The DOI matches its Crossref record; 69 of the 70 references it cites were found in a registry or an index.
Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals
Open accessAbstract
Rationale There is converging evidence for impairments in decision-making in chronic substance users. In the light of findings that substance abuse is associated with disruptions of the functioning of the striato-thalamo-orbitofrontal circuits, it has been suggested that decision-making impairments are linked to frontal lobe dysfunction. We sought to investigate this possibility using functional neuroimaging.Methods Decision-making was investigated using the Cambridge Risk Task during H2(15)O PET scans. A specific feature of the Risk Task is the decisional conflict between an unlikely high reward option and a likely low reward option. Four groups, each consisting of 15 participants, were compared: chronic amphetamine users, chronic opiate users, ex-drug users who had been long-term amphetamine/opiate users but are abstinent from all drugs of abuse for at least 1 year and healthy matched controls without a drug-taking history.Results During decision-making, control participants showed relatively greater activation in the right dorsolateral prefrontal cortex, whereas participants engaged in current or previous drug use showed relatively greater activation in the left orbitofrontal cortex.Conclusion Our results indicate a disturbance in the mediation by the prefrontal cortex of a risky decision-making task associated with amphetamine and opiate abuse. Moreover, this disturbance was observed in a group of former drug users who had been abstinent for at least 1 year.
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“converging evidence that perturbation of cognitive control is a hallmark of addiction (Ersche et al., 2005; Garavan and Stout, 2005; Wilson et al., 2007).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Ersche et al., 2005
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“numerous neuroimaging studies have found abnormal OFC function associated with substance abuse (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
From Impulsivity, frontal lobes and risk for addiction (2009) · cites this paper as Ersche et al., 2005
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Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904
Drug addiction: updating actions to habits to compulsions ten years on
Everitt, B. J., & Robbins, T. W. (2016) · Annual Review of Psychology · doi:10.1146/annurev-psych-122414-033457 · Cited by 1,225
Self-citationEveritt, B. J., Belin, D., Economidou, D., Pelloux, Y., Dalley, J. W., & Robbins, T. W. (2008) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2008.0089 · Cited by 974
From the ventral to the dorsal striatum: devolving views of their roles in drug addiction
Everitt, B. J., & Robbins, T. W. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.02.010 · Cited by 675
Impulsivity, frontal lobes and risk for addiction
Crews, F. T., & Boettiger, C. A. (2009) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2009.04.018 · Cited by 679
“Consistent with the data described above is the fact that numerous neuroimaging studies have found abnormal OFC function associated with substance abuse (Boettiger et al., 2007; Dom et al., 2005; Ersche et al., 2005; London et al., 2000; Volkow and Fowler, 2000).”
Background
Metadata
- Authors
- Ersche, K. D., Fletcher, P. C., Lewis, S. J. G., Clark, L., Stocks-Gee, G., London, M., Deakin, J. B., Robbins, T. W., & Sahakian, B. J.
- Affiliations
- University of Cambridge (GB)
- Brookfields Hospital (GB)
- Corresponding author
- Sahakian, B. J.
- Venue
- Psychopharmacology
- Published
- 2005-03-15
- Volume
- 180
- Issue
- 4
- Pages
- 612-623
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC3664787
- OpenAlex
- W2059944696
- Cited by
- 199
- References
- 70
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 16
- FWCI
- 6.62
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Wellcome Trust (019407, 064351)
- Medical Research Council
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- decision-making, amphetamine dependence, opioid use disorder, former drug users, orbitofrontal cortex, dorsolateral prefrontal cortex, risky decision making, frontal lobe dysfunction, drug abstinence
- MeSH terms
- Adult, Analysis of Variance, Brain Mapping, Decision Making, Female, Humans, Male, Memory, Short-Term, Middle Aged, Opioid-Related Disorders, Neuropsychological Tests, Psychomotor Performance, Time Factors, Prefrontal Cortex, Age of Onset, Amphetamine-Related Disorders, Positron-Emission Tomography
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