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Prefrontal and temporal gray matter density decreases in opiate dependence
Abstract
Rationale There have been only a few structural brain-imaging studies, with varied findings, of opiate-dependent subjects. Voxel-based morphometry (VBM) is suitable for studying whole brain-wise structural brain changes in opiate-dependent subjects.Objectives The objective of the current study is to explore gray matter density in opiate-dependent subjects.Methods Gray matter density in 63 opiate-dependent subjects and 46 age- and sex-matched healthy comparison subjects was compared using VBM.Results Relative to healthy comparison subjects, opiate-dependent subjects exhibited decreased gray matter density in bilateral prefrontal cortex [Brodmann areas (BA) 8, 9, 10, 11, and 47], bilateral insula (BA 13), bilateral superior temporal cortex (BA 21 and 38), left fusiform cortex (BA 37), and right uncus (BA 28).Conclusions This study reports that opiate-dependent subjects have gray matter density decreases in prefrontal and temporal cortex, which may be associated with behavioral and neuropsychological dysfunction in opiate-dependent subjects.
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“Opiate abuse has been associated with changes in cortical blood flow (Fu et al., 2008; Lubman et al., 2009), grey matter loss (Lyoo et al., 2006) and impaired connectivity (Schmidt et al., 2015).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Lyoo et al., 2006
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Metadata
- Authors
- Lyoo, I. K., Pollack, M. H., Silveri, M. M., Ahn, K. H., Diaz, C. I., Hwang, J., Kim, S. J., Yurgelun-Todd, D. A., Kaufman, M. J., & Renshaw, P. F.
- Affiliations
- Harvard University (US)
- Massachusetts General Hospital (US)
- Seoul National University (KR)
- Gachon University Gil Medical Center (KR)
- Corresponding author
- Lyoo, In Kyoon
- ORCID
- Venue
- Psychopharmacology
- Published
- 2005-12-21
- Volume
- 184
- Issue
- 2
- Pages
- 139-144
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2058459387
- Cited by
- 178
- References
- 25
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 5 · 2023: 7 · 2022: 8 · 2021: 15 · 2020: 13 · 2019: 7 · 2018: 10 · 2017: 11 · 2016: 12 · 2015: 9 · 2014: 9 · 2013: 13 · 2012: 13
- FWCI
- 5.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Seoul National University Open Repository (Seoul National University) (submittedVersion)
- Funders
- National Institutes of Health (5r01da011231-05)
- National Institute on Drug Abuse (K24DA015116, DA15116, DA-09448, R01DA009448, K02DA017324, DA017324, DA11231)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- opioid use disorder, gray matter density, prefrontal cortex, temporal cortex, insula, superior temporal cortex, fusiform cortex, uncus, brain structural changes, addiction
- MeSH terms
- Adult, Axons, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Opioid-Related Disorders, Psychiatric Status Rating Scales, Temporal Lobe, Prefrontal Cortex
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