Cited by 196Effects and risks of endocrine disrupting chemicalsPesticide Exposure and ToxicitySperm and Testicular Function

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Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression

Romano, Marco Aurelio, Romano, Renata Marino, Santos, Luciana Dalazen, Wisniewski, Patricia, Campos, Daniele Antonelo, de Souza, Paula Bargi, Viau, Priscila, Bernardi, Maria Martha, Nunes, Maria Tereza, de Oliveira, Claudio Alvarenga·2012·Archives of Toxicology

DOI 10.1007/s00204-011-0788-9

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Abstract

Sexual differentiation in the brain takes place from late gestation to the early postnatal days. This is dependent on the conversion of circulating testosterone into estradiol by the enzyme aromatase. The glyphosate was shown to alter aromatase activity and decrease serum testosterone concentrations. Thus, the aim of this study was to investigate the effect of gestational maternal glyphosate exposure (50 mg/kg, NOAEL for reproductive toxicity) on the reproductive development of male offspring. Sixty-day-old male rat offspring were evaluated for sexual behavior and partner preference; serum testosterone concentrations, estradiol, FSH and LH; the mRNA and protein content of LH and FSH; sperm production and the morphology of the seminiferous epithelium; and the weight of the testes, epididymis and seminal vesicles. The growth, the weight and age at puberty of the animals were also recorded to evaluate the effect of the treatment. The most important findings were increases in sexual partner preference scores and the latency time to the first mount; testosterone and estradiol serum concentrations; the mRNA expression and protein content in the pituitary gland and the serum concentration of LH; sperm production and reserves; and the height of the germinal epithelium of seminiferous tubules. We also observed an early onset of puberty but no effect on the body growth in these animals. These results suggest that maternal exposure to glyphosate disturbed the masculinization process and promoted behavioral changes and histological and endocrine problems in reproductive parameters. These changes associated with the hypersecretion of androgens increased gonadal activity and sperm production.

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Authors: Romano, M. A., Romano, R. M., Santos, L. D., Wisniewski, P., Campos, D. A., de Souza, P. B., Viau, P., Bernardi, M. M., Nunes, M. T., & de Oliveira, C. A.
Affiliations: Universidade de São Paulo (BR)
Universidade Estadual do Centro-Oeste (BR)
ORCID: Romano, Renata Marino
Santos, Luciana Dalazen
Bernardi, Maria Martha
Nunes, Maria Tereza
Venue: Archives of Toxicology
Publisher: Springer Science and Business Media LLC
Published: 2011-11-26
Volume: 86
Issue: 4
Pages: 663-673
ISSN: 0340-5761 (ISSN-L)
1432-0738
DOI: 10.1007/s00204-011-0788-9
OpenAlex: W2032234709
Semantic Scholar: 88db08f59552be68f6728f8dc2bc605721c9715f
Cited by: 196
References: 61
Citations by year: 2026: 5 · 2025: 7 · 2024: 11 · 2023: 12 · 2022: 13 · 2021: 20 · 2020: 34 · 2019: 21 · 2018: 15 · 2017: 7 · 2016: 14 · 2015: 9 · 2014: 12 · 2013: 8 · 2012: 7
FWCI: 6.48
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Archives of Toxicology (publishedVersion)
PubMed (publishedVersion)
Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) (publishedVersion)
Funders: Conselho Nacional de Desenvolvimento Científico e Tecnológico
National Institutes of Health
Topics: Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Pesticide Exposure and Toxicity
Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
Keywords: glyphosate, prenatal exposure, male reproductive development, gonadotropins, luteinizing hormone, follicle-stimulating hormone, aromatase, testosterone, estradiol, sexual behavior, mate preferences, masculinization, puberty onset, spermatogenesis, seminiferous epithelium, reproductive toxicity, endocrine disruption
MeSH terms: Glyphosate, Animals, Brain, Estradiol, Female, Glycine, Gonadotropins, Pituitary, Herbicides, Luteinizing Hormone, Male, Pituitary Gland, Pregnancy, Prenatal Exposure Delayed Effects, Reproduction, RNA, Messenger, Seminiferous Epithelium, Sexual Maturation, Spermatogenesis, Testosterone, Gene Expression Regulation, Developmental, Maternal Exposure, Rats, Mating Preference, Animal

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Glyphosate impairs male offspring reproductive development by disrupting gonadotropin expression

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