Cited by 104Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorNeural dynamics and brain function

How Human Electrophysiology Informs Psychopharmacology: from Bottom-up Driven Processing to Top-Down Control

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Kenemans, J Leon, Kähkönen, Seppo·2011·Neuropsychopharmacology

Abstract

This review surveys human event-related brain potential (ERP) and event-related magnetic field (ERF) approaches to psychopharmacology and psychopathology, and the way in which they complement behavioral studies and other neuroimaging modalities. The major paradigms involving ERP/ERF are P50 suppression, loudness-dependent auditory evoked potential (LDAEP), mismatch negativity (MMN), P300, mental chronometry, inhibitory control, and conflict processing (eg, error-related negativity (ERN)). Together these paradigms cover a range of more bottom-up driven to more top-down controlled processes. A number of relationships between the major neurotransmitter systems and electrocortical mechanisms are highlighted. These include the role of dopamine in conflict processing, and perceptual processing vs motor preparation; the role of serotonin in P50 suppression, LDAEP, and MMN; glutamate/NMDA and MMN; and the role of acetylcholine in P300 generation and memory-related processes. A preliminary taxonomy for these relationships is provided, which should be helpful in attuning possible new treatments or new applications of existing treatments to various disorders.

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  • It has been shown that psychopharmacological medication affect P300 and OFC activity.

    “However, it has been shown that psychopharmacological medication affect P300 and OFC activity [73, 74].”

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Authors
Kenemans, J. L., & Kähkönen, S.
Affiliations
  • Utrecht University (NL)
  • Helsinki University Hospital (FI)
Corresponding author
Kenemans, J Leon
Venue
Neuropsychopharmacology
Published
2010-10-06
Volume
36
Issue
1
Pages
26-51
ISSN
  • 0893-133X (ISSN-L)
  • 1740-634X
OpenAlex
W2021386843
Cited by
104
References
206
Citations by year
2025: 2 · 2024: 4 · 2023: 2 · 2022: 4 · 2021: 9 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 2 · 2016: 8 · 2015: 13 · 2014: 9 · 2013: 16 · 2012: 7
FWCI
0.77
Type
journal article
Language
en
Open access
Locations
  • Neuropsychopharmacology (publishedVersion)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
event-related potentials, event-related magnetic fields, psychopharmacology, psychopathology, P50 suppression, mismatch negativity, P300, mental chronometry, inhibitory control, conflict processing, error-related negativity, dopamine, serotonin, acetylcholine, neurotransmitter systems, perceptual processing, motor preparation, top-down control, bottom-up processing
MeSH terms
Brain, Brain Chemistry, Electroencephalography, Electrophysiology, Humans, Mental Processes, Psychopharmacology, Magnetoencephalography, Neurotransmitter Agents, Event-Related Potentials, P300, Executive Function

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