CoChat
Sign Up
Cited by 229Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorForensic Toxicology and Drug Analysis

The DOI matches its Crossref record.

Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

Harris, Debra S., Baggott, Matthew, Mendelson, Jack H., Mendelson, John E., Jones, Reese T.·2002·Psychopharmacology
DOI 10.1007/s00213-002-1131-1
Open this paper in CoChat — free account

Abstract

Rationale 3,4-Methylenedioxymethamphetamine (MDMA) is a widely used phenethylamine. Reports have described the effects of MDMA in a controlled laboratory setting, but the full range of effects of MDMA in humans is still not completely characterized.Objectives To describe the physiological, subjective, and hormonal changes after single doses of MDMA in a laboratory setting and examine relationships between these effects.Methods Eight MDMA-experienced volunteers each received placebo, 0.5 mg/kg, and 1.5 mg/kg oral doses of MDMA in a double-blind crossover study.Results The 1.5 mg/kg dose (comparable to that typically used by most participants) produced significant subjective effects, peaking at about 2 h after dosing, including some effects commonly associated with stimulant drugs, hallucinogens, and entactogens. MDMA significantly increased plasma cortisol, prolactin, and dehydroepiandrosterone (DHEA) levels. Increase in plasma cortisol after the 1.5 mg/kg dose correlated with increased heart rate, rate-pressure product, and drug liking. Rise in DHEA correlated with euphoria.Conclusions A typically used dose of MDMA produced effects commonly associated with stimulants and hallucinogens. Subjects liked MDMA. Correlations between cortisol and DHEA levels and some physiological and psychological effects are consistent with animal data suggesting that hormones modulate some responses to drugs of abuse.

Overview

Integrity signals

Registry

Crossref · 10.1007/s00213-002-1131-1

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Still being checked.

Cited by

Sorted by citations

Items 201–229 of 229

Related

See all

Metadata

Authors
Harris, D. S., Baggott, M., Mendelson, J. H., Mendelson, J. E., & Jones, R. T.
Affiliations
  • University of California, San Francisco (US)
  • Harvard University (US)
ORCID
Venue
Psychopharmacology
Publisher
Springer Science and Business Media LLC
Published
2002-06-27
Volume
162
Issue
4
Pages
396-405
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
DOI
10.1007/s00213-002-1131-1
OpenAlex
W2085124531
Cited by
229
References
0
Citations by year
2026: 2 · 2025: 7 · 2024: 3 · 2023: 26 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 10 · 2012: 14
FWCI
8.39
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Purdue University
  • National Institutes of Health (5p50da001696-18, 5m01rr000079-42)
  • University of California, San Francisco
  • National Institute on Drug Abuse (P01DA014528, DA-14528, DA-01696, DA 12393, P30DA012393, DA00053, DA 00064)
  • National Center for Research Resources (5-MO1-RR00079)
  • NIH Clinical Center
Topics
  • Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Keywords
MDMA, ecstasy, subjective effects, plasma cortisol, prolactin, dehydroepiandrosterone, heart rate, rate-pressure product, drug liking, euphoria, entactogens, stimulants, hallucinogens, dose-response relationship
MeSH terms
Adult, Analysis of Variance, Cardiovascular Physiological Phenomena, Dehydroepiandrosterone, Dose-Response Relationship, Drug, Double-Blind Method, Female, Hallucinogens, Hormones, Humans, Hydrocortisone, Male, Prolactin, Psychometrics, Surveys and Questionnaires, Time Factors, Cross-Over Studies, N-Methyl-3,4-methylenedioxyamphetamine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review