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Cited by 212Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMemory and Neural MechanismsChild and Adolescent Psychosocial and Emotional Development

Baseline and fear-potentiated startle in panic disorder patients

Grillon, Christian, Ameli, Rezvan, Goddard, Andrew, Woods, Scott W., Davis, Michael·1994·Biological Psychiatry
DOI 10.1016/0006-3223(94)90040-x
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Abstract

The present study investigated whether patients with panic disorder had an increase in the startle response and whether this effect, if present, was specific to anticipatory anxiety. The eyeblink component of the acoustic startle reflex was measured in a paradigm involving the anticipation of electric shocks (fear-potentiated startle) in 34 patients with panic disorder and 49 healthy controls. Startle was also recorded in the absence of specific threat at the beginning and at the end of the testing. The testing consisted of three phases: adaptation, fear-potentiated startle, and recovery. In the adaptation and recovery phases, startle stimuli were delivered in the absence of threat. In the fear-potentiated startle phase, startle stimuli were delivered in threat conditions, when subjects anticipated shocks, and in safe conditions that predicted the absence of shocks. Startle was larger in the younger patients (age or = 39 years old), compared to the older controls. The results are discussed in terms of the contextual effects of the experimental setting.

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Crossref · 10.1016/0006-3223(94)90040-x

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  • In panic disorder, startle is larger in a threatening context but not at baseline when no stressor is present.

    “startle is exaggerated in panic disorder when tested in a threatening context (Grillon et al, 1994a), but not at baseline without obvious stressors (Amrhein et al, 2005; Ludewig et al, 2002; McTeague et al, 2009).”

    From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Grillon et al, 1994a

  • Panic disorder shows increased startle with diffuse distal threat, not with proximal threat.

    “In panic disorder, enhanced startle is associated with diffuse distal threat but not proximal threat (Grillon et al, 1994a).”

    From Phasic vs Sustained Fear in Rats and Humans: Role of the Extended Amygdala in Fear vs Anxiety (2010) · cites this paper as Grillon et al, 1994a

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Authors
Grillon, C., Ameli, R., Goddard, A., Woods, S. W., & Davis, M.
Affiliations
  • Yale University (US)
  • Connecticut Mental Health Center (US)
Corresponding author
Grillon, Christian
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1994-04
Volume
35
Issue
7
Pages
431-439
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/0006-3223(94)90040-x
OpenAlex
W2030392869
Cited by
212
References
45
Citations by year
2026: 1 · 2025: 3 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 4 · 2020: 5 · 2019: 2 · 2018: 7 · 2017: 6 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 14 · 2012: 11
FWCI
6.36
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5r29mh050720-05)
  • National Institute of Mental Health (NIMH 1 R29 MH50720, NIMH MH-47840, 2-PO1-MH25642, P01MH025642)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
panic disorder, fear-potentiated startle, acoustic startle response, anticipatory anxiety, eyeblink response, age differences, contextual effects, threat anticipation
MeSH terms
Adolescent, Adult, Anxiety, Blinking, Electromyography, Fear, Female, Humans, Middle Aged, Psychiatric Status Rating Scales, Reflex, Startle, Panic Disorder

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