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Controversies in translational research: drug self-administration.
Open accessAbstract
Rationale Laboratory animal and human models of drug self-administration are used to evaluate potential pharmacotherapies for drug abuse, yet the utility of these models in predicting clinically useful medications is variable.Objective The objective of this study was to track how antagonist, agonist, and partial agonist medication approaches influence heroin and cocaine self-administration by rodents, non-human primates, and humans and to compare these results to clinical outcomes.Results Across species, heroin self-administration was decreased by all three medication approaches, paralleling their demonstrated clinical utility. The heroin data emphasize the importance of assessing a medication's abuse liability preclinically to predict medication abuse and compliance and of considering subject characteristics (e.g., opioid dependence) when interpreting medication effects. For cocaine, the effects of ecopipam, modafinil, and aripiprazole were consistent in the laboratory and clinic, provided that the medications were administered repeatedly before self-administration sessions. Modafinil attenuated cocaine's reinforcing effects in the human laboratory and improved treatment outcome, while ecopipam and aripiprazole increased the reinforcing effects of cocaine and do not appear promising in the clinic.Conclusions The self-administration model has reliably identified medications to treat opioid dependence, and the recent data with modafinil suggest that the human laboratory model also identifies medications to treat cocaine dependence. There have been numerous false positives when subjective effects are the primary outcome measure, but not when self-administration is the outcome. Factors relevant to the predictive validity of self-administration procedures include medication maintenance and the concurrent assessment of a range of behaviors to determine abuse liability and the specificity of effect.
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“It has been noted that acute compared with chronic antagonism of the dopamine receptor elicits opposite effects on cocaine reinforcement in both human and non-human subjects 76.”
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Citations
Cites
Multiple receptors for dopamine
Kebabian, J. W., & Calne, D. B. (1979) · Nature · doi:10.1038/277093a0 · Cited by 3,756
Cocaine Receptors on Dopamine Transporters Are Related to Self-Administration of Cocaine
Ritz, M. C., Lamb, R. J., Goldberg, S. R., & Kuhar, M. J. (1987) · Science · doi:10.1126/science.2820058 · Cited by 2,180
Richardson, N. R., & Roberts, D. C. S. (1996) · Journal of Neuroscience Methods · doi:10.1016/0165-0270(95)00153-0 · Cited by 1,373
Dole, V. P. (1965) · JAMA · doi:10.1001/jama.1965.03090080008002 · Cited by 1,240
Self-administration of psychoactive substances by the monkey
Deneau, G. A., Yanagita, T., & Seevers, M. H. (1969) · Psychopharmacology · doi:10.1007/bf00405254 · Cited by 808
Jasinski, D. R. (1978) · Archives of General Psychiatry · doi:10.1001/archpsyc.1978.01770280111012 · Cited by 782
Methods of Assessing the Reinforcing Properties of Abused Drugs
Bozarth, M. A. (1987) · Springer eBooks · doi:10.1007/978-1-4612-4812-5 · Cited by 693
Experimental Morphine Addiction: Method for Automatic Intravenous Injections in Unrestrained Rats
Weeks, J. R. (1962) · Science · doi:10.1126/science.138.3537.143 · Cited by 658
A Comparison of Levomethadyl Acetate, Buprenorphine, and Methadone for Opioid Dependence
Johnson, R. E., Chutuape, M. A., Strain, E. C., Walsh, S. L., Stitzer, M. L., & Bigelow, G. E. (2000) · New England Journal of Medicine · doi:10.1056/nejm200011023431802 · Cited by 623
Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems
Ettenberg, A., Pettit, H. O., Bloom, F. E., & Koob, G. F. (1982) · Psychopharmacology · doi:10.1007/bf00428151 · Cited by 563
Research works printed but not linked: 2
- Emmett-Oglesby M, Mathis D (1988) Chronic administration of SCH 23390 produces sensitization to the discriminative stimulus properties of cocaine. In: Harris LS (ed) Problems of drug dependence. Proceedings of the 50th Annual Scientific Meeting, The College on Problems of Drug Dependence. United States Department of Health and Human Services, Rockville, MD, p 367
- Jasinksi DR, Pervnick JS, Griffith JD (1978) Human pharmacology and abuse potential of the analgesic buprenorphine. Arch Gen Psychiatry 35:601–616
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Gauvin, D. V., Guha, M., & Baird, T. J. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00003-5 · Cited by 4
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Cheng, M.-C., Hsu, S.-H., & Chen, C. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2010.09.002 · Cited by 4
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Roache, J. D. (2010) · Springer eBooks · doi:10.1007/978-1-4419-0338-9_7 · Cited by 4
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Hulin, M. W., Lawrence, M., Amato, R. J., Weed, P. F., & Winsauer, P. J. (2015) · Alcohol · doi:10.1016/j.alcohol.2014.07.024 · Cited by 3
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Slosky, L. M., Pires, A., Bai, Y., Clark, N., Hauser, E. R., Gross, J., Porkka, F., Zhou, Y., Chen, X., Pogorelov, V. M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.11.25.398503 · Cited by 3
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Shellenberg, T., Strickland, J. C., Regnier, S. D., Tolbert, P. T., Lake, S., Wesley, M. J., Stoops, W. W., Cooper, Z. D., Haney, M., & Lile, J. A. (2025) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/j.jpet.2025.103622 · Cited by 2
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Stoops, W. W. (2022) · Perspectives on Behavior Science · doi:10.1007/s40614-022-00330-5 · Cited by 2
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Silva, M. I. G., Citó, M. D. C. D. O., Vasconcelos, P. F. C., Vasconcelos, S. M. M., & de Sousa, F. C. F. (2010) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.20344/amp.609 · Cited by 2
Schwienteck, K. L., Negus, S. S., Poklis, J. L., & Banks, M. L. (2015) · Experimental and Clinical Psychopharmacology · doi:10.1037/pha0000023 · Cited by 2
Holtyn, A. F., Davis, C. M., & Weerts, E. M. (2019) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2019.107665 · Cited by 2
O'Connell, A. (2020) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17149181.v1 · Cited by 1
Bosch, P. (2013) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.22756706 · Cited by 1
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DaSilva, J. K., Horton, D. B., Butler, P., & Goody, S. M. G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-812206-8.00011-x · Cited by 1
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Onge, C. M. S., Heslep, N., Townsend, E. A., Zhang, Y., & Banks, M. L. (2026) · Psychopharmacology · doi:10.1007/s00213-026-07047-2 · Cited by 1
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Johansen, A. N., Smith, M. A., & Stoops, W. W. (2026) · Pharmacological Reviews · doi:10.1016/j.pharmr.2026.100145 · Cited by 1
John, W. S., Newman, A. H., & Nader, M. A. (2015) · The FASEB Journal · doi:10.1096/fasebj.29.1_supplement.930.5 · Cited by 1
Neurobiologie de la toxicomanie : avancées récentes et nouvelles stratégies d’intervention
Jutras‐Aswad, D., Bruneau, J., & Hurd, Y. L. (2010) · Drogues santé et société · doi:10.7202/044471ar · Cited by 1
Stangl, B. L., Byrd, N. D., Soundararajan, S., Plawecki, M. H., O’Connor, S., & Ramchandani, V. A. (2022) · Journal of Visualized Experiments · doi:10.3791/63576-v · Cited by 1
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Silva, G. M., & Hamilton, P. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-18516-8.00008-9 · Cited by 1
K v 7 channel opener retigabine reduces self‐administration of cocaine but not sucrose in rats
Urena, E. S., Diezel, C. C., Serna, M., Hala’ufia, G., Majuta, L. A., Barber, K. R., Vanderah, T. W., & Riegel, A. C. (2024) · Addiction Biology · doi:10.1111/adb.13428
Cannabinoids to Treat Cannabis Use Disorders
Brezing, C., & LEVIN, F. R. (2018) · Springer eBooks · doi:10.1007/978-3-319-90365-1_19 · Cited by 1
Drug self-administration in head-restrained mice for simultaneous multiphoton imagingPreprint
Vollmer, K. M., Doncheck, E. M., Grant, R. I., Winston, K. T., Romanova, E. V., Bowen, C. W., Siegler, P. N., Bobadilla, A., Trujillo‐Pisanty, I., Kalivas, P. W., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.25.354209 · Cited by 1
Ewald, A. W. M. (2016) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17148113 · Cited by 1
Evaluation of Modafinil in Preclinical Behavioral Assays of Abuse Liability
Quisenberry, A. J. (2013) · ScholarWorks - WMU (Western Michigan University)
Clinical Evaluation of Abuse Potential for New Pharmaceuticals
Vosburg, S. K., & Sokolowska, M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-420172-9.00009-6
Ojala, K. (2010) · Työväentutkimus Vuosikirja
The Roots and Individual Diversity of Addiction
Leis, A. B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-420190-3.00031-4
Targeting the trace amine-associated receptor 1 in psychomotor stimulant addiction.
Pei, Y. (2016) · UC Research Repository (University of Canterbury) · doi:10.26021/8251
Preclinical Models for Assessment of Antidepressant Abuse Potential
Lazenka, M. F., & Hutsell, B. A. (2017) · Current Sexual Health Reports · doi:10.1007/s11930-017-0128-z
Atigari, D. V. (2019) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.17136338.v1
Dezfouli, A., Ekhtiari, H., & Mokri, A. (2010) · DOAJ (DOAJ: Directory of Open Access Journals)
Current Strategies for Abuse Liability Assessment of New Chemical Entities
Gauvin, D. V., Dalton, J. A., & Baird, T. J. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-387815-1.00019-8
Czoty, P. W., Gould, R. W., O’Donovan, C. A., & Nader, M. A. (2021) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2021.173217
ΔFosB: A Molecular Mechanism of MDMA Dependence
Foote, J. (2017) · doi:10.26686/wgtn.17068457.v1
ΔFosB: A Molecular Mechanism of MDMA Dependence
Foote, J. (2017) · doi:10.26686/wgtn.17068457
Fulton, B. S. (2014) · Wiley eBooks · doi:10.1002/9781118943670.refs
Environmental influence on the preclinical evaluation of substance use disorder therapeutics
Banks, M. L. (2022) · Advances in pharmacology · doi:10.1016/bs.apha.2021.10.004
Kosten, T. R. (2011) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.13284987.14644090
Effects of nicotine on responding maintained by environmental stimuli in rats
Raiff, B. R. (2008) · University of Florida Digital Collections (University of Florida)
Gabapentinoids for the treatment of cannabis use disorder: A focus on human laboratory research
Lile, J. A., Stoops, W. W., & Wesley, M. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-89862-1.00042-8
Current Strategies for Abuse Liability Assessment of New Chemical Entities
Gauvin, D. V., & Zimmermann, Z. J. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-85704-8.00028-1
Robison, J. H., Aston, E. R., Matoska, C. T., Smit, T., Neighbors, C., Businelle, M. S., Zvolensky, M. J., & Garey, L. (2024) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2024.112492
Novel Approaches for Treating Substance Use Disorders
Banks, M. L. (2025) · Oxford University Press eBooks · doi:10.1093/med/9780197640654.003.0051
Sharafshah, A., Thanos, P. K., Pinhasov, A., Bowirrat, A., Hanna, C., Lewandrowski, K.-U., Rowan, C., Elman, I., Gold, M. S., Dennen, C. A., et al. (2025) · Current Neuropharmacology · doi:10.2174/011570159x390146250831143523 · Cited by 1
Moore, C. F., Bedillion, M. F., Haney, M., & Weerts, E. M. (2025) · Current Addiction Reports · doi:10.1007/s40429-025-00705-z
Self-citationMarsh, S. A., & Banks, M. L. (2026) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2026.113180
Human behavioral pharmacology of cannabis: Insights on cannabis use disorder
Haney, M., Arout, C. A., & Bedillion, M. F. (2026) · Preventive Medicine · doi:10.1016/j.ypmed.2026.108663
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Metadata
- Authors
- Haney, M., & Spealman, R.
- Affiliations
- New York State Psychiatric Institute (US)
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Haney, Margaret
- ORCID
- Haney, Margaret
- Venue
- Psychopharmacology
- Published
- 2008-02-19
- Volume
- 199
- Issue
- 3
- Pages
- 403-419
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- PMC
- PMC2731701
- OpenAlex
- W1965528317
- Cited by
- 270
- References
- 187
- Citations by year
- 2026: 6 · 2025: 8 · 2024: 7 · 2023: 5 · 2022: 12 · 2021: 12 · 2020: 16 · 2019: 18 · 2018: 13 · 2017: 17 · 2016: 23 · 2015: 21 · 2014: 15 · 2013: 14 · 2012: 16
- FWCI
- 1.86
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Drug Abuse (DA-09236, DA11054, R01DA019239, DA11928, DA 19239, R01DA017700, R01DA011054, P50DA009236, DA17700, 09236, R01DA011928)
- National Center for Research Resources (RR00 168, K26RR000168, P51RR000168)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Opioid Use Disorder Treatment
- Keywords
- self-administration, translational research, heroin addiction, cocaine dependence, opioid antagonists, opioid agonists, partial agonists, modafinil, ecopipam, aripiprazole, abuse liability, predictive validity, non-human primates
- MeSH terms
- Animals, Disease Models, Animal, Heroin Dependence, Humans, Primates, Rodentia, Self Administration, Substance-Related Disorders, Cocaine-Related Disorders
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