How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control
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This review surveys human event-related brain potential (ERP) and event-related magnetic field (ERF) approaches to psychopharmacology and psychopathology, and the way in which they complement behavioral studies and other neuroimaging modalities. The major paradigms involving ERP/ERF are P50 suppression, loudness-dependent auditory evoked potential (LDAEP), mismatch negativity (MMN), P300, mental chronometry, inhibitory control, and conflict processing (eg, error-related negativity (ERN)). Together these paradigms cover a range of more bottom-up driven to more top-down controlled processes. A number of relationships between the major neurotransmitter systems and electrocortical mechanisms are highlighted. These include the role of dopamine in conflict processing, and perceptual processing vs motor preparation; the role of serotonin in P50 suppression, LDAEP, and MMN; glutamate/NMDA and MMN; and the role of acetylcholine in P300 generation and memory-related processes. A preliminary taxonomy for these relationships is provided, which should be helpful in attuning possible new treatments or new applications of existing treatments to various disorders.
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It has been shown that psychopharmacological medication affect P300 and OFC activity.
“However, it has been shown that psychopharmacological medication affect P300 and OFC activity [73, 74].”
From P300 and delay-discounting in obsessive–compulsive disorder (2022) · cites this paper as [73]
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Panksepp, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021236 · Cited by 342 · see citing works
A perceptual inference mechanism for hallucinations linked to striatal dopamine
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- Authors
- Kenemans, J. L., & Kähkönen, S.
- Affiliations
- Utrecht University (NL)
- Helsinki University Hospital (FI)
- Corresponding author
- Kenemans, J Leon
- ORCID
- Kenemans, J Leon
- Venue
- Neuropsychopharmacology
- Published
- 2010-10-06
- Volume
- 36
- Issue
- 1
- Pages
- 26-51
- ISSN
- 0893-133X (ISSN-L)
- 1740-634X
- PMC
- PMC3055493
- OpenAlex
- W2021386843
- Cited by
- 104
- References
- 206
- Citations by year
- 2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 8 · 2015: 13 · 2014: 9 · 2013: 16 · 2012: 7
- FWCI
- 0.77
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Neuropsychopharmacology (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- event-related potentials, event-related magnetic fields, psychopharmacology, psychopathology, P50 suppression, mismatch negativity, P300, mental chronometry, inhibitory control, conflict processing, error-related negativity, dopamine, serotonin, acetylcholine, neurotransmitter systems, perceptual processing, motor preparation, top-down control, bottom-up processing
- MeSH terms
- Brain, Brain Chemistry, Electroencephalography, Electrophysiology, Humans, Mental Processes, Psychopharmacology, Magnetoencephalography, Neurotransmitter Agents, Event-Related Potentials, P300, Executive Function
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