A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank

He, Dan; Liu, Huan; Wei, Wenming; Zhao, Yijing; Cai, Qingqing; Shi, Sirong; Chu, Xiaoge; Qin, Xiaoyue; Zhang, Na; Xu, Peng; Zhang, Feng

doi:10.1007/s00198-023-06852-1

A longitudinal genome-wide association study of bone mineral density mean and variability in the UK Biobank

Bone mineral density (BMD) is an essential predictor of osteoporosis and fracture. We conducted a genome-wide trajectory analysis of BMD and analyzed the BMD change. Purpose This study aimed to identify the genetic architecture and potential biomarkers of BMD. Methods Our analysis included 141,26…