Acquired deficit of forebrain glucocorticoid receptor produces depression-like changes in adrenal axis regulation and behavior

Protective and Damaging Effects of Stress Mediators

McEwen, B. S. (1998) · New England Journal of Medicine · doi:10.1056/nejm199801153380307 · Cited by 6,733 · see citing works

Brain corticosteroid receptor balance in health and disease

de Kloet, E. R., Vreugdenhil, E., Oitzl, M. S., & Joëls, M. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.3.0331 · Cited by 2,614 · see citing works

The Corticosteroid Receptor Hypothesis of Depression

Holsboer, F. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00159-7 · Cited by 2,181 · see citing works

STRESS AND HIPPOCAMPAL PLASTICITY

McEwen, B. S. (1999) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.22.1.105 · Cited by 2,087 · see citing works

Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety

Tronche, F., Kellendonk, C., Kretz, O., Gass, P., Anlag, K., Orban, P. C., Bock, R., Klein, R., & Schütz, G. (1999) · Nature Genetics · doi:10.1038/12703 · Cited by 1,841 · see citing works

Central mechanisms of stress integration: hierarchical circuitry controlling hypothalamo–pituitary–adrenocortical responsiveness

Herman, J. P., Figueiredo, H., Mueller, N. K., Ulrich-Lai, Y., Ostrander, M. M., Choi, D. C., & Cullinan, W. E. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2003.07.001 · Cited by 1,586 · see citing works

Subregion- and Cell Type–Restricted Gene Knockout in Mouse Brain

Tsien, J. Z., Chen, D. F., Gerber, D., Tom, C., Mercer, E. H., Anderson, D. J., Mayford, M., Kandel, E. R., & Tonegawa, S. (1996) · Cell · doi:10.1016/s0092-8674(00)81826-7 · Cited by 1,280 · see citing works

Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment

Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147 · see citing works

Early Environmental Regulation of Forebrain Glucocorticoid Receptor Gene Expression: Implications for Adrenocortical Responses to Stress; pp. 49–60

Meaney, M. J., Diorio, J., Francis, D., Widdowson, J., LaPlante, P., Caldji, C., Sharma, S., Seckl, J. R., & Plotsky, P. M. (2010) · Developmental Neuroscience · doi:10.1159/000111395 · Cited by 878 · see citing works

Do early‐life events permanently alter behavioral and hormonal responses to stressors?

Anisman, H., Zaharia, M. D., Meaney, M. J., & Merali, Z. (1998) · International Journal of Developmental Neuroscience · doi:10.1016/s0736-5748(98)00025-2 · Cited by 654 · see citing works

Variations in maternal care in infancy regulate the development of stress reactivity

Caldji, C., Diorio, J. C., & Meaney, M. J. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01084-2 · Cited by 574 · see citing works

Regional specificity of brain glucocorticoid receptor mRNA alterations in subjects with schizophrenia and mood disorders

Webster, M. J., Knable, M. B., O'Grady, J., Orthmann, J., & Weickert, C. S. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001139 · Cited by 420 · see citing works

Implication of the hypothalamic-pituitary-adrenal axis in the physiopathology of depression

Barden, N. (2004) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0421 · Cited by 416 · see citing works

Altered Hypothalamic-Pituitary-Adrenocortical Regulation in Healthy Subjects at High Familial Risk for Affective Disorders

Holsboer, F., Lauer, C. J., Schreiber, W., & Krieg, J.-C. (2008) · Neuroendocrinology · doi:10.1159/000127023 · Cited by 369 · see citing works

Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system

Reul, J. M. H. M., Stec, I. S. M., Söder, M., & Holsboer, F. (1993) · Endocrinology · doi:10.1210/endo.133.1.8391426 · Cited by 346 · see citing works

Long-term antidepressant administration alters corticotropin-releasing hormone, tyrosine hydroxylase, and mineralocorticoid receptor gene expression in rat brain. Therapeutic implications.

Brady, L. S., Whitfield, H. J., Fox, R. J., Gold, P. W., & Herkenham, M. A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115086 · Cited by 338 · see citing works

The dexamethasone suppression test: an overview of its current status in psychiatry. The APA Task Force on Laboratory Tests in Psychiatry

(1987) · American Journal of Psychiatry · doi:10.1176/ajp.144.10.1253 · Cited by 262 · see citing works

Glucocorticoid receptor variants: clinical implications

DeRijk, R. H., Schaaf, M. J. M., & de Kloet, E. R. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00062-6 · Cited by 252 · see citing works

Impaired Synaptic Plasticity and cAMP Response Element-Binding Protein Activation in Ca2+/Calmodulin-Dependent Protein Kinase Type IV/Gr-Deficient Mice

Ho, N. Y., Liauw, J. A., Blaeser, F., Feng, W., Hanissian, S. H., Muglia, L. M., Wozniak, D. F., Nardi, A., Arvin, K. L., Holtzman, D. M., et al. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-17-06459.2000 · Cited by 251 · see citing works

Glucocorticoid receptor overexpression in forebrain: A mouse model of increased emotional lability

Wei, Q., Lu, X., Liu, L., Schafer, G. L., Shieh, K.-R., Burke, S., Robinson, T. E., Watson, S. J., Seasholtz, A. F., & Akil, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0402208101 · Cited by 249 · see citing works

Corticosteroid Receptor Function Is Decreased in Depressed Patients

Modell, S., Yassouridis, A., Huber, J., & Holsboer, F. (2008) · Neuroendocrinology · doi:10.1159/000127275 · Cited by 204 · see citing works

Hypothalamic-Pituitary-Adrenocortical Axis Changes in the Rat after Long-Term Treatment with the Reversible Monoamine Oxidase-A Inhibitor Moclobemide

Reul, J. M. H. M., Labeur, M. S., Grigoriadis, D. E., Souza, E. B. D., & Holsboer, F. (2008) · Neuroendocrinology · doi:10.1159/000126788 · Cited by 174 · see citing works

Corticosteroid–serotonin interactions in depression: a review of the human evidence

Porter, R. J., Gallagher, P., Watson, S., & Young, A. H. (2004) · Psychopharmacology · doi:10.1007/s00213-004-1774-1 · Cited by 169 · see citing works

Environmental stress and psychiatric illness

Agid, O., Kohn, Y., & Lerer, B. (2000) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(00)89046-0 · Cited by 169 · see citing works

Glucocorticoids and depression

Steckler, T., Holsboer, F., & Reul, J. M. H. M. (1999) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1053/beem.1999.0046 · Cited by 160 · see citing works

T-cell glucocorticoid receptor is required to suppress COX-2-mediated lethal immune activation

Brewer, J. A., Khor, B., Vogt, S. K., Muglia, L. M., Fujiwara, H., Haegele, K. E., Sleckman, B. P., & Muglia, L. J. (2003) · Nature Medicine · doi:10.1038/nm895 · Cited by 149 · see citing works

Stress, immunity and illness — a review

Dorian, B. J., & Garfinkel, P. E. (1987) · Psychological Medicine · doi:10.1017/s0033291700024958 · Cited by 139 · see citing works

Mice with targeted mutations of glucocorticoid and mineralocorticoid receptors: Models for depression and anxiety?

Gass, P., Reichardt, H. M., Strekalova, T. V., Henn, F. A., & Tronche, F. (2001) · Physiology & Behavior · doi:10.1016/s0031-9384(01)00518-2 · Cited by 117 · see citing works

Antidepressant drugs inhibit glucocorticoid receptor‐mediated gene transcription – a possible mechanism

Budziszewska, B., Jaworska-Feil, L., Kajta, M., & Lasoń, W. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703445 · Cited by 108 · see citing works

Characterization and functional significance of glucocorticoid receptors in patients with major depression: modulation by antidepressant treatment

Calfa, G. D., Kademian, S., Ceschin, D. G., Vega, G., Rabinovich, G. A., & Volosin, M. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(02)00051-3 · Cited by 97 · see citing works

Natural History and Preventative Treatment of Recurrent Mood Disorders

Frank, E., & Thase, M. E. (1999) · Annual Review of Medicine · doi:10.1146/annurev.med.50.1.453 · Cited by 96 · see citing works

Endocrine Profile and Neuroendocrine Challenge Tests in Transgenic Mice Expressing Antisense RNA against the Glucocorticoid Receptor

Barden, N., Stec, I. S. M., Montkowski, A., Holsboer, F., & Reul, J. M. H. M. (2008) · Neuroendocrinology · doi:10.1159/000127240 · Cited by 94 · see citing works

Repeated treatment with antidepressants differentially alters 5-HT1A agonist-stimulated [35S]GTPγS binding in rat brain regions

Shen, C., Li, H., & Meller, E. (2002) · Neuropharmacology · doi:10.1016/s0028-3908(02)00064-3 · Cited by 80 · see citing works

Hypothalamic-Pituitary-Adrenocortical Axis Changes in a Transgenic Mouse with Impaired Glucocorticoid Receptor Function

Karanth, S., Linthorst, A. C. E., Stalla, G. K., Barden, N., Holsboer, F., & Reul, J. M. H. M. (1997) · Endocrinology · doi:10.1210/endo.138.8.5331 · Cited by 79 · see citing works

Molecular genetic analysis of glucocorticoid signalling in development

Schmid, W., Cole, T. J., Blendy, J. A., & Schütz, G. (1995) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/0960-0760(95)00038-2 · Cited by 70 · see citing works

Effects of antidepressants on monoamine transporters

Langer, S. Z., & Schoemaker, H. E. (1988) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/0278-5846(88)90037-1 · Cited by 58 · see citing works

Pituitary-adrenal cortical axis measures as predictors of sustained remission in major depression

O’Toole, S. M., Sekula, L. K., & Rubín, R. T. (1997) · Biological Psychiatry · doi:10.1016/s0006-3223(96)00293-4 · Cited by 40 · see citing works

High‐Quality Antidepressant Discovery by Understanding Stress Hormone Physiology

HOLSBOER, F. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1286.038 · Cited by 22 · see citing works

Dissecting Adrenal and Behavioral Responses to Stress by Targeted Gene Inactivation in Mice

Brewer, J. A., Bethin, K. E., Schaefer, M. L., Muglia, L. M., Vogt, S. K., Weninger, S. C., Majzoub, J. A., & Muglia, L. J. (2003) · Stress · doi:10.1080/1025389031000116460 · Cited by 11 · see citing works

Stress and the brain: from adaptation to disease

de Kloet, E. R., Joëls, M., & Holsboer, F. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1683 · Cited by 4,621 · see citing works

Epigenetic regulation of the glucocorticoid receptor in human brain associates with childhood abuse

McGowan, P. O., Sasaki, A., D'Alessio, A. C., Dymov, S., Labonté, B., Szyf, M., Turecki, G., & Meaney, M. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2270 · Cited by 3,531 · see citing works

Neural regulation of endocrine and autonomic stress responses

Ulrich-Lai, Y. M., & Herman, J. P. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2647 · Cited by 3,318 · see citing works

Major depressive disorder

Belmaker, R. H., & Agam, G. (2008) · New England Journal of Medicine · doi:10.1056/nejmra073096 · Cited by 2,166 · see citing works

New approaches to antidepressant drug discovery: beyond monoamines

Berton, O., & Nestler, E. J. (2006) · Nature Reviews Neuroscience · doi:10.1038/nrn1846 · Cited by 1,589 · see citing works

The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders

Binder, E. B. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.05.021 · Cited by 968 · see citing works

Chronic restraint stress causes anxiety- and depression-like behaviors, downregulates glucocorticoid receptor expression, and attenuates glutamate release induced by brain-derived neurotrophic factor in the prefrontal cortex

Chiba, S., Numakawa, T., Ninomiya, M., Richards, M. C., Wakabayashi, C., & Kunugi, H. (2012) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2012.05.018 · Cited by 673 · see citing works

Linking Molecules to Mood: New Insight Into the Biology of Depression

Krishnan, V., & Nestler, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.10030434 · Cited by 643 · see citing works

Limbic Regulation of Hypothalamo‐Pituitary‐Adrenocortical Function during Acute and Chronic Stress

Jankord, R., & Herman, J. P. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1410.012 · Cited by 578 · see citing works

The glucocorticoid receptor: Pivot of depression and of antidepressant treatment?

Anacker, C., Zunszain, P. A., Carvalho, L. A., & Pariante, C. M. (2011) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2010.03.007 · Cited by 592 · see citing works

Multi-target strategies for the improved treatment of depressive states: Conceptual foundations and neuronal substrates, drug discovery and therapeutic application

Millan, M. J. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.11.006 · Cited by 549 · see citing works

Animal Models of Depression: Molecular Perspectives

Krishnan, V., & Nestler, E. J. (2011) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2010_108 · Cited by 528 · see citing works

The HPA – Immune Axis and the Immunomodulatory Actions of Glucocorticoids in the Brain

Bellavance, M.-A., & Rivest, S. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00136 · Cited by 419 · see citing works

A users guide to HPA axis research

Spencer, R. L., & Terrence Deak, B. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.014 · Cited by 408 · see citing works

Neural control of chronic stress adaptation

Herman, J. P. (2013) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2013.00061 · Cited by 384 · see citing works

Neurodevelopmental sequelae of postnatal maternal care in rodents: clinical and research implications of molecular insights

Kaffman, A., & Meaney, M. J. (2007) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01730.x · Cited by 385 · see citing works

Mice with Genetically Altered Glucocorticoid Receptor Expression Show Altered Sensitivity for Stress-Induced Depressive Reactions

Ridder, S., Chourbaji, S., Hellweg, R., Urani, A., Zacher, C., Schmid, W., Zink, M., Hörtnagl, H., Flor, H., Henn, F. A., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.0736-05.2005 · Cited by 382 · see citing works

The recent progress in animal models of depression

Wang, Q., Timberlake, M. A., Prall, K., & Dwivedi, Y. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.04.008 · Cited by 370 · see citing works

Epigenetic Mechanisms for the Early Environmental Regulation of Hippocampal Glucocorticoid Receptor Gene Expression in Rodents and Humans

Zhang, T. Y., Labonté, B., Wen, X. L., Turecki, G., & Meaney, M. J. (2013) · Neuropsychopharmacology · doi:10.1038/npp.2012.149 · Cited by 347 · see citing works

Differential Glucocorticoid Receptor Exon 1B, 1C, and 1H Expression and Methylation in Suicide Completers with a History of Childhood Abuse

Labonte, B., Yerko, V., Gross, J., Mechawar, N., Meaney, M. J., Szyf, M., & Turecki, G. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.034 · Cited by 345 · see citing works

Maternal programming of steroid receptor expression and phenotype through DNA methylation in the rat

Szyf, M., Weaver, I. C. G., Champagne, F. A., Diorio, J., & Meaney, M. J. (2005) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2005.10.002 · Cited by 348 · see citing works

Glucocorticoid actions on synapses, circuits, and behavior: Implications for the energetics of stress

Myers, B., McKlveen, J. M., & Herman, J. P. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2013.12.003 · Cited by 318 · see citing works

Polymorphisms of the Glucocorticoid Receptor Gene and Major Depression

van Rossum, E. F. C., Binder, E. B., Majer, M., Koper, J. W., Ising, M., Modell, S., Salyakina, D., Lamberts, S. W. J., & Holsboer, F. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.02.007 · Cited by 324 · see citing works

Metabolic disturbances connecting obesity and depression

Hryhorczuk, C., Sharma, S., & Fulton, S. E. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00177 · Cited by 322 · see citing works

Neural regulation of the stress response: glucocorticoid feedback mechanisms

Herman, J. P., McKlveen, J. M., Solomon, M. B., Carvalho-Netto, E., & Myers, B. (2012) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2012007500041 · Cited by 307 · see citing works

Mood, food, and obesity

Singh, M. (2014) · Frontiers in Psychology · doi:10.3389/fpsyg.2014.00925 · Cited by 337 · see citing works

FK506 Binding Protein 5 Shapes Stress Responsiveness: Modulation of Neuroendocrine Reactivity and Coping Behavior

Touma, C., Gassen, N. C., Herrmann, L., Cheung‐Flynn, J., Büll, D., Ionescu, I. A., Heinzmann, J.-M., Knapman, A., Siebertz, A., Depping, A., et al. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.07.023 · Cited by 270 · see citing works

Glucocorticoid regulation of brain-derived neurotrophic factor: Relevance to hippocampal structural and functional plasticity

Suri, D., & Vaidya, V. A. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.065 · Cited by 253 · see citing works

An affective disorder in zebrafish with mutation of the glucocorticoid receptor

Ziv, L., Muto, A., Schoonheim, P. J., Meijsing, S. H., Strasser, D., Ingraham, H. A., Schaaf, M. J. M., Yamamoto, K. R., & Baier, H. (2012) · Molecular Psychiatry · doi:10.1038/mp.2012.64 · Cited by 241 · see citing works

Intracellular Glucocorticoid Signaling: A Formerly Simple System Turns Stochastic

Chrousos, G. P., & Kino, T. (2005) · Science s STKE · doi:10.1126/stke.3042005pe48 · Cited by 241 · see citing works

Role of the ventral subiculum in stress integration

Herman, J. P., & Mueller, N. K. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.05.035 · Cited by 235 · see citing works

Prolonged Restraint Stress Increases IL-6, Reduces IL-10, and Causes Persistent Depressive-Like Behavior That Is Reversed by Recombinant IL-10

Voorhees, J. L., Tarr, A. J., Wohleb, E. S., Godbout, J. P., Mo, X., Sheridan, J. F., Eubank, T. D., & Marsh, C. B. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058488 · Cited by 236 · see citing works

Mineralocorticoid and glucocorticoid receptor balance in control of HPA axis and behaviour

Harris, A. P., Holmes, M. C., de Kloet, E. R., Chapman, K. E., & Seckl, J. R. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.08.007 · Cited by 231 · see citing works

Microbiota modulate anxiety-like behavior and endocrine abnormalities in hypothalamic-pituitary-adrenal axis

Huo, R., Zeng, B., Zeng, L., Cheng, K., Li, B., Luo, Y., Wang, H., Zhou, C., Fang, L., Li, W., et al. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00489 · Cited by 221 · see citing works

Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives

Watt, D. F., & Panksepp, J. (2009) · Neuropsychoanalysis · doi:10.1080/15294145.2009.10773593 · Cited by 207 · see citing works

Maternal programming of defensive responses through sustained effects on gene expression

Zhang, T.-Y., Bagot, R., Parent, C., Nesbitt, C., Bredy, T. W., Caldji, C., Fish, E., Anisman, H., Szyf, M., & Meaney, M. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.009 · Cited by 206 · see citing works

Mineralocorticoid receptor overexpression in forebrain decreases anxiety-like behavior and alters the stress response in mice

Rozeboom, A. M., Akil, H., & Seasholtz, A. F. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606067104 · Cited by 206 · see citing works

Therapy Insight: is there an imbalanced response of mineralocorticoid and glucocorticoid receptors in depression?

de Kloet, E. R., DeRijk, R. H., & Meijer, O. C. (2007) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0403 · Cited by 193 · see citing works

The glucocorticoid receptor: part of the solution or part of the problem?

Pariante, C. M. (2006) · Journal of Psychopharmacology · doi:10.1177/1359786806066063 · Cited by 192 · see citing works

Chronic stress exposure may affect the brain’s response to high calorie food cues and predispose to obesogenic eating habits

Tryon, M. S., Carter, C. S., DeCant, R., & Laugero, K. D. (2013) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.08.010 · Cited by 191 · see citing works

The exercise-glucocorticoid paradox: How exercise is beneficial to cognition, mood, and the brain while increasing glucocorticoid levels

Chen, C., Nakagawa, S., An, Y., Ito, K., Kitaichi, Y., & Kusumi, I. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2016.12.001 · Cited by 191 · see citing works

Understanding stress: Insights from rodent models

Atrooz, F., Alkadhi, K. A., & Salim, S. (2021) · Current Research in Neurobiology · doi:10.1016/j.crneur.2021.100013 · Cited by 201 · see citing works

The Role of the Forebrain Glucocorticoid Receptor in Acute and Chronic Stress

Furay, A. R., Packard, A. E. B., & Herman, J. P. (2008) · Endocrinology · doi:10.1210/en.2008-0642 · Cited by 189 · see citing works

Differential expression of glucocorticoid receptor transcripts in major depressive disorder is not epigenetically programmed

Alt, S. R., Turner, J. D., Klok, M. D., Meijer, O. C., Lakke, E. A. J. F., DeRijk, R. H., & Muller, C. P. (2010) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.09.001 · Cited by 184 · see citing works

Hypothalamic‐Pituitary‐Adrenal (HPA) Axis and Aging

Gupta, D., & Morley, J. E. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130049 · Cited by 196 · see citing works

Brain-derived neurotrophic factor and glucocorticoids: Reciprocal influence on the central nervous system

Numakawa, T., Adachi, N., Richards, M., Chiba, S., & Kunugi, H. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.073 · Cited by 180 · see citing works

Mapping Acute Systemic Effects of Inhaled Particulate Matter and Ozone: Multiorgan Gene Expression and Glucocorticoid Activity

Thomson, E. M., Vladisavljevic, D., Mohottalage, S., Kumarathasan, P., & Vincent, R. (2013) · Toxicological Sciences · doi:10.1093/toxsci/kft137 · Cited by 177 · see citing works

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

Kaidanovich‐Beilin, O., Lipina, T. V., Takao, K., van Eede, M., Hattori, S., Laliberté, C. L., Khan, M., Okamoto, K., Chambers, J. W., Fletcher, P. J., et al. (2009) · Molecular Brain · doi:10.1186/1756-6606-2-35 · Cited by 176 · see citing works

Neural Regulation of the Stress Response: The Many Faces of Feedback

Myers, B., McKlveen, J. M., & Herman, J. P. (2012) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-012-9801-y · Cited by 175 · see citing works

Forebrain Glucocorticoid Receptors Modulate Anxiety-Associated Locomotor Activation and Adrenal Responsiveness

Boyle, M. P., Kolber, B. J., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.2173-05.2006 · Cited by 172 · see citing works

Central amygdala glucocorticoid receptor action promotes fear-associated CRH activation and conditioning

Kolber, B. J., Roberts, M. S., Howell, M. P., Wozniak, D. F., Sands, M. S., & Muglia, L. J. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803216105 · Cited by 169 · see citing works

Cellular Plasticity Cascades: Genes-To-Behavior Pathways in Animal Models of Bipolar Disorder

Einat, H., & Manji, H. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.11.004 · Cited by 154 · see citing works

Glucocorticoid Receptor Gene-Based SNP Analysis in Patients with Recurrent Major Depression

West, D. V., Eede, F. V. D., Del‐Favero, J., Souery, D., Norrback, K., van Duijn, C. M., Sluijs, S., Adolfsson, R., Mendlewicz, J., Deboutte, D., et al. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300898 · Cited by 155 · see citing works

Mineralocorticoid and glucocorticoid receptor-mediated control of genomic responses to stress in the brain

Mifsud, K. R., & Reul, J. M. H. M. (2018) · Stress · doi:10.1080/10253890.2018.1456526 · Cited by 154 · see citing works

Hypothalamus-pituitary-adrenal and gut-brain axes in biological interaction pathway of the depression

Bertollo, A. G., Santos, C. F., Bagatini, M. D., & Ignácio, Z. M. (2025) · Frontiers in Neuroscience · doi:10.3389/fnins.2025.1541075 · Cited by 177 · see citing works

Age-related differences in glucocorticoid receptor mRNA levels in the human brain

Perlman, W. R., Webster, M. J., Herman, M. M., Kleinman, J. E., & Weickert, C. S. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2006.01.010 · Cited by 152 · see citing works

Glucocorticoid Receptor Function<i>In Vitro</i>in Patients with Major Depression

Pariante, C. M. (2004) · Stress · doi:10.1080/10253890500069650 · Cited by 147 · see citing works

Conditional gene targeting in the mouse nervous system: Insights into brain function and diseases

Gavériaux‐Ruff, C., & Kieffer, B. L. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.12.003 · Cited by 146 · see citing works

Endogenous cortisol is associated with functional connectivity between the amygdala and medial prefrontal cortex

Veer, I. M., Oei, N. Y. L., Spinhoven, P., van Buchem, M. A., Elzinga, B. M., & Rombouts, S. A. R. B. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2011.12.001 · Cited by 140 · see citing works

Postnatal ontogeny of expression of the corticosteroid receptor genes in mammalian brains: Inter-species and intra-species differences

Pryce, C. R. (2007) · Brain Research Reviews · doi:10.1016/j.brainresrev.2007.08.005 · Cited by 144 · see citing works

Association between Glucocorticoid Receptor Methylation and Hippocampal Subfields in Major Depressive Disorder

Na, K., Chang, H. S., Won, E., Han, K., Choi, S., Tae, W., Yoon, H., Kim, Y., Joe, S., Jung, I., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0085425 · Cited by 144 · see citing works

Hippocampal Neuronal Nitric Oxide Synthase Mediates the Stress-Related Depressive Behaviors of Glucocorticoids by Downregulating Glucocorticoid Receptor

Zhou, Q., Zhu, L., Chen, C., Wu, H., Luo, C., Chang, L., & Zhu, D. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0004-11.2011 · Cited by 143 · see citing works

Treatment-resistant depression: are animal models of depression fit for purpose?

Willner, P., & Belzung, C. (2015) · Psychopharmacology · doi:10.1007/s00213-015-4034-7 · Cited by 140 · see citing works

Are BDNF and glucocorticoid activities calibrated?

Jeanneteau, F. D., & Chao, M. V. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.09.017 · Cited by 141 · see citing works

The cortisol switch between vulnerability and resilience

de Kloet, E. R., & Joëls, M. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01934-8 · Cited by 153 · see citing works

Mechanisms of Glucocorticoid Action During Development

Busada, J. T., & Cidlowski, J. A. (2017) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2016.12.004 · Cited by 141 · see citing works

Neurobiological Mechanisms of Stress Resilience and Implications for the Aged Population

Faye, C., McGowan, J. C., Denny, C. A., & David, D. J. P. (2018) · Current Neuropharmacology · doi:10.2174/1570159x15666170818095105 · Cited by 137 · see citing works

Cyclin-Dependent Kinase 5 Differentially Regulates the Transcriptional Activity of the Glucocorticoid Receptor through Phosphorylation: Clinical Implications for the Nervous System Response to Glucocorticoids and Stress

Kino, T., Ichijo, T., Amin, N. D., Kesavapany, S., Wang, Y., Kim, N., Rao, S., Player, A. N., Zheng, Y., Garabedian, M. J., et al. (2007) · Molecular Endocrinology · doi:10.1210/me.2006-0345 · Cited by 129 · see citing works

Metabotropic Glutamate Receptor Subtype 7 Ablation Causes Dysregulation of the HPA Axis and Increases Hippocampal BDNF Protein Levels: Implications for Stress-Related Psychiatric Disorders

Mitsukawa, K., Mombereau, C., Loetscher, E., Uzunov, D. P., van der Putten, H., Flor, P. J., & Cryan, J. F. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300926 · Cited by 128 · see citing works

Psychological stress increases histone H3 phosphorylation in adult dentate gyrus granule neurons: involvement in a glucocorticoid receptor‐dependent behavioural response

Bilang‐Bleuel, A., Ulbricht, S., Chandramohan, Y., Carli, S. D., Droste, S. K., & Reul, J. M. H. M. (2005) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2005.04358.x · Cited by 126 · see citing works

Glucocorticoid Signaling in Health and Disease: Insights From Tissue-Specific GR Knockout Mice

Whirledge, S., & DeFranco, D. B. (2017) · Endocrinology · doi:10.1210/en.2017-00728 · Cited by 126 · see citing works

A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure

Watson, M. L., Baehr, L. M., Reichardt, H. M., Tuckermann, J. P., Bodine, S. C., & Furlow, J. D. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00512.2011 · Cited by 120 · see citing works

Stress-induced mechanisms in mental illness: A role for glucocorticoid signalling

Cattaneo, A., & Riva, M. A. (2016) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2015.07.021 · Cited by 118 · see citing works

Action control is mediated by prefrontal BDNF and glucocorticoid receptor binding

Gourley, S. L., Swanson, A. M., Jacobs, A. M., Howell, J. L., Mo, M., Dileone, R., Koleske, A. J., & Taylor, J. R. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1208342109 · Cited by 118 · see citing works

Synaptic regulation of the hypothalamic–pituitary–adrenal axis and its modulation by glucocorticoids and stress

Levy, B. H., & Tasker, J. G. (2012) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2012.00024 · Cited by 153 · see citing works

The Interface of Pain and Mood Disturbances in the Rheumatic Diseases

Goldenberg, D. L. (2009) · Seminars in Arthritis and Rheumatism · doi:10.1016/j.semarthrit.2008.11.005 · Cited by 112 · see citing works

Corticosterone and related receptor expression are associated with increased β-amyloid plaques in isolated Tg2576 mice

Dong, H., Yuede, C. M., Yoo, H.-S., Martin, M. V., Deal, C., Mace, A. G., & Csernansky, J. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.017 · Cited by 112 · see citing works

HPA axis function in mood disorders

Watson, S., & Mackin, P. (2006) · Psychiatry · doi:10.1383/psyt.2006.5.5.166 · Cited by 111 · see citing works

The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats

Szymańska, M., Budziszewska, B., Jaworska-Feil, L., Basta‐Kaim, A., Kubera, M., Leśkiewicz, M., Regulska, M., & Lasoń, W. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.012 · Cited by 110 · see citing works

Genetic approaches to hypothalamic-pituitary-adrenal axis regulation

Arnett, M. G., Muglia, L. M., Laryea, G., & Muglia, L. J. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.215 · Cited by 105 · see citing works

Open questions in current models of antidepressant action

Tanti, A., & Belzung, C. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00585.x · Cited by 109 · see citing works

Maternal separation and maternal care act independently on the development of HPA responses in male rats

Macrı̀, S., Chiarotti, F., & Würbel, H. (2008) · Behavioural Brain Research · doi:10.1016/j.bbr.2008.03.031 · Cited by 109 · see citing works

Disrupting hypothalamic glucocorticoid receptors causes HPA axis hyperactivity and excess adiposity

Laryea, G., Schütz, G., & Muglia, L. J. (2013) · Molecular Endocrinology · doi:10.1210/me.2013-1187 · Cited by 106 · see citing works

Behavioral Despair and Home-Cage Activity in Mice with Chronically Elevated Baseline Corticosterone Concentrations

Malisch, J. L., Breuner, C. W., Kolb, E. M., Wada, H., Hannon, R. M., Chappell, M. A., Middleton, K. M., & Garland, T. (2008) · Behavior Genetics · doi:10.1007/s10519-008-9246-8 · Cited by 107 · see citing works

Hypothalamic–pituitary–adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function: Review

Kolber, B. J., Wieczorek, L., & Muglia, L. J. (2008) · Stress · doi:10.1080/10253890701821081 · Cited by 106 · see citing works

Depression‐like behavior in the forced swimming test in PACAP‐deficient mice: amelioration by the atypical antipsychotic risperidone

Hashimoto, H., Hashimoto, R., Shintani, N., Tanaka, K., Yamamoto, A., Hatanaka, M., Guo, X., Morita, Y., Tanida, M., Nagai, K., et al. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06168.x · Cited by 105 · see citing works

Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders

Bravo, J. A., Dinan, T. G., & Cryan, J. F. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000994 · Cited by 103 · see citing works

HPA Axis Interactions with Behavioral Systems

Packard, A. E. B., Egan, A. E., & Ulrich‐Lai, Y. M. (2016) · Comprehensive physiology · doi:10.1002/cphy.c150042 · Cited by 130 · see citing works

Genetic Strain Differences in Learned Fear Inhibition Associated with Variation in Neuroendocrine, Autonomic, and Amygdala Dendritic Phenotypes

Camp, M., MacPherson, K. P., Lederle, L. I., Graybeal, C., Gaburro, S., DeBrouse, L., Ihne, J. L., Bravo, J. A., O’Connor, R. M., Ciocchi, S., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.340 · Cited by 101 · see citing works

Glucocorticoid receptor-dependent astrocytes mediate stress vulnerability

Lu, C.-L., Ren, J., Mo, J.-W., Fan, J., Guo, F., Chen, L.-Y., Wen, Y.-L., Li, S.-J., Fang, Y.-Y., Wu, Z.-F., et al. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2021.11.022 · Cited by 97 · see citing works

Emerging roles of SIRT1 activator, SRT2104, in disease treatment

Chang, N., Li, J., Lin, S., Zhang, J., Zeng, W.-Q., Ma, G., & Wang, Y. (2024) · Scientific Reports · doi:10.1038/s41598-024-55923-8 · Cited by 104 · see citing works

The prefrontal–limbic network in depression: Modulation by hypothalamus, basal ganglia and midbrain

Bennett, M. R. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.01.006 · Cited by 97 · see citing works

Forced swim stressor: Trends in usage and mechanistic consideration

Molendijk, M. L., & de Kloet, E. R. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15139 · Cited by 97 · see citing works

Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females

Solomon, M. B., Furay, A. R., Jones, K., Packard, A. E. B., Packard, B. A., Wulsin, A. C., & Herman, J. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.014 · Cited by 96 · see citing works

Transient Early-Life Forebrain Corticotropin-Releasing Hormone Elevation Causes Long-Lasting Anxiogenic and Despair-Like Changes in Mice

Kolber, B. J., Boyle, M. P., Wieczorek, L., Kelley, C. L., Onwuzurike, C., Nettles, S. A., Vogt, S. K., & Muglia, L. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.4470-09.2010 · Cited by 94 · see citing works

Stress and the brain: Solving the puzzle using microdialysis

Linthorst, A. C. E., & Reul, J. M. H. M. (2007) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2007.09.019 · Cited by 94 · see citing works

The hypothalamic-pituitary-adrenal axis as a substrate for stress resilience: Interactions with the circadian clock

Kinlein, S. A., & Karatsoreos, I. N. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100819 · Cited by 98 · see citing works

Maternal Programming of Defensive Responses Through Sustained Effects on Gene Expression

Meaney, M. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0007 · Cited by 92 · see citing works

The immediate early gene early growth response gene 3 mediates adaptation to stress and novelty

Gallitano, A. L., Izumi, Y., Tokuda, K., Zorumski, C. F., Howell, M., Muglia, L. J., Wozniak, D. F., & Milbrandt, J. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.05.050 · Cited by 90 · see citing works

Persistent depressive state after chronic stress in rats is accompanied by HPA axis dysregulation and reduced prefrontal dopaminergic neurotransmission

Mizoguchi, K., Shoji, H., Ikeda, R., Tanaka, Y., & Tabira, T. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.07.002 · Cited by 89 · see citing works

Genetic Dissection of Stress Response Pathways In Vivo

Boyle, M. P., Brewer, J. A., Vogt, S. K., Wozniak, D. F., & Muglia, L. J. (2004) · Endocrine Research · doi:10.1081/erc-200044120 · Cited by 10 · see citing works

Sensitivity of depression-like behavior to glucocorticoids and antidepressants is independent of forebrain glucocorticoid receptors

Vincent, M. Y., Hussain, R. J., Zampi, M. E., Sheeran, K., Solomon, M. B., Herman, J. P., Khan, A. A., & Jacobson, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.05.031 · Cited by 26 · see citing works

Increased antidepressant sensitivity after prefrontal cortex glucocorticoid receptor gene deletion in mice

Hussain, R. J., & Jacobson, L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.10.019 · Cited by 6 · see citing works

The effect of antidepressant drugs on the HPA axis activity, glucocorticoid receptor level and FKBP51 concentration in prenatally stressed rats

Szymańska, M., Budziszewska, B., Jaworska-Feil, L., Basta‐Kaim, A., Kubera, M., Leśkiewicz, M., Regulska, M., & Lasoń, W. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.12.012 · Cited by 110 · see citing works

Deletion of forebrain glucocorticoid receptors impairs neuroendocrine stress responses and induces depression-like behavior in males but not females

Solomon, M. B., Furay, A. R., Jones, K., Packard, A. E. B., Packard, B. A., Wulsin, A. C., & Herman, J. P. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2011.12.014 · Cited by 96 · see citing works