The role of stress in addiction relapse

Sinha, Rajita

doi:10.1007/s11920-007-0050-6

Cited by 423Substance Abuse Treatment and OutcomesNeurotransmitter Receptor Influence on BehaviorStress Responses and Cortisol

The role of stress in addiction relapse

Sinha, Rajita·2007·Current Psychiatry Reports

DOI 10.1007/s11920-007-0050-6

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Abstract

Stress is an important factor known to increase alcohol and drug relapse risk. This paper examines the stress-related processes that influence addiction relapse. First, individual patient vignettes of stress- and cue-related situations that increase drug seeking and relapse susceptibility are presented. Next, empirical findings from human laboratory and brain-imaging studies that are consistent with clinical observations and support the specific role of stress processes in the drug-craving state are reviewed. Recent findings on differences in stress responsivity in addicted versus matched community social drinkers are reviewed to demonstrate alterations in stress pathways that could explain the significant contribution of stress-related mechanisms on craving and relapse susceptibility. Finally, significant implications of these findings for clinical practice are discussed, with a specific focus on the development of novel interventions that target stress processes and drug craving to improve addiction relapse outcomes.

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Heart Rate Variability and Sympathetic Skin Response in Male Patients Suffering From Acute Alcohol Withdrawal Syndrome
Bär, K., Boettger, M. K., Neubauer, R., Grotelüschen, M., Jochum, T., Baier, V., Sauer, H., & Voss, A. (2006) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2006.00191.x · Cited by 40 · see citing works
Abnormal adrenal gland metabolism in opioid addicts: implications for clinical treatment.
Tennant, F., Shannon, J. A., Nork, J. G., Sagherian, A., & Berman, M. L. (1991) · Journal of Psychoactive Drugs · doi:10.1080/02791072.1991.10472232 · Cited by 24 · see citing works
Magnetic Resonance Spectroscopic Studies of Alcoholism: From Heavy Drinking to Alcohol Dependence and Back Again
Mason, G. F., Bendszus, M., Meyerhoff, D. J., Hetherington, H. P., Schweinsburg, B. C., Ross, B. D., Taylor, M. J., & Krystal, J. H. (2005) · Alcoholism Clinical and Experimental Research · doi:10.1097/01.alc.0000150010.72739.58 · Cited by 24 · see citing works
Stress and drug abuse
Sinha, R. (2005) · Techniques in the behavioral and neural sciences · doi:10.1016/s0921-0709(05)80063-x · Cited by 22 · see citing works
Self-citation
Enhanced Emotional and Physiological Sensitivity to Stress and Drug/Alcohol Craving in Abstinent Cocaine-Dependent Individuals Compared to Socially Drinking Controls
Fox, H. C., Hong, K., Siedlarz, K. M., & Sinha, R. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301426 · Cited by 8 · see citing works
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Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications
Goldstein, R. Z., & Volkow, N. D. (2011) · Nature Reviews Neuroscience · doi:10.1038/nrn3119 · Cited by 2,749 · see citing works
Chronic stress, drug use, and vulnerability to addiction
Sinha, R. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1441.030 · Cited by 1,904 · see citing works
Self-citation
Cognitive neuroscience of self-regulation failure
Heatherton, T. F., & Wagner, D. D. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2010.12.005 · Cited by 1,033 · see citing works
Gene–Stress–Epigenetic regulation of FKBP5: clinical and translational implications
Zannas, A. S., Wiechmann, T., Gassen, N. C., & Binder, E. B. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.235 · Cited by 622 · see citing works
Stress and the HPA axis: role of glucocorticoids in alcohol dependence
Stephens, M. (2012) · Alcohol Research: Current Reviews · doi:10.35946/arcr.v34.4.11 · Cited by 571 · see citing works
Enhanced Negative Emotion and Alcohol Craving, and Altered Physiological Responses Following Stress and Cue Exposure in Alcohol Dependent Individuals
Sinha, R., Fox, H. C., Hong, K. A., Bergquist, K., Bhagwagar, Z., & Siedlarz, K. M. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2008.78 · Cited by 466 · see citing works
Self-citation
Inhibitory control and emotional stress regulation: Neuroimaging evidence for frontal–limbic dysfunction in psycho-stimulant addiction
Li, C.-S. R., & Sinha, R. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2007.10.003 · Cited by 345 · see citing works
Self-citation
Ghrelin mediates stress-induced food-reward behavior in mice
Chuang, J.-C., Perelló, M., Sakata, I., Osborne-Lawrence, S. L., Savitt, J. M., Lutter, M. L., & Zigman, J. M. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57660 · Cited by 341 · see citing works
Mindfulness Training Modifies Cognitive, Affective, and Physiological Mechanisms Implicated in Alcohol Dependence: Results of a Randomized Controlled Pilot Trial
Garland, E. L., Gaylord, S. A., Boettiger, C. A., & Howard, M. O. (2010) · Journal of Psychoactive Drugs · doi:10.1080/02791072.2010.10400690 · Cited by 319 · see citing works
Modeling stress and drug craving in the laboratory: implications for addiction treatment development
Sinha, R. (2009) · Addiction Biology · doi:10.1111/j.1369-1600.2008.00134.x · Cited by 314 · see citing works
Self-citation
Depression, loneliness and Internet addiction: How important is low self-control?
Özdemir, Y., Kuzucu, Y., & Ak, Ş. (2014) · Computers in Human Behavior · doi:10.1016/j.chb.2014.02.009 · Cited by 312 · see citing works
Systematic Review of Electronic Cigarette Use (Vaping) and Mental Health Comorbidity Among Adolescents and Young Adults
Becker, T. D., Arnold, M. K., Ro, V., Martin, L. K., & Rice, T. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa171 · Cited by 301 · see citing works
Neural Correlates of Stress-Induced and Cue-Induced Drug Craving: Influences of Sex and Cocaine Dependence
Potenza, M. N., Hong, K., Lacadie, C., Fulbright, R. K., Tuit, K. L., & Sinha, R. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11020289 · Cited by 288 · see citing works
Self-citation
Ventral tegmental area dopamine revisited: effects of acute and repeated stress
Holly, E. N., & Miczek, K. A. (2016) · Psychopharmacology · doi:10.1007/s00213-015-4151-3 · Cited by 265 · see citing works
Chronic alcohol neuroadaptation and stress contribute to susceptibility for alcohol craving and relapse
Breese, G. R., Sinha, R., & Heilig, M. A. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.09.007 · Cited by 262 · see citing works
Self-citation
The effect of job loss on overweight and drinking
Deb, P., Gallo, W. T., Ayyagari, P., Fletcher, J. M., & Sindelar, J. L. (2011) · Journal of Health Economics · doi:10.1016/j.jhealeco.2010.12.009 · Cited by 229 · see citing works
Pain and suicidality: Insights from reward and addiction neuroscience
Elman, I., Borsook, D., & Volkow, N. D. (2013) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2013.06.003 · Cited by 220 · see citing works
Noradrenergic transmission in the extended amygdala: role in increased drug-seeking and relapse during protracted drug abstinence
Smith, R. J., & Aston-Jones, G. (2008) · Brain Structure and Function · doi:10.1007/s00429-008-0191-3 · Cited by 206 · see citing works
Association of frontal and posterior cortical gray matter volume with time to alcohol relapse: a prospective study
Rando, K., Hong, K.-I., Bhagwagar, Z., Li, C.-S. R., Bergquist, K., Guarnaccia, J., & Sinha, R. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10020233 · Cited by 189 · see citing works
Self-citation
Psychostimulant abuse and neuroinflammation: emerging evidence of their interconnection.
Clark, K. H., Wiley, C. A., & Bradberry, C. W. (2013) · Neurotoxicity Research · doi:10.1007/s12640-012-9334-7 · Cited by 165 · see citing works
A Gender Perspective of Addictive Disorders
Fonseca, F., Robles-Martínez, M., Tirado-Muñoz, J., Alías-Ferri, M., Mestre-Pintó, J. I., Coratu, A. M., & Torrens, M. (2021) · Current Addiction Reports · doi:10.1007/s40429-021-00357-9 · Cited by 192 · see citing works
Cue-elicited heart rate variability and attentional bias predict alcohol relapse following treatment
Garland, E. L., Franken, I. H. A., & Howard, M. O. (2012) · Psychopharmacology · doi:10.1007/s00213-011-2618-4 · Cited by 170 · see citing works
Bi-directional associations of electronic and combustible cigarette use onset patterns with depressive symptoms in adolescents
Lechner, W. V., Janssen, T., Kahler, C. W., Audrain-McGovern, J. E., & Leventhal, A. M. (2016) · Preventive Medicine · doi:10.1016/j.ypmed.2016.12.034 · Cited by 170 · see citing works
Simultaneous Glucocorticoid and Noradrenergic Activity Disrupts the Neural Basis of Goal-Directed Action in the Human Brain
Schwabe, L., Tegenthoff, M., Höffken, O., & Wolf, O. T. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.1304-12.2012 · Cited by 162 · see citing works
Prazosin Effects on Stress‐ and Cue‐Induced Craving and Stress Response in Alcohol‐Dependent Individuals: Preliminary Findings
Fox, H. C., Anderson, G. M., Tuit, K. L., Hansen, J., Kimmerling, A., Siedlarz, K. M., MORGAN, P. T., & Sinha, R. (2011) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01628.x · Cited by 157 · see citing works
Self-citation
A Corticotropin Releasing Factor Pathway for Ethanol Regulation of the Ventral Tegmental Area in the Bed Nucleus of the Stria Terminalis
Silberman, Y., Matthews, R. T., & Winder, D. G. (2013) · The Journal of Neuroscience · doi:10.1523/jneurosci.2949-12.2013 · Cited by 144 · see citing works
Engaging women with an embodied conversational agent to deliver mindfulness and lifestyle recommendations: A feasibility randomized control trial
Gardiner, P. M., McCue, K. D., Negash, L. M., Cheng, T., White, L. F., Yinusa-Nyahkoon, L., Jack, B. W., & Bickmore, T. W. (2017) · Patient Education and Counseling · doi:10.1016/j.pec.2017.04.015 · Cited by 139 · see citing works
Dopamine and addiction: what have we learned from 40 years of research
Solinas, M., Belujon, P., Fernagut, P., Jaber, M., & Thiriet, N. (2018) · Journal of Neural Transmission · doi:10.1007/s00702-018-1957-2 · Cited by 155 · see citing works
Sex Differences in Drug-Related Stress-System Changes
Fox, H. C., & Sinha, R. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902899680 · Cited by 152 · see citing works
Self-citation
How does stress lead to risk of alcohol relapse?
Sinha, R. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.07 · Cited by 147 · see citing works
Self-citation
Effect of prazosin and guanfacine on stress-induced reinstatement of alcohol and food seeking in rats
Lê, A. D., Funk, D. R., Juzytsch, W., Coen, K. M., Navarre, B. M., Cifani, C., & Shaham, Y. (2011) · Psychopharmacology · doi:10.1007/s00213-011-2178-7 · Cited by 130 · see citing works
Resting-State Synchrony During Early Alcohol Abstinence Can Predict Subsequent Relapse
Camchong, J., Stenger, A., & Fein, G. (2012) · Cerebral Cortex · doi:10.1093/cercor/bhs190 · Cited by 126 · see citing works
Making a bad thing worse: adverse effects of stress on drug addiction
Cleck, J. N., & Blendy, J. A. (2008) · Journal of Clinical Investigation · doi:10.1172/jci33946 · Cited by 122 · see citing works
The effects of psychosocial stress on dopaminergic function and the acute stress response
Bloomfield, M. A., McCutcheon, R. A., Kempton, M., Freeman, T. P., & Howes, O. (2019) · eLife · doi:10.7554/elife.46797 · Cited by 112 · see citing works
“Our findings may be highly relevant in terms of our understanding of addiction, as a history of exposure to aversive stimuli is strongly associated with later addictive behaviour, with both clinical and preclinical work demonstrating that stress plays a powerful role in the initiation, escalation, and relapse to drug…”
Background
How adaptation of the brain to alcohol leads to dependence: a pharmacological perspective.
Clapp, P., Bhave, S. V., & Hoffman, P. L. (2008) · PubMed Central · Cited by 116 · see citing works
Memory under stress: from single systems to network changes
Schwabe, L. (2016) · European Journal of Neuroscience · doi:10.1111/ejn.13478 · Cited by 114 · see citing works
How emotionally intelligent are pre-service teachers?
Corcoran, R. P., & Tormey, R. (2012) · Teaching and Teacher Education · doi:10.1016/j.tate.2012.02.007 · Cited by 114 · see citing works
Memory dynamics under stress
Quaedflieg, C. W. E. M., & Schwabe, L. (2017) · Memory · doi:10.1080/09658211.2017.1338299 · Cited by 104 · see citing works
Epigenetic mechanisms of alcoholism and stress-related disorders
Palmisano, M., & Pandey, S. C. (2017) · Alcohol · doi:10.1016/j.alcohol.2017.01.001 · Cited by 104 · see citing works
Immediate Effects of Interoceptive Awareness Training through Mindful Awareness in Body-Oriented Therapy (Mabt) for Women in Substance Use Disorder Treatment
Price, C. J., Thompson, E. A., Crowell, S. E., Pike, K., Cheng, S. C., Parent, S., & Hooven, C. (2019) · Substance Abuse · doi:10.1080/08897077.2018.1488335 · Cited by 94 · see citing works
Self-medication among traumatized youth: structural equation modeling of pathways between trauma history, substance misuse, and psychological distress
Garland, E. L., Pettus‐Davis, C., & Howard, M. O. (2012) · Journal of Behavioral Medicine · doi:10.1007/s10865-012-9413-5 · Cited by 99 · see citing works
Oxytocin Acts in Nucleus Accumbens to Attenuate Methamphetamine Seeking and Demand
Cox, B. M., Bentzley, B. S., Regen-Tuero, H. C., See, R. E., Reichel, C. M., & Aston‐Jones, G. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.11.011 · Cited by 98 · see citing works
Sex differences in the effects of allopregnanolone on yohimbine-induced reinstatement of cocaine seeking in rats
Anker, J. J., & Carroll, M. E. (2009) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2009.11.002 · Cited by 98 · see citing works
Inducing Negative Affect Increases the Reward Value of Appetizing Foods in Dieters
Wagner, D. D., Boswell, R. G., Kelley, W. M., & Heatherton, T. F. (2012) · Journal of Cognitive Neuroscience · doi:10.1162/jocn_a_00238 · Cited by 95 · see citing works
Resting‐State Synchrony in Long‐Term Abstinent Alcoholics
Camchong, J., Stenger, A., & Fein, G. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2012.01859.x · Cited by 95 · see citing works
Attentional bias, inhibitory control and acute stress in current and former opiate addicts
Constantinou, N., Morgan, C. J. A., Battistella, S., O’Ryan, D., Davis, P. W., & Curran, H. V. (2010) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2010.01.012 · Cited by 92 · see citing works
Predicting Internet Gaming Disorder symptoms in young adolescents: A one-year follow-up study
Peeters, M., Koning, I. M., & van den Eijnden, R. J. J. M. (2017) · Computers in Human Behavior · doi:10.1016/j.chb.2017.11.008 · Cited by 95 · see citing works
Emerging Role for Corticotropin Releasing Factor Signaling in the Bed Nucleus of the Stria Terminalis at the Intersection of Stress and Reward
Silberman, Y., & Winder, D. G. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00042 · Cited by 91 · see citing works
Stress-Induced Potentiation of Cocaine Reward: A Role for CRFR1 and CREB
Kreibich, A. S., Briand, L., Cleck, J. N., Ecke, L., Rice, K. C., & Blendy, J. A. (2009) · Neuropsychopharmacology · doi:10.1038/npp.2009.91 · Cited by 89 · see citing works
Dopaminergic control of anxiety in young and aged zebrafish
Kacprzak, V., Patel, N. A., Riley, E., Yu, L., Yeh, J.-R. J., & Zhdanova, I. V. (2017) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2017.01.005 · Cited by 88 · see citing works
Motivational and mindfulness intervention for young adult female marijuana users
de Dios, M. A., Herman, D. S., Britton, W. B., Hagerty, C. E., Anderson, B. J., & Stein, M. D. (2012) · Journal of Substance Abuse Treatment · doi:10.1016/j.jsat.2011.08.001 · Cited by 86 · see citing works
Behavioral and neural mechanisms underlying habitual and compulsive drug seeking
Smith, R. J., & Laiks, L. (2017) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2017.09.003 · Cited by 87 · see citing works
Mindfulness and alcohol problems in college students: the mediating effects of stress
Bodenlos, J. S., Noonan, M., & Wells, S. Y. (2013) · Journal of American College Health · doi:10.1080/07448481.2013.805714 · Cited by 81 · see citing works
Stress-Induced and Cue-Induced Craving for Alcohol in Heavy Drinkers: Preliminary Evidence of Genetic Moderation by the OPRM1 and CRH-BP Genes
Ray, L. A. (2010) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2010.01333.x · Cited by 81 · see citing works
The use of α-2A adrenergic agonists for the treatment of attention-deficit/hyperactivity disorder
Arnsten, A. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.133 · Cited by 80 · see citing works
Amygdala involvement in human avoidance, escape and approach behavior
Schlund, M. W., & Cataldo, M. F. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.06.058 · Cited by 81 · see citing works
Substance use modulates stress reactivity: Behavioral and physiological outcomes
Fosnocht, A. Q., & Briand, L. A. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.02.024 · Cited by 80 · see citing works
Dark Times: The Role of Negative Reinforcement in Methamphetamine Addiction
May, A. C., Aupperle, R. L., & Stewart, J. L. (2020) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2020.00114 · Cited by 80 · see citing works
Personal support networks, social capital, and risk of relapse among individuals treated for substance use issues
Panebianco, D., Gallupe, O., Carrington, P. J., & Colozzi, I. (2015) · International Journal of Drug Policy · doi:10.1016/j.drugpo.2015.09.009 · Cited by 79 · see citing works
Neural stress reactivity relates to smoking outcomes and differentiates between mindfulness and cognitive-behavioral treatments
Kober, H., Brewer, J. A., Height, K. L., & Sinha, R. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2016.09.042 · Cited by 75 · see citing works
Self-citation
Neural pathways of stress integration: relevance to alcohol abuse
Herman, J. P. (2012) · Alcohol research · doi:10.35946/arcr.v34.4.08 · Cited by 77 · see citing works
Guanfacine’s mechanism of action in treating prefrontal cortical disorders: Successful translation across species
Arnsten, A. F. T. (2020) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2020.107327 · Cited by 75 · see citing works
“Stress exposure is also often a cause of substance abuse, which in turn further weakens PFC abilities, creating a vicious cycle (Sinha, 2007).”
Fish oil supplementation reduces cortisol basal levels and perceived stress: A randomized, placebo‐controlled trial in abstinent alcoholics
Barbadoro, P., Annino, I., Ponzio, E., Romanelli, R. M. L., D’Errico, M. M., Prospero, E., & Minelli, A. (2013) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201200676 · Cited by 76 · see citing works
Conceptualising social media addiction: a longitudinal network analysis of social media addiction symptoms and their relationships with psychological distress in a community sample of adults
Tullett-Prado, D., Doley, J. R., Zarate, D., Gomez, R., & Stavropoulos, V. (2023) · BMC Psychiatry · doi:10.1186/s12888-023-04985-5 · Cited by 77 · see citing works
Nothing to fear? Neural systems supporting avoidance behavior in healthy youths
Schlund, M., Siegle, G., Ladouceur, C., Silk, J., Cataldo, M., Forbes, E. E., Dahl, R., & Ryan, N. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.04.244 · Cited by 74 · see citing works
The genetics of alcoholism
Stacey, D., Clarke, T., & Schumann, G. (2009) · Current Psychiatry Reports · doi:10.1007/s11920-009-0055-4 · Cited by 67 · see citing works
Avoidance-based human Pavlovian-to-instrumental transfer
Lewis, A. H., Niznikiewicz, M. A., Delamater, A., & Delgado, M. R. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12377 · Cited by 75 · see citing works
A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment
Wemm, S., Larkin, C., Hermes, G., Tennen, H. A., & Sinha, R. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107569 · Cited by 65 · see citing works
Self-citation
Psychosocial Stress and Its Relationship to Gambling Urges in Individuals with Pathological Gambling
Elman, I., Tschibelu, E., & Borsook, D. (2010) · American Journal on Addictions · doi:10.1111/j.1521-0391.2010.00055.x · Cited by 64 · see citing works
The therapeutic potential of GLP-1 analogues for stress-related eating and role of GLP-1 in stress, emotion and mood: a review
Guerrero-Hreins, E., Goldstone, A. P., Brown, R. M., & Sumithran, P. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2021.110303 · Cited by 62 · see citing works
From personal tragedy to personal challenge: responses to stigma among sober living home residents and operators
Heslin, K. C., Singzon, T. K., Aimiuwu, O., Sheridan, D., & Hamilton, A. (2011) · Sociology of Health & Illness · doi:10.1111/j.1467-9566.2011.01376.x · Cited by 63 · see citing works
Social defeat stress and escalation of cocaine and alcohol consumption: Focus on CRF
Newman, E. L., Leonard, M. Z., Arena, D. T., de Almeida, R. M. M., & Miczek, K. A. (2018) · Neurobiology of Stress · doi:10.1016/j.ynstr.2018.09.007 · Cited by 63 · see citing works
Thought suppression, impaired regulation of urges, and Addiction-Stroop predict affect-modulated cue-reactivity among alcohol dependent adults
Garland, E. L., Carter, K., Ropes, K., & Howard, M. O. (2012) · Biological Psychology · doi:10.1016/j.biopsycho.2011.09.010 · Cited by 62 · see citing works
A Clinical Trial with Combined Transcranial Direct Current Stimulation and Attentional Bias Modification in Alcohol‐Dependent Patients
den Uyl, T. E., Gladwin, T. E., Lindenmeyer, J., & Wiers, R. W. H. J. (2018) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.13841 · Cited by 63 · see citing works
The detrimental effects of emotional process dysregulation on decision-making in substance dependence
Murphy, A., Taylor, E., & Elliott, R. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00101 · Cited by 60 · see citing works
Sex-Specific Dissociations in Autonomic and HPA Responses to Stress and Cues in Alcohol-Dependent Patients with Cocaine Abuse
Fox, H. C., Hong, K.-I. A., Siedlarz, K. M., Bergquist, K. L., Anderson, G. M., Kreek, M. J., & Sinha, R. (2009) · Alcohol and Alcoholism · doi:10.1093/alcalc/agp060 · Cited by 59 · see citing works
Self-citation
Neural Activity to a Partner's Facial Expression Predicts Self-Regulation After Conflict
Hooker, C. I., Gyurak, A., Verosky, S. C., Miyakawa, A., & Ayduk, Ö. N. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.014 · Cited by 57 · see citing works
Event-related potentials in a Go/Nogo task of abnormal response inhibition in heroin addicts
Yang, B., Yang, S., Zhao, L., Yin, L., Liu, X., & An, S. (2009) · Science in China Series C Life Sciences · doi:10.1007/s11427-009-0106-4 · Cited by 59 · see citing works
Self-regulation and its failure: The seven deadly threats to self-regulation.
Wagner, D. D., & Heatherton, T. F. (2014) · American Psychological Association eBooks · doi:10.1037/14341-026 · Cited by 60 · see citing works
For better or for worse? A pre–post exploration of the impact of the COVID‐19 lockdown on cannabis users
Cousijn, J., Kuhns, L., Larsen, H., & Kroon, E. (2021) · Addiction · doi:10.1111/add.15387 · Cited by 56 · see citing works
Perceived control alters the effect of acute stress on persistence.
Bhanji, J. P., Kim, E. S., & Delgado, M. R. (2016) · Journal of Experimental Psychology General · doi:10.1037/xge0000137 · Cited by 58 · see citing works
Sleep disturbance as a therapeutic target to improve opioid use disorder treatment.
Huhn, A. S., & Finan, P. H. (2021) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000477 · Cited by 58 · see citing works
The influence of stress on the transition from drug use to addiction.
Wand, G. S. (2008) · Europe PMC (PubMed Central) · Cited by 55 · see citing works
The Role of the Glucocorticoids in Developing Resilience to Stress and Addiction
Srinivasan, S., Shariff, M. R., & Bartlett, S. E. (2013) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2013.00068 · Cited by 61 · see citing works
Opioid withdrawal, craving, and use during and after outpatient buprenorphine stabilization and taper: A discrete survival and growth mixture model
Northrup, T. F., Stotts, A. L., Green, C., Potter, J. S., Marino, E. N., Walker, R., Weiss, R. D., & Trivedi, M. H. (2014) · Addictive Behaviors · doi:10.1016/j.addbeh.2014.09.021 · Cited by 57 · see citing works
Perceived Control Influences Neural Responses to Setbacks and Promotes Persistence
Bhanji, J. P., & Delgado, M. R. (2014) · Neuron · doi:10.1016/j.neuron.2014.08.012 · Cited by 57 · see citing works
Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine
de la Fuente, A., Sedeño, L., Vignaga, S. S., Ellmann, C., Sonzogni, S., Belluscio, L., García-Cordero, I., Castagnaro, E., Boano, M., Cetkovich, M., et al. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0370-3 · Cited by 55 · see citing works
Human Laboratory Paradigms in Alcohol Research
Plebani, J. G., Ray, L. A., Morean, M. E., Corbin, W. R., MacKillop, J. M., Amlung, M. T., & King, A. C. (2012) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2011.01704.x · Cited by 56 · see citing works
Chronic Corticosterone Exposure during Adolescence Reduces Impulsive Action but Increases Impulsive Choice and Sensitivity to Yohimbine in Male Sprague-Dawley Rats
Torregrossa, M. M., Xie, M., & Taylor, J. R. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2012.11 · Cited by 55 · see citing works
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Authors: Sinha, R.
Affiliations: Yale University (US)
Corresponding author: Sinha, Rajita
ORCID: Sinha, Rajita
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2007-10
Volume: 9
Issue: 5
Pages: 388-395
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-007-0050-6
OpenAlex: W2043621158
Cited by: 423
References: 93
Citations by year: 2026: 17 · 2025: 13 · 2024: 21 · 2023: 24 · 2022: 23 · 2021: 30 · 2020: 39 · 2019: 23 · 2018: 29 · 2017: 26 · 2016: 15 · 2015: 24 · 2014: 17 · 2013: 16 · 2012: 27
FWCI: 2.31
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute on Alcohol Abuse and Alcoholism (R01AA013892, R01-AA-13892)
National Institute on Drug Abuse (K02 DA17232, P50DA016556, K02DA017232, R01-DA18219, R01DA018219, P50-DA16556)
Topics: Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords: stress, addiction relapse, drug craving, alcohol relapse, drug-seeking behavior, stress responsivity, stress response pathways
MeSH terms: Alcoholism, Arousal, Brain, Conditioning, Psychological, Humans, Magnetic Resonance Imaging, Motivation, Illicit Drugs, Stress, Psychological, Substance Withdrawal Syndrome, Neurotransmitter Agents, Substance-Related Disorders, Secondary Prevention

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