung, Y., Gaisano, G., Gao, X., Chen, Y., Fox, J. E. M., Bhattacharjee, A., Wheeler, M. B., Gaisano, H. Y., & Tsushima, R. G. (2007) · Endocrinology · doi:10.1210/en.2006-1296 · Cited by 54 · see citing works

Blockade of Na+ Channels in Pancreatic α-Cells Has Antidiabetic Effects

Dhalla, A. K., Yang, M., Ning, Y., Kahlig, K. M., Krause, M., Rajamani, S., & Belardinelli, L. (2014) · Diabetes · doi:10.2337/db13-1562 · Cited by 53 · see citing works

A beta cell-specific knockout of hormone-sensitive lipase in mice results in hyperglycaemia and disruption of exocytosis

Fex, M., Haemmerle, G., Wierup, N., Nitert, M. D., Rehn, M., Ristow, M., Zechner, R., Sundler, F., Holm, C., Eliasson, L., et al. (2008) · Diabetologia · doi:10.1007/s00125-008-1191-9 · Cited by 53 · see citing works

Acute stimulation of glucagon secretion by linoleic acid results from GPR40 activation and [Ca2+]i increase in pancreatic islet α-cells

Wang, L., Zhao, Y., Gui, B., Fu, R., Ma, F., Yu, J. M., Qü, P., Dong, L., & Chen, C. (2011) · Journal of Endocrinology · doi:10.1530/joe-11-0132 · Cited by 52 · see citing works

cAMP Induces Stromal Interaction Molecule 1 (STIM1) Puncta but neither Orai1 Protein Clustering nor Store-operated Ca2+ Entry (SOCE) in Islet Cells

Tian, G., Tepikin, A. V., Tengholm, A., & Gylfe, E. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.292854 · Cited by 50 · see citing works

BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells

Düfer, M., Neye, Y., Hörth, K., Krippeit-Drews, P., Hennige, A., Widmer, H., McClafferty, H., Shipston, M. J., Häring, H.-U., Ruth, P., et al. (2011) · Diabetologia · doi:10.1007/s00125-010-1936-0 · Cited by 50 · see citing works

A plasma membrane-associated glycolytic metabolon is functionally coupled to KATP channels in pancreatic α and β cells from humans and mice

Ho, T., Potapenko, E., Davis, D., & Merrins, M. (2022) · bioRxiv · doi:10.1016/j.celrep.2023.112394 · Cited by 35 · see citing works

Reestablishment of Glucose Inhibition of Glucagon Secretion in Small Pseudoislets

Reissaus, C. A., & Piston, D. W. (2017) · Diabetes · doi:10.2337/db16-1291 · Cited by 47 · see citing works

Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell

Andersson, S. A., Pedersen, M. G., Vikman, J., & Eliasson, L. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0979-5 · Cited by 46 · see citing works

The short-term effect of fatty acids on glucagon secretion is influenced by their chain length, spatial configuration, and degree of unsaturation: studies in vitro

Hong, J., Abudula, R., Chen, J., Jeppesen, P. B., Dyrskog, S., Xiao, J., Colombo, M., & Hermansen, K. (2005) · Metabolism · doi:10.1016/j.metabol.2005.04.022 · Cited by 45 · see citing works

Glucose-dependent docking and SNARE protein-mediated exocytosis in mouse pancreatic alpha-cell

Andersson, S. A., Pedersen, M. G., Vikman, J., & Eliasson, L. (2011) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-011-0979-5 · Cited by 46 · see citing works

Capacitance measurements of exocytosis in mouse pancreatic α‐, β‐ and δ‐cells within intact islets of Langerhans

Göpel, S., Zhang, Q., Eliasson, L., Ma, X., Galvanovskis, J., Kanno, T., Salehi, A., & Rorsman, P. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2003.059675 · Cited by 160 · see citing works

Mathematical modelling of local calcium and regulated exocytosis during inhibition and stimulation of glucagon secretion from pancreatic alpha-cells

Montefusco, F., & Pedersen, M. G. (2015) · The Journal of Physiology · doi:10.1113/jp270777 · Cited by 35 · see citing works

Regulation of glucagon release in mouse α‐cells by K_ATP channels and inactivation of TTX‐sensitive Na⁺ channels

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Glucose Inhibits Glucagon Secretion from Pancreatic Alpha-Cells by Closure of KATP-Channels

Zhang, Q., Ramracheya, R. D., Braha, O., & Rorsman, P. (2011) · Biophysical Journal · doi:10.1016/j.bpj.2010.12.3310