Clinical predictors of mortality due to COVID-19 based on an analysis of data of 150 patients from Wuhan, China

Epidemiological and clinical characteristics of 99 cases of 2019 novel Coronavirus pneumonia in Wuhan, China: a descriptive study.

Chen, N., Zhou, M., Dong, X., Qu, J., Gong, F., Han, Y., Qiu, Y., Wang, J., Liu, Y., Wei, Y., et al. (2020) · The Lancet · doi:10.1016/s0140-6736(20)30211-7 · Cited by 21,415

Coronavirus: covid-19 has killed more people than SARS and MERS combined, despite lower case fatality rate

Mahase, E. (2020) · BMJ · doi:10.1136/bmj.m641 · Cited by 727

Chinese society of cardiology expert consensus statement on the diagnosis and treatment of adult fulminant myocarditis

Section of Precision Medicine Group of Chinese Society of Cardiology, Wang, D. W., Editorial Board of Chinese Journal of Cardiology, Working Group of Adult Fulminant Myocarditis, Li, S., Jiang, J., Yan, J., Zhao, C., Wang, Y., Ye-xin, M., et al. (2018) · Science China Life Sciences · doi:10.1007/s11427-018-9385-3 · Cited by 128

Role of Inflammatory Cytokines in COVID-19 Patients: A Review on Molecular Mechanisms, Immune Functions, Immunopathology and Immunomodulatory Drugs to Counter Cytokine Storm

Rabaan, A. A., Al-Ahmed, S. H., Muhammad, J., Khan, A., Sule, A. A., Tirupathi, R., Mutair, A. S. A., Alhumaid, S., Al‐Omari, A., Dhawan, M. K., et al. (2021) · Vaccines · doi:10.3390/vaccines9050436 · Cited by 262

Obesity: A critical risk factor in the COVID ‐19 pandemic

Kwok, S., Adam, S., Ho, J. H., Iqbal, Z., Turkington, P. M., Razvi, S., le Roux, C. W., Soran, H., & Syed, A. A. (2020) · Clinical Obesity · doi:10.1111/cob.12403 · Cited by 264

Pilot trial of high-dose vitamin C in critically ill COVID-19 patients

Zhang, J., Rao, X., Li, Y., Zhu, Y., Liu, F., Guo, G., Luo, G., Meng, Z., Backer, D. D., Xiang, H., et al. (2021) · Annals of Intensive Care · doi:10.1186/s13613-020-00792-3 · Cited by 258

Prevalence of phenotypes of acute respiratory distress syndrome in critically ill patients with COVID-19: a prospective observational study

Sinha, P., Calfee, C. S., Cherian, S., Brealey, D. A., Cutler, S., King, C., Killick, C., Richards, O., Cheema, Y., Bailey, C., et al. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30366-0 · Cited by 250

Beneficial effects of colchicine for moderate to severe COVID-19: a randomised, double-blinded, placebo-controlled clinical trial

Lopes, M. I. F., Bonjorno, L. P., Giannini, M. C., do Amaral, N. B., Menezes, P. I., DIB, S. M., GIGANTE, S. L. G., Benatti, M. N., Rezek, U. C., Emrich-Filho, L. L., et al. (2021) · RMD Open · doi:10.1136/rmdopen-2020-001455 · Cited by 250

Echocardiographic Findings in Pediatric Multisystem Inflammatory Syndrome Associated With COVID-19 in the United States

Matsubara, D., Kauffman, H., Wang, Y., Calderon-Anyosa, R. J. C., Nadaraj, S., Elias, M. D., White, T. J., Torowicz, D. L., Yubbu, P., Giglia, T. M., et al. (2020) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2020.08.056 · Cited by 251

Understanding pathways to death in patients with COVID-19

Vincent, J., & Taccone, F. S. (2020) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(20)30165-x · Cited by 251

COVID-19 and Neutrophils: The Relationship between Hyperinflammation and Neutrophil Extracellular Traps

Borges, L., Pithon-Curi, T. C., Curi, R., & Hatanaka, E. (2020) · Mediators of Inflammation · doi:10.1155/2020/8829674 · Cited by 235

Management of critically ill patients with COVID-19 in ICU: statement from front-line intensive care experts in Wuhan, China

Shang, Y., Pan, C. S., Yang, X., Zhong, M., Shang, X., Wu, Z., Yu, Z., Zhang, W., Zhong, Q., Zheng, X., et al. (2020) · Annals of Intensive Care · doi:10.1186/s13613-020-00689-1 · Cited by 254

Predictors of in-hospital COVID-19 mortality: A comprehensive systematic review and meta-analysis exploring differences by age, sex and health conditions

Mesas, A. E., Cavero‐Redondo, I., Álvarez‐Bueno, C., Cabrera, M. A. S., de Andrade, S. M., Sequí‐Domínguez, I., & Martínez‐Vizcaíno, V. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241742 · Cited by 245

The Characteristics of 50 Hospitalized COVID-19 Patients With and Without ARDS

Dreher, M., Kersten, A., Bickenbach, J., Balfanz, P., Hartmann, B., Cornelissen, C. G., Daher, A., Stöhr, R., Kleines, M., Lemmen, S., et al. (2020) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2020.0271 · Cited by 247

Extracorporeal membrane oxygenation network organisation and clinical outcomes during the COVID-19 pandemic in Greater Paris, France: a multicentre cohort study

Lebreton, G., Schmidt, M., Ponnaiah, M., Folliguet, T. A., Para, M., Guihaire, J., Lansac, E., Sage, É., Cholley, B., Mégarbane, B., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00096-5 · Cited by 244

Editorial: Nicotine and SARS-CoV-2: COVID-19 may be a disease of the nicotinic cholinergic system

Farsalinos, K. E., NIAURA, R. S., Houezec, J. L., Barbouni, A., Tsatsakis, A. M., Kouretas, D., Vantarakis, A., & Poulas, K. A. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.04.012 · Cited by 251

COVID-19 in older people: a rapid clinical review

Lithander, F. E., Neumann, S., Tenison, E., Lloyd, K., Welsh, T. J., Rodrigues, J. C. L., Higgins, J. P. T., Scourfield, L., Christensen, H., Haunton, V. J., et al. (2020) · Age and Ageing · doi:10.1093/ageing/afaa093 · Cited by 250

Longitudinal immune profiling reveals key myeloid signatures associated with COVID-19

Mann, E. R., Menon, M., Knight, S., Konkel, J. E., Jagger, C. P., Shaw, T. N., Krishnan, S., Rattray, M., Ustianowski, A., Bakerly, N. D., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.abd6197 · Cited by 237

Laboratory findings in COVID-19 diagnosis and prognosis

Pourbagheri‐Sigaroodi, A., Bashash, D., Fateh, F., & Abolghasemi, H. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.08.019 · Cited by 250

Review of Emerging Pharmacotherapy for the Treatment of Coronavirus Disease 2019

Barlow, A., Landolf, K. M., Barlow, B., Yeung, S. Y. A., Heavner, J. J., Claassen, C. W., & Heavner, M. S. (2020) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/phar.2398 · Cited by 239

Monoclonal antibodies for COVID-19 therapy and SARS-CoV-2 detection

Hwang, Y., Lu, R., Su, S.-C., Chiang, P.-Y., Ko, S.-H., Ke, F.-Y., Liang, K.-H., Hsieh, T.-Y., & Wu, H. (2022) · Journal of Biomedical Science · doi:10.1186/s12929-021-00784-w · Cited by 247

Factors associated with death outcome in patients with severe coronavirus disease-19 (COVID-19): a case-control study

Pan, F., Yang, L., Li, Y., Liang, B., Lin, L., Ye, T., Li, L., Liu, D., Gui, S., Hu, Y., et al. (2020) · International Journal of Medical Sciences · doi:10.7150/ijms.46614 · Cited by 236

Interleukin-6 blockade with sarilumab in severe COVID-19 pneumonia with systemic hyperinflammation: an open-label cohort study

Della‐Torre, E., Campochiaro, C., Cavalli, G., Luca, G. D. D., Napolitano, A., Marca, S. L., Boffini, N., PRAT, V. D., Terlizzi, G. D., Lanzillotta, M., et al. (2020) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2020-218122 · Cited by 236

Deciphering the COVID‐19 cytokine storm: Systematic review and meta‐analysis

Mulchandani, R., Lyngdoh, T., & Kakkar, A. K. (2020) · European Journal of Clinical Investigation · doi:10.1111/eci.13429 · Cited by 251

Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19

Thwaites, R. S., Uruchurtu, A. S. S., Siggins, M. K., Liew, F., Russell, C. D., Moore, S. C., Fairfield, C. J., Carter, E., Abrams, S. T., Short, C.-E. S., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abg9873 · Cited by 228

Diabetes is most important cause for mortality in COVID-19 hospitalized patients: Systematic review and meta-analysis

Corona, G., Pizzocaro, A., Vena, W., Rastrelli, G., Semeraro, F. F., Isidori, A. M., Pivonello, R., Salonia, A., Sforza, A., & Maggi, M. (2021) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-021-09630-8 · Cited by 233

A brief-review of the risk factors for covid-19 severity

Rod, J. E., Oviedo-Trespalacios, Ó., & Cortés-Ramírez, J. (2020) · Revista de Saúde Pública · doi:10.11606/s1518-8787.2020054002481 · Cited by 232

Prevalence of underlying diseases in died cases of COVID-19: A systematic review and meta-analysis

Javanmardi, F., Keshavarzi, A., Akbari, A., Emami, A., & Pirbonyeh, N. (2020) · PLoS ONE · doi:10.1371/journal.pone.0241265 · Cited by 236

The Janus kinase 1/2 inhibitor ruxolitinib in COVID-19 with severe systemic hyperinflammation

Rosée, F. L., Bremer, H., Gehrke, I., Kehr, A. K., Hochhaus, A., Birndt, S., Fellhauer, M., Henkes, M., Kumle, B., Russo, S. G., et al. (2020) · Leukemia · doi:10.1038/s41375-020-0891-0 · Cited by 232

Inflammation Triggered by SARS-CoV-2 and ACE2 Augment Drives Multiple Organ Failure of Severe COVID-19: Molecular Mechanisms and Implications

Iwasaki, M., Saito, J., Zhao, H., Sakamoto, A., Hirota, K., & Ma, D. (2020) · Inflammation · doi:10.1007/s10753-020-01337-3 · Cited by 234

Expansion of myeloid-derived suppressor cells in patients with severe coronavirus disease (COVID-19)

Agrati, C., Sacchi, A., Bordoni, V., Cimini, E., Notari, S., Grassi, G., Casetti, R., Tartaglia, E., Lalle, E., D’Abramo, A., et al. (2020) · Cell Death and Differentiation · doi:10.1038/s41418-020-0572-6 · Cited by 218

Machine Learning to Predict Mortality and Critical Events in a Cohort of Patients With COVID-19 in New York City: Model Development and Validation

Vaid, A., Somani, S. S., Russak, A. J., Freitas, J. K. D., Chaudhry, F. F., Paranjpe, I., Johnson, K. W., Lee, S. J., Miotto, R., Zhao, S., et al. (2020) · Journal of Medical Internet Research · doi:10.2196/24018 · Cited by 238

Tocilizumab plus standard care versus standard care in patients in India with moderate to severe COVID-19-associated cytokine release syndrome (COVINTOC): an open-label, multicentre, randomised, controlled, phase 3 trial

Soin, A. S., Kumar, K., Choudhary, N. S., Sharma, P., Mehta, Y. B., Kataria, S., Govil, D., Deswal, V., Chaudhry, D., Singh, P., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00081-3 · Cited by 232

Obesity and COVID-19: immune and metabolic derangement as a possible link to adverse clinical outcomes

Korakas, E., Ikonomidis, I., Kousathana, F., Balampanis, K., Kountouri, A., Raptis, A. E., Palaiodimou, L., Kokkinos, A. D., & Lambadiari, V. (2020) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00198.2020 · Cited by 226

Short- and potential long-term adverse health outcomes of COVID-19: a rapid review

Leung, M. T. Y., Chan, A. Y. L., Chan, E. W., Chan, V. K. Y., Chui, C. S. L., Cowling, B. J., Gao, L., Ge, M. Q., Hung, I. F., Ip, M. S. M., et al. (2020) · Emerging Microbes & Infections · doi:10.1080/22221751.2020.1825914 · Cited by 228

Neurological and Neuropsychiatric Impacts of COVID-19 Pandemic

Roy, D., Ghosh, R., Dubey, S., Dubey, M. J., Benito‐León, J., & Ray, B. K. (2020) · Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques · doi:10.1017/cjn.2020.173 · Cited by 230

Cardiovascular Manifestations of COVID-19 Infection

Magadum, A., & Kishore, R. (2020) · Cells · doi:10.3390/cells9112508 · Cited by 230

Obesity in COVID-19 era, implications for mechanisms, comorbidities, and prognosis: a review and meta-analysis

Aghili, S. M. M., Ebrahimpur, M., Arjmand, B., Shadman, Z., Sani, M. P., Qorbani, M., Larijani, B. A., & Payab, M. (2021) · International Journal of Obesity · doi:10.1038/s41366-021-00776-8 · Cited by 246

Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19

Vella, L. A., Giles, J. R., Baxter, A. E., Oldridge, D. A., Diorio, C. J., Kuri-Cervantes, L., Alanio, C., Pampena, M. B., Wu, J. E., Chen, Z., et al. (2021) · Science Immunology · doi:10.1126/sciimmunol.abf7570 · Cited by 225

The Innate Immune System: Fighting on the Front Lines or Fanning the Flames of COVID-19?

McKechnie, J. L., & Blish, C. A. (2020) · Cell Host & Microbe · doi:10.1016/j.chom.2020.05.009 · Cited by 218

COVID-19 pandemic and troponin: indirect myocardial injury, myocardial inflammation or myocarditis?

Imazio, M., Klingel, K., Kindermann, I., Brucato, A. L., Rosa, F. G. D., Adler, Y., & Ferrari, G. M. D. (2020) · Heart · doi:10.1136/heartjnl-2020-317186 · Cited by 222

Acute Physiology and Chronic Health Evaluation II Score as a Predictor of Hospital Mortality in Patients of Coronavirus Disease 2019

Zou, X., Li, S., Fang, M., Hu, M., Bian, Y., Ling, J., Yu, S., Jing, L., Li, D., & Huang, J. (2020) · Critical Care Medicine · doi:10.1097/ccm.0000000000004411 · Cited by 218

IL-6 serum levels predict severity and response to tocilizumab in COVID-19: An observational study

Galván‐Román, J. M., Rodríguez-García, S. C., Roy‐Vallejo, E., Marcos‐Jiménez, A., Sánchez‐Alonso, S., Fernández-Díaz, C., Alcaraz‐Serna, A., Mateu‐Albero, T., Rodríguez-Cortés, P., Sánchez‐Cerrillo, I., et al. (2020) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.09.018 · Cited by 223

Coagulation and anticoagulation in COVID-19

Hadid, T. H., Kafri, Z., & Al-Katib, A. (2020) · Blood Reviews · doi:10.1016/j.blre.2020.100761 · Cited by 229

Machine learning approaches in COVID-19 diagnosis, mortality, and severity risk prediction: A review

Alballa, N., & Al-Turaiki, I. M. (2021) · Informatics in Medicine Unlocked · doi:10.1016/j.imu.2021.100564 · Cited by 232

Cardiac injury is associated with mortality and critically ill pneumonia in COVID-19: A meta-analysis

Santoso, A., Pranata, R., Wibowo, A., Farabi, M. J. A., Huang, I., & Antariksa, B. (2020) · The American Journal of Emergency Medicine · doi:10.1016/j.ajem.2020.04.052 · Cited by 220

Prognostic factors associated with mortality risk and disease progression in 639 critically ill patients with COVID-19 in Europe: Initial report of the international RISC-19-ICU prospective observational cohort

Wendel‐Garcia, P. D., Fumeaux, T., Guerci, P., Heuberger, D. M., Montomoli, J., Roche‐Campo, F., Schuepbach, R. A., Hilty, M. P., Alfaro-Farias, M., Margarit, A., et al. (2020) · EClinicalMedicine · doi:10.1016/j.eclinm.2020.100449 · Cited by 218

The intersection of COVID-19 and autoimmunity

Knight, J. S., Caricchio, R., Casanova, J., Combes, A. J., Diamond, B., Fox, S. E., Hanauer, D. A., James, J. A., Kanthi, Y. M., Ladd, V., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci154886 · Cited by 219

SARS-CoV-2 Infection and Cardiovascular Disease: COVID-19 Heart

Dhakal, B. P., Sweitzer, N. K., Indik, J. H., Acharya, D., & William, P. (2020) · Heart Lung and Circulation · doi:10.1016/j.hlc.2020.05.101 · Cited by 216

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2): a Systemic Infection

Synowiec, A., Szczepański, A., Barreto-Durán, E., Lie, L. K., & Pyrć, K. (2021) · Clinical Microbiology Reviews · doi:10.1128/cmr.00133-20 · Cited by 228

Colchicine in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

RECOVERY Collaborative Group, Horby, P. W., Campbell, M., Spata, E., Emberson, J., Staplin, N., Pessoa-Amorim, G., Peto, L., Wiselka, M., Wiffen, L., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00435-5 · Cited by 229

Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques

Hoang, T. N., Pino, M., Boddapati, A. K., Viox, E. G., Starke, C. E., Upadhyay, A. A., Gumber, S., Nekorchuk, M., Busman-Sahay, K., Strongin, Z., et al. (2021) · Cell · doi:10.1016/j.cell.2020.11.007 · Cited by 212

Cardiovascular Complications in Patients with COVID-19: Consequences of Viral Toxicities and Host Immune Response

Zhu, H., Rhee, J., Cheng, P. P., Waliany, S., Chang, A., Witteles, R. M., Maecker, H. T., Davis, M. M., Nguyen, P. K. P., & Wu, S. M. (2020) · Current Cardiology Reports · doi:10.1007/s11886-020-01292-3 · Cited by 211

COVID-19 as part of the hyperferritinemic syndromes: the role of iron depletion therapy

Perricone, C., Bartoloni, E., Bursi, R., Cafaro, G., Guidelli, G. M., Shoenfeld, Y., & Gerli, R. (2020) · Immunologic Research · doi:10.1007/s12026-020-09145-5 · Cited by 238

The Immune Response and Immunopathology of COVID-19

Mortaz, E., Tabarsi, P., Varahram, M., Folkerts, G., & Adcock, I. M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02037 · Cited by 210

SARS-CoV-2 in Spanish Intensive Care Units: Early experience with 15-day survival in Vitoria

Barrasa, H., Rello, J., Tejada, S., Martín, A. H. S., Balziskueta, G., Vinuesa, C., Fernández-Miret, B., Villagra, A. L. R., Vallejo, A., Sebastián, A. S., et al. (2020) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2020.04.001 · Cited by 205

Renal complications in COVID-19: a systematic review and meta-analysis

Kunutsor, S. K., & Laukkanen, J. A. (2020) · Annals of Medicine · doi:10.1080/07853890.2020.1790643 · Cited by 209

T‐cell responses and therapies against SARS‐CoV‐2 infection

Toor, S. M., Saleh, R., Nair, V. S., Taha, R. Z., & Elkord, E. (2020) · Immunology · doi:10.1111/imm.13262 · Cited by 208

JAK inhibition reduces SARS-CoV-2 liver infectivity and modulates inflammatory responses to reduce morbidity and mortality

Stebbing, J., Nievas, G. S., Falcone, M., Youhanna, S. C., Richardson, P. J., Ottaviani, S., Shen, J. X., Sommerauer, C., Tiseo, G., Ghiadoni, L., et al. (2020) · Science Advances · doi:10.1126/sciadv.abe4724 · Cited by 208

Cytokine adsorption in patients with severe COVID-19 pneumonia requiring extracorporeal membrane oxygenation (CYCOV): a single centre, open-label, randomised, controlled trial

Supady, A., Weber, E., Rieder, M., Lother, A., Niklaus, T., Zahn, T., Frech, F., Müller, S., Kuhl, M., Benk, C., et al. (2021) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(21)00177-6 · Cited by 205

Overview: Systemic Inflammatory Response Derived From Lung Injury Caused by SARS-CoV-2 Infection Explains Severe Outcomes in COVID-19

Polidoro, R. B., Hagan, R. S., Santiago, R. R. D. S., & Schmidt, N. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01626 · Cited by 208

Systematic review of the prevalence of current smoking among hospitalized COVID-19 patients in China: could nicotine be a therapeutic option? Reply

Farsalinos, K. E., Barbouni, A., & NIAURA, R. S. (2020) · Internal and Emergency Medicine · doi:10.1007/s11739-020-02457-2 · Cited by 206

GM-CSF blockade with mavrilimumab in severe COVID-19 pneumonia and systemic hyperinflammation: a single-centre, prospective cohort study

De Luca, G., Cavalli, G., Campochiaro, C., Della-Torre, E., Angelillo, P., Tomelleri, A., Boffini, N., Tentori, S., Mette, F., Farina, N., et al. (2020) · The Lancet Rheumatology · doi:10.1016/s2665-9913(20)30170-3 · Cited by 202

The association between international and domestic air traffic and the coronavirus (COVID-19) outbreak

Lau, H., Khosrawipour, V., Kocbach, P., Mikołajczyk, A., Ichii, H., Zacharski, M., Bania, J., & Khosrawipour, T. (2020) · Journal of Microbiology Immunology and Infection · doi:10.1016/j.jmii.2020.03.026 · Cited by 203

Diet Supplementation, Probiotics, and Nutraceuticals in SARS-CoV-2 Infection: A Scoping Review

Infusino, F., Marazzato, M., Mancone, M., Fedele, F., Mastroianni, C. M., Severino, P., Ceccarelli, G., Santinelli, L., Cavarretta, E., Marullo, A. G. M., et al. (2020) · Nutrients · doi:10.3390/nu12061718 · Cited by 205

Epidemiological characteristics of COVID-19: a systematic review and meta-analysis

Khalili, M., Karamouzian, M., Nasiri, N., Javadi, S., Mirzazadeh, A., & Sharifi, H. P. (2020) · Epidemiology and Infection · doi:10.1017/s0950268820001430 · Cited by 200

Cytokine storm syndrome in coronavirus disease 2019: A narrative review

Gao, Y.-M., Xu, G., Wang, B., & Liu, B. (2020) · Journal of Internal Medicine · doi:10.1111/joim.13144 · Cited by 204

Viral Dynamics and Immune Correlates of Coronavirus Disease 2019 (COVID-19) Severity

Young, B. E., Ong, S. W. X., Ng, L. F. P., Anderson, D. E., Chia, W. N., Chia, P. Y., Ang, L. W., Mak, T. M., Kalimuddin, S., Chai, L. Y. A., et al. (2020) · Clinical Infectious Diseases · doi:10.1093/cid/ciaa1280 · Cited by 202

COVID-19 and myocarditis: a systematic review and overview of current challenges

Castiello, T., Georgiopoulos, G. A., Finocchiaro, G., Claudia, M., Gianatti, A., Delialis, D., Aimo, A., & Prasad, S. K. (2021) · Heart Failure Reviews · doi:10.1007/s10741-021-10087-9 · Cited by 211

Off-label use of tocilizumab for the treatment of SARS-CoV-2 pneumonia in Milan, Italy

Morena, V., Milazzo, L., Oreni, L. M., Bestetti, G., Fossali, T., Bassoli, C. R., Torre, A., Cossu, M. V., Minari, C., Ballone, E., et al. (2020) · European Journal of Internal Medicine · doi:10.1016/j.ejim.2020.05.011 · Cited by 204

Genetics Insight for COVID-19 Susceptibility and Severity: A Review

Fricke-Galindo, I., & Falfán‐Valencia, R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.622176 · Cited by 200

Leukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19

Alon, R., Sportiello, M., Kozlovski, S., Kumar, A., Reilly, E. C., Zarbock, A., Garbi, N., & Topham, D. J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00470-2 · Cited by 197

Uncontrolled Innate and Impaired Adaptive Immune Responses in Patients with COVID-19 Acute Respiratory Distress Syndrome

Hüe, S., Beldi‐Ferchiou, A., Bendib, I., Surénaud, M., Fourati, S., Frapard, T., Rivoal, S., Razazi, K., Carteaux, G., Delfau‐Larue, M., et al. (2020) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.202005-1885oc · Cited by 198

The impact of 2019 novel coronavirus on heart injury: A Systematic review and Meta-analysis

Li, J.-W., Han, T., Woodward, M., Anderson, C. S., Zhou, H., Chen, Y.-D., & Neal, B. C. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.04.008 · Cited by 193

Acute myocardial injury is common in patients with COVID-19 and impairs their prognosis

Wei, J., Huang, F., Xiong, T., Liu, Q., Chen, H., Wang, H., Huang, H., Luo, Y.-C., Zhou, X., Liu, Z., et al. (2020) · Heart · doi:10.1136/heartjnl-2020-317007 · Cited by 192

Clinical manifestation and disease progression in COVID-19 infection

Tsai, P., Lai, W.-Y., Lin, Y.-Y., Luo, Y., Lin, Y.-T., Chen, H.-K., Chen, Y.-M., Lai, Y.-C., Kuo, L.-C., Chen, S.-D., et al. (2020) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000463 · Cited by 200

The Impact of Pre-existing Comorbidities and Therapeutic Interventions on COVID-19

Callender, L. A., Curran, M., Bates, S. M., Mairesse, M., Weigandt, J., & Betts, C. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01991 · Cited by 195

Integrating deep learning CT-scan model, biological and clinical variables to predict severity of COVID-19 patients

Lassau, N., Ammari, S., Chouzenoux, É., Gortais, H., Hérent, P., Devilder, M., Soliman, S., Meyrignac, O., Talabard, M.-P., Lamarque, J.-P., et al. (2021) · Nature Communications · doi:10.1038/s41467-020-20657-4 · Cited by 187

Immuno-proteomic profiling reveals aberrant immune cell regulation in the airways of individuals with ongoing post-COVID-19 respiratory disease

Vijayakumar, B., Boustani, K., Ogger, P. P., Papadaki, A., Tonkin, J., Orton, C. M., Ghai, P., Suveizdytė, K., Hewitt, R. J., Desai, S. R., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.01.017 · Cited by 188

Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis

Aggarwal, G., Cheruiyot, I., Aggarwal, S., Wong, J., Lippi, G., Lavie, C. J., Henry, B. M., & Sanchis‐Gomar, F. (2020) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2020.100617 · Cited by 189

Early Predictors of Clinical Deterioration in a Cohort of 239 Patients Hospitalized for Covid-19 Infection in Lombardy, Italy

Cecconi, M., Piovani, D., Brunetta, E., Aghemo, A., Greco, M., Ciccarelli, M., Angelini, C., Voza, A., Omodei, P., Vespa, E., et al. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9051548 · Cited by 194

Molecular, serological, and biochemical diagnosis and monitoring of COVID-19: IFCC taskforce evaluation of the latest evidence

Bohn, M. K., Lippi, G., Horvath, A. R., Sethi, S. K., Koch, D. D., Ferrari, M., Wang, C.-B., Mancini, N., Steele, S., & Adeli, K. (2020) · Clinical Chemistry and Laboratory Medicine (CCLM) · doi:10.1515/cclm-2020-0722 · Cited by 190

Extrapulmonary complications of COVID‐19: A multisystem disease?

Zheng, K. I., Feng, G., Liu, W., Targher, G., Byrne, C. D., & Zheng, M. (2020) · Journal of Medical Virology · doi:10.1002/jmv.26294 · Cited by 188

COVID-19 in the heart and the lungs: could we “Notch” the inflammatory storm?

Rizzo, P., Sega, F. V. D., Fortini, F., Marracino, L., Rapezzi, C., & Ferrari, R. (2020) · Basic Research in Cardiology · doi:10.1007/s00395-020-0791-5 · Cited by 190

Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment

Hrusak, O., Kalina, T., Wolf, J., Balduzzi, A., Provenzi, M., Rizzari, C., Rives, S., del Pozo Carlavilla, M., Alonso, M. E. V., Domínguez-Pinilla, N., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2020.03.021 · Cited by 187

Selective CD8 cell reduction by SARS-CoV-2 is associated with a worse prognosis and systemic inflammation in COVID-19 patients

Urra, J. M., Cabrera, C. M., Porras, L., & Ródenas, I. (2020) · Clinical Immunology · doi:10.1016/j.clim.2020.108486 · Cited by 187

COVID-19 mortality risk assessment: An international multi-center study

Bertsimas, D., Lukin, G., Mingardi, L., Nohadani, O., Orfanoudaki, A., Stellato, B., Wiberg, H., González-García, S., Parra-Calderón, C. L., Robinson, K. J., et al. (2020) · PLoS ONE · doi:10.1371/journal.pone.0243262 · Cited by 187

Clinical characteristics and outcomes of critically ill patients with novel coronavirus infectious disease (COVID-19) in China: a retrospective multicenter study

Xie, J., Wu, W., Li, S., Hu, Y., Hu, M., Li, J., Yang, Y., Huang, T., Zheng, K. C., Wang, Y., et al. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06211-2 · Cited by 187

Alternative Pathways of IL-1 Activation, and Its Role in Health and Disease

Pyrillou, K., Burzynski, L. C., & Clarke, M. C. H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.613170 · Cited by 202

Performance of pneumonia severity index and CURB-65 in predicting 30-day mortality in patients with COVID-19

Satıcı, C., Demirkol, M. A., Altunok, E. S., Gürsoy, B., Alkan, M., Kamat, S., Demirok, B., Sürmeli, C. D., Çalık, M., Çavuş, Z., et al. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.06.038 · Cited by 185

Epidemiological and clinical features of 2019 novel coronavirus diseases (COVID-19) in the South of Iran

Shahriarirad, R., Khodamoradi, Z., Erfani, A., Hosseinpour, H., Ranjbar, K., Emami, Y., Mirahmadizadeh, A., Lotfi, M., Yeganeh, B. S., Nejad, A. D., et al. (2020) · BMC Infectious Diseases · doi:10.1186/s12879-020-05128-x · Cited by 178

Radiographic severity index in COVID-19 pneumonia: relationship to age and sex in 783 Italian patients

Borghesi, A., Zigliani, A., Masciullo, R., Golemi, S., Maculotti, P., Farina, D., & Maroldi, R. (2020) · La radiologia medica · doi:10.1007/s11547-020-01202-1 · Cited by 183

Mechanism of inflammatory response in associated comorbidities in COVID-19

de Lucena, T. M. C., Santos, A. F. D. S., de Lima, B. R., Borborema, M. E. D. A., & Silva, J. D. A. (2020) · Diabetes & Metabolic Syndrome Clinical Research & Reviews · doi:10.1016/j.dsx.2020.05.025 · Cited by 186

Controlling Cytokine Storm Is Vital in COVID-19

Tang, L., Yin, Z., Hu, Y., & Mei, H. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.570993 · Cited by 183

Diabetes increases the mortality of patients with COVID-19: a meta-analysis

Wu, Z., Tang, Y., & Cheng, Q. (2020) · Acta Diabetologica · doi:10.1007/s00592-020-01546-0 · Cited by 183

Efficacy of glutathione therapy in relieving dyspnea associated with COVID-19 pneumonia: A report of 2 cases

Horowitz, R. I., Freeman, P. R., & Bruzzese, J. (2020) · Respiratory Medicine Case Reports · doi:10.1016/j.rmcr.2020.101063 · Cited by 184

Antimicrobial Resistance Threats in the emerging COVID-19 pandemic: Where do we stand?

Ghosh, S. B., Bornman, C., & Zafer, M. M. (2021) · Journal of Infection and Public Health · doi:10.1016/j.jiph.2021.02.011 · Cited by 182

Inflamm-aging: Why older men are the most susceptible to SARS-CoV-2 complicated outcomes

Bonafè, M., Prattichizzo, F., Giuliani, A., Storci, G., Sabbatinelli, J., & Olivieri, F. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.04.005 · Cited by 184

The Relationship of COVID-19 Severity with Cardiovascular Disease and Its Traditional Risk Factors: A Systematic Review and Meta-Analysis

Matsushita, K., Ding, N., Kou, M., Hu, X. F., Chen, M., Gao, Y., Honda, Y., Zhao, D., Dowdy, D. W., Mok, Y., et al. (2020) · Global Heart · doi:10.5334/gh.814 · Cited by 180

Risk Factors for Mortality in 244 Older Adults With COVID ‐19 in Wuhan, China: A Retrospective Study

Sun, H., Ning, R., Tao, Y., Yu, C., Deng, X., Zhao, C., Meng, S., Tang, F., & Xu, D. (2020) · Journal of the American Geriatrics Society · doi:10.1111/jgs.16533 · Cited by 179

Psychotic symptoms in COVID-19 patients. A retrospective descriptive study

Parra, A., de Juanes, A., Losada, C. P., Álvarez-Sesmero, S., Santana, V., Martí, I., Urricelqui, J., & Rentero, D. (2020) · Psychiatry Research · doi:10.1016/j.psychres.2020.113254 · Cited by 187

Rationale and evidence on the use of tocilizumab in COVID-19: a systematic review

Cortegiani, A., Ippolito, M., Greco, M., Granone, V., Protti, A., Gregoretti, C., Giarratano, A., Einav, S., & Cecconi, M. (2020) · Pulmonology · doi:10.1016/j.pulmoe.2020.07.003 · Cited by 179

The role of high cholesterol in SARS-CoV-2 infectivity

Wang, H., Yuan, Z., Pavel, M. A., Jablonski, S. M., Jablonski, J. A., Hobson, R. J., Valente, S. T., Reddy, C. B., & Hansen, S. B. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.104763 · Cited by 178

Relative Lymphocytosis in COVID-19—A Ray of Hope

Ish, P., Malhotra, N., Agrawal, S. P., & Gupta, N. (2020) · Advances in respiratory medicine · doi:10.5603/arm.a2020.0098 · Cited by 11

15-day mortality and associated risk factors for hospitalized patients with COVID-19 in Wuhan, China: an ambispective observational cohort study

Wang, K., Zhang, Z., Yu, M., Tao, Y., & Xie, M. (2020) · Intensive Care Medicine · doi:10.1007/s00134-020-06047-w · Cited by 87

Short Term Outcomes and Risk Factors for Mortality in Patients with COVID-19 in Wuhan, China: A Retrospective StudyPreprint

Zhang, S., Guo, M., Duan, L., Wu, F., Wang, Z., Xu, J., Ma, Y., Lv, Z., Tan, X., Zhang, S., et al. (2020) · SSRN Electronic Journal · doi:10.2139/ssrn.3551390 · Cited by 8

“Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.” Rong-Hui Du, Li-Rong Liang, Cheng-Qing Yang, Wen Wang, Tan-Ze Cao, Ming Li, Guang-Yun Guo, Juan Du, Chun-Lan Zheng, Qi Zhu, Ming Hu, Xu-Yan Li, Peng Peng and Huan-Zhong Shi. Eur Respir J 2020; 55: 2000524.

European Respiratory Society (2020) · European Respiratory Journal · doi:10.1183/13993003.50524-2020 · Cited by 18

Clinical prediction model for mortality of adult diabetes inpatients with COVID-19 in Wuhan, China: A retrospective pilot study

Su, M., Yuan, J., Peng, J., Wu, M., Yang, Y., & Peng, Y. (2020) · Journal of Clinical Anesthesia · doi:10.1016/j.jclinane.2020.109927 · Cited by 5