A functional MRI study of the effects of bromocriptine, a dopamine receptor agonist, on component processes of working memory
Abstract
Rationale Dopamine is abundant in the prefrontal cortex and striatum, regions implicated in working memory processes. Monkey studies suggest that subpopulations of prefrontal neurons are sensitive to component processes of working memory, and that dopaminergic actions at D1 and D2 receptors differentially affect these neurons. However, it is not known to what extent the effects of dopaminergic stimulation may differ in human subjects across the processing stages of working memory, and whether these effects are found throughout the network of task-related brain regions. Objective In this study we tested the effects of the D2 dopamine agonist bromocriptine during the performance of a delayed recognition task using functional magnetic resonance imaging (fMRI). Methods We measured blood oxygenation level dependent (BOLD) signals as subjects performed a spatial and object delayed recognition task. Subjects were scanned twice, once following 1.25 mg of bromocriptine and once following lactose placebo in a randomized double-blind design. Using an event-related design allowed for separate investigation of encoding, delay, and response period effects of dopaminergic stimulation. Results A group analysis revealed that bromocriptine treatment decreased activity in the task network at encoding and increased activity at response. There was no clear pattern of change in the delay period network. Across subjects, these BOLD signal changes were accompanied by reductions in accuracy and incre…
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Excessive D2 receptor stimulation impairs prefrontal cortex working memory function in animals and humans and is associated with increased response-related firing in monkeys and increased response-related blood oxygen level-dependent signals in human imaging studies.
“excessive D2 receptor stimulation impairs PFC working memory function in animals69 and humans70 and is associated with increased response-related firing in monkeys71 and increased response-related blood oxygen level-dependent signals in human imaging studies70.”
From Stress signalling pathways that impair prefrontal cortex structure and function (2009) · cites this paper as [70]
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- Authors
- Gibbs, S. E. B., & D'Esposito, M.
- Affiliations
- University of California, Berkeley (US)
- Corresponding author
- Gibbs, Sasha E. B.
- Venue
- Psychopharmacology
- Published
- 2005-07-07
- Volume
- 180
- Issue
- 4
- Pages
- 1-10
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W1971536386
- Cited by
- 88
- References
- 4
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 5 · 2019: 3 · 2018: 2 · 2017: 4 · 2016: 9 · 2015: 1 · 2014: 5 · 2013: 6 · 2012: 8
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01da011754-04)
- National Institute of Mental Health (R01MH063901, MH 63901)
- National Institute on Drug Abuse (DA11754)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Keywords
- bromocriptine, dopamine agonists, working memory, dopamine D2 receptor, delayed recognition, encoding, delay period, prefrontal cortex, striatum, BOLD signal
- MeSH terms
- Adult, Analysis of Variance, Arousal, Brain, Brain Mapping, Bromocriptine, Cues, Double-Blind Method, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Memory, Short-Term, Neuropsychological Tests, Oxygen, Reaction Time, Dopamine Agonists
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