The DOI matches its Crossref record.
How much nicotine kills a human? Tracing back the generally accepted lethal dose to dubious self-experiments in the nineteenth century
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Mayer [43] suggesting that the lower limit causing fatal outcomes is 6.5–13 mg kg−1 orally.”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [43]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
No references could be resolved yet.
Research works printed but not linked: 21
- Corkery JM, Button J, Vento AE, Schifano F (2010) Two UK suicides using nicotine extracted from tobacco employing instructions available on the Internet. Forensic Sci Int 199:e9–e13 · DOI
- Esser A, Kühn A (1933) Nikotin-vergiftungen, akute. Arch Toxicol 4:C29–C36 · DOI
- Gourlay SG, Benowitz NL (1997) Arteriovenous differences in plasma concentration of nicotine and catecholamines and related cardiovascular effects after smoking, nicotine nasal spray, and intravenous nicotine. Clin Pharmacol Ther 62:453–463 · DOI
- Hayes WJ (1982) Pesticides studied in man. Lippincott Williams & Wilkins, Baltimore, pp 86–91
- Henningfield JE, Miyasato K, Jasinski DR (1983) Cigarette smokers self-administer intravenous nicotine. Pharmacol Biochem Behav 19:887–890 · DOI
- Hukkanen J, Jacob P III, Benowitz NL (2005) Metabolism and disposition kinetics of nicotine. Pharmacol Rev 57:79–115 · DOI · Paper page
- Kobert R (1906) Lehrbuch der Intoxikationen II. Band Spezieller Teil. Verlag von Ferdinand Enke, Stuttgart, pp 1064–1065
- Larson PS, Haag HB, Silvette H (1961) Tobacco. Experimental and clinical studies: a comprehensive account of the world literature. The Williams & Wilkins Company, Baltimore, pp 464–471
- Lazutka FA, Vasilyauskene AD, Gefen SG (1969) Toxicological assessment of the insecticide nicotine sulfate. Hyg Sanit 34:30–33
- Lehmann AJ (1949) Pharmacological considerations of insecticides. Assoc Food Drug Off US 13:65–70
- Maehly AC, Bonnichsen R (1963) 46 tödliche Vergiftungsfälle mit Nicotin in Schweden 1956–1963. Dtsch Z Gerichtl Med 54:367–375
- Malizia E, Andreucci G, Alfani F, Smeriglio M, Nicholai P (1983) Acute intoxication with nicotine alkaloids and cannabinoids in children from ingestion of cigarettes. Hum Toxicol 2:315–316 · DOI
- Matsushima D, Prevo ME, Gorsline J (1995) Absorption and adverse effects following topical and oral administration of three transdermal nicotine products to dogs. J Pharm Sci 84:365–369 · DOI
- Metzler W, Wronski R, Bewig B (2005) Die tödliche Zigaretten-Ingestion bei Erwachsenen. Gibt es sie wirklich? [The lethal ingestion of cigarettes in adults: Does it really exist?]. Dtsch Med Wochenschr 130:1491–1493 · DOI
- Reil W (1857) Materia medica der reinen chemischen Pflanzenstoffe. Verlag von August Hirschwald, Berlin, p 234
- Sanchez P, Ducassé JL, Lapeyre-Mestre M et al (1996) Nicotine poisoning as a cause of cardiac arrest? Clin Toxicol 34:475–476 · DOI
- Schmidt M (1931) Nikotin-vergiftung (Selbstmordversuch). Arch Toxicol 2:15–16 · DOI
- Schroff CD (1856) Pharmacologie. Wilhelm Braumüller, Wien, pp 523–525
- Smolinske SC, Spoerke DG, Spiller SK, Wruk KM, Kulig K, Rumack BH (1988) Cigarette and nicotine chewing gum toxicity in children. Hum Toxicol 7:27–31 · DOI
- Solarino B, Rosenbaum F, Rießelmann B, Buschmann CT, Tsokos M (2010) Death due to ingestion of nicotine-containing solution: case report and review of the literature. Forensic Sci Int 195:e19–e22 · DOI
- Tiess D, Nagel KH (1966) Akute tödliche Vergiftung mit “Nikotin 95/98%”. Beitrag zur Analytik des Gifts am frischen, gelagerten und formalinfixierten Organmaterial. Arch Toxicol [Archiv für Toxikologie] 22:68–79 · DOI
Cited by
Hajek, P., Etter, J., Benowitz, N., Eissenberg, T., & McRobbie, H. (2014) · Addiction · doi:10.1111/add.12659 · Cited by 546
Mündel, T. (2017) · Sports Medicine · doi:10.1007/s40279-017-0764-5 · Cited by 71
Metadata
- Authors
- Mayer, B.
- Venue
- Archives of Toxicology
- Published
- 2013-10-04
- Volume
- 88
- Issue
- 1
- Pages
- 5-7
- ISSN
- 0340-5761
- 1432-0738
- Cited by
- 224
- References
- 0
- Language
- en
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.