The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
CECAL LIGATION AND PUNCTURE
Abstract
The model of cecal ligation and puncture (CLP) in rodents has been used extensively to investigate the clinical settings of sepsis and septic shock. This model produces a hyperdynamic, hypermetabolic state that can lead to a hypodynamic, hypometabolic stage, and eventual death. Blood cultures are positive for enteric organisms very early after CLP. The model has been widely used over the past 26 years and is highly versatile in adapting to a range of severity and testing objectives. It is inexpensive to prepare and technically straightforward. Aspects of sepsis research investigated using CLP include energetics, metabolism, resuscitation, antibiotic therapy, microbial factors, cardiovascular responses, immune function, mediator release, and cytokine expression patterns. The challenge of the small circulating blood volume in rodents can be overcome by using micromethods that enable analysis of small volumes, or alternatively, by using a large number of animals to obtain serial samples.
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Cites
Ritter, C., Andrades, M. E., Reinke, A., Menna-Barreto, S., Moreira, J. C. F., & Dal-Pizzol, F. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000109454.13145.ca · Cited by 233
Cited by
Németh, K., Leelahavanichkul, A., Yuen, P. S. T., Mayer, B., Parmelee, A., Doi, K., Robey, P. G., Leelahavanichkul, K., Koller, B. H., Brown, J. M., et al. (2009) · Nature Medicine · doi:10.1038/nm.1905 · Cited by 2,364
Immunodesign of experimental sepsis by cecal ligation and puncture
Rittirsch, D., Huber-Lang, M. S., Flierl, M. A., & Ward, P. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.214 · Cited by 2,209
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis
Cools-Lartigue, J., Spicer, J., McDonald, B., Gowing, S., Chow, S., Giannias, B., Bourdeau, F., Kubes, P., & Ferri, L. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67484 · Cited by 1,395
The disconnect between animal models of sepsis and human sepsis
Rittirsch, D., Hoesel, L. M., & Ward, P. A. (2007) · Journal of Leukocyte Biology · doi:10.1189/jlb.0806542 · Cited by 406
Venet, F., Chung, C.-S., Kherouf, H., Geeraert, A., Malcus, C., Poitevin, F., Bohé, J., Lepape, A., Ayala, A., & Monneret, G. (2009) · Intensive Care Medicine · doi:10.1007/s00134-008-1337-8 · Cited by 320
Metadata
- Authors
- Hubbard, W. J., Choudhry, M., Schwacha, M. G., Kerby, J. D., Rue, L. W., Bland, K. I., & Chaudry, I. H.
- Venue
- Shock
- Published
- 2005-12
- Volume
- 24
- Issue
- Supplement 1
- Pages
- 52-57
- ISSN
- 1073-2322 (ISSN-L)
- OpenAlex
- W2029619625
- Cited by
- 792
- References
- 1
- FWCI
- 14.61
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hubbard, W. J., Choudhry, M., Schwacha, M. G., Kerby, J. D., Rue, L. W., Bland, K. I., & Chaudry, I. H. (2005). CECAL LIGATION AND PUNCTURE. Shock. https://doi.org/10.1097/01.shk.0000191414.94461.7e
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
