Cited by 563Neurotransmitter Receptor Influence on BehaviorNeuropeptides and Animal PhysiologyNeural and Behavioral Psychology Studies

Heroin and cocaine intravenous self-administration in rats: Mediation by separate neural systems

Ettenberg, Aaron, Pettit, Hugh O., Bloom, Floyd E., Koob, George F.·1982·Psychopharmacology

Abstract

The hypothesis that separate neural systems mediate the reinforcing properties of opiate and psychomotor stimulant drugs was tested in rats trained to lever-press of IV injections of either cocaine or heroin during daily 3-h sessions. Pretreatment with the opiate receptor antagonist drug naltrexone produced dose-dependent increases in heroin self-administration, but had no effect on the rate or pattern of cocaine self-administration. Similarly, pretreatment with low doses of the dopamine antagonist drug alpha-flupenthixol produced dose-dependent increases in cocaine but not heroin self-administration. High doses of alpha-flupenthixol eliminated all responding for cocaine and slightly reduced heroin self-administration. The specificity with which the two antagonist drugs exerted their behavioral effects strongly suggests that independent neural substrates are responsible for the reinforcing actions of heroin and cocaine.

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Crossref · 10.1007/bf00428151

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Authors
Ettenberg, A., Pettit, H. O., Bloom, F. E., & Koob, G. F.
Venue
Psychopharmacology
Published
1982-11
Volume
78
Issue
3
Pages
204-209
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W2047464854
Cited by
563
References
46
Citations by year
2026: 5 · 2025: 1 · 2024: 8 · 2023: 5 · 2022: 13 · 2021: 6 · 2020: 16 · 2019: 12 · 2018: 12 · 2017: 10 · 2016: 10 · 2015: 9 · 2014: 10 · 2013: 13 · 2012: 18
FWCI
2.31
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
heroin, cocaine, intravenous self-administration, drug reinforcement, opioid receptors, psychostimulants, naltrexone, alpha-flupenthixol, dopamine antagonists, opioid reinforcement, cocaine reinforcement
MeSH terms
Animals, Cocaine, Conditioning, Operant, Heroin, Dose-Response Relationship, Drug, Flupenthixol, Infusions, Parenteral, Male, Motor Activity, Naltrexone, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Opioid, Self Administration, Rats

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