Cited by 229Psychedelics and Drug StudiesNeurotransmitter Receptor Influence on BehaviorForensic Toxicology and Drug Analysis

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Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

Harris, Debra S., Baggott, Matthew, Mendelson, Jack H., Mendelson, John E., Jones, Reese T.·2002·Psychopharmacology

DOI 10.1007/s00213-002-1131-1

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Abstract

Rationale 3,4-Methylenedioxymethamphetamine (MDMA) is a widely used phenethylamine. Reports have described the effects of MDMA in a controlled laboratory setting, but the full range of effects of MDMA in humans is still not completely characterized.Objectives To describe the physiological, subjective, and hormonal changes after single doses of MDMA in a laboratory setting and examine relationships between these effects.Methods Eight MDMA-experienced volunteers each received placebo, 0.5 mg/kg, and 1.5 mg/kg oral doses of MDMA in a double-blind crossover study.Results The 1.5 mg/kg dose (comparable to that typically used by most participants) produced significant subjective effects, peaking at about 2 h after dosing, including some effects commonly associated with stimulant drugs, hallucinogens, and entactogens. MDMA significantly increased plasma cortisol, prolactin, and dehydroepiandrosterone (DHEA) levels. Increase in plasma cortisol after the 1.5 mg/kg dose correlated with increased heart rate, rate-pressure product, and drug liking. Rise in DHEA correlated with euphoria.Conclusions A typically used dose of MDMA produced effects commonly associated with stimulants and hallucinogens. Subjects liked MDMA. Correlations between cortisol and DHEA levels and some physiological and psychological effects are consistent with animal data suggesting that hormones modulate some responses to drugs of abuse.

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Authors: Harris, D. S., Baggott, M., Mendelson, J. H., Mendelson, J. E., & Jones, R. T.
Affiliations: University of California, San Francisco (US)
Harvard University (US)
ORCID: Baggott, Matthew
Mendelson, John E.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2002-06-27
Volume: 162
Issue: 4
Pages: 396-405
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-002-1131-1
OpenAlex: W2085124531
Cited by: 229
References: 0
Citations by year: 2026: 2 · 2025: 7 · 2024: 3 · 2023: 26 · 2022: 6 · 2021: 10 · 2020: 8 · 2019: 9 · 2018: 13 · 2017: 9 · 2016: 10 · 2015: 14 · 2014: 15 · 2013: 10 · 2012: 14
FWCI: 8.39
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Funders: Purdue University
National Institutes of Health (5p50da001696-18, 5m01rr000079-42)
University of California, San Francisco
National Institute on Drug Abuse (P01DA014528, DA-14528, DA-01696, DA 12393, P30DA012393, DA00053, DA 00064)
National Center for Research Resources (5-MO1-RR00079)
NIH Clinical Center
Topics: Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
Keywords: MDMA, ecstasy, subjective effects, plasma cortisol, prolactin, dehydroepiandrosterone, heart rate, rate-pressure product, drug liking, euphoria, entactogens, stimulants, hallucinogens, dose-response relationship
MeSH terms: Adult, Analysis of Variance, Cardiovascular Physiological Phenomena, Dehydroepiandrosterone, Dose-Response Relationship, Drug, Double-Blind Method, Female, Hallucinogens, Hormones, Humans, Hydrocortisone, Male, Prolactin, Psychometrics, Surveys and Questionnaires, Time Factors, Cross-Over Studies, N-Methyl-3,4-methylenedioxyamphetamine

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Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans

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