Cited by 684Adrenal Hormones and DisordersStress Responses and CortisolClinical Laboratory Practices and Quality Control

Salivary cortisol: a better measure of adrenal cortical function than serum cortisol

Vining, Ross F, McGinley, Robynne A, Maksvytis, Joseph J, Ho, Kian Y·1983·Annals of Clinical Biochemistry International Journal of Laboratory Medicine

Abstract

Salivary cortisol concentration was found to be directly proportional to the serum unbound cortisol concentration both in normal men and women and in women with elevated cortisol-binding globulin (CBG). The correlation was excellent in dynamic tests of adrenal function (dexamethasone suppression, ACTH stimulation), in normals and patients with adrenal insufficiency, in tests of circadian variation and randomly collected samples. Women in the third trimester of normal pregnancy exhibited elevated salivary cortisol throughout the day. The relationship between salivary and serum total cortisol concentration was markedly non-linear with a more rapid increase in salivary concentration once the serum CBG was saturated. The rate of equilibrium of cortisol between blood and saliva was very fast, being much less than 5 minutes. These data, combined with a simple, stress-free, non-invasive collection procedure, lead us to suggest that salivary cortisol is a more appropriate measure for the clinical assessment of adrenocortical function than is serum cortisol.

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Crossref · 10.1177/000456328302000601

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Authors
Vining, R. F., McGinley, R. A., Maksvytis, J. J., & Ho, K. Y.
Affiliations
Garvan Institute of Medical Research (AU)
Venue
Annals of Clinical Biochemistry International Journal of Laboratory Medicine
Published
1983-11
Volume
20
Issue
6
Pages
329-335
ISSN
  • 0004-5632 (ISSN-L)
  • 1758-1001
OpenAlex
W2062000903
Cited by
684
References
18
Citations by year
2026: 16 · 2025: 19 · 2024: 15 · 2023: 38 · 2022: 29 · 2021: 21 · 2020: 19 · 2019: 19 · 2018: 26 · 2017: 30 · 2016: 24 · 2015: 22 · 2014: 40 · 2013: 29 · 2012: 32
FWCI
1.87
Type
journal article
Language
en
Open access
closed
Locations
  • Annals of Clinical Biochemistry International Journal of Laboratory Medicine (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Physiology › Clinical Laboratory Practices and Quality Control
Keywords
salivary cortisol, serum cortisol, corticosteroid-binding globulin, adrenal function testing, dexamethasone suppression test, ACTH stimulation test, adrenal insufficiency, pregnancy
MeSH terms
Adrenal Cortex, Adrenal Cortex Function Tests, Adrenocorticotropic Hormone, Adult, Carrier Proteins, Circadian Rhythm, Dexamethasone, Female, Humans, Hydrocortisone, Male, Pregnancy, Pregnancy Trimester, Third, Saliva, Sex Factors

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