Universal prevention of schizophrenia and surrogate endpoints at population level
Open accessAbstract
Despite significant progresses in our knowledge of the risk factors for schizophrenia, we still are several steps short of implementing effective prevention strategies. Universal prevention strategies have several theoretical advantages but their implementation has been limited to date by their costs and lack of methods to assess their efficiency. To overcome this limitation, we suggest, based on research from therapeutic trials at individual level, the use of surrogate endpoints (SEs) at population level. We further suggest that subclinical measures of psychosis at population level are good SEs candidates for assessing universal measures for schizophrenia prevention.
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Demonstrating an impact on the incidence of psychosis and bipolar disorder would be, if at all feasible, long and expensive.
“Demonstrating an impact on the incidence of these disorders would be, if at all feasible, long and expensive 158”
From Preventive psychiatry: a blueprint for improving the mental health of young people (2021) · cites this paper as [158]
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“Given the continuity between SP and threshold psychotic disorders, some authors have proposed the use of population-level measures of PLEs or schizotypy as surrogates of clinical disorders for research purposes (Szöke, Kirkbride, & Schürhoff, 2014).”
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Self-citation
- Authors
- Szöke, A., Kirkbride, J. B., & Schürhoff, F.
- Affiliations
- Inserm (FR)
- University of Cambridge (GB)
- Corresponding author
- Szöke, A.
- Venue
- Social Psychiatry and Psychiatric Epidemiology
- Published
- 2014-02-02
- Volume
- 49
- Issue
- 9
- Pages
- 1347-1351
- ISSN
- 0933-7954 (ISSN-L)
- 1433-9285
- OpenAlex
- W1976287357
- Cited by
- 17
- References
- 17
- Citations by year
- 2025: 1 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2018: 2 · 2017: 2 · 2016: 2
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Social Psychiatry and Psychiatric Epidemiology (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Funders
- Wellcome Trust (101272)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Physical Sciences › Mathematics › Statistics and Probability › Statistical Methods in Clinical Trials
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- schizophrenia, universal prevention, surrogate endpoints, population-level prevention, subclinical psychosis, psychosis risk factors
- MeSH terms
- Humans, Risk Factors, Schizophrenia, Biomarkers
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