The DOI matches its Crossref record; 65 of the 65 references it cites were found in a registry or an index.
Attenuated adrenocorticotropic responses to psychological stress are associated with early smoking relapse
Abstract
Rationale Research has demonstrated that psychosocial stressors increase smoking and risk for smoking relapse. Alterations in biological systems involved in the stress response caused by chronic smoking may contribute to early relapse.Objectives We examined the extent to which pituitary-adrenocortical and cardiovascular responses to stress following the first 24 h of a quit attempt predict early relapse.Methods Seventy-two smokers interested in cessation attended a laboratory stress session 24 h after the beginning of their cessation attempt. Adrenocorticotropin (ACTH), plasma and salivary cortisol concentrations, systolic and diastolic blood pressure (BP), and heart rate (HR) responses to acute psychological stressors (public speaking and cognitive challenges) were used to predict relapse over a 4-week follow-up period.Results Those who relapsed within 4 weeks showed attenuated hormonal and cardiovascular responses to stress and exaggerated withdrawal symptoms. Cox proportional hazards survival analysis showed that attenuated ACTH, plasma cortisol, systolic and diastolic BP, positive affect, and exaggerated withdrawal symptoms and smoking urges during acute stress predicted early relapse. Stepwise model showed that ACTH, diastolic BP, and exaggerated withdrawal symptoms remain as significant predictors. When baseline smoking and psychological measures were included in the model, changes in ACTH, diastolic BP, and both factors of smoking urges remained significant predictors of relapse.Conclusions These results demonstrate that altered stress response predicts increased vulnerability for smoking relapse.
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Metadata
- Authors
- al’Absi, M., Hatsukami, D., & Davis, G. L.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- al’Absi, Mustafa
- Venue
- Psychopharmacology
- Published
- 2005-04-15
- Volume
- 181
- Issue
- 1
- Pages
- 107-117
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2054126870
- Semantic Scholar
- b0aaa798e85905b41bad4f90fe30b203072b0f56
- Cited by
- 192
- References
- 60
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 6 · 2023: 5 · 2022: 8 · 2021: 7 · 2020: 9 · 2019: 6 · 2018: 12 · 2017: 12 · 2016: 16 · 2015: 18 · 2014: 12 · 2013: 13 · 2012: 11
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r03da013435-01)
- National Institute on Drug Abuse (DA013435, R01DA016351, DA 016351)
- National Cancer Institute (R21CA088272, CA88272)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Keywords
- smoking relapse, psychological stress, ACTH, cortisol, pituitary-adrenal axis, cardiovascular stress response, blood pressure, heart rate, nicotine withdrawal symptoms, smoking urges, smoking cessation
- MeSH terms
- Adrenocorticotropic Hormone, Adult, Blood Pressure, Breath Tests, Carbon Monoxide, Female, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Middle Aged, Recurrence, Regression Analysis, Saliva, Sex Factors, Stress, Psychological, Substance Withdrawal Syndrome, Time Factors, Smoking Cessation
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