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Metabolism and Disposition Kinetics of Nicotine
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“its addictiveness sustains continued tobacco product use and the associated exposure to an array of bioactive compounds and carcinogens contributes to tobacco use being the leading cause of preventable death globally each year [31, 60].”
From Nicotine: Sporting Friend or Foe? A Review of Athlete Use, Performance Consequences and Other Considerations (2017) · cites this paper as [31]
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Shimada, T., Yamazaki, H., Mimura, M., Inui, Y., & Guengerich, F. P. (1994) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)22379-5 · Cited by 2,785 · cited 2×
“Significant gender differences have not been detected in the amount or activity of CYP2A6 in liver microsomes in several studies with a small number of samples (Pearce et al., 1992; Shimada et al., 1994; Bourrie et al., 1996; Chauret et al., 1997; Baker et al., 2001; Schmidt et al., 2001).”
BackgroundBenowitz, N. L., Porchet, H., Sheiner, L., & Jacob, P. (1988) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1988.107 · Cited by 619
Self-citationRelation of nicotine yield of cigarettes to blood nicotine concentrations in smokers.
Russell, M. A., Jarvis, M., Iyer, R., & Feyerabend, C. (1980) · BMJ · doi:10.1136/bmj.280.6219.972 · Cited by 465
Luck, W., Nau, H., Hansen, R., & Steldinger, R. (2017) · Developmental Pharmacology and Therapeutics · doi:10.1159/000457063 · Cited by 444
Risks and Benefits of Nicotine to Aid Smoking Cessation in Pregnancy
Dempsey, D. A., & Benowitz, N. L. (2001) · Drug Safety · doi:10.2165/00002018-200124040-00005 · Cited by 346 · cited 1×
“Nicotine crosses the placental barrier easily, and there is evidence for the accumulation of nicotine in fetal serum and amnionic fluid in slightly higher concentrations than in maternal serum (Luck et al., 1985; Pastrakuljic et al., 1998; Dempsey and Benowitz, 2001).”
BackgroundSelf-citationCigarette Smoking: A Dependence on High-Nicotine Boli
Russell, M. A. H., & Feyerabend, C. (1978) · Drug Metabolism Reviews · doi:10.3109/03602537808993776 · Cited by 253
Nicotine and cotinine elimination pharmacokinetics in smokers and nonsmokers
Benowitz, N. L., & Jacob III, P. (1993) · Clinical Pharmacology and Therapeutics · doi:10.1038/clpt.1993.27 · Cited by 232 · cited 2×
“However, we found that the clearance of nicotine was significantly slower in cigarette smokers compared with nonsmokers (Benowitz and Jacob, 1993).”
BackgroundSelf-citationNicotine Replacement Therapy: What Has Been Accomplished - Can We Do Better?
Benowitz, N. L. (1993) · Drugs · doi:10.2165/00003495-199345020-00001 · Cited by 174
Self-citationNicotine metabolism and elimination kinetics in newborns
Dempsey, D. (2000) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2000.106129 · Cited by 112
Site of nicotine absorption from a vapour inhaler - comparison with cigarette smoking
Lunell, E., Molander, L., Ekberg, K., & Wahren, J. (2000) · European Journal of Clinical Pharmacology · doi:10.1007/s002280050007 · Cited by 94
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Metadata
- Authors
- Hukkanen, J., Jacob, P., & Benowitz, N. L.
- Venue
- Pharmacological Reviews
- Publisher
- Elsevier BV
- Published
- 2005-03
- Volume
- 57
- Issue
- 1
- Pages
- 79-115
- ISSN
- 0031-6997
- Cited by
- 1,321
- References
- 12
- Language
- en
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