The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices
Abstract
Although present in great variety in the brain, the role of Na(+)/H(+) exchangers (NHEs) in hippocampal plasticity is still unknown and the effect of NHE inhibition on long-term potentiation (LTP) has not been studied yet. As it is conceivable that NHE inhibitors may severely affect mechanisms that are considered to underlie learning and memory we investigated whether the broad-spectrum NHE inhibitor 5'-(N-ethyl-N-isopropyl)-amiloride (EIPA, 10 microM) influences LTP induced by different stimuli based on a theta burst in interface hippocampus slices from 7-8-week-old Wistar and 30-month-old Fischer 344/Brown-Norway F1 hybrid (F344/BN) rats. EIPA did not affect basal synaptic transmission, paired pulse inhibition, or LTP induced by a weak stimulus, but improved the maintenance of the LTP of the population spike induced by a strong tetanus. Our data suggest that NHE activity serves as a negative feedback mechanism to control neuronal excitability and plasticity in both young and senescent animals.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Consistent with previous results (Rönicke et al., 2009), we found that EMD87580 increased input-output (I/O) ratios in the ApoE3-KI mice (Figure 7A).”
From Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) · cites this paper as Rönicke et al., 2009
In the citing paper
“consistent with previous findings that have shown that the NHE inhibitor ethyl-isopropyl amiloride (EIPA) can enhance theta-burst-induced LTP (Rönicke et al., 2009).”
From Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease (2018) · cites this paper as Rönicke et al., 2009
Citations
Cites
A synaptic model of memory: long-term potentiation in the hippocampus
Bliss, T. V. P., & Collingridge, G. L. (1993) · Nature · doi:10.1038/361031a0 · Cited by 11,566
Bliss, T. V. P., & Gardner-Medwin, A. R. (1973) · The Journal of Physiology · doi:10.1113/jphysiol.1973.sp010274 · Cited by 7,424
Regulation and Modulation of pH in the Brain
Chesler, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00010.2003 · Cited by 900
Diversity of the mammalian sodium/proton exchanger SLC9 gene family
Orlowski, J., & Grinstein, S. (2004) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-003-1110-3 · Cited by 659
Na+/H+ Exchangers of Mammalian Cells
Orlowski, J., & Grinstein, S. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.36.22373 · Cited by 571
Proton inhibition of N-methyl-D-aspartate receptors in cerebellar neurons
Traynelis, S. F., & Cull-Candy, S. G. (1990) · Nature · doi:10.1038/345347a0 · Cited by 566
Long-Term Plasticity of Intrinsic Excitability: Learning Rules and MechanismsPreprint
Daoudal, G., & Debanne, D. (2003) · Learning & Memory · doi:10.1101/lm.64103 · Cited by 555
Andersen, P., Sundberg, S. H., Sveen, O., Swann, J. W., & Wigström, H. (1980) · The Journal of Physiology · doi:10.1113/jphysiol.1980.sp013256 · Cited by 366
Facilitated induction of hippocampal long-lasting potentiation during blockade of inhibition
Wigström, H., & Gustafsson, B. (1983) · Nature · doi:10.1038/301603a0 · Cited by 351
Reymann, K. G., & Frey, J. U. (2007) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.026 · Cited by 331
Self-citation
Cited by
Reversal of ApoE4-induced recycling block as a novel prevention approach for Alzheimer’s disease
Xian, X., Pohlkamp, T., Durakoglugil, M. S., Wong, C. H., Beck, J. K., Lane-Donovan, C., Plattner, F., & Herz, J. (2018) · eLife · doi:10.7554/elife.40048 · Cited by 98
Metadata
- Authors
- Rönicke, R., Schröder, U. H., Böhm, K., & Reymann, K. G.
- Venue
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Published
- 2008-10-30
- Volume
- 379
- Issue
- 3
- Pages
- 233-239
- ISSN
- 0028-1298
- 1432-1912
- Cited by
- 11
- References
- 32
- Language
- en
- Licence
- www.springer.com/tdm (tdm)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices. https://app.cochat.ai/papers/10.1007/s00210-008-0364-x
- The paper
- Rönicke, R., Schröder, U. H., Böhm, K., & Reymann, K. G. (2009). The Na+/H+ exchanger modulates long-term potentiation in rat hippocampal slices. Naunyn-Schmiedeberg's Archives of Pharmacology. https://doi.org/10.1007/s00210-008-0364-x
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
