The DOI matches its Crossref record; 153 of the 153 references it cites were found in a registry or an index.
Corticosteroid–serotonin interactions in depression: a review of the human evidence
Open accessAbstract
Rationale It has been suggested that corticosteroid-serotonin interactions are central to the pathophysiology of depression. These interactions have been investigated in healthy and depressed humans, primarily using neuroendocrine techniques.Objectives To review the evidence regarding the nature of these interactions in healthy and depressed humans.Methods Electronic searches were performed for relevant papers, employing MEDLINE and Web of Science. To focus the review, we selected only those articles involving (i) assessment of serotonergic function following experimental manipulation of the HPA axis in healthy volunteers; and (ii) assessment of both serotonergic and HPA axis function in clinically depressed subjects.Results Pre-treatment with hydrocortisone, both acutely and sub-acutely attenuates the GH response to GHRH in healthy subjects. This complicates the interpretation of 5-HT neuroendocrine studies employing GH output as a measure. In depression there is evidence that reduced availability of l-tryptophan impairs HPA axis feedback. There is also evidence that depressed and healthy subjects may adapt differently both to low tryptophan and hypercortisolaemic challenges. There is no consistent evidence of a simple relationship between HPA axis function and 5-HT function in depression.Conclusions The putative reduction in central 5-HT function has not been shown to be a direct consequence of hypercortisolaemia. Rather, the 5-HT system and HPA axis have complex inter-relationships. Challenges to either system, such as stress or reduced dietary tryptophan, may perturb the other and subjects vulnerable to depression may fail to adapt to such challenges.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Serotonin is an upstream modulator of SRS activity through its action on the amygdala and hypothalamus; serotonergic neurotransmission, in turn, is reciprocally affected by cortisol (Porter et al., 2004; van Goozen et al., 2007)”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Porter et al., 2004
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,845
A molecular and cellular theory of depression
Duman, R. S. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830190015002 · Cited by 2,129
Antidepressants and Hypothalamic-Pituitary-Adrenocortical Regulation
HOLSBOER, F., & Barden, N. (1996) · Endocrine Reviews · doi:10.1210/edrv-17-2-187 · Cited by 860
Disrupted 24-hour patterns of cortisol secretion in psychotic depression
Sachar, E. J. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750310011002 · Cited by 775
Gold, P. W., Loriaux, D. L., Roy, A., Kling, M. A., Calabrese, J. R., Kellner, C. H., Nieman, L. K., Post, R. M., Pickar, D., Gallucci, W. T., et al. (1986) · New England Journal of Medicine · doi:10.1056/nejm198605223142101 · Cited by 766
Salivary cortisol: a better measure of adrenal cortical function than serum cortisol
Vining, R. F., McGinley, R. A., Maksvytis, J. J., & Ho, K. Y. (1983) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456328302000601 · Cited by 684
Pet imaging of serotonin 1A receptor binding in depression
Drevets, W. C., Frank, E., Price, J. C., Kupfer, D. J., Holt, D., Greer, P. J., Huang, Y., Gautier, C., & Mathis, C. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00189-4 · Cited by 666
The combined dexamethasone/CRH test: A refined laboratory test for psychiatric disorders
Heuser, I., Yassouridis, A., & Holsboer, F. (1994) · Journal of Psychiatric Research · doi:10.1016/0022-3956(94)90017-5 · Cited by 662
Brain Serotonin1A Receptor Binding Measured by Positron Emission Tomography With [11C]WAY-100635
Sargent, P. A., Kjaer, K. H., Bench, C. J., Rabiner, E. A., Messa, C., Meyer, J., Gunn, R. N., Grasby, P. M., & Cowen, P. J. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.2.174 · Cited by 642
(1996) · PubMed · Cited by 547
Cited by
Sorted by citations
The Adaptive Calibration Model of stress responsivity
Del Giudice, M., Ellis, B. J., & Shirtcliff, E. A. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.11.007 · Cited by 1,373
HPA Axis Reactivity: A Mechanism Underlying the Associations Among 5-HTTLPR, Stress, and Depression
Gotlib, I. H., Joormann, J., Minor, K. L., & Hallmayer, J. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.10.008 · Cited by 558
The evidence for a neurobiological model of childhood antisocial behavior
van Goozen, S. H. M., Fairchild, G., Snoek, H., & Harold, G. T. (2007) · Psychological Bulletin · doi:10.1037/0033-2909.133.1.149 · Cited by 475
Boyle, M. P., Brewer, J. A., Funatsu, M., Wozniak, D. F., Tsien, J. Z., Izumi, Y., & Muglia, L. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0406458102 · Cited by 378
Serotonergic vulnerability and depression: assumptions, experimental evidence and implications
Jans, L. A. W., Riedel, W. J., Markus, C. R., & Blokland, A. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001920 · Cited by 382
Metadata
- Authors
- Porter, R. J., Gallagher, P., Watson, S., & Young, A. H.
- Affiliations
- Royal Victoria Infirmary (GB)
- Corresponding author
- Porter, Richard J.
- Venue
- Psychopharmacology
- Published
- 2004-04-01
- Volume
- 173
- Issue
- 1-2
- Pages
- 1-17
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2106308884
- Cited by
- 169
- References
- 153
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 2 · 2023: 1 · 2022: 4 · 2021: 6 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 7 · 2016: 1 · 2015: 5 · 2014: 12 · 2013: 8 · 2012: 13
- FWCI
- 5.48
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Newcastle University ePrints (Newcastle Univesity)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- depression, hypothalamic-pituitary-adrenal axis, serotonin, cortisol, growth hormone, growth hormone-releasing hormone, tryptophan, hypercortisolism, stress adaptation, neuroendocrine function
- MeSH terms
- Adrenal Cortex Hormones, Animals, Depression, Humans, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Serotonin, MEDLINE, Evidence-Based Medicine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
