Is Ecstasy an “Empathogen”? Effects of +/- 3,4-Methylenedioxymethamphetamine on Prosocial Feelings and Identification of Emotional States in Others
Open accessAbstract
Background Users of ±3,4-methylenedioxymethamphetamine (MDMA), "ecstasy," report that the drug produces unusual psychological effects, including increased empathy and prosocial feelings. These "empathogenic" effects are cited as reasons for recreational ecstasy use and also form the basis for the proposed use of MDMA in psychotherapy. However, they have yet to be characterized in controlled studies. Here, we investigate effects of MDMA on an important social cognitive capacity, the identification of emotional expression in others, and on socially relevant mood states.Methods Over four sessions, healthy ecstasy-using volunteers (n = 21) received MDMA (.75, 1.5 mg/kg), methamphetamine (METH) (20 mg), and placebo under double-blind, randomized conditions. They completed self-report ratings of relevant affective states and undertook tasks in which they identified emotions from images of faces, pictures of eyes, and vocal cues.Results MDMA (1.5 mg/kg) significantly increased ratings of feeling "loving" and "friendly", and MDMA (.75 mg/kg) increased "loneliness". Both MDMA (1.5 mg/kg) and METH increased "playfulness"; only METH increased "sociability". MDMA (1.5 mg/kg) robustly decreased accuracy of facial fear recognition relative to placebo.Conclusions The drug MDMA increased "empathogenic" feelings but reduced accurate identification of threat-related facial emotional signals in others, findings consistent with increased social approach behavior rather than empathy. This effect of MDMA on social cognition has implications for both recreational and therapeutic use. In recreational users, acute drug effects might alter social risk-taking while intoxicated. Socioemotional processing alterations such as those documented here might underlie possible psychotherapeutic benefits of this drug; further investigation of such mechanisms could inform treatment design to maximize active components of MDMA-assisted psychotherapy.
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- Findingown data
MDMA 1.5 mg/kg increased playfulness ratings relative to placebo and MDMA 0.75 mg/kg.
“MDMA1.5 increasing playfulness relative to PBO and MDMA0.75”
Quote in the paperNot a substantial claim - Findingown data
Accuracy on the Eyes and DANVA-2 tasks was unaffected by MDMA.
“MDMA did not affect accuracy on the Eyes or the DANVA-2 tests (Table 1).”
Quote in the paperSubstantial claim - Findingown data
DANVA-2 scores showed no drug-by-emotion interaction.
“There was no interaction between drug condition and emotion type on DANVA-2 scores.”
Quote in the paperSubstantial claim - Findingown data
MDMA 1.5 mg/kg significantly increased loving ratings relative to placebo.
“MDMA1.5 significantly increased loving and friendliness ratings”
- Also stated in: § RESULTS · hedged
“Follow-up analyses indicated that MDMA1.5 increased loving feelings relative to PBO.”
Quote in the paperSubstantial claim - Also stated in: § RESULTS · hedged
- Findingown data
MDMA 0.75 mg/kg increased loneliness ratings relative to methamphetamine and placebo.
“Post-hoc analysis showed that MDMA0.75 increased loneliness ratings relative to METH and PBO”
Quote in the paperSubstantial claim
- Findingown data
In an uncorrected exploratory test, 1.5 mg/kg MDMA made participants more likely to label emotional faces as neutral than placebo did.
“MDMA1.5 increased the tendency to misclassify emotional expressions as neutral, compared to PBO (p < 0.05, uncorrected; Table 1).”
Quote in the paperNot a substantial claim - Findingown data
With Bonferroni correction, no significant drug effects appeared for angry, happy, neutral, or sad face identification.
“After Bonferroni correction of the Type 1 error rate, simple main effects analysis did not yield significant effects of drug on identification of angry, happy, neutral, or sad faces.”
Quote in the paperSubstantial claim - Findingown data
Methamphetamine increased sociability ratings relative to placebo.
“METH increased sociability relative to PBO”
Quote in the paperNot a substantial claim - Findingown data
Drug condition and emotion type interacted significantly in predicting accuracy on the facial emotion recognition task.
“There was a significant interaction between drug condition and emotion on the FER accuracy of emotion identification (F(5.2, 104.6) = 3.23, p = 0.008).”
Quote in the paperSubstantial claim - Findingown data
Methamphetamine increased playfulness ratings relative to placebo.
“METH increasing playfulness compared to PBO.”
Quote in the paperNot a substantial claim - Findingown data
All five subjective state ratings were raised by the administered drugs.
“The drugs increased ratings on all five subjective state measures.”
Quote in the paperNot a substantial claim - Findingown data
MDMA 1.5 mg/kg decreased accuracy of fear recognition relative to placebo.
“drug condition affected identification of fearful facial expressions (F(2.8, 56.0) = 4.45, p = 0.008, η2 = 0.18), indicating that MDMA1.5 decreased accuracy of fear recognition relative to placebo”
Quote in the paperSubstantial claim - Findingown data
Participants' guesses about which drug they had received were unrelated to every measure that showed drug effects.
“There was no significant relationship between drug identification and any of the measures that were sensitive to drug effects.”
Quote in the paperSubstantial claim - Findingown data
Friendliness scores were higher after 1.5 mg/kg MDMA than after either placebo or the 0.75 mg/kg dose.
“MDMA1.5 increased friendliness ratings compared to both PBO and MDMA0.75.”
Quote in the paperSubstantial claim - Premisereasoning
At the time, no human study had published behavioral effects of experimentally given MDMA on empathy- or sociability-related tasks.
“Despite these reports on subjective effects of the drug, there have been no published reports in humans of the effect of controlled administration of MDMA on behaviors related to empathy and sociability.”
Quote in the paperSubstantial claim - Premisecitation
The FER task is sensitive to serotonin and norepinephrine reuptake inhibition.
“The Facial Emotional Recognition task (FER) is sensitive to serotonin and norepinephrine reuptake inhibition [30].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [30] Harmer, 2004, Increased positive versus negative affective perception and memory in healthy volunteers following selective serotonin and norepinephrine reuptake inhibition, Am J Psychiatry source
Not checked in the free run.
- Interpretationreasoning
If patients notice others' negative cues less, they may voice thoughts or feelings they had held back due to feared disapproval.
“Moreover, reduced sensitivity to subtle signs of negative emotions in others (e.g., the therapist) may enable a patient to express thoughts or feelings that were previously inhibited because of perceived negative responses in the listener.”
Quote in the paperSubstantial claim - Interpretationnone given
The authors state that no earlier human study had published a clear behavioral effect of MDMA.
“this is the first published demonstration of an overt behavioral effect of MDMA in humans.”
Quote in the paperSubstantial claim - Interpretationown data
MDMA's social benefits might not be as specific as once thought.
“Thus, the prosocial effects of MDMA may be less selective than believed.”
Quote in the paperSubstantial claim - Interpretationown data
Methamphetamine might be more socially positive than earlier assumed.
“A more likely alternative is that methamphetamine may have a more prosocial profile than previously thought.”
Quote in the paperSubstantial claim - Interpretationcitation
Since everyone had used ecstasy or MDMA before, the results might not apply to people with no prior exposure.
“A final limitation is that, for ethical reasons, all participants had prior experience with ecstasy or MDMA, so the findings may not generalize to MDMA-naive individuals [see 42].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [42] Thompson, 2008, Reduced sensitivity to MDMA-induced facilitation of social behavior in MDMA pre-exposed rats, Prog Neuropsychopharmacol Biol Psychiatry source
Not checked in the free run.
- Interpretationown data
Because drug guesses were unrelated to outcomes, the authors suggest expectancy had little influence on the findings.
“follow-up analyses revealed that participants’ guesses about the drug received were not significantly related to outcome measures, suggesting that expectancies play a minor role in these results.”
Quote in the paperSubstantial claim- Rests on an assumption: Participants' guesses about which drug they received are a valid index of their expectancies.
- Study design and conductreasoning
The tasks may have missed some of the atypical social effects linked to MDMA.
“First, as noted above, the behavioral tasks we used may not have been sensitive to all of the unusual social effects attributed to MDMA.”
Quote in the paperNot a substantial claim - Interpretationreasoning
The drug's performance changes seem tied to visual processing of full faces.
“Thus, it appears that performance alterations arising from MDMA are specific to processing of whole-face visual affective cues.”
Quote in the paperSubstantial claim- Rests on an assumption: The FER, Eyes, and DANVA-2 tasks are comparable in their sensitivity to MDMA's effects on emotion recognition.
- Interpretationreasoning
The findings might reflect greater social approach rather than greater empathy.
“The pattern of findings in our study may be more consistent with increased social approach behavior (i.e. sociability) than increased empathy.”
Quote in the paperSubstantial claim - Interpretationreasoning
MDMA might ease social contact by blunting the effect of others' negative feelings, not by improving how well those feelings are read.
“Thus, MDMA may facilitate social interactions because it reduces the impact of others’ negative emotions, rather than by enhancing recognition of, and sensitivity to, others’ emotions.”
Quote in the paperSubstantial claim - Interpretationcitation
Reduced recognition of negative emotions, especially threat cues like fear, could promote approaching others socially.
“A decreased ability to identify negative emotions, particularly threat-related signals such as fear, may facilitate social approach behavior [12, 35].”
Quote in the paperSubstantial claim0 of 2 sources checked- cites [12] Bedi, 2009, Effects of MDMA on sociability and neural response to social threat and social reward, Psychopharmacology source
Not checked in the free run.
- cites [35] Porter, 2007, The neuropsychological basis of hypersociability in Williams and Down syndrome, Neuropsychologia source
Not checked in the free run.
- May combine two claims. 17
- Classified as probably not a substantial claim. 13
May combine two claims.
Findingown dataThe higher MDMA dose raised loving and friendliness scores above placebo, but those scores did not differ significantly from methamphetamine.
“whereas MDMA (1.5mg/kg) significantly increased loving feelings and friendliness compared to placebo, these ratings were not significantly different from ratings on methamphetamine.”
Quote in the paperSubstantial claimClassified as probably not a substantial claim.
PremisecitationThe drug's supposed empathogenic properties are a key reason it has been proposed as an adjunct in psychotherapy.
“MDMA’s apparent empathogenic effects are also central to the rationale for the use of the drug as a psychotherapeutic adjunct [1, 5–6].”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [1] Parrott, 2007, The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): An evidence-based review, Psychopharmacology source
Not checked in the free run.
- cites [5] Holland, 2001
Not checked in the free run.
- cites [6] Johansen, 2009, How could ecstasy help anxiety disorders?, J Psychopharmacol source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataRemoving two DANVA outliers did not change the findings, so the original values were kept.
“Truncation of two outlying data points (both in DANVA scores) did not alter results and original data were retained.”
Quote in the paperNot a substantial claimClassified as probably not a substantial claim.
Study design and conductown dataCompliance with drug abstinence requirements was verified using urine, saliva, and breathalyzer screens.
“Compliance was verified with urine (QuickTox Drug Screen Dipcard, Branan Medical Corporation, Irvine, CA), saliva (Oratect III, Branan Medical Corporation) and breathalyzer (Alco-sensor III, Intoximeters, St. Louis, MO) screens.”
Quote in the paperSubstantial claimMay combine two claims.
Study design and conductcitationMDMA doses were selected based on prior research showing they are safe and produce mood alterations.
“Drug doses were selected based on previous research; MDMA doses in this low-to-moderate range have been safely administered to humans previously, and produce modest to robust alterations in mood state [24].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [24] Dumont, 2006, A review of acute effects of 3,4-methylenedioxymethamphetmine in healthy volunteers, J Psychopharmacol source
Not checked in the free run.
Classified as probably not a substantial claim.
PremisecitationMDMA is reported to cause atypical mental effects, such as heightened empathy and prosocial sentiment.
“MDMA (±3,4-methylenedioxymethamphetamine, ‘ecstasy’) is reported to have unusual, so-called ‘empathogenic’ effects, such as increased empathy and prosocial feelings [e.g. see 1].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [1] Parrott, 2007, The psychotherapeutic potential of MDMA (3,4-methylenedioxymethamphetamine): An evidence-based review, Psychopharmacology source
Not checked in the free run.
Classified as probably not a substantial claim.
Study design and conductcitationThe cognitive tests were started 65 min after dosing so that they would occur when drug effects were expected to peak.
“Participants started cognitive tasks (e.g. emotional recognition) 65 minutes after capsule administration, to coincide with peak drug effect onset [26].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [26] Cami, 2000, Human pharmacology of 3,4-methylenedioxymethamphetamine (“ecstasy”): Psychomotor performance and subjective effects, J Clin Psychopharmacol source
Not checked in the free run.
May combine two claims.
Study design and conductcitationA 20 mg methamphetamine dose was chosen for its safety and its ability to produce strong stimulant and euphoric responses in people without prior amphetamine use.
“For the current study, we selected a methamphetamine dose (20mg) that is safe, and induces robust stimulant and euphoric effects, in amphetamine-naive volunteers [27].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [27] Wachtel, 2002, The effects of acute haloperidol or risperidone on subjective responses to methamphetamine in healthy volunteers, Drug Alcohol Depend source
Not checked in the free run.
May combine two claims.
PremisecitationEarlier controlled lab work suggests MDMA raises self-reported states tied to empathy and social ease, but findings are mixed.
“These studies indicate that MDMA increases feelings related to empathy and sociability, including self-rated friendliness [7–8], extroversion [9–10], closeness to others [11], sociability [7, 12], talkativeness [7–8], amicability, and gregariousness [13], although some of these effects are inconsistent [14–16].”
Quote in the paperSubstantial claim0 of 7 sources checked- cites [7] Tancer, 2003, Reinforcing, subjective, and physiological effects of MDMA in humans: A comparison with d-amphetamine and mCPP, Drug Alcohol Depend source
Not checked in the free run.
- cites [8] Tancer, 2007, The effects of fluoxetine on the subjective and physiological effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans, Psychopharmacology source
Not checked in the free run.
- cites [9] Vollenweider, 1999, Opposite effects of 3,4-methylenedioxymethamphetamine (MDMA) on sensorimotor gating in rats versus healthy humans, Psychopharmacology source
Not checked in the free run.
- cites [10] Liechti, 2000, Psychological and physiological effects of MDMA (“ecstasy”) after pretreatment with the 5-HT-sub-2 antagonist ketanserin in healthy humans, Neuropsychopharmacology source
Not checked in the free run.
- cites [14] Liechti, 2000, Acute psychological effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) are attenuated by the serotonin uptake inhibitor citalopram, Neuropsychopharmacology source
Not checked in the free run.
- cites [15] Johanson, 2006, Discriminative stimulus effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans trained to discriminate among d-amphetamine, meta-chlorophenylpiperazine and placebo, Drug Alcohol Depend source
Not checked in the free run.
- cites [16] Harris, 2002, Subjective and hormonal effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans, Psychopharmacology source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataThe order in which sessions occurred showed no significant effect in any analysis, so it was dropped from the models.
“Session order did not have a significant effect in any of the analyses, and was therefore not retained in the models.”
Quote in the paperNot a substantial claimMay combine two claims.
PremisecitationThe authors' earlier imaging work found MDMA changed brain responses to social cues, yet it left behavioral accuracy for recognizing facial emotions unchanged.
“Using fMRI, we recently reported effects of MDMA on neural processing of social material [12], but in that study the drug did not alter the behavioral response to the stimuli (i.e. accuracy of identification of emotions from pictures of facial effect).”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [12] Bedi, 2009, Effects of MDMA on sociability and neural response to social threat and social reward, Psychopharmacology source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
Study design and conductown dataFour outcomes had non-normal distributions; non-parametric tests matched parametric results for all but VAS Lonely, and for that measure non-parametric results are reported.
“Data for four outcome measures were non-normal (VAS Loving, VAS Lonely, POMS Friendly, and DANVA scores). In these cases, we conducted non-parametric analysis (Friedman’s ANOVA followed by Wilcoxon signed rank tests). In all cases except VAS Lonely, the non-parametric approach yielded the same results; therefore parametric statistics are reported. For VAS Lonely, non-parametric statistics yielded”
Quote in the paperNot a substantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationThe Eyes test is sensitive to oxytocin administration.
“The Eyes test is sensitive to oxytocin administration [33].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [33] Domes, 2007, Oxytocin improves “mind-reading” in humans, Biol Psychiatry source
Not checked in the free run.
Probably not a substantial claim: may not pass S3 (load-bearing). May combine two claims.
PremisecitationThe drug's empathogenic effects are given as a reason people use ecstasy recreationally and may add to its reinforcing properties.
“Such effects are cited as a motivation to use ecstasy recreationally [2–3] and may contribute to its reinforcing capacity [4].”
Quote in the paperNot a substantial claim0 of 3 sources checked- cites [2] Thompson, 2007, A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine (“ecstasy”), Neuroscience source
Not checked in the free run.
- cites [3] Sumnall, 2006, The varieties of ecstasy experience: An exploration of the subjective experiences of ecstasy, J Psychopharmacol source
Not checked in the free run.
- cites [4] McGregor, 2008, From ultrasocial to antisocial: A role for oxytocin in the acute reinforcing effects and long-term adverse consequences of drug use?, Br J Pharmacol source
Not checked in the free run.
May combine two claims.
PremisecitationReading emotions from faces, voices, or posture is a core social-cognitive ability and an early component of empathy.
“Identification of others’ emotions based on facial, vocal or postural cues is a critical social cognitive capacity and an important ‘first step’ in empathy [17]”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [17] Clark, 2008, Autism and the extraction of emotion from briefly presented facial expressions: Stumbling at the first step of empathy, Emotion source
Not checked in the free run.
Classified as probably not a substantial claim. May combine two claims.
Study design and conductown dataThe study used a 4-session, within-participants, double-blind design with randomized drug order.
“A 4-session, within-participants, double-blind design was employed.”
- Also stated in: § Experimental Protocol · plain
“capsules were administered in randomized order.”
Quote in the paperSubstantial claim- Also stated in: § Experimental Protocol · plain
May combine two claims.
PremisecitationThe earlier imaging study could not optimally detect a behavioral drug effect because its facial expressions were obvious, shown for four seconds, and limited to a few basic emotions.
“The emotional expressions shown were not subtle [18], they were presented for a long period (4 seconds) [17], and we selected a relatively narrow range of basic emotions (e.g. fear, anger and happiness [19]), excluding more complex, culturally-determined affective states, such as shame and jealousy [20].”
Quote in the paperSubstantial claim0 of 3 sources checked- cites [18] Philippot, 2003, Nonverbal deficits and interpersonal regulation in alcoholics
Not checked in the free run.
- cites [17] Clark, 2008, Autism and the extraction of emotion from briefly presented facial expressions: Stumbling at the first step of empathy, Emotion source
Not checked in the free run.
- cites [19] Ekman, 2003
Not checked in the free run.
Classified as probably not a substantial claim.
InterpretationcitationLess intense fear perception could help patients engage with traumatic material in MDMA-assisted therapy.
“reductions in the intensity of fear perception, including but not limited to those reported here, might facilitate engagement with traumatic material during therapy [49].”
Quote in the paperSubstantial claim0 of 1 sources checked- cites [49] Mithoefer, 2010, The safety and efficacy of ± 3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: The first randomized, controlled pilot study [published online ahead of print July 19], J Psychopharmacol
Not checked in the free run.
May combine two claims.
Interpretationown dataThe 1.5 mg/kg MDMA dose changed a behavioral social-cognition measure: it lowered fear-face recognition while leaving other emotion recognition from faces and voices intact.
“We found that MDMA (1.5mg/kg only) altered a behavioral indicator of social cognition. Specifically, it robustly reduced recognition of fearful faces, without changing recognition of other emotions from facial or vocal cues.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
InterpretationreasoningImpaired social understanding could lead to greater social risk-taking during ecstasy intoxication.
“For instance, compromised social cognition may increase social risk-taking while under the influence of the drug.”
Quote in the paperNot a substantial claimMay combine two claims.
Interpretationown dataMDMA's social-cognitive effect appeared confined to whole-face emotion recognition, with no clear effect on eye-region or vocal cues.
“The effect of MDMA on social cognition was limited to identification of emotions from facial expressions, with no apparent effect on recognition of affective cues from the eye region or from voices.”
Quote in the paperSubstantial claim- Rests on an assumption: The FER, Eyes, and DANVA-2 tasks are comparable in their sensitivity to MDMA's effects on emotion recognition.
May combine two claims.
Study design and conductown dataWeight-based dosing for MDMA but not methamphetamine probably did not matter much, since body weights were similar and only playfulness correlated with weight.
“A third possible limitation was that we adjusted the dose to the body weight for MDMA but not for methamphetamine. This is unlikely to be a major factor because participants were within a narrow weight range (BMI 18.5 – 30), and post-hoc analysis indicated that only one measure of methamphetamine’s effects (playfulness) correlated with body weight (r = − 0.45, p = 0.04).”
Quote in the paperNot a substantial claimMay combine two claims.
Study design and conductnone givenNo task known to the authors combines social and non-social cues, so the social specificity of the results is hard to establish.
“Second, we are not aware of tasks that include both social and non-social stimuli, making it difficult to determine the specificity of these findings to social stimuli.”
Quote in the paperSubstantial claimMay combine two claims.
Interpretationown dataThe 1.5 mg/kg dose made participants more often call non-neutral faces neutral, which seems to lower sensitivity to subtle emotional cues.
“we found that MDMA (1.5mg/kg) increased the number of non-neutral faces erroneously identified as neutral, apparently reducing the capacity to detect subtle emotional signals.”
Quote in the paperSubstantial claimProbably not a substantial claim: may not pass S3 (load-bearing).
PremisecitationStill facial photographs may have less real-world validity than moving images.
“For example, the static photos of facial affect we employed may be less ecologically valid than dynamic stimuli [e.g. see 41].”
Quote in the paperNot a substantial claim0 of 1 sources checked- cites [41] Zaki, 2008, It takes two: The interpersonal nature of empathic accuracy, Psychol Sci source
Not checked in the free run.
The paper relies on this without support.
Participants' guesses about which drug they received are a valid index of their expectancies.
“There was no significant relationship between drug identification and any of the measures that were sensitive to drug effects.”
“suggesting that expectancies play a minor role in these results.”
The paper relies on this without support.
The FER, Eyes, and DANVA-2 tasks are comparable in their sensitivity to MDMA's effects on emotion recognition.
“The effect of MDMA on social cognition was limited to identification of emotions from facial expressions, with no apparent effect on recognition of affective cues from the eye region or from voices.”
“whereas the facial task required participants to identify emotions based on subtle, briefly presented pictures, there were no time limits on responding to items in the Eyes task.”
The paper relies on this without support.
The study had sufficient statistical power to detect the reported effects and to support the null findings.
“Over four sessions, healthy ecstasy-using volunteers (N=21) received MDMA (0.75mg/kg; 1.5mg/kg), methamphetamine (20mg; METH), and placebo (PBO) under double-blind, randomized conditions.”
“MDMA did not affect accuracy on the Eyes or the DANVA-2 tests (Table 1).”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MDMA at 1.5 mg/kg, but not 0.75 mg/kg, decreased the accuracy of fear recognition and of anger and fear recognition.
“This is in line with further results showing that 1.5 mg/kg but not 0.75 mg/kg MDMA decreased the accuracy of fear recognition (55) and anger and fear recognition (36).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [55]
Two studies did not find an effect of MDMA at 0.75 mg/kg, 1.5 mg/kg, and 75 mg on the RMET.
“In line with results obtained with the MET, two studies did not find an effect of MDMA (0.75 mg/kg, 1.5 mg/kg, and 75 mg) on the RMET (52, 55).”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [55]
The increased empathy for positive emotions and decreased recognition of negative emotions shown in these studies is in line with the interpretation by Bedi et al. that a decreased ability to identify negative emotions might facilitate social approach behavior and thus social interaction.
“The increased empathy for positive emotions and decreased recognition of negative emotions shown in these studies is in line with the interpretation by Bedi et al. (55) that a decreased ability to identify negative emotions might facilitate social approach behavior and thus social interaction.”
From Modulation of Social Cognition via Hallucinogens and “Entactogens” (2019) · cites this paper as [55]
Statistics recomputed
Every reported test result, recomputed from its test statistic and degrees of freedom. A result shows as not adding up only once an independent check has confirmed it.
- Not confirmedF(5.2, 104.6) = 3.23reported p = .008 · recomputed p = .009
“F(5.2, 104.6) = 3.23, p = .008”
- ConsistentF(3, 57) = 5.04reported p = .004 · recomputed p = .004
“F(3,57) = 5.04, p = .004”
- ConsistentF(2.7, 51) = 6.81reported p = .001 · recomputed p < .001
“F(2.7,51) = 6.81, p = .001”
- Consistentχ²(3) = 11.94reported p = .008 · recomputed p = .008
“χ2(3) = 11.94, p = .008”
- ConsistentF(3, 57) = 8.57reported p < .001 · recomputed p < .001
“F(3,57) = 8.57, p < .001”
- ConsistentF(2.5, 47.7) = 3.06reported p < .05 · recomputed p = .045
“F(2.5, 47.7) = 3.06, p < .05”
- ConsistentF(2.8, 56) = 4.45reported p = .008 · recomputed p = .008
“F(2.8, 56.0) = 4.45, p = .008”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
MDMA comparison dose is given in two different units
MinorThe same comparison with 20 mg amphetamine describes the MDMA dose first as 2 mg/kg and then as 2 mg. Those are different doses.
“Tancer et al. (2003) used d-amphetamine 10mg and 20mg, and reported overlapping reinforcing and subjective effects of MDMA (2mg/kg) and 20mg amphetamine, although in many cases MDMA (2mg) produced higher ratings.”
“MDMA (2mg/kg) and 20mg amphetamine”
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- Authors
- Bedi, G., Hyman, D., & de Wit, H.
- Affiliations
- University of Chicago (US)
- Corresponding author
- Bedi, Gillinder
- ORCID
- Bedi, Gillinder
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2010-12
- Volume
- 68
- Issue
- 12
- Pages
- 1134-1140
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2997873
- OpenAlex
- W1994271186
- Cited by
- 247
- References
- 53
- Citations by year
- 2026: 12 · 2025: 20 · 2024: 23 · 2023: 38 · 2022: 8 · 2021: 12 · 2020: 13 · 2019: 10 · 2018: 16 · 2017: 14 · 2016: 13 · 2015: 15 · 2014: 21 · 2013: 13 · 2012: 9
- FWCI
- 10.86
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA02812)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychedelics and Drug Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
- Keywords
- MDMA, ecstasy, emotion recognition, methamphetamine, social cognition, MDMA-assisted psychotherapy, social approach behavior, loneliness, playfulness, sociability, recreational drug use
- MeSH terms
- Adolescent, Adult, Affect, Empathy, Facial Expression, Female, Humans, Male, Methamphetamine, Photic Stimulation, Psychomotor Performance, N-Methyl-3,4-methylenedioxyamphetamine, Self Report
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