Molecular identification and evolution of the cyclic peptide hepatotoxins, microcystin and nodularin, synthetase genes in three orders of cyanobacteria

CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice

Thompson, J. D., Higgins, D. G., & Gibson, T. J. (1994) · Nucleic Acids Research · doi:10.1093/nar/22.22.4673 · Cited by 64,617 · see citing works

PHYLIP-Phylogeny inference package (Version 3.2)

Felsenstein, J. (1989) · Cladistics · Cited by 17,848 · see citing works

Cases in which Parsimony or Compatibility Methods Will be Positively Misleading

Felsenstein, J. (1978) · Systematic Biology · doi:10.1093/sysbio/27.4.401 · Cited by 3,221 · see citing works

Toxic Cyanobacteria in Water

Bartram, J., & Chorus, I. (1999) · CRC Press eBooks · doi:10.1201/9781482295061 · Cited by 2,581 · see citing works

Toxic cyanobacteria in water. A guide to their public health consequences, monitoring, and management

Christoffersen, K., & Kaas, H. (2000) · Limnology and Oceanography · doi:10.4319/lo.2000.45.5.1212 · Cited by 2,067 · see citing works

Toxic Cyanobacteria in Water

(1999) · Taylor & Francis eBooks · doi:10.4324/9780203478073 · Cited by 1,556 · see citing works

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system

Tillett, D., Dittmann, E., Erhard, M., von Döhren, H., Börner, T., & Neilan, B. A. (2000) · Chemistry & Biology · doi:10.1016/s1074-5521(00)00021-1 · Cited by 996 · see citing works

Health Effects of Toxin-Producing Cyanobacteria: “The CyanoHABs”

Carmichael, W. W. (2001) · Human and Ecological Risk Assessment An International Journal · doi:10.1080/20018091095087 · Cited by 991 · see citing works

THE CULTURE COLLEVTION OF ALGAE AT THE UNIVERSITY OF TEXAS ATAUSTIN123

Starr, R. C. (1978) · Journal of Phycology · doi:10.1111/j.1529-8817.1978.tb02507.x · Cited by 832 · see citing works

UTEX—THE CULTURE COLLECTION OF ALGAE AT THE UNIVERSITY OF TEXAS AT AUSTIN 1993 LIST OF CULTURES 1

Starr, R. C., & Zeikus, J. A. (1993) · Journal of Phycology · doi:10.1111/j.0022-3646.1993.00001.x · Cited by 743 · see citing works

Phylogenetic evidence for the early evolution of microcystin synthesis

Ylinen, A., Fewer, D. P., Hisbergues, M., Rouhiainen, L., Vaitomaa, J., Börner, T., & Sivonen, K. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0304489101 · Cited by 553 · see citing works

Cyanobacterial toxins, exposure routes and human health

Codd, G. A., Bell, S. G., Kaya, K., et al. (1999) · European Journal of Phycology · doi:10.1080/09670269910001736462 · Cited by 542 · see citing works

Use of a colorimetric protein phosphatase inhibition assay and enzyme linked immunosorbent assay for the study of microcystins and nodularins

An, J., & Carmichael, W. W. (1994) · Toxicon · doi:10.1016/0041-0101(94)90308-5 · Cited by 477 · see citing works

Cyanobacterial toxins: removal during drinking water treatment, and human risk assessment.

Hitzfeld, B., Höger, S., & Dietrich, D. R. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108s1113 · Cited by 438 · see citing works

Microcystin Biosynthesis in Planktothrix : Genes, Evolution, and Manipulation

Christiansen, G., Fastner, J., Erhard, M., Börner, T., & Dittmann, E. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.2.564-572.2003 · Cited by 374 · see citing works

Effects of light, temperature, nitrate, orthophosphate, and bacteria on growth of and hepatotoxin production by Oscillatoria agardhii strains

Sivonen, K. (1990) · Applied and Environmental Microbiology · doi:10.1128/aem.56.9.2658-2666.1990 · Cited by 365 · see citing works

HUMAN HEALTH ASPECTS

Bartram, J., & Chorus, I. (1999) · CRC Press eBooks · doi:10.1201/9781482295061-10 · Cited by 347 · see citing works

Quantitative Real-Time PCR for Determination ofMicrocystin Synthetase E Copy Numbers for Microcystis and Anabaena inLakes

Vaitomaa, J., Ylinen, A., Halinen, K., et al. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.12.7289-7297.2003 · Cited by 329 · see citing works

Ecological and molecular investigations of cyanotoxin production

Kaebernick, M., & Neilan, B. A. (2001) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2001.tb00782.x · Cited by 323 · see citing works

Nonribosomal Peptide Synthesis and Toxigenicity of Cyanobacteria

Neilan, B. A., Dittmann, E., Rouhiainen, L., et al. (1999) · Journal of Bacteriology · doi:10.1128/jb.181.13.4089-4097.1999 · Cited by 307 · see citing works

The mycosubtilin synthetase of Bacillus subtilis ATCC6633: A multifunctional hybrid between a peptide synthetase, an amino transferase, and a fatty acid synthase

Duitman, E. H., Hamoen, L. W., Rembold, M., Venema, G., Seitz, H., Saenger, W., Bernhard, F., Reinhardt, R., Schmidt, M., Ullrich, C., et al. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13294 · Cited by 285 · see citing works

PCR-based identification of microcystin-producing genotypes of different cyanobacterial genera

Hisbergues, M., Christiansen, G., Rouhiainen, L., Sivonen, K., & Börner, T. (2003) · Archives of Microbiology · doi:10.1007/s00203-003-0605-9 · Cited by 283 · see citing works

Application of Real-Time PCR for Quantification of Microcystin Genotypes in a Population of the Toxic Cyanobacterium Microcystis sp

Kurmayer, R., & Kutzenberger, T. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.11.6723-6730.2003 · Cited by 274 · see citing works

Characterization of the Nodularin Synthetase Gene Cluster and Proposed Theory of the Evolution of Cyanobacterial Hepatotoxins

Moffitt, M. C., & Neilan, B. A. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.11.6353-6362.2004 · Cited by 273 · see citing works

The Water Environment: Algal Toxins And Health

Carmichael, W. W. (2011) · Medical Entomology and Zoology · Cited by 272 · see citing works

Genes Coding for Hepatotoxic Heptapeptides (Microcystins) in the Cyanobacterium Anabaena Strain 90

Rouhiainen, L., Vakkilainen, T., Siemer, B. L., et al. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.2.686-692.2004 · Cited by 266 · see citing works

Detection of Toxigenicity by a Probe for the Microcystin Synthetase A Gene ( mcyA) of the Cyanobacterial Genus Microcystis : Comparison of Toxicities with 16S rRNA and Phycocyanin Operon (Phycocyanin Intergenic Spacer) Phylogenies

Tillett, D., Parker, D. L., & Neilan, B. A. (2001) · Applied and Environmental Microbiology · doi:10.1128/aem.67.6.2810-2818.2001 · Cited by 264 · see citing works

Isolation and toxicity of Cylindrospermopsis raciborskii from an ornamental lake

Hawkins, P. R., Chandrasena, N. R., Jones, G. J., et al. (1997) · Toxicon · doi:10.1016/s0041-0101(96)00185-7 · Cited by 263 · see citing works

Molecular characterization of planktic cyanobacteria of Anabaena, Aphanizomenon, Microcystis and Planktothrix genera.

Lyra, C., Suomalainen, S., Gugger, M. F., Vézie, C., Sundman, P., Paulin, L. G., & Sivonen, K. (2001) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-51-2-513 · Cited by 257 · see citing works

Polyketide Synthase Gene Coupled to the Peptide Synthetase Module Involved in the Biosynthesis of the Cyclic Heptapeptide Microcystin

Nishizawa, T., Ueda, A., Asayama, M., Fujii, K., Harada, K., Ochi, K., & Shirai, M. (2000) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a022670 · Cited by 257 · see citing works

Natural Variation in the Microcystin Synthetase Operon mcyABC and Impact on Microcystin Production in Microcystis Strains

Mikalsen, B., Boison, G., Skulberg, O. M., et al. (2003) · Journal of Bacteriology · doi:10.1128/jb.185.9.2774-2785.2003 · Cited by 241 · see citing works

Microbial diversity of extant stromatolites in the hypersaline marine environment of Shark Bay, Australia

Burns, B. P., Goh, F. Q. Y., Allen, M. A., & Neilan, B. A. (2004) · Environmental Microbiology · doi:10.1111/j.1462-2920.2004.00651.x · Cited by 218 · see citing works

Abundance of active and inactive microcystin genotypes in populations of the toxic cyanobacterium Planktothrix spp.

Kurmayer, R., Christiansen, G., Fastner, J., et al. (2004) · Environmental Microbiology · doi:10.1111/j.1462-2920.2004.00626.x · Cited by 213 · see citing works

Discovery of Rare and Highly Toxic Microcystins from Lichen-Associated Cyanobacterium Nostoc sp. Strain IO-102-I

Oksanen, I., Jokela, J. K., Fewer, D. P., et al. (2004) · Applied and Environmental Microbiology · doi:10.1128/aem.70.10.5756-5763.2004 · Cited by 156 · see citing works

Benthic cyanobacteria (Oscillatoriaceae) that produce microcystin-LR, isolated from four reservoirs in southern California

Izaguirre, G., Jungblut, A., & Neilan, B. A. (2006) · Water Research · doi:10.1016/j.watres.2006.10.012 · Cited by 152 · see citing works

Determination of cyanobacterial hepatotoxins directly in water using a protein phosphatase inhibition assay

Heresztyn, T. (2001) · Water Research · doi:10.1016/s0043-1354(01)00018-5 · Cited by 141 · see citing works

Enzyme-Linked Immunosorbent Assay for Microcystins in Blue-Green Algal Blooms

Chu, F. S., Huang, X., & Wei, R. D. (1990) · Journal of AOAC INTERNATIONAL · doi:10.1093/jaoac/73.3.451 · Cited by 133 · see citing works

Three new microcystins, cyclic heptapeptide hepatotoxins, from Nostoc sp. strain 152

Sivonen, K., Namikoshi, M., Evans, W., et al. (1992) · Chemical Research in Toxicology · doi:10.1021/tx00028a003 · Cited by 131 · see citing works

TWO MORPHOLOGICAL FORMS OF CYLINDROSPERMOPSIS RACIBORSKII (CYANOBACTERIA) ISOLATED FROM SOLOMON DAM, PALM ISLAND, QUEENSLAND

Saker, M. L., Neilan, B. A., & GRIFFITHS, D. J. (1999) · Journal of Phycology · doi:10.1046/j.1529-8817.1999.3530599.x · Cited by 121 · see citing works

Monitoring Changing Toxigenicity of a Cyanobacterial Bloom by Molecular Methods

Baker, J. A., Entsch, B., Neilan, B. A., et al. (2002) · Applied and Environmental Microbiology · doi:10.1128/aem.68.12.6070-6076.2002 · Cited by 117 · see citing works

The effects of incubation time, temperature, light, salinity, and phosphorus on growth and hepatotoxin production by Nodularia strains

Lehtimäki, J., Sivonen, K., Luukkainen, R., et al. (1994) · Archiv für Hydrobiologie · doi:10.1127/archiv-hydrobiol/130/1994/269 · Cited by 114 · see citing works

GENETIC, MORPHOLOGICAL, AND TOXICOLOGICAL VARIATION AMONG GLOBALLY DISTRIBUTED STRAINS OF NODULARIA (CYANOBACTERIA)

Bolch, C. J. S., Orr, P. T., Jones, G. J., et al. (1999) · Journal of Phycology · doi:10.1046/j.1529-8817.1999.3520339.x · Cited by 111 · see citing works

On the presence of peptide synthetase and polyketide synthase genes in the cyanobacterial genusNodularia

Moffitt, M. C., & Neilan, B. A. (2001) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.2001.tb10566.x · Cited by 105 · see citing works

Presence of Planktothrix sp. and cyanobacterial toxins in Lake Ammersee, Germany and their impact on whitefish (Coregonus lavaretus L.)

Ernst, B., Hitzfeld, B., & Dietrich, D. R. (2001) · Environmental Toxicology · doi:10.1002/tox.10006 · Cited by 105 · see citing works

Anatoxin‐a toxin in the cyanobacterium Planktothrix rubescens from a fishing pond in northern Italy

Viaggiu, E., Melchiorre, S., Volpi, F., et al. (2004) · Environmental Toxicology · doi:10.1002/tox.20011 · Cited by 103 · see citing works

The cyanobacterium Nodularia PCC 7804, of freshwater origin, produces [L-Har2]nodularin

Beattie, K. A., Kaya, K., & Codd, G. A. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00045-5 · Cited by 85 · see citing works

Detection of hepatotoxic Microcystis strains by PCR with intact cells from both culture and environmental samples

Pan, H., Song, L., Liu, Y., et al. (2002) · Archives of Microbiology · doi:10.1007/s00203-002-0464-9 · Cited by 74 · see citing works

Microcystin-la from a blue-green alga belonging to the stigonematales

Prinsep, M. R., Caplan, F. R., Moore, R. E., et al. (1992) · Phytochemistry · doi:10.1016/0031-9422(92)80269-k · Cited by 71 · see citing works

Molecular Identification of Cyanobacteria Associated with Stromatolites from Distinct Geographical Locations

Neilan, B. A., Burns, B. P., Relman, D. A., & Lowe, D. R. (2002) · Astrobiology · doi:10.1089/153110702762027853 · Cited by 64 · see citing works

PROPERTIES OF MICROCYSTIS AERUGINOSA AND M. FLOS‐AQUAE (CYANOPHYTA) IN CULTURE: TAXONOMIC IMPLICATIONS1

Doers, M. P., & Parker, D. L. (1988) · Journal of Phycology · doi:10.1111/j.1529-8817.1988.tb04254.x · Cited by 61 · see citing works

Aerobic nitrogen fixation in pure cultures of a benthic marineOscillatoria(cyanobacteria)

Stal, L. J., & Krumbein, W. E. (1981) · FEMS Microbiology Letters · doi:10.1111/j.1574-6968.1981.tb06983.x · Cited by 60 · see citing works

Biosynthesis of Cyanobacterial Tetrapyrrole Pigments: Hemes, Chlorophylls, and Phycobilins

Beale, S. I. (1994) · Springer eBooks · doi:10.1007/978-94-011-0227-8_17 · Cited by 59 · see citing works

Geographical patterns of occurrence and composition of saxitoxins in the cyanobacterial genus Anabaena (Nostocales, Cyanophyta) in Australia

Velzeboer, R. M. A., Baker, P., Rositano, J., et al. (2000) · Phycologia · doi:10.2216/i0031-8884-39-5-395.1 · Cited by 57 · see citing works

Radioreceptor Assays for Sensitive Detection and Quantitation of Saxitoxin and Its Analogues from Strains of the Freshwater Cyanobacterium, Anabaena circinalis

Llewellyn, L. E., Negri, A. P., Doyle, J. R., et al. (2001) · Environmental Science & Technology · doi:10.1021/es001575z · Cited by 54 · see citing works

Performance characteristics of reversed-phase bonded silica cartridges for serum bile acid extraction

Rodrigues, C. M. P., & Setchell, K. D. R. (1996) · Biomedical Chromatography · doi:10.1002/(sici)1099-0801(199601)10:1 · Cited by 32 · see citing works

Toxicological Studies on Microcystis

Eloff, J. N., & van der Westhuizen, A. J. (1981) · Springer eBooks · doi:10.1007/978-1-4613-3267-1_25 · Cited by 29 · see citing works

Detection and identification of cyanobacteria associated with toxic blooms: DNA amplification protocols

Neilan, B. A. (1996) · Phycologia · doi:10.2216/i0031-8884-35-6s-147.1 · Cited by 25 · see citing works

The purine degradation pathway

Pomati, F., Manarolla, G., Rossi, O., et al. (2001) · Environment International · doi:10.1016/s0160-4120(01)00101-5 · Cited by 19 · see citing works

Molecular Detection of Genes Responsible for Cyanobacterial Toxin Production in the Genera Microcystis, Nodularia, and Cylindrospermopsis

Burns, B. P., Saker, M. L., Moffitt, M. C., et al. (2004) · Humana Press eBooks · doi:10.1385/1-59259-766-1:213 · Cited by 17 · see citing works

Hepatocarcinogenesis in Female Sprague-Dawley Rats following Discontinuous Treatment with 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Walker, N. J. (2000) · Toxicological Sciences · doi:10.1093/toxsci/54.2.330 · Cited by 16 · see citing works

The promising future of microalgae: Current status, challenges, and optimization of a sustainable and renewable industry for biofuels, feed, and other products

Khan, M. I., Shin, J. H., & Kim, J. D. (2018) · Microbial Cell Factories · doi:10.1186/s12934-018-0879-x · Cited by 2,082 · see citing works

Methods for determining microcystins (peptide hepatotoxins) and microcystin-producing cyanobacteria

Sangolkar, L. N., Maske, S. S., & Chakrabarti, T. (2006) · Water Research · doi:10.1016/j.watres.2006.08.010 · Cited by 132 · see citing works

The first report about the presence of cyanobacterial toxins in Polish lakes.

Kabziński, A. K. M., Juszczak, R., Miękoś, E., et al. (2000) · Cited by 19 · see citing works

Isolation and Characterization of Microcystins, Cyclic Heptapeptide Hepatotoxins from a Lake Erie Strain of Microcystis aeruginosa

Brittain, S. M., Wang, J., Babcock-Jackson, L., et al. (2000) · Journal of Great Lakes Research · doi:10.1016/s0380-1330(00)70690-3 · Cited by 145 · see citing works

A new quantitative PCR assay for the detection of hepatotoxigenic cyanobacteria

Al-Tebrineh, J., Gehringer, M. M., Akçaalan, R., et al. (2010) · Toxicon · doi:10.1016/j.toxicon.2010.12.018 · Cited by 74 · see citing works

Quantitative Real-Time PCR for Determination ofMicrocystin Synthetase E Copy Numbers for Microcystis and Anabaena inLakes

Vaitomaa, J., Ylinen, A., Halinen, K., et al. (2003) · Applied and Environmental Microbiology · doi:10.1128/aem.69.12.7289-7297.2003 · Cited by 329 · see citing works