The role of neuropeptide Y in the antiobesity action of the obese gene product

Stephens, Thomas W.; Basinski, Margret; Bristow, Pamela K.; Bue-Valleskey, Juliana M.; Burgett, Stanley G.; Craft, Libbey; Hale, John; Hoffmann, James; Hsiung, Hansen M.; Kriauciunas, Aidas; MacKellar, Warren; Rosteck, Paul R.; Schoner, Brigitte; Smith, Dennis; Tinsley, Frank C.; Zhang, Xing-Yue; Heiman, Mark

doi:10.1038/377530a0

Cited by 1,498Regulation of Appetite and ObesityAdipokines, Inflammation, and Metabolic DiseasesNeuropeptides and Animal Physiology

The role of neuropeptide Y in the antiobesity action of the obese gene product

Stephens, Thomas W., Basinski, Margret, Bristow, Pamela K., Bue-Valleskey, Juliana M., Burgett, Stanley G., Craft, Libbey, Hale, John, Hoffmann, James +9 more·1995·Nature

DOI 10.1038/377530a0

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Abstract

Recently Zhang et al. cloned a gene that is expressed only in adipose tissue of the mouse. The obese phenotype of the ob/ob mouse is linked to a mutation in the obese gene that results in expression of a truncated inactive protein. Human and rat homologues for this gene are known. Previous experiments predict such a hormone to have a hypothalamic target. Hypothalamic neuropeptide Y stimulates food intake, decreases thermogenesis, and increases plasma insulin and corticosterone levels making it a potential target. Here we express the obese protein in Escherichia coli and find that it suppresses food intake and decreases body weight dramatically when administered to normal and ob/ob mice but not db/db (diabetic) mice, which are thought to lack the appropriate receptor. High-affinity binding was detected in the rat hypothalamus. One mechanism by which this protein regulated food intake and metabolism was inhibition of neuropeptide-Y synthesis and release.

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Stress is associated with higher body weight.
“higher body weight (Stephens et al., 1995).”
From The impact of stress on students in secondary school and higher education (2020) · cites this paper as Stephens et al., 1995

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Authors: Stephens, T. W., Basinski, M., Bristow, P. K., Bue-Valleskey, J. M., Burgett, S. G., Craft, L., Hale, J., Hoffmann, J., Hsiung, H. M., Kriauciunas, A., MacKellar, W., Rosteck, P. R., Schoner, B., Smith, D., Tinsley, F. C., Zhang, X.-Y., & Heiman, M.
Affiliations: Eli Lilly (United States) (US)
ORCID: Hale, John
Heiman, Mark
Venue: Nature
Publisher: Springer Science and Business Media LLC
Published: 1995-10
Volume: 377
Issue: 6549
Pages: 530-532
ISSN: 0028-0836 (ISSN-L)
1476-4687
DOI: 10.1038/377530a0
OpenAlex: W2075019242
Cited by: 1,498
References: 2
Citations by year: 2026: 5 · 2025: 10 · 2024: 11 · 2023: 7 · 2022: 9 · 2021: 21 · 2020: 10 · 2019: 12 · 2018: 9 · 2017: 26 · 2016: 26 · 2015: 24 · 2014: 37 · 2013: 32 · 2012: 29
FWCI: 56.86
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: neuropeptide Y, obese gene, leptin, ob/ob mice, anti-obesity, food intake regulation, hypothalamus, neuropeptide Y receptors, body weight, thermogenesis, insulin, corticosterone, leptin receptor, adipose tissue
MeSH terms: Animals, Body Weight, Cell Membrane, Diabetes Mellitus, Experimental, Eating, Escherichia coli, Humans, Hypothalamus, Neuropeptide Y, Obesity, Proteins, Recombinant Proteins, Leptin, Mice, Rats, In Vitro Techniques

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The role of neuropeptide Y in the antiobesity action of the obese gene product

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