Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems
Abstract
The hypothesis that separate neural systems mediate the reinforcing properties of opiate and psychomotor stimulant drugs was tested in rats trained to lever-press of IV injections of either cocaine or heroin during daily 3-h sessions. Pretreatment with the opiate receptor antagonist drug naltrexone produced dose-dependent increases in heroin self-administration, but had no effect on the rate or pattern of cocaine self-administration. Similarly, pretreatment with low doses of the dopamine antagonist drug alpha-flupenthixol produced dose-dependent increases in cocaine but not heroin self-administration. High doses of alpha-flupenthixol eliminated all responding for cocaine and slightly reduced heroin self-administration. The specificity with which the two antagonist drugs exerted their behavioral effects strongly suggests that independent neural substrates are responsible for the reinforcing actions of heroin and cocaine.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
DA receptor antagonists administered systemically increase the rate of operant responding for cocaine in animals.
“By contrast, DA receptor antagonists administered systemically increase the rate of operant responding for cocaine in animals [134-136].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [136]
Cites
Dopamine Receptor Binding Predicts Clinical and Pharmacological Potencies of Antischizophrenic Drugs
Creese, I., Burt, D. R., & Snyder, S. H. (1976) · Science · doi:10.1126/science.3854 · Cited by 2,220 · see citing works
The Pharmacological Basis for Therapeutics
JOHNS, M. E. (1981) · Archives of Otolaryngology - Head and Neck Surgery · doi:10.1001/archotol.1981.00790410063020 · Cited by 2,011 · see citing works
[Drug addiction and drug abuse].
Feuerlein, W. (1969) · PubMed · Cited by 1,415 · see citing works
Self-administration of psychoactive substances by the monkey
Deneau, G. A., Yanagita, T., & Seevers, M. H. (1969) · Psychopharmacology · doi:10.1007/bf00405254 · Cited by 811 · see citing works
Catecholamine theories of reward: A critical review
Wise, R. A. (1978) · Brain Research · doi:10.1016/0006-8993(78)90253-6 · Cited by 769 · see citing works
Roberts, D. C. S., Koob, G. F., Klonoff, P., & Fibiger, H. C. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90166-5 · Cited by 730 · see citing works
Self-citationOn the role of ascending catecholaminergic systems in intravenous self-administration of cocaine
Roberts, D. C. S., Corcoran, M. E., & Fibiger, H. C. (1977) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(77)90084-3 · Cited by 728 · see citing works
Yokel, R. A., & Wise, R. A. (1975) · Science · doi:10.1126/science.1114313 · Cited by 545 · see citing works
Spiperone: A ligand of choice for neuroleptic receptors
Leysen, J. E., Gommeren, W., & Laduron, P. M. (1978) · Biochemical Pharmacology · doi:10.1016/0006-2952(78)90233-2 · Cited by 544 · see citing works
Intracranial self-administration of morphine into the ventral tegmental area in rats
Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90148-x · Cited by 503 · see citing works
Self Administration of and Behavioral Dependence on Drugs
Schuster, C. R., & Thompson, T. I. (1969) · Annual Review of Pharmacology · doi:10.1146/annurev.pa.09.040169.002411 · Cited by 492 · see citing works
de Wit, H., & Wise, R. A. (1977) · Canadian Journal of Psychology / Revue canadienne de psychologie · doi:10.1037/h0081662 · Cited by 491 · see citing works
Heikkila, R. E., Orlansky, H., & Cohen, G. (1975) · Biochemical Pharmacology · doi:10.1016/0006-2952(75)90152-5 · Cited by 468 · see citing works
COCAINE-REINFORCED BEHAVIOR IN RATS: EFFECTS OF REINFORCEMENT MAGNITUDE AND FIXED-RATIO SIZE
Pickens, R. W., & Thompson, T. (1968) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)27954-x · Cited by 427 · see citing works
Naltrexone, an Antagonist for the Treatment of Heroin Dependence
Martin, W. R. (1973) · Archives of General Psychiatry · doi:10.1001/archpsyc.1973.01750360022003 · Cited by 393 · see citing works
Attenuation of intravenous amphetamine reinforcement by central dopamine blockade in rats
Yokel, R. A., & Wise, R. A. (1976) · Psychopharmacology · doi:10.1007/bf00496868 · Cited by 369 · see citing works
Handbook of psychopharmacology, vol. 16
Woolf, C. J. (1985) · Pain · doi:10.1016/0304-3959(85)90237-4 · Cited by 366 · see citing works
Reinforcing effects of morphine microinjection into the ventral tegmental area
Phillips, A. G., & LePiane, F. G. (1980) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(80)90460-8 · Cited by 339 · see citing works
Heroin reward is dependent on a dopaminergic substrate
Bozarth, M. A., & Wise, R. A. (1981) · Life Sciences · doi:10.1016/0024-3205(81)90519-1 · Cited by 334 · see citing works
Self-administration of d-amphetamine by rats
Pickens, R. W., & Harris, W. C. (1968) · Psychopharmacology · doi:10.1007/bf00401545 · Cited by 296 · see citing works
Naltrexone: Disposition, metabolism, and effects after acute and chronic dosing
Verebey, K., Volavka, J., Mulé, S. J., & Resnick, R. B. (1976) · Clinical Pharmacology & Therapeutics · doi:10.1002/cpt1976203315 · Cited by 270 · see citing works
Inhibition of the uptake of tritiated catecholamines by antidepressant and related agents
Ross, S. B., & Rényi, A. L. (1967) · European Journal of Pharmacology · doi:10.1016/0014-2999(67)90084-2 · Cited by 253 · see citing works
Factors affecting the action of narcotics
Adler, M. W., Manara, L., SAMANIN, R., & Negri, I. D. R. F. M. (1978) · Raven Press eBooks · Cited by 245 · see citing works
Fibiger, H. C., Zis, A. P., & Phillips, A. G. (1975) · European Journal of Pharmacology · doi:10.1016/0014-2999(75)90114-4 · Cited by 184 · see citing works
Drug level of d- and l-amphetamine during intravenous self-administration
Yokel, R. A., & Pickens, R. W. (1974) · Psychopharmacology · doi:10.1007/bf00421966 · Cited by 169 · see citing works
Response Artifact in the Measurement of Neuroleptic-Induced Anhedonia
Ettenberg, A., Koob, G. F., & Bloom, F. E. (1981) · Science · doi:10.1126/science.7244622 · Cited by 167 · see citing works
Self-citationSELF-ADMINISTRATION OF OPTICAL ISOMERS OF AMPHETAMINE AND METHYLAMPHETAMINE BY RATS
Yokel, R. A., & Pickens, R. W. (1973) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)29645-8 · Cited by 161 · see citing works
An analysis of chlorpromazine-induced suppression of the avoidance response
Posluns, D. (1962) · Psychopharmacology · doi:10.1007/bf00408321 · Cited by 152 · see citing works
Reinforcement Properties of Morphine, Cocaine, and SPA as a Function of Unit Dose
Woods, J. H., & Schuster, C. R. (1968) · International Journal of the Addictions · doi:10.3109/10826086809042898 · Cited by 151 · see citing works
Clinical trials with amphetamine-blocking drugs.
Lm, G., Änggård, E., & Jönsson, L. E. (1972) · PubMed · Cited by 146 · see citing works
The use of conditioned suppression to evaluate the nature of neuroleptic-induced avoidance deficits.
Beninger, R. J., Mason, S. T., Phillips, A. G., & Fibiger, H. C. (1980) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)32116-6 · Cited by 144 · see citing works
The Comparative Pharmacology of Flupenthixol and some Reference Neuroleptics
Nielsen, I. M., Pedersen, V., Nymark, M., Franck, K. F., Boeck, V., Fjalland, B., & Christensen, A. V. (1973) · Acta Pharmacologica et Toxicologica · doi:10.1111/j.1600-0773.1973.tb01537.x · Cited by 132 · see citing works
THE PHARMACOLOGIC IMPLICATIONS OF THE FATE OF MORPHINE AND ITS SURROGATES
Way, E. L., & Adler, T. K. (1960) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)07438-1 · Cited by 131 · see citing works
Naloxone, naltrexone, and related noroxymorphones.
Blumberg, H., & Dayton, H. B. (1973) · PubMed · Cited by 108 · see citing works
NALORPHINE-INDUCED CHANGES IN MORPHINE SELF-ADMINISTRATION IN RHESUS MONKEYS
Goldberg, S. R., Woods, J. H., & Schuster, C. R. (1971) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(25)28806-1 · Cited by 104 · see citing works
Drug Self-Administration: An Analysis of the Reinforcing Effects of Drugs
Pickens, R. W., Meisch, R. A., & Thompson, T. I. (1978) · Springer eBooks · doi:10.1007/978-1-4684-3186-5_1 · Cited by 71 · see citing works
Depression of Morphine-seeking Behaviour by Dopamine Inhibition
Schwartz, A. S., & Marchok, P. L. (1974) · Nature · doi:10.1038/248257a0 · Cited by 68 · see citing works
Glick, S. D., Cox, R., & Crane, A. M. (1975) · Psychopharmacology · doi:10.1007/bf00428927 · Cited by 58 · see citing works
Changes in morphine self-administration in rats induced by prostaglandin E1 and naloxone
Weeks, J. R., & Collins, R. J. (1976) · Prostaglandins · doi:10.1016/s0090-6980(76)80003-2 · Cited by 53 · see citing works
Stimulant self-administration by animals: some comparisons with opiate self-administration.
Thompson, T. N., & Pickens, R. W. (1970) · PubMed · Cited by 48 · see citing works
Magistretti, P. J., & Schorderet, M. (1979) · Life Sciences · doi:10.1016/0024-3205(79)90409-0 · Cited by 45 · see citing works
Smith, S. G., & Davis, W. M. (1973) · The Psychological Record · doi:10.1007/bf03394158 · Cited by 40 · see citing works
Regulation of Dopamine Synthesis in Rat Brain Striatal Synaptosomes
Patrick, R. L., Snyder, T. E., & Barchas, J. D. (1975) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)10688-3 · Cited by 31 · see citing works
A dose-response comparison between methadone and morphine self-administration
Werner, T. E., Smith, S. G., & Davis, W. M. (1976) · Psychopharmacology · doi:10.1007/bf00735825 · Cited by 28 · see citing works
Yokel, R. A., & Pickens, R. W. (1976) · Physiological Psychology · doi:10.3758/bf03326542 · Cited by 18 · see citing works
Thompson, T. I., Griffiths, R. R., & Pickens, R. W. (1973) · Bayer-Symposium · doi:10.1007/978-3-642-87987-6_12 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience?
Berridge, K. C., & Robinson, T. E. (1998) · Brain Research Reviews · doi:10.1016/s0165-0173(98)00019-8 · Cited by 4,127 · see citing works
Dopamine, learning and motivation.
Wise, R. A. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1406 · Cited by 3,379 · see citing works
Drug Addiction, Dysregulation of Reward, and Allostasis
Koob, G. (2001) · Neuropsychopharmacology · doi:10.1016/s0893-133x(00)00195-0 · Cited by 2,953 · see citing works
Self-citationA psychomotor stimulant theory of addiction.
Wise, R. A., & Bozarth, M. A. (1987) · Psychological Review · doi:10.1037/0033-295x.94.4.469 · Cited by 2,747 · see citing works
Drugs of abuse: anatomy, pharmacology and function of reward pathways
Koob, G. F. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90060-j · Cited by 2,070 · see citing works
Self-citationThe reinstatement model of drug relapse: history, methodology and major findings
Shaham, Y., Shalev, U., Lu, L., de Wit, H., & Stewart, J. (2003) · Psychopharmacology · doi:10.1007/s00213-002-1224-x · Cited by 1,615 · see citing works
Conditioned place preference: what does it add to our preclinical understanding of drug reward?
Bardo, M. T., & Bevins, R. A. (2000) · Psychopharmacology · doi:10.1007/s002130000569 · Cited by 1,233 · see citing works
Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway.
Spanagel, R., Herz, A., & Shippenberg, T. S. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.6.2046 · Cited by 1,005 · see citing works
Nucleus accumbens shell and core dopamine: differential role in behavior and addiction
Di Chiara, G. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00286-3 · Cited by 996 · see citing works
The dopamine hypothesis of the reinforcing properties of cocaine
Kuhar, M. J., Ritz, M. C., & Boja, J. W. (1991) · Trends in Neurosciences · doi:10.1016/0166-2236(91)90141-g · Cited by 989 · see citing works
The dopamine hypothesis of reward: past and current status
Spanagel, R., & Weiss, F. (1999) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01447-2 · Cited by 967 · see citing works
depue, R. A., & morrone-strupinsky, J. V. (2005) · Behavioral and Brain Sciences · doi:10.1017/s0140525x05000063 · Cited by 958 · see citing works
Pierce, R. C., & Kumaresan, V. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2005.04.016 · Cited by 913 · see citing works
Neurobiology of relapse to heroin and cocaine seeking: a review
Shalev, U., Grimm, J. W., & Shaham, Y. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.1.1 · Cited by 880 · see citing works
Addictive Drugs and Brain Stimulation Reward
Wise, R. A. (1996) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.19.030196.001535 · Cited by 792 · see citing works
Endogenous opioid systems and alcohol addiction
Herz, A. (1997) · Psychopharmacology · doi:10.1007/s002130050169 · Cited by 749 · see citing works
Psychobiology of novelty seeking and drug seeking behavior
Bardo, M. T., Donohew, R. L., & Harrington, N. G. (1996) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00203-0 · Cited by 667 · see citing works
Pettit, H. O., Ettenberg, A., Bloom, F. E., & Koob, G. F. (1984) · Psychopharmacology · doi:10.1007/bf00427441 · Cited by 651 · see citing works
Self-citationThe role of dopamine in drug abuse viewed from the perspective of its role in motivation
Chiara, G. D. (1995) · Drug and Alcohol Dependence · doi:10.1016/0376-8716(95)01118-i · Cited by 624 · see citing works
Neural Mechanisms of Drug Reinforcementa
Koob, G. F. (1992) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1992.tb25966.x · Cited by 607 · see citing works
Self-citationThe involvement of nucleus accumbens dopamine in appetitive and aversive motivation
Salamone, J. D. (1994) · Behavioural Brain Research · doi:10.1016/0166-4328(94)90153-8 · Cited by 584 · see citing works
Nicotine maintains robust self-administration in rats on a limited-access schedule
Corrigall, W. A., & Coen, K. M. (1989) · Psychopharmacology · doi:10.1007/bf00589894 · Cited by 578 · see citing works
Neurobiological mechanisms in the transition from drug use to drug dependence
Koob, G. F., Ahmed, S. H., Boutrel, B., Chen, S. A., Kenny, P. J., Markou, A., O’Dell, L. E., Parsons, L. H., & Sanna, P. P. (2003) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2003.11.007 · Cited by 576 · see citing works
Self-citationThe neurobiology of drug addiction
Koob, G. F., & Nestler, E. J. (1997) · Journal of Neuropsychiatry · doi:10.1176/jnp.9.3.482 · Cited by 572 · see citing works
Self-citationThe neurobiology of craving: Implications for the understanding and treatment of addiction.
Wise, R. A. (1988) · Journal of Abnormal Psychology · doi:10.1037/0021-843x.97.2.118 · Cited by 564 · see citing works
The neurobiology of social play behavior in rats
Vanderschuren, L. J. M. J., Niesink, R. J. M., & Van Pee, J. M. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00020-6 · Cited by 559 · see citing works
Markou, A., Weiss, F., Gold, L. H., Caine, S. B., Schulteis, G., & Koob, G. F. (1993) · Psychopharmacology · doi:10.1007/bf02244907 · Cited by 551 · see citing works
Self-citationChiara, G. D., & North, R. A. (1992) · Trends in Pharmacological Sciences · doi:10.1016/0165-6147(92)90062-b · Cited by 538 · see citing works
Salamone, J. D., Cousins, M. S., & Snyder, B. J. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00017-6 · Cited by 514 · see citing works
Ethanol increases the firing rate of dopamine neurons of the rat ventral tegmental area in vitro
Brodie, M. S., Shefner, S. A., & Dunwiddie, T. V. (1990) · Brain Research · doi:10.1016/0006-8993(90)91118-z · Cited by 485 · see citing works
The transition to compulsion in addiction
Lüscher, C., Robbins, T. W., & Everitt, B. J. (2020) · Nature reviews. Neuroscience · doi:10.1038/s41583-020-0289-z · Cited by 475 · see citing works
Opiate versus psychostimulant addiction: the differences do matter
Badiani, A., Belin, D., Epstein, D. H., Calu, D. J., & Shaham, Y. (2011) · Nature reviews. Neuroscience · doi:10.1038/nrn3104 · Cited by 466 · see citing works
Role of brain dopamine in food reward and reinforcement
Wise, R. A. (2006) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2006.1854 · Cited by 436 · see citing works
The role of reward pathways in the development of drug dependence
Wise, R. A. (1987) · Pharmacology & Therapeutics · doi:10.1016/0163-7258(87)90108-2 · Cited by 432 · see citing works
Absence of opiate rewarding effects in mice lacking dopamine D2 receptors
Maldonado, R. J., Saiardi, A., Valverde, O., Samad, T. A., Roques, B. P., & Borrelli, E. (1997) · Nature · doi:10.1038/41567 · Cited by 431 · see citing works
The neurocircuitry of addiction: an overview
Feltenstein, M. W., & See, R. E. (2008) · British Journal of Pharmacology · doi:10.1038/bjp.2008.51 · Cited by 421 · see citing works
Wise, R. A., & Robble, M. A. (2020) · Annual Review of Psychology · doi:10.1146/annurev-psych-010418-103337 · Cited by 418 · see citing works
Mello, N. K. (1996) · Neuropsychopharmacology · doi:10.1016/0893-133x(95)00274-h · Cited by 390 · see citing works
Electrophysiological Characterization of GABAergic Neurons in the Ventral Tegmental Area
Steffensen, S. C., Svingos, A. L., Pickel, V. M., & Henriksen, S. J. (1998) · Journal of Neuroscience · doi:10.1523/jneurosci.18-19-08003.1998 · Cited by 388 · see citing works
Pettit, H. O., & Justice, J. B. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(89)90291-8 · Cited by 375 · see citing works
Self-citationPersistent Increase in the Motivation to Take Heroin in Rats with a History of Drug Escalation
Ahmed, S. H. (2000) · Neuropsychopharmacology · doi:10.1016/s0893-133x(99)00133-5 · Cited by 361 · see citing works
Opioid receptors: drivers to addiction?
Darcq, E., & Kieffer, B. L. (2018) · Nature reviews. Neuroscience · doi:10.1038/s41583-018-0028-x · Cited by 354 · see citing works
One Is Not Enough: Understanding and Modeling Polysubstance Use
Crummy, E. A., O’Neal, T. J., Baskin, B. M., & Ferguson, S. M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00569 · Cited by 351 · see citing works
There and Back Again: A Tale of Norepinephrine and Drug Addiction
Weinshenker, D., & Schroeder, J. P. (2006) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301263 · Cited by 347 · see citing works
The Role of the Striatopallidal and Extended Amygdala Systems in Drug Addiction
Koob, G. F. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb09282.x · Cited by 322 · see citing works
Self-citationNeurobiology of Addiction: Toward the Development of New Therapies
Koob, G. F. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06682.x · Cited by 314 · see citing works
Self-citationVentral medial prefrontal cortex neuronal ensembles mediate context-induced relapse to heroin
Bossert, J. M., Stern, A. L., Theberge, F. R. M., Cifani, C., Koya, E., Hope, B. T., & Shaham, Y. (2011) · Nature Neuroscience · doi:10.1038/nn.2758 · Cited by 302 · see citing works
Opioids, Reward and Addiction: An Encounter of Biology, Psychology, and Medicine
van Ree, J. M., Gerrits, M. A. F. M., & Vanderschuren, L. J. M. J. (1999) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01405-4 · Cited by 300 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Opiate reward: Sites and substrates
Wise, R. A. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80021-1 · Cited by 286 · see citing works
Hemby, S. E., Co, C., Koves, T. R., Smith, J. E., & Dworkin, S. I. (1997) · Psychopharmacology · doi:10.1007/s002130050365 · Cited by 278 · see citing works
Selective dopamine antagonists reduce nicotine self-administration
Corrigall, W. A., & Coen, K. M. (1991) · Psychopharmacology · doi:10.1007/bf02244174 · Cited by 276 · see citing works
Localization of drug reward mechanisms by intracranial injections
Wise, R. A., & Hoffman, D. C. (1992) · Synapse · doi:10.1002/syn.890100307 · Cited by 276 · see citing works
Microinjection of cocaine into the nucleus accumbens elicits locomotor activation in the rat
Delfs, J. M., Schreiber, L., & Kelley, A. (1990) · Journal of Neuroscience · doi:10.1523/jneurosci.10-01-00303.1990 · Cited by 274 · see citing works
The D1 dopamine receptor antagonist SCH 23390 increases cocaine self-administration in the rat
Koob, G. F., Le, H. T., & Creese, I. (1987) · Neuroscience Letters · doi:10.1016/0304-3940(87)90451-4 · Cited by 274 · see citing works
Self-citationNeural Systems Underlying Opiate Addiction
De Vries, T. J., & Shippenberg, T. S. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-09-03321.2002 · Cited by 270 · see citing works
Controversies in translational research: drug self-administration.
Haney, M., & Spealman, R. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1079-x · Cited by 270 · see citing works
Vorel, S. R., Ashby, C. R., Paul, M., Liu, X., Hayes, R., Hagan, J. J., Middlemiss, D. N., Stemp, G., & Gardner, E. L. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09595.2002 · Cited by 269 · see citing works
Opponent process theory of motivation: Neurobiological evidence from studies of opiate dependence
Koob, G. F., Stinus, L., Moal, M. L., & Bloom, F. E. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80022-3 · Cited by 268 · see citing works
Self-citationConditioned Withdrawal Drives Heroin Consumption and Decreases Reward Sensitivity
Kenny, P. J., Chen, S. A., Kitamura, O., Markou, A., & Koob, G. F. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.0740-06.2006 · Cited by 268 · see citing works
Self-citationSwerdlow, N. R., Vaccarino, F. J., Amalric, M., & Koob, G. F. (1986) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(86)90261-3 · Cited by 259 · see citing works
Self-citationNeural substrates of conditioned-cued relapse to drug-seeking behavior
See, R. E. (2002) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00682-7 · Cited by 257 · see citing works
Excessive cocaine use results from decreased phasic dopamine signaling in the striatum
Willuhn, I., Burgeno, L. M., Groblewski, P. A., & Phillips, P. E. M. (2014) · Nature Neuroscience · doi:10.1038/nn.3694 · Cited by 257 · see citing works
Brain reward circuitry: Four circuit elements “wired” in apparent series
Wise, R. A., & Bozarth, M. A. (1984) · Brain Research Bulletin · doi:10.1016/0361-9230(84)90190-4 · Cited by 252 · see citing works
Markou, A., & Koob, G. F. (1992) · Physiology & Behavior · doi:10.1016/0031-9384(92)90211-j · Cited by 251 · see citing works
Self-citationBrain substrates for increased drug seeking during protracted withdrawal
Aston‐Jones, G., & Harris, G. C. (2004) · Neuropharmacology · doi:10.1016/j.neuropharm.2004.06.020 · Cited by 233 · see citing works
Zito, K. A., Vickers, G., & Roberts, D. C. S. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90110-8 · Cited by 228 · see citing works
Nicotine self-administration in rats
Donny, E. C., Caggiula, A. R., Knopf, S., & Brown, C. (1995) · Psychopharmacology · doi:10.1007/bf02246272 · Cited by 227 · see citing works
Neurobiology of relapse to alcohol in rats
Lê, A. D., & Shaham, Y. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00200-0 · Cited by 227 · see citing works
Weiss, F., Mitchiner, M., Bloom, F. E., & Koob, G. F. (1990) · Psychopharmacology · doi:10.1007/bf02244123 · Cited by 227 · see citing works
Self-citationBasal ganglia circuit loops, dopamine and motivation: a review and enquiry
Ikemoto, S., Yang, C., & Tan, A. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.04.018 · Cited by 226 · see citing works
“On the other hand, high doses of DA receptor antagonists diminish such self-administration behavior [46,47].”
Effect of dose on cocaine self-administration behavior and dopamine levels in the nucleus accumbens
Pettit, H. O., & Justice, J. B. (1991) · Brain Research · doi:10.1016/0006-8993(91)90690-w · Cited by 225 · see citing works
Self-citationBossert, J. M., Stern, A. L., Theberge, F. R. M., Marchant, N. J., Wang, H.-L., Morales, M., & Shaham, Y. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.0005-12.2012 · Cited by 223 · see citing works
Critical assessment of how to study addiction and its treatment: Human and non-human animal models
O’Brien, C. P., & Gardner, E. L. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2005.06.018 · Cited by 221 · see citing works
Neural Mechanisms of the Reinforcing Action of Cocaine
Wise, R. A. (1984) · PsycEXTRA Dataset · doi:10.1037/e497012006-003 · Cited by 219 · see citing works
The ventral pallidum plays a role in mediating cocaine and heroin self-administration in the rat
Hubner, C. B., & Koob, G. F. (1990) · Brain Research · doi:10.1016/0006-8993(90)91112-t · Cited by 218 · see citing works
Self-citationStewart, J. (1984) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(84)90017-0 · Cited by 210 · see citing works
Rogers, J. L., Ghee, S. M., & See, R. E. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.012 · Cited by 204 · see citing works
Bechara, A., & van der Kooy, D. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-10-03400.1989 · Cited by 204 · see citing works
Negus, S. S. (2002) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300096 · Cited by 203 · see citing works
Abuse and dependence liability of benzodiazepine-type drugs: GABAA receptor modulation and beyond
Licata, S. C., & Rowlett, J. K. (2008) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2008.01.001 · Cited by 201 · see citing works
Anderson, S. M., & Pierce, R. C. (2005) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2004.12.004 · Cited by 200 · see citing works
Vries, T. J. D., Homberg, J. R., Binnekade, R., Raasø, H. S., & Schoffelmeer, A. N. M. (2003) · Psychopharmacology · doi:10.1007/s00213-003-1422-1 · Cited by 197 · see citing works
Opponent Process Model and Psychostimulant Addiction
Koob, G. F., Caine, S. B., Parsons, L., Markou, A., & Weiss, F. (1997) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(96)00438-8 · Cited by 196 · see citing works
Self-citationShaham, Y., & Stewart, J. (1996) · Psychopharmacology · doi:10.1007/bf02246022 · Cited by 194 · see citing works
Dopamine signaling in the nucleus accumbens of animals self-administering drugs of abuse
Willuhn, I., Wanat, M. J., Clark, J. J., & Phillips, P. E. M. (2010) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2009_27 · Cited by 193 · see citing works
The predictive validity of the rat self-administration model for abuse liability
O’Connor, E. C., Chapman, K. L., Butler, P., & Mead, A. N. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.10.012 · Cited by 191 · see citing works
Wise, R. A., Leone, P., Rivest, R., & Leeb, K. (1995) · Synapse · doi:10.1002/syn.890210207 · Cited by 190 · see citing works
Flupenthixol as a potential pharmacotreatment of alcohol and cocaine abuse/dependence
Soyka, M., & Vry, J. D. (2000) · European Neuropsychopharmacology · doi:10.1016/s0924-977x(00)00088-2 · Cited by 187 · see citing works
Dopamine, addiction and reward
Koob, G. F. (1992) · Seminars in Neuroscience · doi:10.1016/1044-5765(92)90012-q · Cited by 184 · see citing works
Self-citationInvolvement of the Olfactory Tubercle in Cocaine Reward: Intracranial Self-Administration Studies
Ikemoto, S. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-28-09305.2003 · Cited by 183 · see citing works
Animal model for investigating the anxiogenic effects of self-administered cocaine
Ettenberg, A., & Geist, T. D. (1991) · Psychopharmacology · doi:10.1007/bf02244244 · Cited by 181 · see citing works
Self-citationCarelli, R. M., & Deadwyler, S. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-12-07735.1994 · Cited by 180 · see citing works
Mackey, W. B., & van der Kooy, D. (1985) · Pharmacology Biochemistry and Behavior · doi:10.1016/0091-3057(85)90492-7 · Cited by 179 · see citing works
Richardson, N. R., & Roberts, D. C. S. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90248-a · Cited by 178 · see citing works
Experimental approach to individual vulnerability to psychostimulant addiction
Deminiere, J. M., Piazza, P. V., Le Moal, M., & Simon, H. (1989) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(89)80023-5 · Cited by 177 · see citing works
Baclofen Inhibits Heroin Self-Administration Behavior and Mesolimbic Dopamine Release
Xi, Z.-X., & Stein, E. A. (1999) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35044-x · Cited by 177 · see citing works
Wise, R. A., Murray, A., & Bozarth, M. A. (1990) · Psychopharmacology · doi:10.1007/bf02244606 · Cited by 173 · see citing works
Vela, G., Martı́n, S., Garcı́a-Gil, L., Crespo, J. A., Ruiz‐Gayo, M., Fernández-Ruiz, J. J., Garcı́a-Lecumberri, C., Pélaprat, D., Fuentes, J. A., Ramos, J. A., et al. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00766-5 · Cited by 172 · see citing works
Blockade of nucleus accumbens opiate receptors attenuates intravenous heroin reward in the rat
Vaccarino, F. J., Bloom, F. E., & Koob, G. F. (1985) · Psychopharmacology · doi:10.1007/bf00431681 · Cited by 172 · see citing works
Self-citation
- Authors
- Ettenberg, A., Pettit, H. O., Bloom, F. E., & Koob, G. F.
- ORCID
- Koob, George F.
- Venue
- Psychopharmacology
- Published
- 1982-11
- Volume
- 78
- Issue
- 3
- Pages
- 204-209
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2047464854
- Cited by
- 563
- References
- 46
- Citations by year
- 2026: 5 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 13 · 2021: 6 · 2020: 16 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 18
- FWCI
- 2.31
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- heroin, cocaine, intravenous self-administration, drug reinforcement, opioid receptors, psychostimulants, naltrexone, alpha-flupenthixol, dopamine antagonists, opioid reinforcement, cocaine reinforcement
- MeSH terms
- Animals, Cocaine, Conditioning, Operant, Heroin, Dose-Response Relationship, Drug, Flupenthixol, Infusions, Parenteral, Male, Motor Activity, Naltrexone, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Opioid, Self Administration, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review