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Cited by 616Treatment of Major DepressionNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

In search of a depressed mouse: utility of models for studying depression-related behavior in genetically modified mice

Cryan, J F, Mombereau, C·2004·Molecular Psychiatry
DOI 10.1038/sj.mp.4001457
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Abstract

The ability to modify mice genetically has been one of the major breakthroughs in modern medical science affecting every discipline including psychiatry. It is hoped that the application of such technologies will result in the identification of novel targets for the treatment of diseases such as depression and to gain a better understanding of the molecular pathophysiological mechanisms that are regulated by current clinically effective antidepressant medications. The advent of these tools has resulted in the need to adopt, refine and develop mouse-specific models for analyses of depression-like behavior or behavioral patterns modulated by antidepressants. In this review, we will focus on the utility of current models (eg forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, drug-withdrawal-induced anhedonia) and research strategies aimed at investigating novel targets relevant to depression in the mouse. We will focus on key questions that are considered relevant for examining the utility of such models. Further, we describe other avenues of research that may give clues as to whether indeed a genetically modified animal has alterations relevant to clinical depression. We suggest that it is prudent and most appropriate to use convergent tests that draw on different antidepressant-related endophenotypes, and complimentary physiological analyses in order to provide a program of information concerning whether a given phenotype is functionally relevant to depression-related pathology.

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Crossref · 10.1038/sj.mp.4001457

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  • An activated brain CRF system following partner loss negatively impacts striatal OT signaling, causing increased passive stress-coping behavior indicative of depressive-like behavior.

    “Taken together, these data provide striking evidence for the significant negative impact of an activated brain CRF system following partner loss on striatal OT signaling, thereby causing the increased passive stress-coping behavior indicative of depressive-like behavior”

    From Oxytocin and Social Relationships: From Attachment to Bond Disruption (2017) · cites this paper as Cryan and Mombereau 2004

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Authors
Cryan, J. F., & Mombereau, C.
Affiliations
Novartis (Switzerland) (CH)
Corresponding author
Cryan, J F
ORCID
Venue
Molecular Psychiatry
Publisher
Springer Science and Business Media LLC
Published
2004-01-13
Volume
9
Issue
4
Pages
326-357
ISSN
  • 1359-4184 (ISSN-L)
  • 1476-5578
DOI
10.1038/sj.mp.4001457
OpenAlex
W2155181385
Cited by
616
References
424
Citations by year
2026: 8 · 2025: 9 · 2024: 14 · 2023: 17 · 2022: 25 · 2021: 33 · 2020: 27 · 2019: 27 · 2018: 34 · 2017: 28 · 2016: 25 · 2015: 43 · 2014: 40 · 2013: 26 · 2012: 33
FWCI
3.33
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Molecular Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (U01MH069062, MH69062)
Topics
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
depression, genetically modified mice, animal models of depression, depression-like behavior, antidepressants, forced swim test, tail suspension test, olfactory bulbectomy, learned helplessness, chronic mild stress, endophenotypes, antidepressant targets
MeSH terms
Animals, Behavior, Animal, Depressive Disorder, Disease Models, Animal, Mice, Mutant Strains, Sensitivity and Specificity, Reproducibility of Results, Animals, Genetically Modified, Mice

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