Effects of intravenous neuropeptide Y on insulin secretion and insulin sensitivity in skeletal muscle in normal rats
Open accessAbstract
Intracerebroventricular administration of neuropeptide Y to normal rats induces a syndrome characterised by obesity, hyperinsulinaemia, insulin resistance and over expression of the adipose tissue ob gene. Little is known about the effect of circulating neuropeptide Y on glucose metabolism, insulin secretion and leptin. We therefore aimed to evaluate the effect of an intravenous infusion of neuropeptide Y on glucose disposal, endogenous glucose production, whole body glycolytic flux, and glucose storage as assessed during euglycaemic hyperinsulinaemic clamp. In addition, the insulin-stimulated glucose utilisation index in individual tissues was measured by the 2-deoxy-[1-3H]-glucose technique. The effect of neuropeptide Y on insulin secretion was evaluated by hyperglycaemic clamp. Infusion did not induce any change in endogenous glucose production during basal conditions or at the end of the clamp. Glucose disposal was significantly increased in the rats given neuropeptide Y compared with controls (27.8 +/- 1.3 vs 24.3 +/- 1.6 mg x min(-1) x kg(-1); p < 0.05) as was the glycolytic flux (18.9 +/- 1.6 vs 14.4 +/- 0.8 mg x min(-1) x kg(-1); p < 0.05), while glucose storage was comparable in the two groups. In skeletal muscle, the glucose utilisation index was increased significantly in rats given neuropeptide Y. The glucose utilisation index in subcutaneous and epididimal adipose tissue was not significantly different between the two groups. Plasma leptin was significantly increased by hyperinsulinaemia, but was not affected by neuropeptide Y infusion. Both the early and late phase of the insulin response to hyperglycaemia were significantly reduced by neuropeptide Y. In conclusion neuropeptide Y infusion may increase insulin-induced glucose disposal in normal rats, accelerating its utilisation through the glycolytic pathway. Neuropeptide Y reduces both phases of the insulin response to hyperglycaemia.
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Neuropeptide Y, mainly expressed in sympathetic nerve fibers of the autonomic nervous system, blunts insulin release.
“The neurotransmitter Neuropeptide Y (NPY), which is mainly expressed in the sympathetic nerve fibers of the autonomic nervous system, also blunts insulin release,118, 119”
From Pancreatic regulation of glucose homeostasis. (2016) · cites this paper as [118]
The Abstract and Discussion (page not available in our copy) report that intravenous neuropeptide Y reduced both phases of the insulin response to hyperglycaemia in normal rats. The paper also places neuropeptide Y in sympathetic nerve terminals, but does not establish that it is mainly expressed there; it describes wide distribution in the central nervous system. The claim omits the study's hyperglycaemic condition. (LLM, conf=0.87)
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Cites
The role of neuropeptide Y in the antiobesity action of the obese gene product
Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., et al. (1995) · Nature · doi:10.1038/377530a0 · Cited by 1,498 · see citing works
Regulation of Splanchnic and Peripheral Glucose Uptake by Insulin and Hyperglycemia in Man
DeFronzo, R. A., Ferrannini, E., Hendler, R., Felig, P., & Wahren, J. (1983) · Diabetes · doi:10.2337/diab.32.1.35 · Cited by 509 · see citing works
Zarjevski, N., Cusin, I., Vettor, R., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1993) · Endocrinology · doi:10.1210/endo.133.4.8404618 · Cited by 476 · see citing works
Self-citationVos, P. D., Saladin, R., Auwerx, J. H., & Staels, B. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.27.15958 · Cited by 469 · see citing works
Teitelman, G., Alpert, S., Polak, J. M., Martı́nez, A., & Hanahan, D. (1993) · Development · doi:10.1242/dev.118.4.1031 · Cited by 368 · see citing works
Ferré, P., Leturque, A., Burnol, A., Pénicaud, L., & Girard, J. R. (1985) · Biochemical Journal · doi:10.1042/bj2280103 · Cited by 337 · see citing works
The ob Gene and Insulin: A Relationship Leading to Clues to the Understanding of Obesity
Cusin, I., Sainsbury, A., Doyle, P., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1995) · Diabetes · doi:10.2337/diab.44.12.1467 · Cited by 276 · see citing works
Self-citationRossetti, L., & Giaccari, A. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114636 · Cited by 249 · see citing works
Neuropeptide Y as an autonomic neurotransmitter
Potter, E. K. (1988) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(88)90028-9 · Cited by 233 · see citing works
Neuropeptide Y: Direct and indirect action on insulin secretion in the rat
Moltz, J. H., & McDonald, J. K. (1985) · Peptides · doi:10.1016/0196-9781(85)90443-7 · Cited by 213 · see citing works
In Vivo Hepatic and Peripheral Insulin Resistance in Genetically Obese (fa/fa) Rats*
Terrettaz, J., & Jeanrenaud, B. (1983) · Endocrinology · doi:10.1210/endo-112-4-1346 · Cited by 132 · see citing works
Self-citationVettor, R., Zarjevski, N., Cusin, I., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1994) · Diabetologia · doi:10.1007/bf00399793 · Cited by 129 · see citing works
Self-citationZarjevski, N., Cusin, I., Vettor, R., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1994) · Diabetes · doi:10.2337/diab.43.6.764 · Cited by 105 · see citing works
Self-citationNeuropeptide Y: Intrapancreatic neuronal localization and effects on insulin secretion in the mouse
Pettersson, M., Ahr�n, B., Lundquist, I., B�ttcher, G., & Sundler, F. (1987) · Cell and Tissue Research · doi:10.1007/bf01239960 · Cited by 100 · see citing works
Differential plasma catecholamine and neuropeptide Y responses to acute stress in rats
Żukowska-Grójec, Z., Konarska, M., & McCarty, R. C. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90440-7 · Cited by 84 · see citing works
The ob gene and insulin. A relationship leading to clues to the understanding of obesity
Cusin, I., Sainsbury, A., Doyle, P. H., et al. (1995) · Diabetes · doi:10.2337/diabetes.44.12.1467 · Cited by 83 · see citing works
Marks, J. L., & Waite, K. (1997) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1997.00554.x · Cited by 80 · cited 1× · see citing works
“In addition, intracerebroventricular neuropeptide Y has been shown to potentiate the insulinaemic response to intravenous glucose, while reducing the ability of insulin to control glucose metabolism and, in particular, to suppress glucose production [46, 47].”
BackgroundWang, Z. L., Bennet, W. M., Wang, R. M., Ghatei, M. A., & Bloom, S. R. (1994) · Endocrinology · doi:10.1210/endo.135.1.8013354 · Cited by 72 · see citing works
Sainsbury, A., Cusin, I., Doyle, P., Rohner‐Jeanrenaud, F., & Jeanrenaud, B. (1996) · Diabetologia · doi:10.1007/bf00418353 · Cited by 65 · see citing works
Self-citationvan Dijk, G., Bottone, A. E., STRUBBE, J. H., & Steffens, A. B. (1994) · Brain Research · doi:10.1016/0006-8993(94)90843-5 · Cited by 62 · see citing works
Abe, M., Saito, M., Ikeda, H., & Shimazu, T. (1991) · Brain Research · doi:10.1016/0006-8993(91)91624-a · Cited by 55 · see citing works
Castan‐Laurell, I., Valet, P., Voisin, T., QUIDEAU, N., Laburthe, M., & Lafontan, M. (1992) · Endocrinology · doi:10.1210/endo.131.4.1327725 · Cited by 55 · see citing works
Jamal, H., JONES, P. M., Byrne, J., Suda, K., Ghatei, M. A., Kanse, S. M., & Bloom, S. R. (1991) · Endocrinology · doi:10.1210/endo-129-6-3372 · Cited by 54 · see citing works
AHLBORG, G., Weitzberg, E., Sollevi, A., & Lundberg, J. M. (1992) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1992.tb09349.x · Cited by 46 · see citing works
Castan‐Laurell, I., Valet, P., Larrouy, D., Voisin, T., Rémaury, A., Daviaud, D., Laburthe, M., & Lafontan, M. (1993) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1993.265.1.e74 · Cited by 45 · see citing works
The presence and actions of NPY in the canine endocrine pancreas
Dunning, B. E., Åhrén, B., Böttcher, G., Sundler, F., & Taborsky, G. J. (1987) · Regulatory Peptides · doi:10.1016/0167-0115(87)90183-2 · Cited by 44 · see citing works
Interaction of neuropeptide Y and the sympathetic nervous system in vascular control in man.
Clarke, J. G., Benjamin, N., Larkin, S. W., Webb, D. J., Maseri, A., & DAVIES, G. J. (1991) · Circulation · doi:10.1161/01.cir.83.3.774 · Cited by 40 · see citing works
MODINI, A., Pernow, J., & Lundberg, J. M. (1993) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1993.tb09525.x · Cited by 39 · see citing works
Takahashi, K., Mouri, T., Itoi, K., Sone, M., Ohneda, M., Murakami, O., Nozuki, M., Tachibana, Y., & YOSHINAGA, K. (1987) · Journal of Hypertension · doi:10.1097/00004872-198712000-00020 · Cited by 38 · see citing works
Sainsbury, A., Rohner-Jeanrenaud, F., Grouzmann, E., & Jeanrenaud, B. (2008) · Neuroendocrinology · doi:10.1159/000126972 · Cited by 34 · see citing works
Self-citationZarjevski, N., Cusin, I., Vettor, R., et al. (1994) · Diabetes · doi:10.2337/diabetes.43.6.764 · Cited by 33 · see citing works
Self-citationSkoglund, G., Gross, R., Bertrand, G., Åhrén, B., & Loubatières-Mariani, M.-M. (1991) · Diabetes · doi:10.2337/diab.40.6.660 · Cited by 28 · see citing works
Insulin induces rapid changes of plasma leptin in lean but not in genetically obese (fa/fa) rats
Pagano, C., Englaro, P., Granzotto, M., Blum, W., Sagrillo, E., Ferretti, E., Federspil, G., & Vettor, R. (1997) · International Journal of Obesity · doi:10.1038/sj.ijo.0800450 · Cited by 28 · see citing works
Self-citationThe Neuroendocrine System OF the Gut—AN Update
Sundler, F., Ekblad, E., & Håkanson, R. (1991) · Acta Oncologica · doi:10.3109/02841869109092396 · Cited by 27 · see citing works
Marks, J. L., & Waite, K. (1996) · Journal of Neuroendocrinology · doi:10.1046/j.1365-2826.1996.04854.x · Cited by 25 · see citing works
Insulin secretion in rats: effects of neuropeptide Y and noradrenaline.
Pettersson, M., & Åhrén, B. (1990) · PubMed · Cited by 22 · see citing works
Sundkvist, G., Bramnert, M., Bergström, B., Manhem, P., Lilja, B., & Ahrén, B. (1992) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(92)90028-p · Cited by 21 · see citing works
Canine liver releases neuropeptide Y during sympathetic nerve stimulation
Taborsky, G. J., Beltramini, L. M., Brown, M., Veith, R. C., & Kowalyk, S. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.5.e804 · Cited by 21 · see citing works
Phentolamine reverses NPY-induced inhibition of insulin secretion in isolated rat islets
ALWMARK, A., & Åhrén, B. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90679-0 · Cited by 18 · see citing works
Neuropeptide Y-induced constriction in small resistance vessels of skeletal muscle
Joshua, I. G. (1991) · Peptides · doi:10.1016/0196-9781(91)90163-j · Cited by 17 · see citing works
Skoglund, G., Gross, R., Bertrand, G. R., et al. (1991) · Diabetes · doi:10.2337/diabetes.40.6.660 · Cited by 16 · see citing works
Effects of neuropeptide Y on insulin and glucagon secretion in the pig
Åhrén, B., Mårtensson, H., & FALCK, B. (1991) · Neuropeptides · doi:10.1016/0143-4179(91)90039-l · Cited by 13 · see citing works
Vettor, R., Zarjevski, N., Cusin, I., et al. (1994) · Diabetologia · doi:10.1007/s001250050236 · Cited by 13 · see citing works
Self-citationInhibitory effects of neuropeptide Y on splanchnic glycogenosis and renin release in humans
AHLBORG, G., & Lundberg, J. M. (1994) · Clinical Physiology · doi:10.1111/j.1475-097x.1994.tb00505.x · Cited by 12 · see citing works
Lactate infusion to normal rats during hyperglycemia enhances in vivo muscle glycogen synthesis
Pagano, C., Granzotto, M., Giaccari, A., Fabris, R., Serra, R., Lombardi, A. M., Federspil, G., & Vettor, R. (1997) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1997.273.6.r2072 · Cited by 10 · see citing works
Self-citationSainsbury, A., Cusin, I., Doyle, P., et al. (1996) · Diabetologia · doi:10.1007/s001250050453 · Cited by 6 · see citing works
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Röder, P. V., Wu, B., Liu, Y., & Han, W. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.6 · Cited by 985 · see citing works
Neuropeptide Y: the universal soldier
Pedrazzini, T., Pralong, F. P., & Grouzmann, E. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s000180300029 · Cited by 286 · see citing works
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Wittwer, M., Flück, M., Hoppeler, H. H., Müller, S., Dominique Desplanches, C., & Billeter-Clark, R. (2002) · The FASEB Journal · doi:10.1096/fj.01-0792fje · Cited by 91 · see citing works
Pickavance, L. C., Brand, C. L., Wassermann, K., & Wilding, J. P. H. (2005) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0706041 · Cited by 71 · see citing works
Transgenic Mice Overexpressing Neuropeptide Y in Noradrenergic Neurons
Ruohonen, S. T., Pesonen, U., Moritz, N., Kaipio, K., Röyttä, M., Koulu, M., & Savontaus, E. (2008) · Diabetes · doi:10.2337/db07-0722 · Cited by 59 · see citing works
Wang, J., Dourmashkin, J. T., Yun, R., & LEIBOWITZ, S. F. (1999) · Brain Research · doi:10.1016/s0006-8993(99)02040-5 · Cited by 48 · see citing works
NPY modulates PYY function in the regulation of energy balance and glucose homeostasis
Zhang, L., Nguyen, A., Lee, I. ‐. J., Yulyaningsih, E., Riepler, S. J., Stehrer, B., Enriquez, R. F., Lin, S., Shi, Y., Baldock, P. A. J., et al. (2012) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2012.01592.x · Cited by 33 · see citing works
Chang, G., Karatayev, O., Davydova, Z., Wortley, K. E., & LEIBOWITZ, S. F. (2005) · Molecular Brain Research · doi:10.1016/j.molbrainres.2004.12.017 · Cited by 32 · see citing works
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Schwab, U., Ågren, J., Valve, R., Hallikainen, M., Sarkkinen, E., Jauhiainen, M., Karvonen, M., Pesonen, U., Koulu, M., Uusitupa, M., et al. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601297 · Cited by 14 · see citing works
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Stamford, A. W., & Parker, E. M. (1999) · Annual reports in medicinal chemistry · doi:10.1016/s0065-7743(08)60566-7 · Cited by 10 · see citing works
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Ruohonen, S. T. (2009) · UTUPub (University of Turku)
- Authors
- Vettor, R., Pagano, C., Granzotto, M., Englaro, P., Angeli, P., Blum, W. F., Federspil, G., Rohner-Jeanrenaud, F., & Jeanrenaud, B.
- Affiliations
- University of Padua (IT)
- Justus-Liebig-Universität Gießen (DE)
- University of Geneva (CH)
- Venue
- Diabetologia
- Published
- 1998-10-20
- Volume
- 41
- Issue
- 11
- Pages
- 1361-1367
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W2019950192
- Cited by
- 20
- References
- 41
- Citations by year
- 2023: 1 · 2020: 2 · 2019: 1 · 2016: 1 · 2012: 3
- FWCI
- 1.11
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Padua Research Archive (University of Padova) (submittedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- neuropeptide Y, insulin secretion, insulin sensitivity, glucose disposal, glycolytic flux, endogenous glucose production, glucose storage, leptin, hyperinsulinemic-euglycemic clamp, hyperglycaemic clamp, adipose tissue, obesity
- MeSH terms
- Insulin Secretion, Adipose Tissue, Animals, Blood Glucose, Deoxyglucose, Gluconeogenesis, Glucose, Glycolysis, Infusions, Intravenous, Insulin, Male, Neuropeptide Y, Proteins, Tritium, Glucose Clamp Technique, Rats, Sprague-Dawley, Muscle, Skeletal, Leptin, Rats
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