The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients
Open accessAbstract
PurposeSepsis syndrome represents the leading cause of death in intensive care unit. Patients present features consistent with a decline in immune responsiveness potentially contributing to mortality. We investigated whether CD4+CD25+ regulatory T cells (Treg) participate in the induction of lymphocyte anergy after sepsis.MethodObservational study in septic shock patients and experimental study in mice.ResultsWe took advantage of the recently described flow cytometric gating strategy using the measurement of CD25 and CD127 expressions for monitoring Treg (CD4+CD25+CD127−Foxp3+). In patients the increased circulating Treg percentage significantly correlated with a decreased lympho-proliferative response. In a murine model of sepsis mimicking these observations, the ex vivo downregulation of Foxp3 expression using siRNA was associated with a restoration of this response.ConclusionThe relative increase in circulating Treg might play a role in lymphocyte anergy described after septic shock and represent a standardizable surrogate marker of declining proliferative capacity after sepsis.
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Bone, R. C., Balk, R. A., Cerra, F. B., Dellinger, R. P., Fein, A. M., Knaus, W. A., Schein, R. M. H., & Sibbald, W. J. (1992) · Chest · doi:10.1378/chest.101.6.1644 · Cited by 13,198
Angus, D. C., Linde-Zwirble, W. T., Lidicker, J., Clermont, G., Carcillo, J., & Pinsky, M. R. (2001) · Critical Care Medicine · doi:10.1097/00003246-200107000-00002 · Cited by 8,503
The Pathophysiology and Treatment of Sepsis
Hotchkiss, R. S., & Karl, I. E. (2003) · New England Journal of Medicine · doi:10.1056/nejmra021333 · Cited by 4,097
The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer
Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,088
CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells
Liu, W., Putnam, A. L., Xu-yu, Z., Szot, G. L., Lee, M. R., Zhu, S., Gottlieb, P. A., Kapranov, P., Gingeras, T. R., de St. Groth, B. F., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060772 · Cited by 2,606
Foxp3+CD25+CD4+ natural regulatory T cells in dominant self‐tolerance and autoimmune disease
Sakaguchi, S., Ono, M., Setoguchi, R., Yagi, H., Hori, S., Fehervari, Z., Shimizu, J., Takahashi, T., & Nomura, T. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00427.x · Cited by 1,555
Seddiki, N., Santner-Nanan, B., Martinson, J., Zaunders, J., Sasson, S., Landay, A., Solomon, M., Selby, W., Alexander, S. I., Nanan, R., et al. (2006) · The Journal of Experimental Medicine · doi:10.1084/jem.20060468 · Cited by 1,512 · cited 1×
“To investigate this, the whole blood percentage of Treg (assessed by using a newly described and reproducible gating strategy based on the CD4, CD25, CD127 and FOXP3 flow cytometric measurement [15,16]) was correlated with the proliferative response of mononuclear cells purified from septic shock patients after mitoge…”
MethodZiegler, S. F. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.24.021605.090547 · Cited by 922
Hubbard, W. J., Choudhry, M., Schwacha, M. G., Kerby, J. D., Rue, L. W., Bland, K. I., & Chaudry, I. H. (2005) · Shock · doi:10.1097/01.shk.0000191414.94461.7e · Cited by 792
Regulatory T cells and infection: a dangerous necessity
Belkaid, Y. (2007) · Nature Reviews Immunology · doi:10.1038/nri2189 · Cited by 745
Cited by
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772
Self-citationThe immune system’s role in sepsis progression, resolution, and long-term outcome
Delano, M. J., & Ward, P. A. (2016) · Immunological Reviews · doi:10.1111/imr.12499 · Cited by 880
The dark side of Tregs during aging
Palatella, M., Guillaume, S. M., Linterman, M. A., & Huehn, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.940705 · Cited by 58
Metadata
- Authors
- Venet, F., Chung, C.-S., Kherouf, H., Geeraert, A., Malcus, C., Poitevin, F., Bohé, J., Lepape, A., Ayala, A., & Monneret, G.
- Venue
- Intensive Care Medicine
- Published
- 2008-10-23
- Volume
- 35
- Issue
- 4
- Pages
- 678-686
- ISSN
- 0342-4642 (ISSN-L)
- 1432-1238
- OpenAlex
- W2039285985
- Cited by
- 320
- References
- 49
- FWCI
- 3.88
- Type
- journal article
- Language
- en
- Open access
- green
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- Venet, F., Chung, C.-S., Kherouf, H., Geeraert, A., Malcus, C., Poitevin, F., Bohé, J., Lepape, A., Ayala, A., & Monneret, G. (2009). Increased circulating regulatory T cells (CD4+CD25+CD127−) contribute to lymphocyte anergy in septic shock patients. Intensive Care Medicine. https://doi.org/10.1007/s00134-008-1337-8
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