Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

Goldstein, Rita Z.; Volkow, Nora D.

doi:10.1038/nrn3119

Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications

The loss of control over drug intake that occurs in addiction was initially believed to result from disruption of subcortical reward circuits. However, imaging studies in addictive behaviours have identified a key involvement of the prefrontal cortex (PFC) both through its regulation of limbic re…