Cited by 199Neural and Behavioral Psychology StudiesSubstance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on Behavior

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Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals

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Ersche, K. D., Fletcher, P. C., Lewis, S. J. G., Clark, L., Stocks-Gee, G., London, M., Deakin, J. B., Robbins, T. W., Sahakian, B. J.·2005·Psychopharmacology

DOI 10.1007/s00213-005-2205-7PMC PMC3664787

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Abstract

Rationale There is converging evidence for impairments in decision-making in chronic substance users. In the light of findings that substance abuse is associated with disruptions of the functioning of the striato-thalamo-orbitofrontal circuits, it has been suggested that decision-making impairments are linked to frontal lobe dysfunction. We sought to investigate this possibility using functional neuroimaging.Methods Decision-making was investigated using the Cambridge Risk Task during H2(15)O PET scans. A specific feature of the Risk Task is the decisional conflict between an unlikely high reward option and a likely low reward option. Four groups, each consisting of 15 participants, were compared: chronic amphetamine users, chronic opiate users, ex-drug users who had been long-term amphetamine/opiate users but are abstinent from all drugs of abuse for at least 1 year and healthy matched controls without a drug-taking history.Results During decision-making, control participants showed relatively greater activation in the right dorsolateral prefrontal cortex, whereas participants engaged in current or previous drug use showed relatively greater activation in the left orbitofrontal cortex.Conclusion Our results indicate a disturbance in the mediation by the prefrontal cortex of a risky decision-making task associated with amphetamine and opiate abuse. Moreover, this disturbance was observed in a group of former drug users who had been abstinent for at least 1 year.

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Authors: Ersche, K. D., Fletcher, P. C., Lewis, S. J. G., Clark, L., Stocks-Gee, G., London, M., Deakin, J. B., Robbins, T. W., & Sahakian, B. J.
Affiliations: University of Cambridge (GB)
Brookfields Hospital (GB)
Corresponding author: Sahakian, B. J.
ORCID: Ersche, K. D.
Fletcher, P. C.
Lewis, S. J. G.
Clark, L.
Deakin, J. B.
Robbins, T. W.
Sahakian, B. J.
Venue: Psychopharmacology
Publisher: Springer Science and Business Media LLC
Published: 2005-03-15
Volume: 180
Issue: 4
Pages: 612-623
ISSN: 0033-3158 (ISSN-L)
1432-2072
DOI: 10.1007/s00213-005-2205-7
PMC: PMC3664787
OpenAlex: W2059944696
Cited by: 199
References: 70
Citations by year: 2026: 1 · 2025: 1 · 2024: 2 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 8 · 2019: 10 · 2018: 7 · 2017: 7 · 2016: 13 · 2015: 13 · 2014: 12 · 2013: 14 · 2012: 16
FWCI: 6.62
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Psychopharmacology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: Wellcome Trust (019407, 064351)
Medical Research Council
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: decision-making, amphetamine dependence, opioid use disorder, former drug users, orbitofrontal cortex, dorsolateral prefrontal cortex, risky decision making, frontal lobe dysfunction, drug abstinence
MeSH terms: Adult, Analysis of Variance, Brain Mapping, Decision Making, Female, Humans, Male, Memory, Short-Term, Middle Aged, Opioid-Related Disorders, Neuropsychological Tests, Psychomotor Performance, Time Factors, Prefrontal Cortex, Age of Onset, Amphetamine-Related Disorders, Positron-Emission Tomography

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Abnormal frontal activations related to decision-making in current and former amphetamine and opiate dependent individuals

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