Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension
Abstract
Dietary nitrite and nitrate have been reported as alternative sources of nitric oxide (NO). In this regard, we reported previously that sodium nitrite added to drinking water was able to exert antihypertensive effects in an experimental model of hypertension in a dose-dependent manner. Taking into consideration that nitrite is continuously converted to nitrate in the bloodstream, here we expanded our previous report and evaluate whether a single daily dose of sodium nitrite could exert antihypertensive effects in 2 kidney-1 clip (2K1C) hypertensive rats. Sham-operated and 2K1C rats were treated with vehicle or sodium nitrite (15 mg/kg/day) for 4 weeks. We evaluated the effects induced by sodium nitrite treatment on systolic blood pressure (SBP) and NO markers such as plasma nitrite, nitrite + nitrate (NOx), cGMP, and blood levels of nitrosyl-hemoglobin. In addition, we also evaluated effects of nitrite on oxidative stress and antioxidant enzymes. Dihydroethidium (DHE) was used to evaluate aortic reactive oxygen species (ROS) production by fluorescence microscopy, and plasma levels of thiobarbituric acid-reactive species (TBARS) were measured in plasma samples from all experimental groups. Red blood cell superoxide dismutase (SOD) and catalase activity were evaluated with commercial kits. Sodium nitrite treatment reduced SBP in 2K1C rats (P < 0.05). We found lower plasma nitrite and NOx levels in 2K1C rats compared with normotensive controls (both P < 0.05). Nitrite treatment restored the lower levels of nitrite and NOx. While no change was found in the blood levels of nitrosyl-hemoglobin (P > 0.05), nitrite treatment increased the plasma levels of cGMP in 2K1C rats (P < 0.05). Higher plasma TBARS levels and aortic ROS levels were found in hypertensive rats compared with controls (P < 0.05), and nitrite blunted these alterations. Lower SOD and catalase activities were found in 2K1C hypertensive rats compared with controls (both P < 0.05). Nitrite treatment restored SOD activity (P < 0.05), whereas catalase was not affected. These data suggest that even a single daily oral dose of sodium nitrite is able to lower SBP and exert antioxidant effects in renovascular hypertension.
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Nitrite normalizes SOD activity in a model of reno-vascular hypertension.
“recent work demonstrating that nitrite normalizes SOD activity in a model of reno-vascular hypertension (129)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [129]
In hypertensive rats, nitrite supplementation reduces staining for superoxide in aortic rings.
“recent findings in hypertensive rats showing reduced staining for superoxide in aortic rings following nitrite supplementation (128, 129)”
From Inorganic nitrite supplementation for healthy arterial aging (2014) · cites this paper as [129]
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Kapil, V. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_17
Estudo de mecanismos anti-hipertensivos do nitrito de sódio na hipertensão renovascular experimental
Pinheiro, L. C. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2017.tde-18032015-230532
Self-citationLopes, J. M. S. (2021) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2021.tde-28012022-104526
Ferreira, G. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-10042023-155808
- Authors
- Montenegro, M. F., Pinheiro, L. C., Amaral, J. H., Marçal, D. M. O., Palei, A. C. T., Costa-Filho, A. J., & Tanus-Santos, J. E.
- Affiliations
- Universidade de São Paulo (BR)
- Corresponding author
- Montenegro, Marcelo F.
- ORCID
- Venue
- Naunyn-Schmiedeberg's Archives of Pharmacology
- Published
- 2012-01-20
- Volume
- 385
- Issue
- 5
- Pages
- 509-517
- ISSN
- 0028-1298 (ISSN-L)
- 1432-1912
- OpenAlex
- W2044950850
- Cited by
- 52
- References
- 42
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 4 · 2019: 6 · 2018: 8 · 2017: 5 · 2016: 5 · 2015: 6 · 2014: 4 · 2013: 1 · 2012: 3
- FWCI
- 3.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Naunyn-Schmiedeberg s Archives of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Scientific Electronic Library Online (São Paulo Research Foundation, Latin American and Caribbean Center on Health Sciences Information, Conselho Nacional de Desenvolvimento Científico e Tecnológico) (publishedVersion)
- Funders
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Keywords
- sodium nitrite, renovascular hypertension, nitric oxide, antihypertensive effect, oxidative stress, antioxidant enzymes, superoxide dismutase, catalase, reactive oxygen species, lipid peroxidation, cyclic GMP, nitrosylhemoglobin, blood pressure, aorta, drinking water supplementation
- MeSH terms
- Animals, Antihypertensive Agents, Antioxidants, Blood Pressure, Catalase, Disease Models, Animal, Cyclic GMP, Hemoglobins, Hypertension, Renovascular, Male, Nitrates, Nitrites, Sodium Nitrite, Superoxide Dismutase, Rats, Wistar, Oxidative Stress, Rats
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