The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
The effect of single doses of pramlintide on gastric emptying of two meals in men with IDDM
Open accessAbstract
In a previous study we have shown that an intravenous infusion of pramlintide (an analogue of human amylin) delayed gastric emptying, but the dose of pramlintide was supraphysiological in relation to the amylin response to food in non-diabetic subjects. The purpose of this study was to examine the dose response relationship of subcutaneous injections of pramlintide on gastric emptying and to determine whether administration of the drug before one meal has an impact on the subsequent meal. Eleven men with insulin-dependent diabetes mellitus were studied in a double-blind, randomised, four-way crossover design. None had autonomic neuropathy. Euglycaemia was maintained overnight before the study day. At -30 min the patients self-injected their usual morning insulin and at -15 min they injected the study drug (either placebo or 30, 60 or 90 microg pramlintide) subcutaneously. At 0 min they ate a standard meal consisting of a pancake, labelled with 99mTc, and a milkshake containing 3-ortho-methylglucose (3-OMG). Gastric emptying images were obtained for the next 8 h. At 240 min the subjects ate a similar meal, but on this occasion the pancake was labelled with (111)In. All three doses of pramlintide delayed emptying of the solid component of the first meal (p < 0.004) with no significant difference between the drug doses. There were no differences between placebo and pramlintide after the second meal. All three doses of pramlintide resulted in a prolongation in the time to peak plasma 3-OMG level (p < 0.0001) after the first meal but there was no difference after the second meal.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Injection prior to meals acts to suppress glucagon secretion, delay gastric emptying, and promote satiety (247-250).”
From The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) (2021) · cites this paper as [248]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A sharper Bonferroni procedure for multiple tests of significance
HOCHBERG, Y. (1988) · Biometrika · doi:10.1093/biomet/75.4.800 · Cited by 4,829
The Design and Analysis of Clinical Experiments
Fleiss, J. L. (1999) · Wiley eBooks · doi:10.1002/9781118032923 · Cited by 4,819
The Design and Analysis of Clinical Experiments.
Hills, M., & Fleiss, J. L. (1987) · Journal of the Royal Statistical Society Series A (General) · doi:10.2307/2982050 · Cited by 3,261
Relationship between oral glucose tolerance and gastric emptying in normal healthy subjects
Horowitz, M., Edelbroek, M. A. L., Wishart, J. M., & Straathof, J. W. (1993) · Diabetologia · doi:10.1007/bf00400362 · Cited by 469
Gastric and oesophageal emptying in patients with Type 2 (non-insulin-dependent) diabetes mellitus
Horowitz, M., Harding, P. E., Maddox, A. F., Wishart, J. M., Akkermans, L. M. A., Chatterton, B. E., & Shearman, D. J. C. (1989) · Diabetologia · doi:10.1007/bf00265086 · Cited by 393
Hyperglycaemia slows gastric emptying in Type 1 (insulin-dependent) diabetes mellitus
Fraser, R., Horowitz, M., Maddox, A., Harding, P., Chatterton, B., & Dent, J. (1990) · Diabetologia · doi:10.1007/bf00400569 · Cited by 359
Effects of Meal Ingestion on Plasma Amylin Concentration in NIDDM and Nondiabetic Humans
Butler, P. C., Chou, J., Carter, W. B., Wang, Y.-N., Bu, B.-H., Chang, D., Chang, J.-K., & Rizza, R. A. (1990) · Diabetes · doi:10.2337/diab.39.6.752 · Cited by 330
The Effect of Acute Hyperglycemia on Gastric Emptying in Man
MacGregor, I. L., Gueller, R., Watts, H. D., & Meyer, J. H. (1976) · Gastroenterology · doi:10.1016/s0016-5085(76)80008-x · Cited by 250
Gastric emptying in patients with insulin-requiring diabetes mellitus.
Keshavarzian, A., Fl, I., & Vaeth, J. (1987) · PubMed · Cited by 201
Hartter, E., Svoboda, T., Ludvik, B., Schuller, M., Lell, B., Kuenburg, E., Brunnbauer, M., Woloszczuk, W., & Prager, R. (1991) · Diabetologia · doi:10.1007/bf00404025 · Cited by 191
Young, A. A., Gedulin, B. R., Vine, W., Percy, A., & RINK, T. J. (1995) · Diabetologia · doi:10.1007/bf00401833 · Cited by 184
Role of the proximal and distal stomach in mixed solid and liquid meal emptying
Collins, P. J., Houghton, L. A., Read, N. W., Horowitz, M., Chatterton, B. E., Heddle, R., & Dent, J. (1991) · Gut · doi:10.1136/gut.32.6.615 · Cited by 175 · cited 1×
“[22] have reported that a dextrose drink delayed gastric emptying of a solid meal, compared with saline, by increasing the lag period and retention in the proximal stomach.”
BackgroundAmylin concentrations and glucose control
Koda, J., Fineman, M. S., RINK, T. J., Dailey, G., Muchmore, D. B., & Linarelli, L. G. (1992) · The Lancet · doi:10.1016/0140-6736(92)90785-2 · Cited by 145
Infusion of pramlintide, a human amylin analogue, delays gastric emptying in men with IDDM
Kong, M.-F., King, P., Macdonald, I. A., Stubbs, T. A., Perkins, A. C., Blackshaw, P. E., Moyses, C., & Tattersall, R. B. (1997) · Diabetologia · doi:10.1007/s001250050646 · Cited by 131
Self-citationHighly variable gastric emptying in patients with insulin dependent diabetes mellitus.
Nowak, T. V., Johnson, C. P., Kalbfleisch, J. H., Roza, A. M., Wood, C. M., Weisbruch, J. P., & Soergel, K. H. (1995) · Gut · doi:10.1136/gut.37.1.23 · Cited by 127
Sugar Absorption Tests, with Special Reference to 3-0-Methyl-d-Glucose and d-Xylose
Fordtran, J. S., CLODI, P. H., SOERGEL, K. H., & Ingelfinger, F. J. (1962) · Annals of Internal Medicine · doi:10.7326/0003-4819-57-6-883 · Cited by 116
Structure and biology of amylin
RINK, T. J., Beaumont, K. C., Koda, J. E., & Young, A. W. (1993) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(93)90081-t · Cited by 105
Evaluation of mannitol for use as a probe marker of gastrointestinal permeability in man
Laker, M. F., BULL, H. J., & Menzies, I. S. (1982) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1982.tb02230.x · Cited by 96
Validity of the geometric mean correction in the quantification of whole bowel transit
HARDY, J. G., & Perkins, A. C. (1985) · Nuclear Medicine Communications · doi:10.1097/00006231-198504000-00005 · Cited by 84
Self-citationKolterman, O., Gottlieb, A., Moyses, C., & Colburn, W. A. (1995) · Diabetes Care · doi:10.2337/diacare.18.8.1179 · Cited by 79
Hyperinsulinaemia impairs gastrointestinal motility and slows carbohydrate absorption
Eliasson, B., Björnsson, E., Urbanavičius, V., Andersson, H. A., Fowelin, J., Attvall, S., Abrahamsson, H., & Smith, U. (1995) · Diabetologia · doi:10.1007/bf02369356 · Cited by 78
Estimation of disaccharides in plasma and urine by gas-liquid chromatography
Laker, M. F. (1979) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)81163-9 · Cited by 68
Mannitol estimation in biological fluids by gas-liquid chromatography of trimethylsilyl derivatives.
Laker, M. F., & Mount, J. N. (1980) · Clinical Chemistry · doi:10.1093/clinchem/26.3.441 · Cited by 50
Mannitol estimation in biological fluids by gas-liquid chromatography of trimethylsilyl derivatives.
Laker, M. F., & Mount, J. N. (1980) · PubMed · Cited by 45
Nowak, T. V., Roza, A. M., Weisbruch, J. P., & Mr, B. (1994) · PubMed · Cited by 34
Islet Amyloid Polypeptide: Does it Play a Pathophysiological Role in the Development of Diabetes?
Bennet, W. M., Smith, D. M., & Bloom, S. R. (1994) · Diabetic Medicine · doi:10.1111/j.1464-5491.1994.tb00363.x · Cited by 10
Cited by
Sorted by citations
Holt, R. I. G., DeVries, J. H., Hess-Fischl, A., Hirsch, I. B., Kirkman, M. S., Klupa, T., Ludwig, B., Nørgaard, K., Pettus, J., Renard, E., et al. (2021) · Diabetes Care · doi:10.2337/dci21-0043 · Cited by 699
Update on the treatment of type 2 diabetes mellitus
Marín-Peñalver, J. J., Martín-Timón, I., Sevillano-Collantes, C., & Cañizo-Gómez, F. J. D. (2016) · World Journal of Diabetes · doi:10.4239/wjd.v7.i17.354 · Cited by 647
Decreased Food Intake With Aging
Morley, J. E. (2001) · The Journals of Gerontology Series A · doi:10.1093/gerona/56.suppl_2.81 · Cited by 430
The New Biology and Pharmacology of Glucagon
Müller, T. D., Finan, B., Clemmensen, C., DiMarchi, R. D., & Tschöp, M. H. (2017) · Physiological Reviews · doi:10.1152/physrev.00025.2016 · Cited by 419
Amylin: Pharmacology, Physiology, and Clinical Potential
Hay, D. L., Chen, S., Lutz, T. A., Parkes, D. G., & Roth, J. D. (2015) · Pharmacological Reviews · doi:10.1124/pr.115.010629 · Cited by 400
Metadata
- Authors
- Kong, M.-F., Stubbs, T. A., King, P., Macdonald, I. A., Lambourne, J. E., Blackshaw, P. E., Perkins, A. C., & Tattersall, R. B.
- Affiliations
- Queen's Medical Centre (GB)
- University of Nottingham (GB)
- Nottingham University Hospitals NHS Trust (GB)
- Venue
- Diabetologia
- Published
- 1998-04-21
- Volume
- 41
- Issue
- 5
- Pages
- 577-583
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2041827953
- Cited by
- 106
- References
- 27
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 3 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 3 · 2015: 1 · 2014: 4 · 2013: 3 · 2012: 2
- FWCI
- 2.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Amylin Pharmaceuticals
- Topics
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- pramlintide, amylin analogues, gastric emptying, type 1 diabetes, dose-response relationship, subcutaneous injection, plasma glucose response, autonomic neuropathy
- MeSH terms
- Adult, Amyloid, Blood Glucose, Energy Intake, Diabetes Mellitus, Type 1, Dose-Response Relationship, Drug, Double-Blind Method, Food, Gastric Emptying, Humans, Hypoglycemic Agents, Insulin, Male, Cross-Over Studies, 3-O-Methylglucose, Islet Amyloid Polypeptide
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
