The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Anxiolytic effects of a novel group II metabotropic glutamate receptor agonist (LY354740) in the fear-potentiated startle paradigm in humans
Open accessAbstract
RationaleLY354740, a structural analogue of glutamate that shows specificity at the mGluR2/3 receptor, has anxiolytic effects in animal models.ObjectiveThis study investigated the anxiolytic effects of LY354740 in humans using the fear-potentiated startle reflex methodology.MethodsSubjects were given either placebo (n=16), 20 mg LY354740 (n=15), or 200 mg LY354740 (n=13). The fear-potentiated startle tests examined startle potentiation to shock anticipation and to darkness.ResultsConsistent with previous results, startle was increased by threat of shock and by darkness. LY354740 did not affect baseline startle. Correspondingly, subjects did not report LY354740 to be sedative. LY354740 significantly reduced the increase in startle magnitude during shock anticipation, but not during darkness. Subjective reports of state anxiety and negative affectivity during the fear-potentiated startle tests were also reduced in a dose-dependent manner by LY354740.ConclusionsThese results suggest that LY354740 has an anxiolytic profile in humans without being sedative.
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Citations
Cites
The role of the amygdala in fear and anxiety
Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357
Emotion, attention, and the startle reflex
Lang, P. J., Bradley, M. M., & Cuthbert, B. N. (1990) · Psychological Review · doi:10.1037/0033-295x.97.3.377 · Cited by 2,205
Walker, D. L., & Davis, M. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-23-09375.1997 · Cited by 627
Charney, D. S. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790190025003 · Cited by 599 · cited 2×
“Subjective reports Analysis of the VAS ratings for the different adjectives assessing sedative effects was conducted with a two-way ANOVA with Treatment (Placebo, mGlu20, mGlu200) and Time (before, after ingestion) as the two factors.”
MethodBenzodiazepines: use, abuse, and consequences.
Woods, J. H., Katz, J. L., & Winger, G. (1992) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)00468-5 · Cited by 560
Fear‐Potentiated Startle in Humans: Effects of Anticipatory Anxiety on the Acoustic Blink Reflex
Grillon, C., AMELI, R., Woods, S. W., Merikangas, K., & Davis, M. (1991) · Psychophysiology · doi:10.1111/j.1469-8986.1991.tb01999.x · Cited by 462
Self-citationBaseline and fear-potentiated startle in panic disorder patients
Grillon, C., Ameli, R., Goddard, A., Woods, S. W., & Davis, M. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)90040-x · Cited by 212
Self-citationAnxiogenic effects of high illumination levels assessed with the acoustic startle response in rats
Walker, D. L., & Davis, M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00441-6 · Cited by 211
Darkness facilitates the acoustic startle reflex in humans
Grillon, C., Pellowski, M., Merikangas, K. R., & Davis, M. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00466-0 · Cited by 193
Self-citationBenzodiazepines have no effect on fear-potentiated startle in humans
Baas, J., Grillon, C., Böcker, K., Brack, A., Morgan, C., Kenemans, L., & Verbaten, M. (2002) · Psychopharmacology · doi:10.1007/s00213-002-1011-8 · Cited by 116
Self-citation
Cited by
Allosteric modulators of GPCRs: a novel approach for the treatment of CNS disorders
Jeffrey Conn, P., Christopoulos, A., & Lindsley, C. W. (2009) · Nature Reviews Drug Discovery · doi:10.1038/nrd2760 · Cited by 1,063
Ionotropic and metabotropic glutamate receptor structure and pharmacology
Kew, J. N. C., & Kemp, J. A. (2005) · Psychopharmacology · doi:10.1007/s00213-005-2200-z · Cited by 788
Cryan, J. F., & Mombereau, C. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001457 · Cited by 616
Metabotropic glutamate receptors as novel targets for anxiety and stress disorders
Swanson, C. J., Bures, M., Johnson, M. P., Linden, A.-M., Monn, J. A., & Schoepp, D. D. (2005) · Nature Reviews Drug Discovery · doi:10.1038/nrd1630 · Cited by 607
Samuels, E., & Szabadi, E. (2008) · Current Neuropharmacology · doi:10.2174/157015908785777193 · Cited by 454
Metadata
- Authors
- Grillon, C., Cordova, J., Levine, L. R., & Morgan, III
- Venue
- Psychopharmacology
- Published
- 2003-08-01
- Volume
- 168
- Issue
- 4
- Pages
- 446-454
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2008956763
- Cited by
- 185
- References
- 16
- FWCI
- 7.89
- Type
- journal article
- Language
- en
- Open access
- green
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